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Andreas H. Laustsen-Kiel @andreaslaustsen.bsky.social · 29d

This opens a path to acid-switched / sweeping antibodies that recycle and neutralise multiple antigens without changing the paratope.

#sweeping #toxins #mAbs #acidswitching

Thanks to all co-authors & funders for making this possible!

Andreas H. Laustsen-Kiel @andreaslaustsen.bsky.social · 29d

I’m excited to share our new paper in mAbs!

We engineered pH-dependent antibodies without histidine “doping,” showing the light chain controls pH sensitivity by modulating water access.

Link: www.tandfonline.com/doi/full/10....

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Andreas H. Laustsen-Kiel @andreaslaustsen.bsky.social · Jul 19

Also a big thanks to our generous funders, Villum Fonden, European Research Council (ERC), Wellcome Trust, and Consejo Nacional de Ciencia y Tecnología!

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Andreas H. Laustsen-Kiel @andreaslaustsen.bsky.social · Jul 19

Johannes R. Loeffler, Andrew B. Ward, Kim Boddum, Jens Preben Morth, and Esperanza Rivera de Torre from @dtu.dk, Universidad Nacional Autónoma de México, Sophion Bioscience, and Scripps Research.

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Andreas H. Laustsen-Kiel @andreaslaustsen.bsky.social · Jul 19

Thanks to great co-authors, including Anna Damsbo Jensen, Nick J. Burlet, Monica L. Fernández-Quintero, Melisa Benard-Valle, Max Overath, Alid Guadarrama-Martínez, Anneline Vlamynck, Ida Bisbo, César Noé Villalobos Carrizosa, Tulika Laprade, Alejandro Alagon...

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Andreas H. Laustsen-Kiel @andreaslaustsen.bsky.social · Jul 19

While the work has immediate implications for snakebite envenoming, the methodologies developed here are generally useful for developing broadly-neutralising antibodies.

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Andreas H. Laustsen-Kiel @andreaslaustsen.bsky.social · Jul 19

Read article here: www.nature.com/articles/s42...

Structural mechanisms behind the neutralisation of long-chain α-neurotoxins by broadly neutralising VHHs discovered using a consensus antigen - Communications Chemistry

Snakebite envenoming remains a critical global health issue due to the diverse antigenic profiles of snake venoms. Here, the authors develop a long-chain consensus α-neurotoxin to identify broadly neu...

www.nature.com

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Andreas H. Laustsen-Kiel @andreaslaustsen.bsky.social · Jul 19

Excited to share the newest research paper from our lab, where we discover #nanobodies against #snake #neurotoxins using specially designed #consensus toxins and phage display technology. Link to paper in first comment.

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Andreas H. Laustsen-Kiel @andreaslaustsen.bsky.social · Jun 29

Thanks also to our generous funders, Villum Fonden, European Research Council, Wellcome Trust, and Consejo Nacional de Ciencia y Tecnología!

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Andreas H. Laustsen-Kiel @andreaslaustsen.bsky.social · Jun 29

Thanks to my fantastic co-authors, Anna Damsbo Jensen,
Melisa Benard-Valle, Tom Jansen, Nick J. Burlet, Max Overath, Alid Guadarrama-Martínez, Kim Boddum, Alejandro Alagon, and Esperanza Rivera de Torre from
DTU, UNAM, and Sophion Biosciences.
.

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Andreas H. Laustsen-Kiel @andreaslaustsen.bsky.social · Jun 29

New research article where we use consensus #toxins as #antigens for discovery of #nanobodies, showcasing this with short-chain alpha-neurotoxins from snakes - notoriously difficult to discover antibodies against.

Read article here:https://www.tandfonline.com/doi/full/10.1080/19420862.2025.2522838

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Andreas H. Laustsen-Kiel @andreaslaustsen.bsky.social · Jun 11

Thanks to Laura Tran for highlighting our work on Binding Proteins against cholera toxin: www.the-scientist.com/new-cholera-...

Original research article: www.nature.com/articles/s41...

Andreas H. Laustsen-Kiel @andreaslaustsen.bsky.social · Jun 5

Happy to share this "Ubegribeligt" podcast episode (in Danish) on venom and antivenom, which I had the pleasure of doing together with Huxi Bach from Danmarks Radio: www.dr.dk/lyd/p1/ubegr...
In the podcast, we discuss animal venoms, antivenom, and R&D, and spinout!

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Andreas H. Laustsen-Kiel @andreaslaustsen.bsky.social · Jun 2

... Sandra Wingaard Thrane & Nuria Canibe.

Thanks to GUDP - Grønt Udviklings- & Demonstrationsprogram for the financial support to make this happen!

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Andreas H. Laustsen-Kiel @andreaslaustsen.bsky.social · Jun 2

The work was done by researchers from
Bactolife, Aarhus University, Technical University of Denmark, and Università degli Studi di Parma, including Jiajia Xu, Melania Andrani, Rikke Brødsgaard Kjærup, Tina Sørensen Dalgaard, Carsten Eriksen, Susanne Brix Pedersen...

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Andreas H. Laustsen-Kiel @andreaslaustsen.bsky.social · Jun 2

The Binding Proteins developed here retain full functionality when subjected to the very harsh process of pelleting, as part of admixing them into piglet feed, as can be seen in the figure.

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Andreas H. Laustsen-Kiel @andreaslaustsen.bsky.social · Jun 2

Pleased to share this new publication on the effects of Binding Proteins against virulence factors from enterotoxigenic E. coli: jasbsci.biomedcentral.com/articles/10....

As an #antibody engineer, I find it super interesting that we in this study show how stable #Binding #Proteins can be!

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Reposted by Andreas H. Laustsen-Kiel

Timothy P. Jenkins @tpjenkins.bsky.social · May 14

🚨 We’re hiring a PhD student! 🚨

Join us at DTU Bioengineering + collaborators Messoud & Håkan Ashina + Esperanza Rivera de Torre to bring preventative migraine therapeutics from 💻 to 🧠

🔗 Apply: lnkd.in/dCRU_EN3

🔍 Project: lnkd.in/dbpi8MwX

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Reposted by Andreas H. Laustsen-Kiel

Anton Autzen @aaaautzen.bsky.social · May 11

I co-wrote an opinion piece in a Danish newspaper. There are a few EU initiatives focused on recruiting american scientist. These ignore that the developments in the US the past years have spread here as well. We need a strategy and stronger political will, if we are to be a safe haven for science.

Janus Juul Eriksen @januseriksen.bsky.social · May 10

Sammen med @kristinabsimonsen.bsky.social & @aaaautzen.bsky.social fra @theyoungacademydk.bsky.social har jeg en kronik i Weekendavisen om problemet i at byde sig til over for amerikanske forskere på jagt efter grønnere græsgange uden først at feje for egen dør.

www.weekendavisen.dk/2025-19/opin...

Krigen mod forskning

Kronik. Hvis vi vil være tilflugtssted for USAs forskere, må vi feje for egen dør først.

www.weekendavisen.dk

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Reposted by Andreas H. Laustsen-Kiel

Timothy P. Jenkins @tpjenkins.bsky.social · May 12

🚨 Big news! We’ve received a NovoNordisk Foundation Tandem Grant for #MIGRAINE — designing #AI-powered #GPCR-targeting biologics for chronic migraine. From computer to human in 4 years. Proud to team up with Messoud and Hakan Ashina, as well as Esperanza Rivera de Torre!
🧠 + 💊 + 🧬 = new hope.

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Andreas H. Laustsen-Kiel @andreaslaustsen.bsky.social · May 6

Read more about the companies: tropicalpharmacology.com/entrepreneur...
These include: Bactolife, VenomAid Diagnostics, Chromologics, Biosyntia, Antag Therapeutics, VenomAb, Combotope Therapeutics ApS, Agrobiomics, and soon-to-be-a-company Y-kings (bii.dk/bio-studio-p...)

Entrepreneurship | Center for Antibody Technologies

In the Center for Antibody Technologies, we strive to use scientific research to solve problems […]

tropicalpharmacology.com

Andreas H. Laustsen-Kiel @andreaslaustsen.bsky.social · May 6

DTU has a large number of excellent and innovative researchers, and each year more than 100 companies are spun out of the university, so receiving this award is very humbling.

Entrepreneurship | Center for Antibody Technologies

In the Center for Antibody Technologies, we strive to use scientific research to solve problems […]

tropicalpharmacology.com

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Andreas H. Laustsen-Kiel @andreaslaustsen.bsky.social · May 6

I am grateful to the Technical University of Denmark (DTU) who kindly awarded me with the university's Innovation Award 2025 for my contributions to innovation, entrepreneurship, and spinout of companies.
www.dtu.dk/nyheder/alle...

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Andreas H. Laustsen-Kiel @andreaslaustsen.bsky.social · May 3

I shared thoughts with @statnews.com on new research aiming to develop a universal antivenom, using antibodies from Tim Friede’s decades of self-immunization. Thanks to @usha.bsky.social for including me in the scientific discussion. 🐍👇 www.statnews.com/2025/05/02/d...

Snake enthusiast survived hundreds of bites. Now his blood is aiding the search for a universal antivenom

Blood from a snake enthusiast who's been bitten hundreds of times aided the search for a universal snakebite treatment

www.statnews.com

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Andreas H. Laustsen-Kiel @andreaslaustsen.bsky.social · May 3

I had the chance to comment on a new study in Cell about the development of human monoclonal antibodies for #snakebite treatments. Grateful to @nerdychristie.bsky.social & @science.org for including me in the scientific discussion! Fascinating work. 🐍👇 www.science.org/content/arti...

He injected himself with venom for decades. Can his antibodies help snakebite victims?

A cocktail of antibodies from snake enthusiast Tim Friede protected mice from many deadly venoms—but some say the study has ethical issues

www.science.org

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