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Alfred Fischer @alfredodistefano.bsky.social · 1h

Remember

Alfred Fischer @alfredodistefano.bsky.social · 22h

New therapies for breast cancer are continually being sought and investigated.

#progress #oncology

breast-cancer-research.biomedcentral.com/articles/10....

Biliverdin reductase B as a new target in breast cancer - Breast Cancer Research

Background Enhanced metabolic and mitochondrial activity inherent in actively proliferating cancer cells is associated with intracellular redox imbalance that impacts cellular viability. To restore re...

breast-cancer-research.biomedcentral.com

Alfred Fischer @alfredodistefano.bsky.social · 22h

Fatigue in eBC patients is often associated with inflammatory markers.

#oncology #breastcancer

pmc.ncbi.nlm.nih.gov/articles/PMC...

Inflammation and dimensions of fatigue in women with early stage breast cancer: A longitudinal examination

Fatigue is a common and long‐lasting side effect of cancer. Although fatigue is a multidimensional symptom, biologic mechanisms of fatigue dimensions have not been identified. Women recently diagnosed...

pmc.ncbi.nlm.nih.gov

Alfred Fischer @alfredodistefano.bsky.social · 22h

10% of breast cancers are lobular

acsjournals.onlinelibrary.wiley.com/doi/full/10....

Lobular breast cancer statistics, 2025

Invasive lobular carcinoma is the second most common breast cancer subtype in the United States, with unique clinical characteristics that distinguish it from the more common ductal carcinoma. Despit...

acsjournals.onlinelibrary.wiley.com

Alfred Fischer @alfredodistefano.bsky.social · 22h

Occult malignancy (OM) is rarely identified in contralateral prophylactic mastectomy (CPM)

link.springer.com/article/10.1...

A Systematic Review of Occult Malignancy and Sentinel Lymph Node Metastasis at the Time of Contralateral Prophylactic Mastectomy - Annals of Surgical Oncology

Background Occult malignancy (OM) identified in contralateral prophylactic mastectomy (CPM) presents a challenge for axillary management. Methods This meta-analysis identified retrospective studies us...

link.springer.com

Alfred Fischer @alfredodistefano.bsky.social · 22h

Adiposity at T4 was significantly associated with overall and heart disease-specific mortality.

breast-cancer-research.biomedcentral.com/articles/10....

Association between thoracic adiposity and survival in non-metastatic breast cancer - Breast Cancer Research

Background Total adiposity measured by abdominal computed tomography (CT) at the third lumbar vertebrae (L3) has been associated with breast cancer survival, but most patients undergo chest CT. If adi...

breast-cancer-research.biomedcentral.com

Alfred Fischer @alfredodistefano.bsky.social · 22h

Reposted by Alfred Fischer

The OncoAlert Network 🚨 @oncoalert.bsky.social · 5d

Day 2 of #ESSO44 in Gothenburg Sweden, Presentation by Dr. Philipp Lennartsson 🇸🇪
Best Swedish Abstracts: The Role of Tumor Location in Pancreatic Cancer on Perioperative Outcome and Long-Term Survival

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Alfred Fischer @alfredodistefano.bsky.social · 5d

The human family tree is becoming increasingly complex

#evolution

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Alfred Fischer @alfredodistefano.bsky.social · 6d

Cancer is a very stressful disease, not only physically but also psychologically. A meta-analysis now shows that patients who have to endure this stress alone are more likely to die than those who have a supportive social environment.

doi.org/10.1136/bmjo...

Impact of loneliness on cancer mortality: a systematic review and meta-analysis

Objective Loneliness and social isolation can have profound emotional and psychological impact on patients with cancer. Previous studies suggest loneliness may adversely impact cancer prognosis and su...

doi.org

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Alfred Fischer @alfredodistefano.bsky.social · 6d

Jugendschutz versagt: E-Zigaretten sind Einstiegsdrogen www.arznei-telegramm.de/html/2025_09...

Jugendschutz versagt: E-Zigaretten sind Einstiegsdrogen

Nach Auswertung von 384 Studien speziell zu jungen Menschen sind E-Zigaretten mit einer erhöhten Wahrscheinlichkeit von nachfolgendem Konsum von Zigaretten, Alkohol, Marihuana u.a. assoziiert.

www.arznei-telegramm.de

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Alfred Fischer @alfredodistefano.bsky.social · 7d

Alfred Fischer @alfredodistefano.bsky.social · 8d

The basics about our body.
Book.

1

Alfred Fischer @alfredodistefano.bsky.social · 8d

About CML therapies.

podcasts.apple.com/at/podcast/o...

Treating and Managing Chronic Myeloid Leukemia (CML) in 2025: Dr. Jorge Cortes

Podcast-Folge · Oncology Brothers: Practice-Changing Cancer Discussions · 13.10.2025 · 20 Min.

podcasts.apple.com

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Alfred Fischer @alfredodistefano.bsky.social · 9d

In the US, only around half of men with metastatic castration-resistant prostate cancer (mCRPC) harboring BRCA1/2 alterations receive a PARP inhibitor

#oncology

jama.jamanetwork.com/article.aspx...

PARP Inhibitors in Metastatic Prostate Cancer Harboring BRCA1/2 Alterations

This cohort study assesses the use of poly(adenosine diphosphate-ribose) polymerase (PARP) inhibitors in patients with metastatic castration–resistant prostate cancer harboring BRCA1/2 alterations.

jama.jamanetwork.com

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Alfred Fischer @alfredodistefano.bsky.social · 9d

Frequent use of hair straighteners/relaxers was associated with a significantly increased incidence of pancreatic cancer.

academic.oup.com/jnci/advance...

Use of hair straighteners and chemical relaxers and incidence of non-reproductive cancers

AbstractBackground. Use of hair straighteners and chemical relaxers has been associated with increased incidence of breast, uterine, and ovarian cancers. H

academic.oup.com

Alfred Fischer @alfredodistefano.bsky.social · 9d

www.cancertherapyadvisor.com/news/medicai...

Medicaid Expansion Linked to Improved Survival Outcomes in Cancer Patients

Survival benefits were seen in patients in rural or high-poverty communities, as well as in patients with a cancer generally linked to a worse prognosis, study researchers reported.

www.cancertherapyadvisor.com

Alfred Fischer @alfredodistefano.bsky.social · 12d

An alternative to classical surgery in breast cancer.

#cryotherapy

www.medscape.com/viewarticle/...

Cryotherapy Alternative to Lumpectomy Wins FDA Marketing Nod

For some older women with early breast cancer, lumpectomy may no longer be necessary.

www.medscape.com

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Alfred Fischer @alfredodistefano.bsky.social · 14d

Gedatolisib was tested with palbociclib in a phase Ib study.

#breastcancer

aacrjournals.org/clincancerre...

Gedatolisib Combined with Palbociclib and Letrozole in Patients with No Prior Systemic Therapy for Hormone Receptor–Positive, HER2-Negative Advanced Breast Cancer

AbstractPurpose:. Nonclinical evidence demonstrating that estrogen receptor, cyclin-dependent kinases 4 and 6 (CDK4/6), and PI3K/AKT/mTOR (PAM) pathways cross-promote tumor proliferation in hormone re...

aacrjournals.org

Alfred Fischer @alfredodistefano.bsky.social · 14d

To switch the CDK In in second line helps.

#breastcancer

t.co/le0TNbSehV

https://www.esmoopen.com/article/S2059-7029(25)01677-1/fulltext

t.co

Alfred Fischer @alfredodistefano.bsky.social · 14d

Epidemiological development of breast cancer in the USA.

Link.

breast-cancer-research.biomedcentral.com/articles/10....

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Alfred Fischer @alfredodistefano.bsky.social · 18d

Die Imago des Schmetterlings lebt oft nicht lange. Ist oft so

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Alfred Fischer @alfredodistefano.bsky.social · 20d

Haben sich eh aufgelehnt. Siehe die großen Revolutionen. Brauchte seine Zeit.

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Alfred Fischer @alfredodistefano.bsky.social · 21d

Breast Cancer Awareness Month

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Alfred Fischer @alfredodistefano.bsky.social · 22d

Previous data suggest synergy between PARP inhibition and immune checkpoint blockade in different genetic settings.

Here a phase II trial in HR+/HER2- patients.

aacrjournals.org/clincancerre...

Combination of olaparib, durvalumab and fulvestrant in patients with advanced ER+/HER2- breast cancer and selected genomic alterations: results of the DOLAF trial

Abstract. Purpose: Previous data suggest synergy between PARP inhibition and immune checkpoint blockade in different genetic settings. The estrogen receptor (ER) pathway remains a key target in metast...

aacrjournals.org