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Reposted by akheel sͩyͬed

Adhithya Sankar @adhithyasankar.bsky.social · 4d

Time for wider adoption of salivary cortisone in endocrinology?
@akheelsyed.bsky.social @addisonsdisease.bsky.social @socendocrinology.bsky.social #AdrenalInsufficiency #Endocrinology #SalivaryCortisone

jamanetwork.com/journals/jam...

Adult Adrenal Insufficiency

To the Editor In the recent Review on adrenal insufficiency in adults,1 the authors discussed noninvasive diagnostic approaches such as salivary cortisol sampling, which is widely used in the assessme...

jamanetwork.com

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akheel sͩyͬed @akheelsyed.bsky.social · 6d

Adult Adrenal Insufficiency url: jamanetwork.com/journals/jam...
The role and value of salivary Cortisone test in investigation of Adrenal Insufficiency in adults

Adult Adrenal Insufficiency

To the Editor In the recent Review on adrenal insufficiency in adults,1 the authors discussed noninvasive diagnostic approaches such as salivary cortisol sampling, which is widely used in the assessme...

jamanetwork.com

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Reposted by akheel sͩyͬed

Eric Topol @erictopol.bsky.social · 23d

More than 2 decades since GLP-1 drugs were introduced, we still don't know why people with diabetes lose about half as much weight as those without diabetes at the same dose
nature.com/articles/s41...

Effects of tirzepatide on weight management in patients with and without diabetes: a systematic review and meta-analysis - International Journal of Obesity

International Journal of Obesity - Effects of tirzepatide on weight management in patients with and without diabetes: a systematic review and meta-analysis

nature.com

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Reposted by akheel sͩyͬed

Eric Topol @erictopol.bsky.social · Sep 16

Big randomized trial of a GLP- pill (vs placebo) achieves significant weight loss
www.nejm.org/doi/full/10....

Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment | NEJM

Orforglipron, a small-molecule, nonpeptide oral glucagon-like peptide-1 (GLP-1) receptor agonist, is being investigated as a treatment for obesity. In this phase 3, multinational, randomized, doubl...

www.nejm.org

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akheel sͩyͬed @akheelsyed.bsky.social · Sep 6

Is that true? Actually, I don't want to know!

akheel sͩyͬed @akheelsyed.bsky.social · Sep 6

Obesity and Metabolic Syndrome: Current Insights and Future Directions. Zaiem Zarkasi, Rajshekhar N. Mudaliar, Waseem A. Majeed, and Akheel A. Syed.
British Journal of Hospital Medicine
www.magonlinelibrary.com/doi/full/10....

Obesity and Metabolic Syndrome: Current Insights and Future Directions | British Journal of Hospital Medicine

Obesity and metabolic syndrome are global health challenges, significantly increasing risks for type 2 diabetes, cardiovascular and cerebrovascular diseases, and overall mortality. This narrative revi...

www.magonlinelibrary.com

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akheel sͩyͬed @akheelsyed.bsky.social · Aug 21

“With only one other drug, resmetirom, specifically approved for the treatment of MASH, the new approval of semaglutide, a drug from a well known and widely used class of medications for type 2 diabetes and obesity, is most welcome.”
www.bmj.com/content/390/...

Semaglutide: FDA approves weight loss jab to treat severe liver disease

The US Food and Drug Administration has approved the weight loss drug semaglutide, marketed as Wegovy, for the treatment of patients with a severe form of liver disease called metabolic associated ste...

www.bmj.com

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akheel sͩyͬed @akheelsyed.bsky.social · Aug 20

Type 2 diabetes: SGLT-2 inhibitors to be offered as first line treatment in major guidance “shake-up”
www.bmj.com/content/390/...

Type 2 diabetes: SGLT-2 inhibitors to be offered as first line treatment in major guidance “shake-up”

Doctors could soon be offering sodium-glucose cotransporter-2 (SGLT-2) inhibitors as a first line treatment option for all patients with diabetes, not just those with heart disease.1 The change has b...

www.bmj.com

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akheel sͩyͬed @akheelsyed.bsky.social · May 17

Incretin-based therapies delay gastric emptying and therefore may reduce the absorption of any oral component of HRT. @annicemukherjeemd.bsky.social et al.

pubmed.ncbi.nlm.nih.gov/40378270/

Use of incretin-based therapies in women using hormone replacement therapy (HRT) - PubMed

Use of incretin-based therapies in women using hormone replacement therapy (HRT)

pubmed.ncbi.nlm.nih.gov

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akheel sͩyͬed @akheelsyed.bsky.social · Apr 17

In this study, more than half the patients with hyperthyroidism had ≥10% peak weight gain after treatment. We need to acknowledge, recognise and manage this issue better.
pubmed.ncbi.nlm.nih.gov/40238086/

Severity of thyrotoxicosis is a risk factor for excessive weight gain in treated hyperthyroidism - PubMed

More than half the patients with hyperthyroidism had ≥10% PWG post-treatment. Indicators of disease severity, namely disease-related weight loss and baseline thyroid hormones, were predictive of exces...

pubmed.ncbi.nlm.nih.gov

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akheel sͩyͬed @akheelsyed.bsky.social · Apr 16

annicemukherjeemd.bsky.social et al discuss considerations when prescribing incretin-based therapies in women using HRT during the menopause transition and postmenopause; and
thebms.org.uk/2025/04/new-...

NEW BMS Tool for Clinicians – Use of incretin-based therapies in women using HRT

thebms.org.uk

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akheel sͩyͬed @akheelsyed.bsky.social · Feb 23

Aisha Awan and colleagues argue for nationally funded training programmes for the integration of displaced refugee and asylum seeking healthcare professionals @bmj.com

www.bmj.com/content/388/...

Training refugee and asylum seeking healthcare professionals: an ethical approach to UK workforce challenges

Aisha Awan and colleagues argue for nationally funded training programmes for the integration of displaced refugee and asylum seeking healthcare professionals Wars in Gaza, Lebanon, Sudan, Syria, Ukr...

www.bmj.com

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Reposted by akheel sͩyͬed

Eric Topol @erictopol.bsky.social · Feb 18

A new way to measure your food intake, from your 💩
www.nature.com/articles/s42...
www.nature.com/articles/s42...
"proof-of-concept for detailed tracking of
individual-specific, health-relevant dietary patterns without the need for questionnaires."

Querying stool for dietary information - Nature Metabolism

Accurately determining food intake remains a substantial challenge in nutrition research. This issue of Nature Metabolism introduces a methodology for assessing dietary intake, using stool metagenomic...

www.nature.com

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Reposted by akheel sͩyͬed

annicemukherjeemd.bsky.social @annicemukherjeemd.bsky.social · Feb 18

Thanks for sharing 🙏🏻
This review is open access and aimed at all health professionals involved in menopause care

akheel sͩyͬed @akheelsyed.bsky.social · Feb 17

Very comprehensive review by two top experts in the field.

onlinelibrary.wiley.com/doi/10.1111/...

Update on Menopause Hormone Therapy; Current Indications and Unanswered Questions

Objective To provide clinicians involved in managing menopause with a summary of current evidence surrounding menopause hormone therapy (MHT). Design The authors evaluate and synthesize existing p...

onlinelibrary.wiley.com

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akheel sͩyͬed @akheelsyed.bsky.social · Feb 17

Very comprehensive review by two top experts in the field.

onlinelibrary.wiley.com/doi/10.1111/...

Update on Menopause Hormone Therapy; Current Indications and Unanswered Questions

Objective To provide clinicians involved in managing menopause with a summary of current evidence surrounding menopause hormone therapy (MHT). Design The authors evaluate and synthesize existing p...

onlinelibrary.wiley.com

1

akheel sͩyͬed @akheelsyed.bsky.social · Feb 11

Good, educational case report 👍
As low-grade TPOAb positivity is not uncommon in the background population, was it an innocent bystander with no predictive value for TED? Or a marker of general autoimmune tendency thereby indicating risk for de novo TRAb production?

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akheel sͩyͬed @akheelsyed.bsky.social · Feb 7

Obesity is the third most important predictor of heart disease. We discuss pathophysiology and management including roles of anti-obesity medications and bariatric surgery.
@ncaresearchnhs.bsky.social

www.sciencedirect.com/science/arti...

Obesity Management for Patients with Coronary Artery Disease and Heart Failure

www.sciencedirect.com

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akheel sͩyͬed @akheelsyed.bsky.social · Feb 3

Accurate prediction of long-term postoperative weight loss is important for advising patients undergoing bariatric surgery.
@adhithyasankar.bsky.social et al.
pubmed.ncbi.nlm.nih.gov/39887840/

@ncaresearchnhs.bsky.social

Actual weight loss trajectories after bariatric surgery compared with the SOPHIA prediction tool: An observational comparison study - PubMed

The SOPHIA study tool provides accurate postoperative weight forecasts for some subgroups of patients, but its precision diminishes with time. This study reiterates the necessity for better personaliz...

pubmed.ncbi.nlm.nih.gov

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Reposted by akheel sͩyͬed

Adhithya Sankar @adhithyasankar.bsky.social · Jan 30

How well can we predict weight loss after bariatric surgery?

Our study assessed the SOPHIA weight prediction tool in our patient population.

dom-pubs.pericles-prod.literatumonline.com/doi/10.1111/...

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akheel sͩyͬed @akheelsyed.bsky.social · Jan 29

We need to embrace multimodality approaches to the treatment of chronic obesity
link.springer.com/article/10.1...

Endoscopic Sleeve Gastroplasty for Obesity Management Should Also Be a Consideration in Patients Unsuitable for Anti-obesity Medications - Obesity Surgery

Obesity Surgery -

link.springer.com

Reposted by akheel sͩyͬed

Eric Topol @erictopol.bsky.social · Jan 10

Combining GLP-1 and insulin for Type 1 diabetes: a small randomized trial showed reduced insulin need, less carbohydrate intake, better glucose regulation, and reduced body weight
www.nature.com/articles/s41...

Subcutaneous weekly semaglutide with automated insulin delivery in type 1 diabetes: a double-blind, randomized, crossover trial - Nature Medicine

In a crossover trial evaluating semaglutide versus placebo as an add-on to automated insulin delivery therapy in adults with type 1 diabetes, the use of semaglutide was associated with an increased pe...

www.nature.com

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akheel sͩyͬed @akheelsyed.bsky.social · Dec 19

Original English language version here:
pubmed.ncbi.nlm.nih.gov/39433316/

Cushing disease presenting with hypertension in association with nonfunctioning unilateral adrenal adenoma - PubMed

Cushing disease presenting with hypertension in association with nonfunctioning unilateral adrenal adenoma

pubmed.ncbi.nlm.nih.gov

akheel sͩyͬed @akheelsyed.bsky.social · Dec 19

A young woman with hypertension, adrenal nodule and hypercortisolism. Adrenal Cushing syndrome, right? Read our article if you enjoy a twist in the tale, republished in the French language edition of CMAJ.
pubmed.ncbi.nlm.nih.gov/39681364/

Maladie de Cushing et hypertension liées à un adénome surrénal unilatéral non fonctionnel - PubMed

Maladie de Cushing et hypertension liées à un adénome surrénal unilatéral non fonctionnel

pubmed.ncbi.nlm.nih.gov

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Reposted by akheel sͩyͬed

Endocrine Oncology @endocrineoncology.bsky.social · Dec 17

We are thrilled to join the endocrine cancer community here on Bluesky 🎉 Let’s connect!

We’re a society-endorsed, #OpenAccess journal publishing research on the interplay between hormones and cancer, and related topics.

Learn more 👉 eo.bioscientifica.com

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