The objectives of this work are to: define murine femoral artery stiffening with age and the modifiability of this process by exercise; impose peripheral arterial disease (PAD) hemodynamics on murine ...

BackgroundRheumatic heart disease (RHD), a sequela of acute rheumatic fever (ARF), remains as the leading cause of acquired cardiac disease in children, posi...

Despite its ubiquity as a clinical sample, whole blood remains inherently challenging to use in diagnostics, leading to routine reliance on serum and plasma in clinical testing. Whole blood is a complex mixture of cells, lipids, proteins, and metabolites, many of which can interfere with assays designed for plasma or serum if used directly, thereby reducing the sensitivity and accuracy. While traditional laboratory workflows use multistep preparations and benchtop instruments such as centrifuges to overcome these challenges, such methods are often impractical for point-of-care applications, particularly in decentralized or resource-limited settings. This review systematically examines whole blood-based point-of-care testing (POCT) platforms that either operate directly on blood samples or integrate current or emerging separation techniques, including centrifugation, microfluidics, membrane filtration, capillary-driven flow, electrophoresis, and acoustofluidics. We highlight the operational principles, performance metrics (yield, purity, turnaround time), and feasibility of these approaches for a reliable integrated POCT deployment. By evaluating these technologies against the functional demands of modern diagnostics, we outline trade-offs among efficiency, cost, complexity, and integration potential. Our goal is to provide a framework for selecting or engineering appropriate blood separation strategies tailored to specific diagnostic needs, ultimately supporting the broader deployment of POCT across community clinics, emergency medicine, and at-home settings.

Compliance mismatch is a significant challenge in endovascular aortic repair, contributing to adverse remodeling and long-term hemodynamic complications. Despite its clinical importance, few in vivo studies have systematically compared the biomechanical and hemodynamic impacts of compliant versus co …

Bicuspid aortic valve (BAV) is a common congenital cardiovascular defect characterized by two, rather than three, cusps. Many BAV patients prematurely develop calcification and aortic stenosis by age ...

Background Upon injury, tissue repair often leads to a loss in functionality, organisation, and structure. The immune system, particularly macrophages, is crucial during tissue healing. Macrophages po...

BACKGROUND: Cardiac sarcomeres generate the fundamental forces of each heartbeat. Cardiac myocytes (CMs) express nonmuscle versions of muscle-specific sarcomere proteins, which have unknown relevance ...

Abstract. Tissue engineering for cardiovascular implants has largely utilized primary human cells to generate human tissue-engineered matrices (hTEMs). How

Background: Xeltis’ aXess hemodialysis (HD) conduit is a novel arteriovenous graft (AVG) made of bioabsorbable polymer, replaced by body-own tissue, through end...

The aortic elasticity plays a vital role in buffering pulsatile blood flow, propelling blood to distal organs and the heart, and reducing cardiac work…

Background Although radiofrequency ablation is effective for treating left ventricular papillary muscle (PM) arrhythmias, procedural complications like catheter entrapment and risk of PM injury are .....

Background Abdominal aortic aneurysm (AAA) is an abnormal dilation of the abdominal aorta that carries up to a 90% mortality rate when ruptured. Although male patients experience AAA at a higher rate ...

BACKGROUND: Familial hypercholesterolemia (FH) is an autosomal dominant genetic disorder that increases risk for premature coronary artery disease and has accessible and effective interventions. The D...

There is a fundamental knowledge gap regarding the effects of neonatal hyperoxia-exposure on the systemic vasculature and its repercussions on the cardio-pulmonary system. Neonatal hyperoxia exposure ...

Mitochondrial transplantation has emerged as a promising cardioprotective strategy for ischemia–reperfusion injury, aiming to restore bioenergetic fun…

Abstract. Computational fluid dynamics (CFD) is commonly used to investigate hemodynamics in the cardiovascular system, particularly in regions prone to cardiovascular disease such as the carotid arte...

Photoacoustic imaging (PAI) is an emerging imaging modality that provides high-resolution, spatiotemporal insights into anatomical structures, functional parameters and molecular characteristics of t...

Clozapine is an effective antipsychotic medication for the management of treatment-resistant schizophrenia. However, the use of clozapine is limited due to severe and sometimes fatal adverse events, i...

In situ vascular tissue engineering aims to create living blood vessel replacements from biodegradable scaffolds. The functionality of these tissue-engineered vascular grafts (TEVGs) has often been li...

Scientific Reports - Aortic calcification is associated with decreased abdominal aortic aneurysm growth

Purpose Borderline left ventricle (BLV) presents a dilemma between pursuing a biventricular repair (BiVR) and a Stage 1 palliation (S1P) because a discordant pursuit of BiVR increases mortality risk. ...

The mechanical impact of the gravid uterus on the vasculature is well known, but its role in hypertensive disorders of pregnancy (HDP) is incompletely understood. Prior studies have demonstrated an...