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Antonio Serrano

@antonioserrano.bsky.social

390 followers 980 following 20 posts

Researcher in Fungal Biology 🍄🔬. Currently Postdoctoral Researcher at @CBGP_Madrid 🇪🇸 Former MSCA IF Postdoc at @ibvnice 🇫🇷 PhD from @tuBraunschweig 🇩🇪

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Antonio Serrano @antonioserrano.bsky.social · Nov 19

🚨 Excited to share our new study on the human fungal pathogen Candida albicans! Thread 👇 (1/11)
biorxiv.org/content/10.1...

#Science #Microbiology #CellBiology

biorxiv.org

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Reposted by Antonio Serrano

Michael Webster @michaelwebster.bsky.social · 7d

Start independent research at the JIC with us 👇.

Really interested in finding those with an interest in structural biology and biochemistry of plants and microbes.

Please do get in touch by email if you'd like to know more 👍

John Innes Centre @johninnescentre.bsky.social · 7d

VACANCY - Independent research fellowships leading to tenured positions

We’re inviting applications from outstanding researchers who either hold, or wish to apply for, Independent Research Fellowships.

APPLICATION DEADLINE: 10 November 2025

Click here to apply: jic.link/Fellows

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Antonio Serrano @antonioserrano.bsky.social · May 23

Really happy to share our latest review article exploring the current knowledge on CW dynamics in the plant-microbe interactions!

Between Host and Invaders: The Subcellular Cell Wall Dynamics at the Plant–Pathogen Interface | Annual Reviews - www.annualreviews.org/content/jour...

Between Host and Invaders: The Subcellular Cell Wall Dynamics at the Plant–Pathogen Interface | Annual Reviews

Plant–pathogen interactions have profound ecological implications and are crucial for food security. Usually studied at the two extreme scales of plant organ symptomatology and host–microbe molecules,...

www.annualreviews.org

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Reposted by Antonio Serrano

microPublication Biology @micropub7n.bsky.social · Dec 19

✋ microPublication Biology has joined Bluesky.

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Reposted by Antonio Serrano

Antonio Serrano @antonioserrano.bsky.social · Dec 8

PhD position avaiable at the CBGP with Clara Sánchez in Madrid, Spain. Share to anyone interested please! Open to international and national students.

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Antonio Serrano @antonioserrano.bsky.social · Dec 8

PhD position avaiable at the CBGP with Clara Sánchez in Madrid, Spain. Share to anyone interested please! Open to international and national students.

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Reposted by Antonio Serrano

1000WomeninSTEM @1000womeninstem.bsky.social · Dec 7

#WIP #womeninSTEM trading cards #1000portraits

Women in STEM trading card with a picture and a short bio.

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Reposted by Antonio Serrano

Ákos T Kovács @evolvedbiofilm.bsky.social · Nov 29

Cool microscopy following AMF formation and collapse on plant root for several days live imaging

Such a cool method visualization of spatial temporal patterns

See their paper on AMslide:
onlinelibrary.wiley.com/doi/full/10....

#KNVMmycology

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Reposted by Antonio Serrano

Carlos Pérez Arques @carlosparq.bsky.social · Nov 27

The European Conference on Fungal Genetics ECFG17🧬 early registration deadline is approaching! Remember to register to the 3rd Symposium on the Basal Fungal Kingdom 🍄, too, for a lovely pre-meeting on the early-diverging fungi. More info @ ecfg17.org/ecfg17-satel...
#ECFG17
#mycology

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Reposted by Antonio Serrano

bioRxivpreprint @biorxivpreprint.bsky.social · Nov 27

PyRID: A Brownian dynamics simulator for reacting and interacting particles written in Python https://www.biorxiv.org/content/10.1101/2024.11.26.625395v1

Recent technological developments in molecular biology led to large data sets providing new insights

www.biorxiv.org

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Reposted by Antonio Serrano

bioRxiv Evolutionary Biology @biorxiv-evobio.bsky.social · Nov 21

Horizontal transfer of accessory chromosomes in fungi - a regulated process for exchange of genetic material? https://www.biorxiv.org/content/10.1101/2024.11.21.624634v1

Horizontal transfer of entire chromosomes has been reported in several fungal pathogens, often signi

www.biorxiv.org

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Antonio Serrano @antonioserrano.bsky.social · Nov 19

Q2) We haven't tried. I know that there are some methods to visualize cytoplasmic dynamics using single-GFP tracking. But just by intensity, I don't know, maybe combine with FRAP?. @robertarkowitz.bsky.social do you think is possible?

Antonio Serrano @antonioserrano.bsky.social · Nov 19

Hi Darren! Thanks for your interest :)
To answer your questions: Q1) I haven't look into it in detail, but check this very interesting work pubmed.ncbi.nlm.nih.gov/37740366/ in yeast; not immobilised but confined and under pressure, from @delarueresearch.bsky.social

A microfluidic mechano-chemostat for tissues and organisms reveals that confined growth is accompanied with increased macromolecular crowding - PubMed

Conventional culture conditions are oftentimes insufficient to study tissues, organisms, or 3D multicellular assemblies. They lack both dynamic chemical and mechanical control over the microenvironmen...

pubmed.ncbi.nlm.nih.gov

Antonio Serrano @antonioserrano.bsky.social · Nov 19

Ready :) bsky.app/profile/anto...

Antonio Serrano @antonioserrano.bsky.social · Nov 19

🚨 Excited to share our new study on the human fungal pathogen Candida albicans! Thread 👇 (1/11)
biorxiv.org/content/10.1...

#Science #Microbiology #CellBiology

biorxiv.org

Antonio Serrano @antonioserrano.bsky.social · Nov 19

PS: I am missing many funding organizations and colleagues in this network, mainly in Europe, I hope they will join soon!

Antonio Serrano @antonioserrano.bsky.social · Nov 19

If you would like to listen to an AI-generated summary of this work, it can be found here: sciencecast.org/casts/rvmtna... - Automatically done after submission of our work to
@biorxivpreprint.bsky.social, really cool use of technology! The AI summary is surprisingly good! (11/11)

Science Cast

Increase your recognition in the scientific world with short video-casts

sciencecast.org

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Antonio Serrano @antonioserrano.bsky.social · Nov 19

and of course the funding organizations for making it possible! @cnrs.bsky.social, Inserm, Université Cote d'Azur, Université Toulouse, UMassChan, Charite Berlin @hhmi.bsky.social, MSCActions, ERC_Research, FRM, Laas-CNRS and Institute Biology Valrose (10/11)

Antonio Serrano @antonioserrano.bsky.social · Nov 19

This work wouldn’t be possible without the incredible collaboration of wonderful colleagues.Thanks to Charles Puerner, Emily Plumb, Louis Chevalier, Johannes Elferich, Ludwig Sinn, Niko Grigorieff, Markus Ralser, @delarueresearch.bsky.social, Martine Bassilana and
@robertarkowitz.bsky.social (9/11)

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Antonio Serrano @antonioserrano.bsky.social · Nov 19

In summary, our results reveal a substantial fluidization of the cytoplasm during morphogenesis, a key process for fungal virulence, via a reduction in ribosome concentration and that importantly inhibition of ribosome biogenesis triggers filamentous growth (8/11)

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Antonio Serrano @antonioserrano.bsky.social · Nov 19

Depletion of a protein critical for ribosome biogenesis resulted in a reduction of rRNA levels and an increase in GEM Deff. Strikingly this also resulted in the induction of the yeast-to-filament transition (both morphologically and of hyphal specific genes) w/o serum. (7/11)

Antonio Serrano @antonioserrano.bsky.social · Nov 19

Mass spectrometry revealed that ribosomal protein levels drop during filamentation. To directly visualize this, we carried out Cryo-EM+2D template matching and observed that filamentous cells have a lower ribosome concentration, which was proportional to their length. (6/11)

Antonio Serrano @antonioserrano.bsky.social · Nov 19

🧮 Mathematical modeling (both theoretical predictive equations and simulations) recapitulate our observations, that is the ~2-fold increase in Deff as cell volume increases. This supports our initial hypothesis: there is a substantial dilution of a cytoplasmic crowder. (5/11)

Antonio Serrano @antonioserrano.bsky.social · Nov 19

We found GEM Deff increases 2x during filamentation, indicating that the cytoplasm becomes more fluid and likely less crowded. Fluidity correlates very nicely with filament length/volume, suggesting a substantial dilution of molecular crowders e.g. ribosomes. (4/11)

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Antonio Serrano @antonioserrano.bsky.social · Nov 19

The cytoplasm is highly crowded, and this affects a range of biological functions. We tracked how crowded the cytoplasm is during morphogenesis by using genetically encoded GEMs. Lower GEM effective diffusion (Deff) = higher crowding. This is the cytoplasm at 30 fps 🎥 (3/11)

Antonio Serrano @antonioserrano.bsky.social · Nov 19

Using a passive fluorescent microrheological probe (GEMs), we reveal how cytoplasmic fluidity changes during yeast-to-filament morphogenesis, a key process for fungal virulence. (2/11)

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