akheel sͩyͬed
@akheelsyed.bsky.social
Consultant Endocrinologist and Professor
Salford Royal, Manchester Academic Health Science Centre, University of Manchester
Salford Royal, Manchester Academic Health Science Centre, University of Manchester
Reposted by akheel sͩyͬed
Thymic hyperplasia:
Thymic hyperplasia, common in children and adolescents, is unusual in adults owing to age-related involution.
➡️ www.cmaj.ca/lookup/doi/10.1503/cmaj.250929
Thymic hyperplasia, common in children and adolescents, is unusual in adults owing to age-related involution.
➡️ www.cmaj.ca/lookup/doi/10.1503/cmaj.250929
Thymic hyperplasia in an adult with Graves disease
A 47-year-old man with discomfort in the upper chest, difficulty swallowing food and drinks, and weight loss of 10 kg over 2 months underwent computed tomography (CT), which excluded malignancy but sh...
www.cmaj.ca
November 24, 2025 at 6:30 PM
Thymic hyperplasia:
Thymic hyperplasia, common in children and adolescents, is unusual in adults owing to age-related involution.
➡️ www.cmaj.ca/lookup/doi/10.1503/cmaj.250929
Thymic hyperplasia, common in children and adolescents, is unusual in adults owing to age-related involution.
➡️ www.cmaj.ca/lookup/doi/10.1503/cmaj.250929
Jack Roddy, Shaishav Dhage and Akheel Syed.
@ncaresearchnhs.bsky.social
Treat the Graves' hyperthyroidism and the thymic hyperplasia resolves.
www.cmaj.ca/content/197/...
@ncaresearchnhs.bsky.social
Treat the Graves' hyperthyroidism and the thymic hyperplasia resolves.
www.cmaj.ca/content/197/...
Thymic hyperplasia in an adult with Graves disease
A 47-year-old man with discomfort in the upper chest, difficulty swallowing food and drinks, and weight loss of 10 kg over 2 months underwent computed tomography (CT), which excluded malignancy but sh...
www.cmaj.ca
November 24, 2025 at 12:05 PM
Jack Roddy, Shaishav Dhage and Akheel Syed.
@ncaresearchnhs.bsky.social
Treat the Graves' hyperthyroidism and the thymic hyperplasia resolves.
www.cmaj.ca/content/197/...
@ncaresearchnhs.bsky.social
Treat the Graves' hyperthyroidism and the thymic hyperplasia resolves.
www.cmaj.ca/content/197/...
Long-term outcomes of Roux-en-Y gastric bypass in the adolescent population: a systematic review and single-arm meta-analysis - Surgery for Obesity and Related Diseases www.soard.org/article/S155...
Long-term outcomes of Roux-en-Y gastric bypass in the adolescent population: a systematic review and single-arm meta-analysis
Long-term outcomes of Roux-en-Y gastric bypass (RYGB) in adolescents are limited.
This systematic review and meta-analysis evaluates the safety and efficacy of RYGB
in adolescents with obesity. A comp...
www.soard.org
November 2, 2025 at 10:35 PM
Long-term outcomes of Roux-en-Y gastric bypass in the adolescent population: a systematic review and single-arm meta-analysis - Surgery for Obesity and Related Diseases www.soard.org/article/S155...
Reposted by akheel sͩyͬed
Time for wider adoption of salivary cortisone in endocrinology?
@akheelsyed.bsky.social @addisonsdisease.bsky.social @socendocrinology.bsky.social #AdrenalInsufficiency #Endocrinology #SalivaryCortisone
jamanetwork.com/journals/jam...
@akheelsyed.bsky.social @addisonsdisease.bsky.social @socendocrinology.bsky.social #AdrenalInsufficiency #Endocrinology #SalivaryCortisone
jamanetwork.com/journals/jam...
Adult Adrenal Insufficiency
To the Editor In the recent Review on adrenal insufficiency in adults,1 the authors discussed noninvasive diagnostic approaches such as salivary cortisol sampling, which is widely used in the assessme...
jamanetwork.com
October 17, 2025 at 9:00 AM
Time for wider adoption of salivary cortisone in endocrinology?
@akheelsyed.bsky.social @addisonsdisease.bsky.social @socendocrinology.bsky.social #AdrenalInsufficiency #Endocrinology #SalivaryCortisone
jamanetwork.com/journals/jam...
@akheelsyed.bsky.social @addisonsdisease.bsky.social @socendocrinology.bsky.social #AdrenalInsufficiency #Endocrinology #SalivaryCortisone
jamanetwork.com/journals/jam...
Adult Adrenal Insufficiency url: jamanetwork.com/journals/jam...
The role and value of salivary Cortisone test in investigation of Adrenal Insufficiency in adults
The role and value of salivary Cortisone test in investigation of Adrenal Insufficiency in adults
Adult Adrenal Insufficiency
To the Editor In the recent Review on adrenal insufficiency in adults,1 the authors discussed noninvasive diagnostic approaches such as salivary cortisol sampling, which is widely used in the assessme...
jamanetwork.com
October 15, 2025 at 8:58 PM
Adult Adrenal Insufficiency url: jamanetwork.com/journals/jam...
The role and value of salivary Cortisone test in investigation of Adrenal Insufficiency in adults
The role and value of salivary Cortisone test in investigation of Adrenal Insufficiency in adults
Reposted by akheel sͩyͬed
More than 2 decades since GLP-1 drugs were introduced, we still don't know why people with diabetes lose about half as much weight as those without diabetes at the same dose
nature.com/articles/s41...
nature.com/articles/s41...
Effects of tirzepatide on weight management in patients with and without diabetes: a systematic review and meta-analysis - International Journal of Obesity
International Journal of Obesity - Effects of tirzepatide on weight management in patients with and without diabetes: a systematic review and meta-analysis
nature.com
September 28, 2025 at 2:45 PM
More than 2 decades since GLP-1 drugs were introduced, we still don't know why people with diabetes lose about half as much weight as those without diabetes at the same dose
nature.com/articles/s41...
nature.com/articles/s41...
Reposted by akheel sͩyͬed
Big randomized trial of a GLP- pill (vs placebo) achieves significant weight loss
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment | NEJM
Orforglipron, a small-molecule, nonpeptide oral glucagon-like peptide-1 (GLP-1) receptor
agonist, is being investigated as a treatment for obesity. In this phase 3, multinational,
randomized, doubl...
www.nejm.org
September 16, 2025 at 11:33 PM
Big randomized trial of a GLP- pill (vs placebo) achieves significant weight loss
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
Obesity and Metabolic Syndrome: Current Insights and Future Directions. Zaiem Zarkasi, Rajshekhar N. Mudaliar, Waseem A. Majeed, and Akheel A. Syed.
British Journal of Hospital Medicine
www.magonlinelibrary.com/doi/full/10....
British Journal of Hospital Medicine
www.magonlinelibrary.com/doi/full/10....
Obesity and Metabolic Syndrome: Current Insights and Future Directions | British Journal of Hospital Medicine
Obesity and metabolic syndrome are global health challenges, significantly increasing risks for type 2 diabetes, cardiovascular and cerebrovascular diseases, and overall mortality. This narrative revi...
www.magonlinelibrary.com
September 6, 2025 at 8:18 PM
Obesity and Metabolic Syndrome: Current Insights and Future Directions. Zaiem Zarkasi, Rajshekhar N. Mudaliar, Waseem A. Majeed, and Akheel A. Syed.
British Journal of Hospital Medicine
www.magonlinelibrary.com/doi/full/10....
British Journal of Hospital Medicine
www.magonlinelibrary.com/doi/full/10....
“With only one other drug, resmetirom, specifically approved for the treatment of MASH, the new approval of semaglutide, a drug from a well known and widely used class of medications for type 2 diabetes and obesity, is most welcome.”
www.bmj.com/content/390/...
www.bmj.com/content/390/...
Semaglutide: FDA approves weight loss jab to treat severe liver disease
The US Food and Drug Administration has approved the weight loss drug semaglutide, marketed as Wegovy, for the treatment of patients with a severe form of liver disease called metabolic associated ste...
www.bmj.com
August 21, 2025 at 5:06 PM
“With only one other drug, resmetirom, specifically approved for the treatment of MASH, the new approval of semaglutide, a drug from a well known and widely used class of medications for type 2 diabetes and obesity, is most welcome.”
www.bmj.com/content/390/...
www.bmj.com/content/390/...
Type 2 diabetes: SGLT-2 inhibitors to be offered as first line treatment in major guidance “shake-up”
www.bmj.com/content/390/...
www.bmj.com/content/390/...
Type 2 diabetes: SGLT-2 inhibitors to be offered as first line treatment in major guidance “shake-up”
Doctors could soon be offering sodium-glucose cotransporter-2 (SGLT-2) inhibitors as a first line treatment option for all patients with diabetes, not just those with heart disease.1
The change has b...
www.bmj.com
August 20, 2025 at 7:00 PM
Type 2 diabetes: SGLT-2 inhibitors to be offered as first line treatment in major guidance “shake-up”
www.bmj.com/content/390/...
www.bmj.com/content/390/...
Incretin-based therapies delay gastric emptying and therefore may reduce the absorption of any oral component of HRT. @annicemukherjeemd.bsky.social et al.
pubmed.ncbi.nlm.nih.gov/40378270/
pubmed.ncbi.nlm.nih.gov/40378270/
Use of incretin-based therapies in women using hormone replacement therapy (HRT) - PubMed
Use of incretin-based therapies in women using hormone replacement therapy (HRT)
pubmed.ncbi.nlm.nih.gov
May 17, 2025 at 11:57 AM
Incretin-based therapies delay gastric emptying and therefore may reduce the absorption of any oral component of HRT. @annicemukherjeemd.bsky.social et al.
pubmed.ncbi.nlm.nih.gov/40378270/
pubmed.ncbi.nlm.nih.gov/40378270/
In this study, more than half the patients with hyperthyroidism had ≥10% peak weight gain after treatment. We need to acknowledge, recognise and manage this issue better.
pubmed.ncbi.nlm.nih.gov/40238086/
pubmed.ncbi.nlm.nih.gov/40238086/
Severity of thyrotoxicosis is a risk factor for excessive weight gain in treated hyperthyroidism - PubMed
More than half the patients with hyperthyroidism had ≥10% PWG post-treatment. Indicators of disease severity, namely disease-related weight loss and baseline thyroid hormones, were predictive of exces...
pubmed.ncbi.nlm.nih.gov
April 17, 2025 at 6:45 PM
In this study, more than half the patients with hyperthyroidism had ≥10% peak weight gain after treatment. We need to acknowledge, recognise and manage this issue better.
pubmed.ncbi.nlm.nih.gov/40238086/
pubmed.ncbi.nlm.nih.gov/40238086/
annicemukherjeemd.bsky.social et al discuss considerations when prescribing incretin-based therapies in women using HRT during the menopause transition and postmenopause; and
thebms.org.uk/2025/04/new-...
thebms.org.uk/2025/04/new-...
NEW BMS Tool for Clinicians – Use of incretin-based therapies in women using HRT
NEW BMS Tool for Clinicians – Use of incretin-based therapies in women using HRT
thebms.org.uk
April 16, 2025 at 8:05 PM
annicemukherjeemd.bsky.social et al discuss considerations when prescribing incretin-based therapies in women using HRT during the menopause transition and postmenopause; and
thebms.org.uk/2025/04/new-...
thebms.org.uk/2025/04/new-...
Aisha Awan and colleagues argue for nationally funded training programmes for the integration of displaced refugee and asylum seeking healthcare professionals @bmj.com
www.bmj.com/content/388/...
www.bmj.com/content/388/...
Training refugee and asylum seeking healthcare professionals: an ethical approach to UK workforce challenges
Aisha Awan and colleagues argue for nationally funded training programmes for the integration of displaced refugee and asylum seeking healthcare professionals
Wars in Gaza, Lebanon, Sudan, Syria, Ukr...
www.bmj.com
February 23, 2025 at 11:21 AM
Aisha Awan and colleagues argue for nationally funded training programmes for the integration of displaced refugee and asylum seeking healthcare professionals @bmj.com
www.bmj.com/content/388/...
www.bmj.com/content/388/...
Reposted by akheel sͩyͬed
A new way to measure your food intake, from your 💩
www.nature.com/articles/s42...
www.nature.com/articles/s42...
"proof-of-concept for detailed tracking of
individual-specific, health-relevant dietary patterns without the need for questionnaires."
www.nature.com/articles/s42...
www.nature.com/articles/s42...
"proof-of-concept for detailed tracking of
individual-specific, health-relevant dietary patterns without the need for questionnaires."
Querying stool for dietary information - Nature Metabolism
Accurately determining food intake remains a substantial challenge in nutrition research. This issue of Nature Metabolism introduces a methodology for assessing dietary intake, using stool metagenomic...
www.nature.com
February 18, 2025 at 2:06 PM
A new way to measure your food intake, from your 💩
www.nature.com/articles/s42...
www.nature.com/articles/s42...
"proof-of-concept for detailed tracking of
individual-specific, health-relevant dietary patterns without the need for questionnaires."
www.nature.com/articles/s42...
www.nature.com/articles/s42...
"proof-of-concept for detailed tracking of
individual-specific, health-relevant dietary patterns without the need for questionnaires."
Reposted by akheel sͩyͬed
Thanks for sharing 🙏🏻
This review is open access and aimed at all health professionals involved in menopause care
This review is open access and aimed at all health professionals involved in menopause care
February 18, 2025 at 1:37 PM
Thanks for sharing 🙏🏻
This review is open access and aimed at all health professionals involved in menopause care
This review is open access and aimed at all health professionals involved in menopause care
Obesity is the third most important predictor of heart disease. We discuss pathophysiology and management including roles of anti-obesity medications and bariatric surgery.
@ncaresearchnhs.bsky.social
www.sciencedirect.com/science/arti...
@ncaresearchnhs.bsky.social
www.sciencedirect.com/science/arti...
Obesity Management for Patients with Coronary Artery Disease and Heart Failure
www.sciencedirect.com
February 7, 2025 at 3:03 PM
Obesity is the third most important predictor of heart disease. We discuss pathophysiology and management including roles of anti-obesity medications and bariatric surgery.
@ncaresearchnhs.bsky.social
www.sciencedirect.com/science/arti...
@ncaresearchnhs.bsky.social
www.sciencedirect.com/science/arti...
Accurate prediction of long-term postoperative weight loss is important for advising patients undergoing bariatric surgery.
@adhithyasankar.bsky.social et al.
pubmed.ncbi.nlm.nih.gov/39887840/
@ncaresearchnhs.bsky.social
@adhithyasankar.bsky.social et al.
pubmed.ncbi.nlm.nih.gov/39887840/
@ncaresearchnhs.bsky.social
Actual weight loss trajectories after bariatric surgery compared with the SOPHIA prediction tool: An observational comparison study - PubMed
The SOPHIA study tool provides accurate postoperative weight forecasts for some subgroups of patients, but its precision diminishes with time. This study reiterates the necessity for better personaliz...
pubmed.ncbi.nlm.nih.gov
February 3, 2025 at 9:23 PM
Accurate prediction of long-term postoperative weight loss is important for advising patients undergoing bariatric surgery.
@adhithyasankar.bsky.social et al.
pubmed.ncbi.nlm.nih.gov/39887840/
@ncaresearchnhs.bsky.social
@adhithyasankar.bsky.social et al.
pubmed.ncbi.nlm.nih.gov/39887840/
@ncaresearchnhs.bsky.social
Reposted by akheel sͩyͬed
How well can we predict weight loss after bariatric surgery?
Our study assessed the SOPHIA weight prediction tool in our patient population.
dom-pubs.pericles-prod.literatumonline.com/doi/10.1111/...
Our study assessed the SOPHIA weight prediction tool in our patient population.
dom-pubs.pericles-prod.literatumonline.com/doi/10.1111/...
January 30, 2025 at 11:36 AM
How well can we predict weight loss after bariatric surgery?
Our study assessed the SOPHIA weight prediction tool in our patient population.
dom-pubs.pericles-prod.literatumonline.com/doi/10.1111/...
Our study assessed the SOPHIA weight prediction tool in our patient population.
dom-pubs.pericles-prod.literatumonline.com/doi/10.1111/...
We need to embrace multimodality approaches to the treatment of chronic obesity
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Endoscopic Sleeve Gastroplasty for Obesity Management Should Also Be a Consideration in Patients Unsuitable for Anti-obesity Medications - Obesity Surgery
Obesity Surgery -
link.springer.com
January 29, 2025 at 7:47 PM
We need to embrace multimodality approaches to the treatment of chronic obesity
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Reposted by akheel sͩyͬed
Combining GLP-1 and insulin for Type 1 diabetes: a small randomized trial showed reduced insulin need, less carbohydrate intake, better glucose regulation, and reduced body weight
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Subcutaneous weekly semaglutide with automated insulin delivery in type 1 diabetes: a double-blind, randomized, crossover trial - Nature Medicine
In a crossover trial evaluating semaglutide versus placebo as an add-on to automated insulin delivery therapy in adults with type 1 diabetes, the use of semaglutide was associated with an increased pe...
www.nature.com
January 10, 2025 at 5:53 PM
Combining GLP-1 and insulin for Type 1 diabetes: a small randomized trial showed reduced insulin need, less carbohydrate intake, better glucose regulation, and reduced body weight
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A young woman with hypertension, adrenal nodule and hypercortisolism. Adrenal Cushing syndrome, right? Read our article if you enjoy a twist in the tale, republished in the French language edition of CMAJ.
pubmed.ncbi.nlm.nih.gov/39681364/
pubmed.ncbi.nlm.nih.gov/39681364/
Maladie de Cushing et hypertension liées à un adénome surrénal unilatéral non fonctionnel - PubMed
Maladie de Cushing et hypertension liées à un adénome surrénal unilatéral non fonctionnel
pubmed.ncbi.nlm.nih.gov
December 19, 2024 at 8:44 PM
A young woman with hypertension, adrenal nodule and hypercortisolism. Adrenal Cushing syndrome, right? Read our article if you enjoy a twist in the tale, republished in the French language edition of CMAJ.
pubmed.ncbi.nlm.nih.gov/39681364/
pubmed.ncbi.nlm.nih.gov/39681364/
Reposted by akheel sͩyͬed
We are thrilled to join the endocrine cancer community here on Bluesky 🎉 Let’s connect!
We’re a society-endorsed, #OpenAccess journal publishing research on the interplay between hormones and cancer, and related topics.
Learn more 👉 eo.bioscientifica.com
We’re a society-endorsed, #OpenAccess journal publishing research on the interplay between hormones and cancer, and related topics.
Learn more 👉 eo.bioscientifica.com
December 17, 2024 at 2:46 PM
We are thrilled to join the endocrine cancer community here on Bluesky 🎉 Let’s connect!
We’re a society-endorsed, #OpenAccess journal publishing research on the interplay between hormones and cancer, and related topics.
Learn more 👉 eo.bioscientifica.com
We’re a society-endorsed, #OpenAccess journal publishing research on the interplay between hormones and cancer, and related topics.
Learn more 👉 eo.bioscientifica.com