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Christian Steinmetzger

@stonebutcher.bsky.social

19 followers 33 following 4 posts

Senior research engineer in the group of Katja Petzold at Uppsala University: https://petzoldlab.com/ Interested in RNA chemical biology and structure, even better if some NMR is involved

petzoldlab.com

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Reposted by Christian Steinmetzger

Rubin Dasgupta @rubindg.bsky.social · 5d

Check out our latest #NMR study together with @stonebutcher.bsky.social at @katjapetzold.bsky.social lab on an intermediate state of #DNA existing between the well-known Watson–Crick-Franklin and Hoogsteen base pairs stabilised by an anticancer drug Actinomycin D www.biorxiv.org/content/10.1...

1H R1ρ Relaxation Identifies a Hidden Intermediate in DNA Base-Pairing

1H R1ρ Relaxation dispersion (RD) NMR experiments provide valuable atomic-level insights into transient, high-energy conformational states of biomolecules. However, cross-relaxation artifacts can hamp...

www.biorxiv.org

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Christian Steinmetzger @stonebutcher.bsky.social · Sep 8

Check out our new method for targeted DNP-enhanced NMR of RNA using site-directed spin labeling, now live as a preprint on ChemRxiv:

doi.org/10.26434/che...

A fruitful collaboration with my colleague @rubindg.bsky.social and the group of Prof. Snorri Th. Sigurdsson from the University of Iceland.

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Christian Steinmetzger @stonebutcher.bsky.social · Apr 6

If you are there: come see me at poster 110 on Tuesday and Thursday to learn about new developments in nucleic acid DNP measurements

Christian Steinmetzger @stonebutcher.bsky.social · Apr 6

Checked in at Asilomar and looking forward to a week of exciting science at the #ENCISMAR2025 conference in sunny Pacific Grove

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Reposted by Christian Steinmetzger

Nature Chemical Biology @natchembio.nature.com · Jan 14

A new paper from the Hoebartner Lab @UniWue @chlab.bsky.social reports the crystal structures of the ribozyme SAMURI, revealing the mechanism of its methyltransferase activity and site-selectivity

www.nature.com/articles/s41...

Structure and catalytic activity of the SAM-utilizing ribozyme SAMURI - Nature Chemical Biology

Crystal structures of the ribozyme SAMURI reveal the alkyltransferase mechanism and show N3-modified adenosine and dealkylated cofactor in the active site, allowing for a comparison with riboswitches ...

www.nature.com

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Reposted by Christian Steinmetzger

Gaston Courtade @gcourtade.bsky.social · Dec 4

Perspective by Higman et al: deposition of data for titrations, relaxation rates, PREs, etc in a standardized way, e.g. the NEF format could help develop AI models to accurately predict the dynamic behaviour of a protein from the primary sequence alone. #NMRchat

doi.org/10.1007/s108...

Perspective: on the importance of extensive, high-quality and reliable deposition of biomolecular NMR data in the age of artificial intelligence - Journal of Biomolecular NMR

Artificial intelligence (AI) models are revolutionising scientific data analysis but are reliant on large training data sets. While artificial training data can be used in the context of NMR processin...

doi.org

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Reposted by Christian Steinmetzger

ENC @enc-conference.org · Dec 4

Hi Team #NMRchat #NMR. Happy to see you out here!

Let's start spreading the word about the ENC-ISMAR Joint Conference, April 6-10, 2025.

Oral Abstract Deadline: January 10

www.enc-conference.org/enc-ismar-2025

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Reposted by Christian Steinmetzger

EHarris @nbgbgb.bsky.social · Dec 1

For the season that’s in it an NMR advent calendar for us Chemistry Nerds #Chemistry

www.nmr.chemistry.manchester.ac.uk/advent24/

Advent Calendar

www.nmr.chemistry.manchester.ac.uk

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Reposted by Christian Steinmetzger

Nadia Izadi-Pruneyre @nadia-izadi.bsky.social · Nov 25

📣📣 XIVth international conference on #NMR a tool for biology. May 26-28, 2025 @pasteur.fr Paris, France. The registration is open 👉 www.nmr2025.conferences-pasteur.org
Coorganized with
@brukercorporation.bsky.social

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Christian Steinmetzger @stonebutcher.bsky.social · Nov 23

The data browser used to be quite unreliable and slow for me in 4.x (at least on MacOS). TS 4.4.1 has significantly improved on that and now it works well again