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alcesbioworks.bsky.social
Alces Bioworks, Inc.
@alcesbioworks.bsky.social
12 followers 50 following 9 posts
Alces Bioworks uses revolutionary protein design technologies to create superior affinity reagents for its customers. Affinity reagents made better and faster. https://www.alcesbioworks.com
www.alcesbioworks.com
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Reposted by Alces Bioworks, Inc.
pdbeurope.bsky.social
Protein Data Bank in Europe (PDBe) @pdbeurope.bsky.social · 10d
AlphaFold DB v6 (synced with UniProt 2025_03) is live! Here are the details:
Totals v4 → v6: 241,070,489 entries.
Since v4: +65,711,653 added, 39,324,993 removed, 276,539 changed (in sequence), 175,082,297 unchanged (metadata refresh, relabelled v6). Details 👇
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Reposted by Alces Bioworks, Inc.
science.org
Science Magazine @science.org · 10d
Scientists have designed an interleukin-21 mimic with increased stability and capacity to induce more potent antitumor activity than the native protein, which could inform improved #immunotherapies.

Learn more in #ScienceImmunology: https://scim.ag/47jQLSW
Design of a potent interleukin-21 mimic for cancer immunotherapy
A de novo IL-21 mimic, 21h10, exhibits improved stability and potent antitumor activity in vivo compared with native IL-21.
scim.ag
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Reposted by Alces Bioworks, Inc.
bpdmc.org
Boston Protein Design and Modeling Club @bpdmc.org · 13d
Join us in Room 181, Building 68 @mit.edu on October 22nd 2025 @ 7pm EDT to see @grocklin.bsky.social present a mind blowing amount of data and learn what becomes possible at this scale

"Predicting protein folding stability and aggregation propensity using large-scale experiments"

bpdmc.org
schedule
introduction and membership Boston Protein Design and Modeling Club (BPDMC) is a community of computational protein engineers and modelers from both academia and industry. While we are based in Boston...
bpdmc.org
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Reposted by Alces Bioworks, Inc.
nature.com
Nature @nature.com · 14d
Success rates for Europe’s leading research grants are declining as a surge in applications far outweighs the funds available

go.nature.com/479Sni6
Is academic research becoming too competitive? Nature examines the data
Applications for European research grants increased in 2025. Scientists say they’re feeling the competition.
go.nature.com
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alcesbioworks.bsky.social
Alces Bioworks, Inc. @alcesbioworks.bsky.social · 14d
Nabla expects first-in-human data from its AI-designed molecules within one to two years, according to Reuters.
cenmag.bsky.social C&EN (Chemical & Engineering News) @cenmag.bsky.social · 14d
Takeda Pharmaceuticals and Nabla Bio, a start-up focused on designing de novo proteins with artificial intelligence, have signed a second round of collaboration.
cen.acs.org/pharmaceutic... #chemsky 🧪
AI-based protein discovery start-up strikes a second deal with Takeda
Nabla Bio's platform is becoming popular with big pharma companies
cen.acs.org
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Reposted by Alces Bioworks, Inc.
chadbourn.bsky.social
Mark Chadbourn @chadbourn.bsky.social · 14d
On course to end new HIV cases in the UK by 2030.
First injection to stop HIV approved
The shot, given six times a year or every other month, is an alternative to taking daily pills to protect against ever catching the virus.
www.bbc.com
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Reposted by Alces Bioworks, Inc.
klanglab.bsky.social
Kathrin Lang @klanglab.bsky.social · 15d
🚨Our paper is out! 🥳
Hijacking a bacterial ABC transporter for efficient genetic code expansion.
Many congrats to everyone involved - a multi-year effort led by @taruniype.bsky.social @maxfottner.bsky.social
www.nature.com/articles/s41...

it all started years ago with a failed experiment
🧵👇 1/9
Hijacking a bacterial ABC transporter for genetic code expansion - Nature
Bacterial ATP-binding cassette (ABC) transporters can be utilized and engineered to transport non-canonical amino acids into Escherichia coli for highly efficient synthesis of proteins with novel func...
www.nature.com
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alcesbioworks.bsky.social
Alces Bioworks, Inc. @alcesbioworks.bsky.social · Sep 26
A new blog post on our website: how to measure binding affinity of an Alcein!

alcesbioworks.com/how-we-measu...
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Reposted by Alces Bioworks, Inc.
science.org
Science Magazine @science.org · Sep 22
At the Berlin node of a global hackathon, teams raced to develop artificial intelligence tools to accelerate the design of drugs and materials. https://scim.ag/3VuZyvR
Researchers customize AI tools at global ‘hackathon’
More than 1200 scientists and developers explore how large language models can be applied to materials science and chemistry
www.science.org
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Reposted by Alces Bioworks, Inc.
financialtimes.com
Financial Times @financialtimes.com · Sep 22
Nvidia to invest up to $100bn in OpenAI on.ft.com/4mxtu5N
Nvidia to invest up to $100bn in OpenAI
Partnership will support massive build-out of data centres for artificial intelligence
on.ft.com
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Reposted by Alces Bioworks, Inc.
timosborne.ca
Tim Osborne Photography 🍁 @timosborne.ca · Sep 15
Always nice to see a moose while out in the woods. Also a note that wildlife photographers have long lenses that make subjects look much closer than they are. Always wise to give moose a lot of space! #wildlife #moose
A bull moose with a nice set of antlers seen in the woods.
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Reposted by Alces Bioworks, Inc.
alcesbioworks.bsky.social
Alces Bioworks, Inc. @alcesbioworks.bsky.social · Sep 5
New review on AI and protein design...

Code to complex: AI-driven de novo binder design: Structure www.cell.com/structure/fu...
Code to complex: AI-driven de novo binder design
In this review, Fox et al. discuss how artificial intelligence has transformed our ability to design new-to-nature proteins that bind target proteins with high affinity and specificity. The authors de...
www.cell.com
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alcesbioworks.bsky.social
Alces Bioworks, Inc. @alcesbioworks.bsky.social · Sep 5
New review on AI and protein design...

Code to complex: AI-driven de novo binder design: Structure www.cell.com/structure/fu...
Code to complex: AI-driven de novo binder design
In this review, Fox et al. discuss how artificial intelligence has transformed our ability to design new-to-nature proteins that bind target proteins with high affinity and specificity. The authors de...
www.cell.com
2 1
Reposted by Alces Bioworks, Inc.
alcesbioworks.bsky.social
Alces Bioworks, Inc. @alcesbioworks.bsky.social · Aug 20
We’re thrilled to announce that Alces Bioworks has joined the NVIDIA Inception program!

This supports our mission to create for our customers superior affinity reagents we call Alceins™.

#NVIDIAInception #AI #BiotechInnovation
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alcesbioworks.bsky.social
Alces Bioworks, Inc. @alcesbioworks.bsky.social · Aug 20
We’re thrilled to announce that Alces Bioworks has joined the NVIDIA Inception program!

This supports our mission to create for our customers superior affinity reagents we call Alceins™.

#NVIDIAInception #AI #BiotechInnovation
3 2
alcesbioworks.bsky.social
Alces Bioworks, Inc. @alcesbioworks.bsky.social · Jul 22
garymarcus.substack.com/p/deepmind-a...
DeepMind and OpenAI achieve IMO Gold. What does it all mean?
What we know, what we would like to know, and what it may take years to know
garymarcus.substack.com
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alcesbioworks.bsky.social
Alces Bioworks, Inc. @alcesbioworks.bsky.social · Jul 7
www.economist.com/science-and-...
AI is helping to design proteins from scratch
They could treat diseases, test drugs and boost crop yields
www.economist.com
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alcesbioworks.bsky.social
Alces Bioworks, Inc. @alcesbioworks.bsky.social · Jun 27
Alces Bioworks is happy to announce its new website! 🎉

www.alcesbioworks.com 🫎

Check it out and let us know what you think. 🧑‍🔬

If you need a new affinity reagent🧪, we are more than happy to take your order.
Al the lab moose - Alces Bioworks, Inc. (C) 2025
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alcesbioworks.bsky.social
Alces Bioworks, Inc. @alcesbioworks.bsky.social · Jun 17
Poorly performing antibodies have plagued biomedical sciences for decades...

www.nature.com/articles/d41...
The antibodies don’t work! The race to rid labs of molecules that ruin experiments
Poorly performing antibodies have plagued biomedical sciences for decades. Several fresh initiatives hope to change this.
www.nature.com
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alcesbioworks.bsky.social
Alces Bioworks, Inc. @alcesbioworks.bsky.social · Jun 17
A recent review of protein design by Zhang et al., 2025.

www.sciencedirect.com/science/arti...
Artificial intelligence methods for protein folding and design
Machine learning has revolutionized protein structure prediction and design. This review discusses current methods for protein folding and inverse fol…
www.sciencedirect.com
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