Ammar Al-Chalabi
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ammaralchalabi.bsky.social
Ammar Al-Chalabi
@ammaralchalabi.bsky.social
Professor of Neurology and Complex Disease Genetics, King's College London. Co-Director UK MND Research Institute https://ukmndri.org #MND #ALS Specialist. Deputy Editor, Brain
Reposted by Ammar Al-Chalabi
⏰1 week to go! Entries to the £7.5M (~$10M) Longitude Prize on ALS are closing next week – submit your application before Wednesday 3rd December 2025.

Your expertise could make the difference.

🔗Learn more and apply today: bit.ly/4nyp6nq
November 26, 2025 at 9:34 AM
Reposted by Ammar Al-Chalabi
@ohenews.bsky.social estimates that eradicating ALS could deliver $143B+ in value over 10 years. The potential global value is huge. #ALS and #MND remain underfunded and breakthroughs are urgently needed.

Full report: lnkd.in/e3-DMaiB
Learn more about the Prize bit.ly/4nyp6nq
November 25, 2025 at 8:52 AM
Reposted by Ammar Al-Chalabi
🚨 Only 2 weeks left to apply! The £7.5M (~$10M) Longitude Prize on ALS is closing soon – submit your application before 3 December 2025 and don’t miss your chance to make a real difference.

🔗 To learn more about the Prize, click here: bit.ly/4nyp6nq
November 19, 2025 at 10:25 AM
People with #ALS #MND with respiratory compromise should be offered COVID immunization by their GPs.

united2endmnd.org/2025/11/14/c...
Covid-19 Boosters in the UK – Statement
Covid-19 Boosters in the UK – Statement This autumn is the first since the Joint Committee on Vaccination and Immunisation (JCVI) changed its policy on who can receive Covid-19 vaccination bo…
united2endmnd.org
November 14, 2025 at 3:08 PM
Reposted by Ammar Al-Chalabi
Drug development is a complex and costly process.

By using medicines approved for other conditions, we can overcome barriers in drug development.

Read our blog explaining why we believe repurposed drugs could help us find new treatments for #MND/#ALS.

ukmndri.org/2025/11/13/r...
Repurposed Drugs: Accelerating MND Treatment Discovery
Discover how repurposed drugs are helping accelerate the search for effective treatments for MND through innovative UK research.
ukmndri.org
November 14, 2025 at 9:34 AM
Reposted by Ammar Al-Chalabi
Yesterday, we attended @mndoddie5.bsky.social's Discovery Network Showcase 2025.

Researchers, clinicians, industry partners, and people affected by #MND/#ALS discussed how the network can drive forward progress in better understanding MND and the development of new treatments.
November 13, 2025 at 1:59 PM
Reposted by Ammar Al-Chalabi
Our Co-Director, Prof. @ammaralchalabi.bsky.social, gave a fantastic talk yesterday, hosted by @mndassoc.bsky.social, on #MND/#ALS genetics, why they matter and how discoveries are shaping new treatments.

Thank you to everyone who joined in person & online!
#MNDresearch #genetics
November 5, 2025 at 8:04 PM
Reposted by Ammar Al-Chalabi
We had the pleasure of catching up with Dr Brian Dickie MBE (@bd365.bsky.social), Chief Scientist at the @mndassoc.bsky.social, the principal funder of the £7.5M Longitude Prize on ALS.

📖 Read the full Q&A here: bit.ly/3KTi1Ap
October 21, 2025 at 11:18 AM
Reposted by Ammar Al-Chalabi
Join us at the #ASHG25 Annual Meeting in Boston, starting today!

Visit us at Booth 46, we’d love to meet you and discuss how the ~$10M Longitude Prize on ALS is harnessing #AI to transform the future of neurodegenerative disease treatment.

@challengeworks.bsky.social @geneticssociety.bsky.social
October 14, 2025 at 9:56 AM
We must find an effective treatment for #ALS #MND

@ukmndri.bsky.social

BBC News - Former England captain Moody reveals MND diagnosis
www.bbc.com/sport/rugby-...
Lewis Moody: Former England captain reveals motor neurone disease diagnosis
Former England captain Lewis Moody reveals he has been diagnosed with motor neurone disease in an exclusive BBC interview.
www.bbc.com
October 6, 2025 at 7:32 AM
Reposted by Ammar Al-Chalabi
⏰ 2 months to go until applications close for the £7.5 million Longitude Prize on ALS.

You could help transform treatment for neurodegenerative diseases like hashtag #ALS, the most common form of motor neurone disease ( #MND ).

Learn more: bit.ly/4mlzSg5
October 3, 2025 at 3:09 PM
Reposted by Ammar Al-Chalabi
Connect with us at #NealsMtg ! We are thrilled to be joining the NEALS meeting once again in person this coming week. For anyone impacted by ALS virtual registration is free. Cheers to NEALS for such an open policy. See more at https://meeting.neals.org/ . #EndtheLegacy #NEALS
October 3, 2025 at 12:26 PM
This is a landmark paper showing a predictive test for #ALS #MND up to 40 years before onset and able to predict age of onset. Huge implications

www.nature.com/articles/s41...
A plasma proteomics-based candidate biomarker panel predictive of amyotrophic lateral sclerosis - Nature Medicine
Plasma proteomic analysis of presymptomatic individuals with amyotrophic lateral sclerosis identifies novel disease-associated proteins and enables the development of an accurate diagnostic biomarker ...
www.nature.com
August 29, 2025 at 8:05 AM
Reposted by Ammar Al-Chalabi
🌍 Be part of the global effort to tackle #ALS.

The £7.5m (~$10m) #LongitudePrizeOnALS is searching for innovators in #AI, #data, #biotech, and #neurology.

🧠 Meet the teams already registered, and find out how you can partner with them below.

🔗https://bit.ly/4mdHxxX
August 12, 2025 at 1:56 PM
Reposted by Ammar Al-Chalabi
🧠 The @ukmndri.bsky.social is an #MND powerhouse, accelerating progress towards new treatments and, ultimately, a cure.

Read their article about how the #LongitudePrizeOnALS could be a game-changer for drug discovery in neurodegenerative diseases.

🔗 bit.ly/40Tmmsh

@ammaralchalabi.bsky.social
Longitude Prize launched to accelerate AI-driven drug discovery
A new international challenge prize has been launched to transform drug discovery for ALS, the most common form of MND through AI.
ukmndri.org
August 5, 2025 at 9:16 AM
Reposted by Ammar Al-Chalabi
Postdoc Research Assistant in Dr Arpan Mehta’s lab at University of Dundee, using CRISPR screens in iPSC-derived motor neurons to study ALS mechanisms. Closing date: 4th August

www.dementiaresearcher.nihr.ac.uk/job/postdoc-...
Postdoc Research Assistant: Investigating C9ORF72
Postdoc Research Assistant in Dr Arpan Mehta’s lab at University of Dundee, using CRISPR screens in iPSC-derived motor neurons to study ALS mechanisms.
www.dementiaresearcher.nihr.ac.uk
July 23, 2025 at 8:38 AM
Reposted by Ammar Al-Chalabi
“MND is one of the most scientifically and biologically challenging diseases to tackle. That said, no mountain is insurmountable…”

Dr. Mike Rogers (@mndassoc.bsky.social) shares why the #LongitudePrizeOnALS is key to creating new opportunities for #ALS & #MND

📰 longevity.technology/news/climbin...
Climbing the ALS mountain
Mike Rogers, MND Association Director of Research and Innovation, looks at how data and AI could unlock new treatments.
longevity.technology
July 22, 2025 at 8:54 AM
Reposted by Ammar Al-Chalabi
Tagging 🧪 🧬🖥️
Sad news:

The dataset behind this famous chart on the decline in costs of genome sequencing has had its NIH funding cut.

I loved this chart because it was the first that made me appreciate the impact of dataviz. But it also tracked progress towards an ambitious goal ($1000 genome) that succeeded.
July 19, 2025 at 1:28 PM
Reposted by Ammar Al-Chalabi
New research has examined how disrupted sleep patterns may signal the early stages of #MND / #ALS or FTD, providing clues to earlier detection.

Read more ⬇️
🔗 ukmndri.org/2025/07/16/r...

This post is part of our Research Snapshot series, powered by Readable Research at @sheffielduni.bsky.social
Could sleep changes signal the early stages of MND or FTD?
Research has found that disrupted sleep may offer some clues to possible early warning signs of the ALS or FTD.
ukmndri.org
July 16, 2025 at 1:23 PM
Reposted by Ammar Al-Chalabi
Researchers reveal that structural variants disrupting the 3D genome can drive diseases like cancer by altering gene expression.

by Sreenivasan VKA, Yumiceba V and Spielmann M in Nat Rev Genet #MedSky

👉 get more here

📖 read the article:
Structural variants in the 3D genome as drivers of disease - Nature Reviews Genetics
Disruption of the 3D genome caused by structural variation contributes to developmental disorders and cancer. The authors review the causes and molecular and clinical consequences of position effects arising from disruptions to the genome architecture.
www.nature.com
July 9, 2025 at 4:48 AM
Reposted by Ammar Al-Chalabi
⏰ Reminder: Our first Welcome Webinar is tomorrow, Tuesday 9th of July at 09:00 BST.

💻 Register below to learn everything you need to know about the #LongitudePrizeOnALS, including how to apply, how the Prize works, and what support is available.
Want to learn more about the £7.5M #LongitudePrizeOnALS?
Join one of our welcome webinars to find out how the Prize works and how to get involved.

Register here:
📅 9 July, 09:00 BST: bit.ly/4nzJuWA
📅 10 July, 17:00 BST: bit.ly/3Tl4u5u

#AIForGood #MND #ALS
July 8, 2025 at 9:29 AM
Reposted by Ammar Al-Chalabi
Research Fellow vacancy at UCL MND Centre. Join Prof Andrea Malaspina’s team to study immune responses and neoantigens in ALS using proteomics and cell phenotyping. Closing date: 20th July

www.dementiaresearcher.nihr.ac.uk/job/research...
Research Fellow: Glial-immune crosstalk and sporadic ALS
Research Fellow vacancy at UCL MND Centre. Join Prof Andrea Malaspina’s team to study immune responses & neoantigens in ALS using proteomics & cell phenotyping
www.dementiaresearcher.nihr.ac.uk
July 6, 2025 at 8:53 PM
Reposted by Ammar Al-Chalabi
🧠 As the principal funder, the @mndassoc.bsky.social has been instrumental in bringing the #LongitudePrizeOnALS to life.

We were joined by Dr Usman Khan last week, who spoke on the power of cross-specialism collaboration.

Learn more about the Prize: bit.ly/4kD3tSh

#AIforGood #MND #ALS
July 3, 2025 at 11:20 AM
Reposted by Ammar Al-Chalabi
Want to learn more about the £7.5M #LongitudePrizeOnALS?
Join one of our welcome webinars to find out how the Prize works and how to get involved.

Register here:
📅 9 July, 09:00 BST: bit.ly/4nzJuWA
📅 10 July, 17:00 BST: bit.ly/3Tl4u5u

#AIForGood #MND #ALS
July 2, 2025 at 9:56 AM
Reposted by Ammar Al-Chalabi
Check out this article from Dr Brian Dickie (@mndassoc.bsky.social), exploring how #AI and quality data can transform treatment progress—and how the £7.5M #LongitudePrizeonALS aims to support #innovation through global collaboration.

🧠 Read here: bit.ly/4nqi4lN
#ALS #MND
Motor neurone disease affects one in 300, but hope for treatment is growing
One in 300 of us will develop motor neurone disease in our lifetime. It is a hideous disease that robs a person of their dignity and eventually their life.
bit.ly
June 30, 2025 at 9:00 AM