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Reposted by Sophie Claudel, MD

Swapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · Jun 30

Design of the CURE study which we hope will disentangle the etiologies and mechanisms of CKDu (beyond mesoamerican nephropathy - there’s one site in India too, though not Sri Lanka ) www.kireports.org/article/S246... in @kireports.bsky.social
#NephSky

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Reposted by Sophie Claudel, MD

Swapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · Jun 5

The first #ERA25 simultaneous pub

CONFIDENCE trial of empagliflozin + finerenone in N = 579

Greater reduction in ACR and BP
Note the impressive GFR dip

www.nejm.org/doi/full/10....

Urinary Albumin-to-Creatinine Ratio, Serum Potassium Level, Estimated Glomerular Filtration Rate, and Systolic Blood Pressure over Time.

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Reposted by Sophie Claudel, MD

Nature Reviews Nephrology @natrevneph.nature.com · Apr 5

ICYMI:

Cardiovascular mortality increases with stage of cardiovascular–kidney–metabolic syndrome

Nature Reviews Nephrology, Published online: 31 March 2025; doi:10.1038/s41581-025-00957-yCardiovascular mortality increases with stage of cardiovascular–kidney–metabolic syndrome

www.nature.com

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Sophie Claudel, MD @sophieclaudel.bsky.social · Mar 27

Thank you @asnkidney.bsky.social for highlighting our work!

@ashunephro.bsky.social

ASN Publications @asnpublications.bsky.social · Mar 27

Cumulative Incidence of Mortality (CKM) syndrome stages 1 to 4 are associated with a graded risk of cardiovascular mortality in a nationally representative sample of U.S. adults. https://bit.ly/JASN0637
#ASNJASN
@ashunephro.bsky.social
@sophieclaudel.bsky.social

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Sophie Claudel, MD @sophieclaudel.bsky.social · Mar 25

Learned quite a lot about interactions, thresholds, and synergistic effects from @ashunephro.bsky.social in this analysis of albuminuria, heart failure, and CKD progression. Our findings emphasize albuminuria as a key biomarker for CKM health. 🫘
@jaccjournals.bsky.social #NephSky

Ashish Verma @ashunephro.bsky.social · Mar 24

Delighted to share our study published in @jaccjournals.bsky.social led by @sophieclaudel.bsky.social. We demonstrated deleterious synergy between albuminuria and heart failure as risk factors for CKD progression.
www.jacc.org/doi/10.1016/...

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Sophie Claudel, MD @sophieclaudel.bsky.social · Mar 11

Thank you @danieljdrucker.bsky.social !!

Daniel Drucker @danieljdrucker.bsky.social · Mar 10

All about albuminuria @ahascience.bsky.social www.ahajournals.org/doi/10.1161/...

Albuminuria in Cardiovascular, Kidney, and Metabolic Disorders: A State-of-the-Art Review | Circulation

Albuminuria—increased urine albumin excretion—is associated with cardiovascular mortality among patients with diabetes, hypertension, chronic kidney disease, or heart failure, as well as among adults ...

www.ahajournals.org

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Sophie Claudel, MD @sophieclaudel.bsky.social · Mar 11

Extremely grateful to @ahascience.bsky.social and @ashunephro.bsky.social for the opportunity to publish this comprehensive review on albuminuria in #Circulation. We cover albuminuria in the spectrum of #CKM disorders. Please take a look!
@nephjc.bsky.social #NephSky

Ashish Verma @ashunephro.bsky.social · Mar 10

Thrilled to share our state of art review led by extraordinary @sophieclaudel.bsky.social
“Albuminuria in Cardiovascular, Kidney, and Metabolic Disorders: A State-of-the-Art Review"
www.ahajournals.org/eprint/SXXGK...

@ahascience.bsky.social
@ahajournals.bsky.social
@asnkidney.bsky.social

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Sophie Claudel, MD @sophieclaudel.bsky.social · Mar 3

Thank you! And yes, I completely agree.

Sophie Claudel, MD @sophieclaudel.bsky.social · Mar 3

Very proud of our #BMCimRes internal medicine residents for coming up with this project idea and seeing it through to publication! We looked at current statin prescribing practices for young adults in the US and their CVD risk.

authors.elsevier.com/a/1khiu2gOwG...

authors.elsevier.com

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Sophie Claudel, MD @sophieclaudel.bsky.social · Feb 22

Excited to share this research letter looking at albuminuria values in healthy adults! We followed IFCC guidelines for establishing references ranges, which had not previously been shown in the literature, and consider what “normal” should be by sex.

Ashish Verma @ashunephro.bsky.social · Feb 21

We sought to quantify the upper limit of normal for albuminuria among US adults by the IFCC standard. Our study led by @sophieclaudel.bsky.social “Albuminuria References Ranges in Healthy US Adults”

academic.oup.com/jalm/advance...

Albuminuria References Ranges in Healthy US Adults

To the Editor:

academic.oup.com

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Sophie Claudel, MD @sophieclaudel.bsky.social · Feb 11

Very proud of this project that started as a casual conversation on #CKM syndrome with @ashunephro.bsky.social over a year ago and is now in print at #JASN! Couldn’t have done it without @ashunephro.bsky.social teaching me about cumulative incidence curves in #NHANES.

Ashish Verma @ashunephro.bsky.social · Feb 11

Thrilled to share our publication led by exceptional @sophieclaudel.bsky.social "Cumulative Incidence of Mortality Associated with Cardiovascular-Kidney-Metabolic Syndrome" in @asnpublications.bsky.social journals.lww.com/jasn/abstrac... @asnkidney.bsky.social @americanheart.bsky.social

Cumulative Incidence of Mortality Associated with... : Journal of the American Society of Nephrology

e corresponding restricted mean survival time over a 15-year period. Methods: This is a longitudinal study of 50,678 community-dwelling U.S. adults aged 20 and older with baseline data for CKM stag...

journals.lww.com

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Reposted by Sophie Claudel, MD

Ashish Verma @ashunephro.bsky.social · Feb 11

Thrilled to share our publication led by exceptional @sophieclaudel.bsky.social "Cumulative Incidence of Mortality Associated with Cardiovascular-Kidney-Metabolic Syndrome" in @asnpublications.bsky.social journals.lww.com/jasn/abstrac... @asnkidney.bsky.social @americanheart.bsky.social

Cumulative Incidence of Mortality Associated with... : Journal of the American Society of Nephrology

e corresponding restricted mean survival time over a 15-year period. Methods: This is a longitudinal study of 50,678 community-dwelling U.S. adults aged 20 and older with baseline data for CKM stag...

journals.lww.com

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Reposted by Sophie Claudel, MD

Yonah Freemark @yonahfreemark.com · Feb 10

The US DOT says it's planning to prioritize areas with high marriage & high birth rates for funding.

Our new analysis @urbaninstitute.bsky.social shows this would disproportionately fund:
—Communities with a higher white resident share
—Low-density areas
—High-income areas
—Car-dependent areas

DOT’s Plan to Distribute Funding by Birth and Marriage Rates Would Leave Communities Most In Need Behind

If enacted, the new US Department of Transportation memo would prioritize funding to whiter, higher-income, more car-dependent areas over communities of color and people who walk, bike, or take public...

www.urban.org

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Sophie Claudel, MD @sophieclaudel.bsky.social · Feb 11

Hyperaldosteronism in CKD (and CVD) is something I’ve been trying to learn more about recently. Hoping to join tonight! #nephjc

Nephrology Journal Club @nephjc.bsky.social · Feb 10

Think primary aldosteronism means hypertension, hypokalemia and metabolic alkalosis...think again. Can undercover hyperaldosteronism be a key to CKD?🔎
#NephJC chat 2/11/25 at 9pm EST #NephSky
www.nephjc.com/news/primary...

Undercover Aldosterone — NephJC

This week, we will discuss the origins of primary hyperaldosteronism in normotensive patients. Could this undetected anomaly be the cause of idiopathic hypertension and CKD?

www.nephjc.com

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Sophie Claudel, MD @sophieclaudel.bsky.social · Jan 6

Very proud of this work! Thanks to @ashunephro.bsky.social and co-mentors for their support of this project

Ashish Verma @ashunephro.bsky.social · Jan 6

Adults with higher levels of albuminuria within the low range (UACR <30 mg/g) and no major cardiovascular risk factors have higher risks of cardiovascular and all-cause mortality. academic.oup.com/eurjpc/artic... @sophieclaudel.bsky.social

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Sophie Claudel, MD @sophieclaudel.bsky.social · Dec 12

Very excited to share this work by my mentor Dr. Ashish Verma and me on #SDOH and #mortality among adults *without* major chronic diseases published in @JGIM! We looked at food insecurity, employment, income, acculturation, education and healthcare access.

link.springer.com/article/10.1...

Social Determinants of Health and Cumulative Incidence of Mortality Among US Adults Without Major Chronic Diseases - Journal of General Internal Medicine

Background Social determinants of health (SDOH) are associated with poor health outcomes among individuals with prevalent diseases. Objective To quantify the association between adverse SDOH and morta...

link.springer.com

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Sophie Claudel, MD @sophieclaudel.bsky.social · Nov 30

The post-Thanksgiving consult bolus is real… 🧂

Sophie Claudel, MD @sophieclaudel.bsky.social · Nov 20

Sophie, enjoying life as a renal fellow in Boston. No COI #NephJC

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Sophie Claudel, MD @sophieclaudel.bsky.social · Nov 17

NHANES 2021-2023 was recently released, but big changes in sampling methodology. And labs released so far don’t include a BMP or UACR! Hopefully soon?? HTN and DM prevalence pubs are out from CDC.

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Sophie Claudel, MD @sophieclaudel.bsky.social · Nov 16

You are too kind, Tony!! I’m excited to be a part of the #medsky community. Kidney content coming soon! 🫘