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Amir Toor
@aat2357.bsky.social
180 followers 350 following 77 posts
Stem cell transplant physician; apply mathematics to immunology; Professor UTSW
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Amir Toor @aat2357.bsky.social · 13h
www.science.org/doi/10.1126/...
Germinal center–mediated broadening of B cell responses to SARS-CoV-2 booster immunization
SARS-CoV-2 variant booster vaccination broadens human B cell responses through the germinal center reaction.
www.science.org
Amir Toor @aat2357.bsky.social · 4d
www.nobelprize.org/prizes/physi...
Nobel Prize in Physics 2025
The Nobel Prize in Physics 2025 was awarded to John Clarke, Michel H. Devoret and John M. Martinis “for the discovery of macroscopic quantum mechanical tunnelling and energy quantisation in an electri...
www.nobelprize.org
Amir Toor @aat2357.bsky.social · 4d
www.science.org/content/arti...
New radioactive isotope therapies promise more targeted attacks on cancer
Recent clinical successes, and profits, have prompted a rush among pharma companies to try new isotopes and targeting strategies
www.science.org
Amir Toor @aat2357.bsky.social · 4d
www.science.org/doi/10.1126/...
The immunology of brain tumors
The cellular and molecular determinants of the antigenicity of brain tumors and the immunosuppressive brain tumor microenvironment are reviewed.
www.science.org
Amir Toor @aat2357.bsky.social · 12d
www.science.org/doi/10.1126/...
Adenosine 2A receptor–dependent activation of AMPK represses TH17 cell pathogenicity through epigenetic and metabolic reprogramming
Epigenetic reprogramming that promotes oxidative metabolism suppresses TH17 cell pathogenicity.
www.science.org
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Amir Toor @aat2357.bsky.social · 12d
www.science.org/doi/10.1126/...
Design of a potent interleukin-21 mimic for cancer immunotherapy
A de novo IL-21 mimic, 21h10, exhibits improved stability and potent antitumor activity in vivo compared with native IL-21.
www.science.org
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Reposted by Amir Toor
bloodjournals.hematology.org
Blood Journals' Portfolio @bloodjournals.hematology.org · Sep 8
T-cell lymphopenia characterizes immunodeficiency in a broad spectrum of TBDs. buff.ly/6B7IlyR #hemesky
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Amir Toor @aat2357.bsky.social · 19d
www.bbc.com/news/article...
Newcastle University hopes to improve sepsis treatment nationwide
Sepsis is treated by antibiotics but using the medication too much can lead to deadly superbugs.
www.bbc.com
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Amir Toor @aat2357.bsky.social · 24d
www.science.org/doi/10.1126/...
Interleukins 15 and 18 synergistically prime the antitumor function of natural killer cells through noncanonical activation of mTORC1
mTORC1 activation by components of a cytokine cocktail enhances NK cell cytotoxicity toward cancer cells.
www.science.org
Amir Toor @aat2357.bsky.social · 24d
www.science.org/doi/10.1126/...
Single-cell multiomics identifies Tcf1 and Lef1 as key initiators of early thymic progenitor fate
Tcf1 and Lef1 prime prethymic progenitors for Notch responsiveness, promoting early thymic progenitor fate and lineage stability.
www.science.org
Amir Toor @aat2357.bsky.social · 26d
www.science.org/doi/10.1126/...
Single-cell multiomics identifies Tcf1 and Lef1 as key initiators of early thymic progenitor fate
Tcf1 and Lef1 prime prethymic progenitors for Notch responsiveness, promoting early thymic progenitor fate and lineage stability.
www.science.org
Amir Toor @aat2357.bsky.social · Sep 10
www.science.org/doi/10.1126/...
Enkephalin-producing regulatory T cells in the skin restrain local inflammation through control of nociception
Regulatory T cells curb noxious sensory signaling to dampen cutaneous inflammation, a neuromodulatory mechanism for immunosuppression.
www.science.org
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Amir Toor @aat2357.bsky.social · Sep 7
www.nature.com/articles/d41...
Depriving brain tumours of an amino acid could enhance chemotherapy
Glioblastoma, an aggressive brain cancer, depends on the amino acid serine as a fuel source. A serine-deficient diet has been shown to slow tumour growth in mice.
www.nature.com
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Amir Toor @aat2357.bsky.social · Sep 7
www.nature.com/articles/d41...
Newfound immune cell in mice hints at why inflammation spikes with old age
Pathogen-consuming cells found in fat tissue also play a part in lipid balance.
www.nature.com
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Reposted by Amir Toor
science.org
Science Magazine @science.org · Sep 7
New research offers a glimpse of how RNA might have helped form the first simple proteins—an event that could have set the stage for evolution. https://scim.ag/466Rkz0
Here’s how the first proteins might have assembled, sparking life
RNA could have helped amino acids join up without preexisting protein machinery, lab study suggests
scim.ag
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Amir Toor @aat2357.bsky.social · Sep 7
www.nature.com/articles/d41...
Hope for diabetes: CRISPR-edited cells pump out insulin in a person – and evade immune detection
Edits create cells that don’t trigger an immune response, allowing implant recipient to forego immune-suppressing drugs.
www.nature.com
Reposted by Amir Toor
seanmcarroll.bsky.social
Sean Carroll @seanmcarroll.bsky.social · Aug 25
First day of classes at @jhuartssciences.bsky.social. A glorious day to learn #QuantumMechanics!

I'm teaching two courses - QM for physics majors, and Philosophy of Cosmology for a general audience. I'm going to try to maintain a thread saying what happens in each class, let's see how I do.
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Amir Toor @aat2357.bsky.social · Sep 1
Targeted Therapy of CAR+ T-Cell Lymphoma after Anti-BCMA CAR T-Cell Therapy | New England Journal of Medicine www.nejm.org/doi/full/10....
Targeted Therapy of CAR+ T-Cell Lymphoma after Anti-BCMA CAR T-Cell Therapy | NEJM
A rare T-cell lymphoma after chimeric antigen receptor (CAR) T-cell therapy for myeloma was linked to CCR4 overexpression and vector integration, which highlights the need for monitoring after CAR ...
www.nejm.org
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Amir Toor @aat2357.bsky.social · Sep 1
www.science.org/doi/10.1126/...
Mapping early human blood cell differentiation using single-cell proteomics and transcriptomics
Single-cell transcriptomics (scRNA-seq) has facilitated the characterization of cell state heterogeneity and recapitulation of differentiation trajectories. However, the exclusive use of mRNA measurem...
www.science.org
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Amir Toor @aat2357.bsky.social · Aug 29
www.science.org/doi/10.1126/...
Reprogramming intratumoral Treg cells by morpholino-mediated splicing of FOXP3 for cancer immunotherapy
Treg cells expressing a short FOXP3 isoform exhibit a TH-like cell phenotype with reduced suppressive function and mediate antitumor immunity.
www.science.org
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Amir Toor @aat2357.bsky.social · Aug 22
www.nejm.org/doi/full/10....
Overall Survival with Neoadjuvant Nivolumab plus Chemotherapy in Lung Cancer | NEJM
Neoadjuvant nivolumab plus chemotherapy significantly improved pathological complete response and event-free survival in patients with resectable non–small-cell lung cancer (NSCLC) in a phase 3 tri...
www.nejm.org
Amir Toor @aat2357.bsky.social · Jul 28
www.sciencedirect.com/science/arti...

Telomere length attrition possibly linked to alloreactivity following allogeneic HCT
Understanding Telomere Biology in Hematopoietic Cell Transplantation: A Dynamical Systems Perspective
T cell proliferation and repertoire reconstitution is a hallmark of successful hematopoietic cell transplantation (HCT). This process may be modeled a…
www.sciencedirect.com
Amir Toor @aat2357.bsky.social · Jul 5
www.dawn.com/news/1922222
Dangerous ‘new normal’
History is testimony to the fallacy that the use of force can bring peace and security.
www.dawn.com
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Amir Toor @aat2357.bsky.social · Jul 3
www.bbc.com/reel/video/p...
The butterfly effect: What is chaos theory?
The world was explained through the laws of physics until a meteorologist saw the pattern of chaos.
www.bbc.com
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Amir Toor @aat2357.bsky.social · Jul 3
www.bbc.com/reel/video/p...
What's inside a black hole?
Black holes are one of the mysteries of the universe where all the laws of nature as we know them stop working.
www.bbc.com
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