Arata Wakimoto
@arataw.bsky.social
Living a life of troubleshooting🫠
A postdoc researcher interested in #StemCells, #DevBio, #EvoDevo.
Love☕ #Coffee and 👾 #Games
🐶Univ. of Washington, JSPS Postdoc fellow ←🌱Univ. of Tsukuba, JSPS Research Fellow DC, PD.
Arata Wakimoto / 脇本 新
JP/EN
A postdoc researcher interested in #StemCells, #DevBio, #EvoDevo.
Love☕ #Coffee and 👾 #Games
🐶Univ. of Washington, JSPS Postdoc fellow ←🌱Univ. of Tsukuba, JSPS Research Fellow DC, PD.
Arata Wakimoto / 脇本 新
JP/EN
Pinned
Arata Wakimoto
@arataw.bsky.social
· Dec 12
Hello Bluesky🖐️ New here and excited to explore this space. I'm a Postdoc at University of Washington studying stem cells and development, interested in chimeras and synthetic biology.
Will be sharing research stuff, and occasionally some hobbies. Happy to connect with the science community here! 🧬☕
Will be sharing research stuff, and occasionally some hobbies. Happy to connect with the science community here! 🧬☕
Reposted by Arata Wakimoto
Congratulations to Karel Svoboda and @jshendure.bsky.social on their election to the National Academy of Medicine (@nam.edu)! Election to the Academy is one of the highest honors in health and medicine. #NAMmtg
More on their journeys to this achievement: alleninstitute.org/news/karel-s...
More on their journeys to this achievement: alleninstitute.org/news/karel-s...
Karel Svoboda and Jay Shendure elected to National Academy of Medicine
The honor recognizes leaders who have demonstrated outstanding achievement and made lasting contributions to the advancement of the medical sciences, health care, and public health
alleninstitute.org
October 20, 2025 at 7:15 PM
Congratulations to Karel Svoboda and @jshendure.bsky.social on their election to the National Academy of Medicine (@nam.edu)! Election to the Academy is one of the highest honors in health and medicine. #NAMmtg
More on their journeys to this achievement: alleninstitute.org/news/karel-s...
More on their journeys to this achievement: alleninstitute.org/news/karel-s...
www.biorxiv.org/content/10.1...
Simplified In Vitro Generation of Human Gastruloids for Modelling Early Development
Simplified In Vitro Generation of Human Gastruloids for Modelling Early Development
Simplified In Vitro Generation of Human Gastruloids for Modelling Early Development
The purpose of this study was to optimize the efficiency and cost of human gastruloid formation by testing and adjusting individual parameters using as examples two distinct human pluripotent stem cel...
www.biorxiv.org
October 17, 2025 at 4:28 AM
www.biorxiv.org/content/10.1...
Simplified In Vitro Generation of Human Gastruloids for Modelling Early Development
Simplified In Vitro Generation of Human Gastruloids for Modelling Early Development
Plasmidsaurus's 50$ RNA-seq is just amazing. I won't do qPCRs anymore
October 15, 2025 at 5:57 PM
Plasmidsaurus's 50$ RNA-seq is just amazing. I won't do qPCRs anymore
Reposted by Arata Wakimoto
🦖 Something HUGE just hatched.
Plasmidsaurus now offers RNA sequencing for gene expression analysis:
• As fast as 3 day turnaround
• $50/sample for academia, $80 for industry
• Up to ~10M unique transcript 3’ end reads per sample
• Interactive results
Explore Plasmidsaurus RNA-Seq today.
Plasmidsaurus now offers RNA sequencing for gene expression analysis:
• As fast as 3 day turnaround
• $50/sample for academia, $80 for industry
• Up to ~10M unique transcript 3’ end reads per sample
• Interactive results
Explore Plasmidsaurus RNA-Seq today.
October 15, 2025 at 4:02 PM
🦖 Something HUGE just hatched.
Plasmidsaurus now offers RNA sequencing for gene expression analysis:
• As fast as 3 day turnaround
• $50/sample for academia, $80 for industry
• Up to ~10M unique transcript 3’ end reads per sample
• Interactive results
Explore Plasmidsaurus RNA-Seq today.
Plasmidsaurus now offers RNA sequencing for gene expression analysis:
• As fast as 3 day turnaround
• $50/sample for academia, $80 for industry
• Up to ~10M unique transcript 3’ end reads per sample
• Interactive results
Explore Plasmidsaurus RNA-Seq today.
Happy Mid-Autumn Festival!!🥮🎑🌕
I love mooncakes so much
I love mooncakes so much
October 6, 2025 at 6:46 PM
Happy Mid-Autumn Festival!!🥮🎑🌕
I love mooncakes so much
I love mooncakes so much
Reposted by Arata Wakimoto
Twenty-four years ago today, our paper “A forkhead-domain gene is mutated in a severe speech and language disorder” was published: www.nature.com/articles/350....
A personal thread about the ups & downs of the journey we took to get to that point....1/n
🗣️🧬🧪
A personal thread about the ups & downs of the journey we took to get to that point....1/n
🗣️🧬🧪
October 4, 2025 at 1:34 PM
Twenty-four years ago today, our paper “A forkhead-domain gene is mutated in a severe speech and language disorder” was published: www.nature.com/articles/350....
A personal thread about the ups & downs of the journey we took to get to that point....1/n
🗣️🧬🧪
A personal thread about the ups & downs of the journey we took to get to that point....1/n
🗣️🧬🧪
Reposted by Arata Wakimoto
Today in @nature.com, we present our work leveraging functional genomics and human blastoids to uncover a human-specific mechanism in preimplantation development driven by the endogenous retrovirus HERVK.
Special thanks to the reviewers whose comments improved our manuscript a lot! rdcu.be/eI3tD
Special thanks to the reviewers whose comments improved our manuscript a lot! rdcu.be/eI3tD
A human-specific regulatory mechanism revealed in a pre-implantation model
Nature - Genetic manipulation of blastoids reveals the role of recently emerged transposable elements and genes in human development.
rdcu.be
October 1, 2025 at 6:08 PM
Today in @nature.com, we present our work leveraging functional genomics and human blastoids to uncover a human-specific mechanism in preimplantation development driven by the endogenous retrovirus HERVK.
Special thanks to the reviewers whose comments improved our manuscript a lot! rdcu.be/eI3tD
Special thanks to the reviewers whose comments improved our manuscript a lot! rdcu.be/eI3tD
📢📢An amazing work from my lab mates!🙌
New paper from my lab and @jshendure.bsky.social lab! Led by the brilliant @zukailiu.bsky.social and @cxqiu.bsky.social. We tackled how anterior and posterior progenitor cells cooperate to self-organize into an embryonic structure (termed AP-gastruloid). (1/n) www.biorxiv.org/content/10.1...
September 27, 2025 at 6:35 AM
📢📢An amazing work from my lab mates!🙌
Reposted by Arata Wakimoto
New paper from my lab and @jshendure.bsky.social lab! Led by the brilliant @zukailiu.bsky.social and @cxqiu.bsky.social. We tackled how anterior and posterior progenitor cells cooperate to self-organize into an embryonic structure (termed AP-gastruloid). (1/n) www.biorxiv.org/content/10.1...
September 26, 2025 at 6:06 PM
New paper from my lab and @jshendure.bsky.social lab! Led by the brilliant @zukailiu.bsky.social and @cxqiu.bsky.social. We tackled how anterior and posterior progenitor cells cooperate to self-organize into an embryonic structure (termed AP-gastruloid). (1/n) www.biorxiv.org/content/10.1...
Thinking about interspecies differences is always fun. Glad to see this story from my previous lab is out!
Sadaki, S., Tsuji, R., Hayashi, T. et al. Large MAF transcription factors reawaken evolutionarily dormant fast-glycolytic type IIb myofibers in human skeletal muscle. Skeletal Muscle 15, 19 (2025). doi.org/10.1186/s133...
Large MAF transcription factors reawaken evolutionarily dormant fast-glycolytic type IIb myofibers in human skeletal muscle - Skeletal Muscle
Background Small mammals such as mice rely on type IIb myofibers, which express the fast-contracting myosin heavy chain isoform Myh4, to achieve rapid movements. In contrast, larger mammals, including...
doi.org
September 8, 2025 at 11:47 PM
Thinking about interspecies differences is always fun. Glad to see this story from my previous lab is out!
Sadaki, S., Tsuji, R., Hayashi, T. et al. Large MAF transcription factors reawaken evolutionarily dormant fast-glycolytic type IIb myofibers in human skeletal muscle. Skeletal Muscle 15, 19 (2025). doi.org/10.1186/s133...
Large MAF transcription factors reawaken evolutionarily dormant fast-glycolytic type IIb myofibers in human skeletal muscle - Skeletal Muscle
Background Small mammals such as mice rely on type IIb myofibers, which express the fast-contracting myosin heavy chain isoform Myh4, to achieve rapid movements. In contrast, larger mammals, including...
doi.org
September 8, 2025 at 9:58 PM
Sadaki, S., Tsuji, R., Hayashi, T. et al. Large MAF transcription factors reawaken evolutionarily dormant fast-glycolytic type IIb myofibers in human skeletal muscle. Skeletal Muscle 15, 19 (2025). doi.org/10.1186/s133...
Are there any reagents/technique available to quench fluorescent proteins (like mCitrin)?
My cell line has a few fluorescent reporters so that they use up channels and I cant stain multiple targets.
Appearently they are still very bright after 4% PFA fixation.
My cell line has a few fluorescent reporters so that they use up channels and I cant stain multiple targets.
Appearently they are still very bright after 4% PFA fixation.
August 29, 2025 at 2:57 AM
Are there any reagents/technique available to quench fluorescent proteins (like mCitrin)?
My cell line has a few fluorescent reporters so that they use up channels and I cant stain multiple targets.
Appearently they are still very bright after 4% PFA fixation.
My cell line has a few fluorescent reporters so that they use up channels and I cant stain multiple targets.
Appearently they are still very bright after 4% PFA fixation.
The generation of viable, structurally integrated human-mouse chimaeras through enhanced hPSCs proliferation
bioRxiv 2025.06.24.661270; doi: doi.org/10.1101/2025...
bioRxiv 2025.06.24.661270; doi: doi.org/10.1101/2025...
The generation of viable, structurally integrated human-mouse chimaeras through enhanced hPSCs proliferation
The generation of human organs in animals through blastocyst complementation offers a promising solution to the shortage of transplantable organs. While human pluripotent stem cells (hPSCs) can contri...
doi.org
August 20, 2025 at 7:13 PM
The generation of viable, structurally integrated human-mouse chimaeras through enhanced hPSCs proliferation
bioRxiv 2025.06.24.661270; doi: doi.org/10.1101/2025...
bioRxiv 2025.06.24.661270; doi: doi.org/10.1101/2025...
Reposted by Arata Wakimoto
🐟 Zebrafish (Danio rerio): Clear as glass, zebrafish embryos let you watch organs form in real time. A powerhouse for studying organogenesis and regeneration, they’re also champions of transgenic expression of fluorescent proteins 🌈 image from Gopi Shah 🧪 #ModelMonday #DevBio
August 18, 2025 at 5:07 PM
🐟 Zebrafish (Danio rerio): Clear as glass, zebrafish embryos let you watch organs form in real time. A powerhouse for studying organogenesis and regeneration, they’re also champions of transgenic expression of fluorescent proteins 🌈 image from Gopi Shah 🧪 #ModelMonday #DevBio
Gemini's Gcal integration is not reliable at all... It cant hook up schedules from multiple calendars
August 1, 2025 at 7:58 PM
Gemini's Gcal integration is not reliable at all... It cant hook up schedules from multiple calendars
First time to see empty I-5
July 19, 2025 at 10:31 PM
First time to see empty I-5
Comparative single-cell analyses reveal evolutionary repurposing of a conserved gene programme in bat wing development
www.nature.com/articles/s41...
"Bats are the only mammals capable of self-powered flight"
so cool
www.nature.com/articles/s41...
"Bats are the only mammals capable of self-powered flight"
so cool
Comparative single-cell analyses reveal evolutionary repurposing of a conserved gene programme in bat wing development - Nature Ecology & Evolution
Single-cell comparison of developing bat and mouse limbs reveals conservation of cell populations and gene expression patterns, and suggests repurposing of genes involved in proximal limb development ...
www.nature.com
July 17, 2025 at 1:16 AM
Comparative single-cell analyses reveal evolutionary repurposing of a conserved gene programme in bat wing development
www.nature.com/articles/s41...
"Bats are the only mammals capable of self-powered flight"
so cool
www.nature.com/articles/s41...
"Bats are the only mammals capable of self-powered flight"
so cool
Reposted by Arata Wakimoto
No new genes needed to fly - just rewire what you have! 🦇🧬
Great new paper from the labs of @fany-real.bsky.social @stemundi.bsky.social @dariloops.bsky.social
doi.org/10.1038/s415...
#EvoDevo #SingleCell #BatWings
Great new paper from the labs of @fany-real.bsky.social @stemundi.bsky.social @dariloops.bsky.social
doi.org/10.1038/s415...
#EvoDevo #SingleCell #BatWings
July 16, 2025 at 1:49 PM
No new genes needed to fly - just rewire what you have! 🦇🧬
Great new paper from the labs of @fany-real.bsky.social @stemundi.bsky.social @dariloops.bsky.social
doi.org/10.1038/s415...
#EvoDevo #SingleCell #BatWings
Great new paper from the labs of @fany-real.bsky.social @stemundi.bsky.social @dariloops.bsky.social
doi.org/10.1038/s415...
#EvoDevo #SingleCell #BatWings
Apparently if you write down 300 random numbers, researchers can identify you with 96.5% accuracy. Cool.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A cognitive fingerprint in human random number generation - Scientific Reports
Scientific Reports - A cognitive fingerprint in human random number generation
www.nature.com
July 7, 2025 at 9:22 PM
Apparently if you write down 300 random numbers, researchers can identify you with 96.5% accuracy. Cool.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Most AI tools for research help me find more papers to read but... what I recently need is AI that helps me read fewer papers.
Drowning in literature, I need it to suggest to me which 8 of my current 50 papers I can safely skip.
Drowning in literature, I need it to suggest to me which 8 of my current 50 papers I can safely skip.
July 7, 2025 at 7:10 PM
Most AI tools for research help me find more papers to read but... what I recently need is AI that helps me read fewer papers.
Drowning in literature, I need it to suggest to me which 8 of my current 50 papers I can safely skip.
Drowning in literature, I need it to suggest to me which 8 of my current 50 papers I can safely skip.
This week marks a year since I moved to Seattle! 🏔️ 🌊🏙️
Pivoting from mouse embryo work to a human embryo model, while moving to a new country, has been a real challenge. But I feel more equipped now - looking forward to what year two brings!
Pivoting from mouse embryo work to a human embryo model, while moving to a new country, has been a real challenge. But I feel more equipped now - looking forward to what year two brings!
July 2, 2025 at 6:43 PM
This week marks a year since I moved to Seattle! 🏔️ 🌊🏙️
Pivoting from mouse embryo work to a human embryo model, while moving to a new country, has been a real challenge. But I feel more equipped now - looking forward to what year two brings!
Pivoting from mouse embryo work to a human embryo model, while moving to a new country, has been a real challenge. But I feel more equipped now - looking forward to what year two brings!
Japan's SPRING fellowship shouldn't exclude international PhD students. Diverse research teams create better learning opportunities. Please don't let nationalism divide science.
www.change.org/p/%E5%8D%9A%...
www.change.org/p/%E5%8D%9A%...
あなたの声がチカラになります
博士課程の学生を国籍で差別しないでください！ ― SPRING制度「日本人限定」見直し方針に反対します ―
www.change.org
June 28, 2025 at 3:52 PM
Japan's SPRING fellowship shouldn't exclude international PhD students. Diverse research teams create better learning opportunities. Please don't let nationalism divide science.
www.change.org/p/%E5%8D%9A%...
www.change.org/p/%E5%8D%9A%...
Many papers from Osaka U have caught my eye recently. Genuinely admire them
June 4, 2025 at 11:05 PM
Many papers from Osaka U have caught my eye recently. Genuinely admire them
Exciting title👀😮
Maternal iron deficiency causes male-to-female sex reversal in mouse embryos
www.nature.com/articles/s41...
Maternal iron deficiency causes male-to-female sex reversal in mouse embryos
www.nature.com/articles/s41...
Maternal iron deficiency causes male-to-female sex reversal in mouse embryos - Nature
Iron-deficient conditions in pregnant mice can cause XY mouse embryos to develop female rather than male genitalia, revealing that iron metabolism has a role in determining male sex in mice.
www.nature.com
June 4, 2025 at 11:01 PM
Exciting title👀😮
Maternal iron deficiency causes male-to-female sex reversal in mouse embryos
www.nature.com/articles/s41...
Maternal iron deficiency causes male-to-female sex reversal in mouse embryos
www.nature.com/articles/s41...