Alfred Fischer
@alfredodistefano.bsky.social
I love science, studied biology and am working with cancer drugs.
Twitter in German: https://x.com/alfredfischer17?s=21
Twitter in German: https://x.com/alfredfischer17?s=21
Immunotherapy is best administered in the morning.
Immune check point therapy
Chronotherapy
Chronobiology
www.ejcancer.com/article/S095...
Immune check point therapy
Chronotherapy
Chronobiology
www.ejcancer.com/article/S095...
Early morning immune checkpoint blockade and overall survival of patients with metastatic cancer: An In-depth chronotherapeutic study
Recent retrospective studies suggest potential large patient’s benefit through proper
timing of immune checkpoint blockers (ICB). The association between ICB treatment
timing and patient survival, neo...
www.ejcancer.com
December 9, 2025 at 9:56 AM
Immunotherapy is best administered in the morning.
Immune check point therapy
Chronotherapy
Chronobiology
www.ejcancer.com/article/S095...
Immune check point therapy
Chronotherapy
Chronobiology
www.ejcancer.com/article/S095...
In this study, tamoxifen and anastrozole appear to be equally effective.
Over 10 years, in low-risk patients,
equal overall survival (OS) and locoregional recurrence (LRR) rates!
#oncology #breastcancer #medication #research #pharmaceuticals
Over 10 years, in low-risk patients,
equal overall survival (OS) and locoregional recurrence (LRR) rates!
#oncology #breastcancer #medication #research #pharmaceuticals
December 8, 2025 at 5:05 PM
In this study, tamoxifen and anastrozole appear to be equally effective.
Over 10 years, in low-risk patients,
equal overall survival (OS) and locoregional recurrence (LRR) rates!
#oncology #breastcancer #medication #research #pharmaceuticals
Over 10 years, in low-risk patients,
equal overall survival (OS) and locoregional recurrence (LRR) rates!
#oncology #breastcancer #medication #research #pharmaceuticals
CDK2 inhibition enhances CDK4/6 inhibitor antitumor activity.
#breast #cancer
pubmed.ncbi.nlm.nih.gov/41339342/
#breast #cancer
pubmed.ncbi.nlm.nih.gov/41339342/
CDK2 inhibition enhances CDK4/6 inhibitor antitumor activity in comprehensive breast cancer PDX model screen - PubMed
Aberrant cyclin-dependent kinase 2 (CDK2) activity is implicated as a resistance mechanism to CDK4/6 inhibitors (CDK4/6i) in hormone receptor-positive (HR+)/human epidermal growth factor receptor 2-negative (HER2-) breast cancer. Using preclinical patient-derived xenograft models, the CDK2i + CDK4/6 …
pubmed.ncbi.nlm.nih.gov
December 8, 2025 at 4:57 PM
CDK2 inhibition enhances CDK4/6 inhibitor antitumor activity.
#breast #cancer
pubmed.ncbi.nlm.nih.gov/41339342/
#breast #cancer
pubmed.ncbi.nlm.nih.gov/41339342/
Inflammatory breast cancer is very aggressive.
The aggressive biology of IBC may override any additional risks imposed by a postpartum diagnosis.
pubmed.ncbi.nlm.nih.gov/40938309/
The aggressive biology of IBC may override any additional risks imposed by a postpartum diagnosis.
pubmed.ncbi.nlm.nih.gov/40938309/
Impact of Postpartum Diagnosis on Survival of Women with Inflammatory Breast Cancer - PubMed
Unlike in noninflammatory invasive breast cancer, postpartum diagnosis did not negatively affect prognosis in IBC. These findings highlight the continuing need to identify unique drivers of aggressive biology in IBC.
pubmed.ncbi.nlm.nih.gov
December 8, 2025 at 4:53 PM
Inflammatory breast cancer is very aggressive.
The aggressive biology of IBC may override any additional risks imposed by a postpartum diagnosis.
pubmed.ncbi.nlm.nih.gov/40938309/
The aggressive biology of IBC may override any additional risks imposed by a postpartum diagnosis.
pubmed.ncbi.nlm.nih.gov/40938309/
Among Chinese women with breast cancer, long-term aspirin use was associated with improved IDFS
pubmed.ncbi.nlm.nih.gov/40986335/
pubmed.ncbi.nlm.nih.gov/40986335/
Aspirin Use and Risk of Breast Cancer Recurrence in Chinese Patients - PubMed
This study provides real-world evidence from an Asian cohort supporting a possible role of aspirin in reducing breast cancer recurrence risk.
pubmed.ncbi.nlm.nih.gov
December 8, 2025 at 4:49 PM
Among Chinese women with breast cancer, long-term aspirin use was associated with improved IDFS
pubmed.ncbi.nlm.nih.gov/40986335/
pubmed.ncbi.nlm.nih.gov/40986335/
With adequate follow-up, distant disease-free survival (DDFS) is a robust surrogate endpoint for predicting final overall survival outcomes in neoadjuvant RCTs for early breast cancer
pubmed.ncbi.nlm.nih.gov/41308675/
pubmed.ncbi.nlm.nih.gov/41308675/
Distant disease-free survival as a surrogate endpoint for overall survival in randomised trials of neoadjuvant therapy for early breast cancer: a pooled analysis of GBG and AGO-B Study Group trials - PubMed
None.
pubmed.ncbi.nlm.nih.gov
December 8, 2025 at 4:48 PM
With adequate follow-up, distant disease-free survival (DDFS) is a robust surrogate endpoint for predicting final overall survival outcomes in neoadjuvant RCTs for early breast cancer
pubmed.ncbi.nlm.nih.gov/41308675/
pubmed.ncbi.nlm.nih.gov/41308675/
For both pre- and postmenopausal patients with stage I–III, T1–T3 tumors and low genomic risk, either medication (Tamoxifen or AI) appears equally effective over a decade
www.americanjournalofsurgery.com/article/S000...
www.americanjournalofsurgery.com/article/S000...
Is Anastrozole Really Better Than Tamoxifen for Low-Risk Breast Cancer?
In 2002, the ATAC trial (Arimidex, Tamoxifen, Alone or in Combination) established
anastrozole as the preferred adjuvant treatment over tamoxifen in postmenopausal women
(disease-free survival at 89.4...
www.americanjournalofsurgery.com
December 8, 2025 at 4:39 PM
For both pre- and postmenopausal patients with stage I–III, T1–T3 tumors and low genomic risk, either medication (Tamoxifen or AI) appears equally effective over a decade
www.americanjournalofsurgery.com/article/S000...
www.americanjournalofsurgery.com/article/S000...
A 400-mg ribociclib starting dose did not match the efficacy of 600 mg in HR+/ERBB2− advanced breast cancer, but had similar progression-free survival and fewer adverse events, supporting 600 mg as the standard dose with reduction to manage toxicity.
jamanetwork.com/journals/jam...
jamanetwork.com/journals/jam...
600- vs 400-mg First-Line Ribociclib in HR+/ERBB2− Advanced Breast Cancer
This randomized clinical trial examines whether a 400-mg ribociclib starting dose can reduce the incidence of adverse events while maintaining efficacy in advanced breast cancer.
jamanetwork.com
December 6, 2025 at 2:05 PM
A 400-mg ribociclib starting dose did not match the efficacy of 600 mg in HR+/ERBB2− advanced breast cancer, but had similar progression-free survival and fewer adverse events, supporting 600 mg as the standard dose with reduction to manage toxicity.
jamanetwork.com/journals/jam...
jamanetwork.com/journals/jam...
Late-onset depression occurred in 13.3% of breast cancer survivors, 11.8% of colorectal cancer survivors, and 8.7% of prostate cancer survivors in the study.
#psychology #oncology
jamanetwork.com/journals/jam...
#psychology #oncology
jamanetwork.com/journals/jam...
Risk of Late-Onset Depression in Long-Term Cancer Survivors
This cohort study of survivors of breast, prostate, or colorectal cancer examines risk factors associated with late-onset depression.
jamanetwork.com
December 5, 2025 at 10:13 AM
Late-onset depression occurred in 13.3% of breast cancer survivors, 11.8% of colorectal cancer survivors, and 8.7% of prostate cancer survivors in the study.
#psychology #oncology
jamanetwork.com/journals/jam...
#psychology #oncology
jamanetwork.com/journals/jam...
Regular opioid treatment can increase the risk of six different cancers: lung, pancreas, bladder, esophagus, oropharynx, and larynx.
doi.org/10.1016/j.ec...
doi.org/10.1016/j.ec...
Redirecting
doi.org
December 5, 2025 at 10:09 AM
Regular opioid treatment can increase the risk of six different cancers: lung, pancreas, bladder, esophagus, oropharynx, and larynx.
doi.org/10.1016/j.ec...
doi.org/10.1016/j.ec...
Can dogs smell malignant breast cancer?
Results show limited ability to distinguish benign from malignant lesions.
www.nature.com/articles/s41...
Results show limited ability to distinguish benign from malignant lesions.
www.nature.com/articles/s41...
A prospective trial for breast cancer diagnosis by canine odorology - Nature Communications
Dog olfaction has been reported to detect different human diseases, including cancer. Here, the authors present a trial where two trained dogs are exposed to human sweat samples to identify breast can...
www.nature.com
December 1, 2025 at 9:35 PM
Can dogs smell malignant breast cancer?
Results show limited ability to distinguish benign from malignant lesions.
www.nature.com/articles/s41...
Results show limited ability to distinguish benign from malignant lesions.
www.nature.com/articles/s41...
Every cancer patient benefits enormously from exercise.
Exercise is as effective as a pill.
#oncology #cancer
ascopubs.org/doi/10.1200/...
Exercise is as effective as a pill.
#oncology #cancer
ascopubs.org/doi/10.1200/...
If Exercise Were a Pill, We'd All Prescribe It to Patients With Cancer. But It's Not
ascopubs.org
December 1, 2025 at 9:26 PM
Every cancer patient benefits enormously from exercise.
Exercise is as effective as a pill.
#oncology #cancer
ascopubs.org/doi/10.1200/...
Exercise is as effective as a pill.
#oncology #cancer
ascopubs.org/doi/10.1200/...
Radiotherapy among breast cancer survivors was not significantly associated with increased overall CVD risk
#oncology
link.springer.com/article/10.1...
#oncology
link.springer.com/article/10.1...
Cardiovascular disease risk following radiotherapy among breast cancer survivors: a nationwide cohort study in South Korea - Breast Cancer Research
Background While radiotherapy (RT) improves breast cancer survival outcomes, concerns persist regarding radiation-induced cardiovascular complications. We aimed to evaluate the incidence and risk of r...
link.springer.com
December 1, 2025 at 9:17 PM
Radiotherapy among breast cancer survivors was not significantly associated with increased overall CVD risk
#oncology
link.springer.com/article/10.1...
#oncology
link.springer.com/article/10.1...
Radiation De-Escalation in Older Women with Breast Cancer.
Patients who are eligible for omission but opt to receive radiotherapy should be considered for PB or UHF radiotherapy regimens.
pubmed.ncbi.nlm.nih.gov/41276771/?ut...
Patients who are eligible for omission but opt to receive radiotherapy should be considered for PB or UHF radiotherapy regimens.
pubmed.ncbi.nlm.nih.gov/41276771/?ut...
Radiation De-Escalation in Older Women with Early-Stage ER+/HER2- Invasive Breast Cancer - PubMed
Despite efforts to promote treatment de-escalation, rates for omission of post-lumpectomy radiotherapy have decreased over time. To avoid overtreatment, patients who are eligible for omission but opt to receive radiotherapy should be considered for PB or UHF radiotherapy regimens.
pubmed.ncbi.nlm.nih.gov
December 1, 2025 at 9:11 PM
Radiation De-Escalation in Older Women with Breast Cancer.
Patients who are eligible for omission but opt to receive radiotherapy should be considered for PB or UHF radiotherapy regimens.
pubmed.ncbi.nlm.nih.gov/41276771/?ut...
Patients who are eligible for omission but opt to receive radiotherapy should be considered for PB or UHF radiotherapy regimens.
pubmed.ncbi.nlm.nih.gov/41276771/?ut...
UK said prostate-specific antigen (PSA) testing alone could not be justified for population screening.
Likely to cause more harm than good - except for BRCA mutated
nationalscreening.blog.gov.uk/2025/11/28/u...
Likely to cause more harm than good - except for BRCA mutated
nationalscreening.blog.gov.uk/2025/11/28/u...
UK NSC opens consultation on draft prostate cancer screening recommendation
The UK NSC has opened a public consultation on the evidence relating to screening for prostate cancer.
nationalscreening.blog.gov.uk
December 1, 2025 at 9:49 AM
UK said prostate-specific antigen (PSA) testing alone could not be justified for population screening.
Likely to cause more harm than good - except for BRCA mutated
nationalscreening.blog.gov.uk/2025/11/28/u...
Likely to cause more harm than good - except for BRCA mutated
nationalscreening.blog.gov.uk/2025/11/28/u...
Getting grey hair is a good sign.
Scientists have discovered that the loss of hair color is closely linked to mechanisms that recognize, repair, or selectively eliminate defective cells to prevent cancer.
t.co/zeMNBUUlpx
Scientists have discovered that the loss of hair color is closely linked to mechanisms that recognize, repair, or selectively eliminate defective cells to prevent cancer.
t.co/zeMNBUUlpx
https://www.nature.com/articles/s41556-025-01769-9
t.co
November 28, 2025 at 10:44 AM
Getting grey hair is a good sign.
Scientists have discovered that the loss of hair color is closely linked to mechanisms that recognize, repair, or selectively eliminate defective cells to prevent cancer.
t.co/zeMNBUUlpx
Scientists have discovered that the loss of hair color is closely linked to mechanisms that recognize, repair, or selectively eliminate defective cells to prevent cancer.
t.co/zeMNBUUlpx
The frequent consumption of highly processed foods could explain the increase in colorectal cancer among younger adults.
#colonca #oncology #epidemiology
doi.org/10.1001/jama...
#colonca #oncology #epidemiology
doi.org/10.1001/jama...
Ultraprocessed Food and Early-Onset Colorectal Cancer Precursors Among Women
This study evaluates the association of the consumption of ultraprocessed foods and the risk of early-onset colorectal cancer (<50 years) in participants of the Nurses’ Health Study II.
doi.org
November 28, 2025 at 10:13 AM
The frequent consumption of highly processed foods could explain the increase in colorectal cancer among younger adults.
#colonca #oncology #epidemiology
doi.org/10.1001/jama...
#colonca #oncology #epidemiology
doi.org/10.1001/jama...
Excess Weight Linked to Increased Risk for Early-Onset Pancreatic Cancer
#obesity #bmi #young #adults
www.ejcancer.com/article/S095...
#obesity #bmi #young #adults
www.ejcancer.com/article/S095...
Increased Risk of Young-Onset Pancreatic Cancer Among Adults Aged 20-39 Years with Overweight or Obesity, but Not Underweight: A Nationwide Cohort Study
The global incidence of pancreatic cancer markedly increased over recent decades.
Pancreatic cancer is projected to become the second leading cause of cancer-related
mortality in the United States and...
www.ejcancer.com
November 28, 2025 at 10:05 AM
Excess Weight Linked to Increased Risk for Early-Onset Pancreatic Cancer
#obesity #bmi #young #adults
www.ejcancer.com/article/S095...
#obesity #bmi #young #adults
www.ejcancer.com/article/S095...
The improved treatment outcomes for breast cancer are increasingly calling into question the necessity of postoperative radiotherapy.
#breast #cancer #oncology
doi.org/10.1056/NEJM...
#breast #cancer #oncology
doi.org/10.1056/NEJM...
Ten-Year Survival after Postmastectomy Chest-Wall Irradiation in Breast Cancer | NEJM
The role of postmastectomy chest-wall irradiation in patients with breast cancer classified
as pN1 (with involvement of one to three axillary nodes) or pN0 (pathologically node
negative) with addit...
doi.org
November 28, 2025 at 9:59 AM
The improved treatment outcomes for breast cancer are increasingly calling into question the necessity of postoperative radiotherapy.
#breast #cancer #oncology
doi.org/10.1056/NEJM...
#breast #cancer #oncology
doi.org/10.1056/NEJM...
There are many different BRCA mutations – depending on the exon – which have different prognoses.
#breastcancer #oncology #cancer #genes #mutation #brca1 #brca2
www.annalsofoncology.org/article/S092...
#breastcancer #oncology #cancer #genes #mutation #brca1 #brca2
www.annalsofoncology.org/article/S092...
ASSOCIATION BETWEEN TYPE AND LOCATION OF GERMLINE BRCA1/2 PATHOGENIC OR LIKELY PATHOGENIC VARIANTS WITH PHENOTYPE AND PROGNOSIS IN YOUNG PATIENTS WITH BREAST CANCER: RESULTS FROM AN INTERNATIONAL COHO...
Clinical implications of specific pathogenic and likely pathogenic variant (LP/PV)
types and locations in the BRCA1 or BRCA2 tumor-suppressor genes remain to be elucidated.
www.annalsofoncology.org
November 27, 2025 at 9:08 PM
There are many different BRCA mutations – depending on the exon – which have different prognoses.
#breastcancer #oncology #cancer #genes #mutation #brca1 #brca2
www.annalsofoncology.org/article/S092...
#breastcancer #oncology #cancer #genes #mutation #brca1 #brca2
www.annalsofoncology.org/article/S092...
Increased incidence of chronic cough with GLP 1 Agonists.
Once again, it's confirmed: There's no effect without a side effect.
Cohort study with half a million people.
#ozempic #wegovy
jamanetwork.com/journals/jam...
Once again, it's confirmed: There's no effect without a side effect.
Cohort study with half a million people.
#ozempic #wegovy
jamanetwork.com/journals/jam...
Glucagon-Like Peptide-1 Receptor Agonists and Chronic Cough
This cohort study examines the clinical association between glucagon-like peptide 1 receptor agonists and chronic cough.
jamanetwork.com
November 27, 2025 at 9:11 AM
Increased incidence of chronic cough with GLP 1 Agonists.
Once again, it's confirmed: There's no effect without a side effect.
Cohort study with half a million people.
#ozempic #wegovy
jamanetwork.com/journals/jam...
Once again, it's confirmed: There's no effect without a side effect.
Cohort study with half a million people.
#ozempic #wegovy
jamanetwork.com/journals/jam...
Lung cancers from smokers and non smokers are different.
November 26, 2025 at 10:25 AM
Lung cancers from smokers and non smokers are different.
In Austria, people with metastatic breast cancer live longer than in the USA.
#epidemiology #oncology #breastcancer #agmt #registry
#epidemiology #oncology #breastcancer #agmt #registry
November 25, 2025 at 10:09 AM
In Austria, people with metastatic breast cancer live longer than in the USA.
#epidemiology #oncology #breastcancer #agmt #registry
#epidemiology #oncology #breastcancer #agmt #registry
ER-low/HER2-negative breast cancers demonstrate BRCA1/2 mutation prevalence and features comparable to TNBC
#breastcancer #oncology
pubmed.ncbi.nlm.nih.gov/41238982/?ut...
#breastcancer #oncology
pubmed.ncbi.nlm.nih.gov/41238982/?ut...
Germline BRCA1/2 Mutation Prevalence in Unselected ER-Low/HER2-Negative Breast Cancer - PubMed
ER-low/HER2-negative breast cancers demonstrate BRCA1/2 mutation prevalence and features comparable to TNBC. Applying testing criteria based solely on ER expression may underdiagnose mutation carriers. These findings support expanding BRCA1/2 testing eligibility to include ER-low/HER2-negative tumor …
pubmed.ncbi.nlm.nih.gov
November 24, 2025 at 11:13 AM
ER-low/HER2-negative breast cancers demonstrate BRCA1/2 mutation prevalence and features comparable to TNBC
#breastcancer #oncology
pubmed.ncbi.nlm.nih.gov/41238982/?ut...
#breastcancer #oncology
pubmed.ncbi.nlm.nih.gov/41238982/?ut...
November 24, 2025 at 11:09 AM