Happy to share our 2025 “Open CNS” achievement! 🎉
Many thanks to my students and collaborators 🙏

Cell Reports: doi.org/10.1016/j.ce...
Nat Commun: doi.org/10.1038/s414...
Sci Adv: doi.org/10.1126/scia...

クテリオファージ由来の小型タンパク質LysMが、Lipid II フリッパーゼMurJの機能を阻害する様子をクライオ電子顕微鏡解析で明らかにしました。

Kohga et al., Sci. Adv. (2025)

t.co/u5ZibBF0kA

Our MurJ/LysM paper has been published in Science Advances.

Kohga et al., Sci. Adv. (2025).

This study elucidates, through cryo-electron microscopy, the mechanism by which the small bacteriophage-derived protein LysM inhibits the lipid II flippase MurJ.

t.co/u5ZibBF0kA

EurekAlert! 4-Aug-2025

Small protein, big impact: Insights into how bacteria stabilize a key outer membrane complex

www.eurekalert.org/news-release...

We revealed, through cryo-EM and functional analyses, that the small lipoprotein LptM stabilizes LptD at a late stage of LptDE complex maturation in the outer membrane.

Miyazaki et al., Cell Reports (2025)

www.cell.com/cell-reports...

Just posted on bioRxiv!

We reveal the structure of the MurJ/LysM (JM) complex.
A small phage protein, LysM (37 residues), binds to MurJ like a wedge and freezes its motion.

www.biorxiv.org/content/10.1...

Structural basis of a phosphotransferase system xylose transporter https://www.biorxiv.org/content/10.1101/2025.04.02.646771v1

I made a (quite incomplete) starter pack of Japanese or in-Japan researchers. Self-identify, and I will add you!
日本人/日本にいる研究者のスターターパックを作りました。リプしていただければ追加します！
go.bsky.app/7kMz86x

We captured the process of a substrate protein through a membrane using HS-AFM.
A string-like protein (peptide) is being translocated by a single SecYEG-SecA.

Kanaoka et al., Nature communications (2025)

www.nature.com/articles/s41...

タンパク質が膜透過する様子を高速AFMで捉えました １ユニットのSecYEG-SecAを、紐状のタンパク質（ペプチド）が通過しています

名古屋大学 内橋研、東京理科大学 森研 との共同研究です。

Kanaoka et al., Nature communications (2025)

www.nature.com/articles/s41...

Structural basis of lipopolysaccharide translocon assembly mediated by the small lipoprotein LptM https://www.biorxiv.org/content/10.1101/2025.01.03.631273v1

Structural basis of lipopolysaccharide translocon assembly mediated by the small lipoprotein LptM https://www.biorxiv.org/content/10.1101/2025.01.03.631273v1

doi.org/10.1101/2025...

LptM の機能とLptDEM複合体の構造解析です
bioRxiv にポストしました