How does the tumor microenvironment change as cancer progresses — and which cells appear, persist, or disappear along the way? In this new study, a wonderful collaboration with Jean Hausser and his l...

By tracking thousands of cells over time, a study in iScience from Johanna Joyce and Jean Hausser exposes how cancer and immunity evolve together and where therapy might strike most effectively. This ...

Immune aging fosters multimorbidity and compromises control of infection and cancer. In a phase 1 randomized controlled trial in middle-aged adults, Denk and colleagues administer the mitophagy induce...

Nature Reviews Clinical Oncology - Anal squamous cell carcinoma (ASCC) is a rare malignancy, albeit with an increasing prevalence in most economically developed countries. Despite considerable...

Gliomas respond poorly to therapy and are considered immunologically “cold” tumors. Cakmak et al. identify tertiary lymphoid structures (TLSs) in a subset of gliomas that show signs of functional adaptive immune activation and are associated with longer overall patient survival and an immune-permissive tumor microenvironment. Such TLSs may represent a key determinant of glioma immune landscape, with clinical relevance.

A newly developed molecule brings together two powerful immunotherapy strategies in one treatment. Researchers at the University of Basel and University Hospital Basel have demonstrated that this fusi...

Researchers’ access to scientific research findings remains inequitable owing to financial and geographical barriers, highlighting the need for more sustainable and inclusive modes of communication to...

Researchers’ access to scientific research findings remains inequitable owing to financial and geographical barriers, highlighting the need for more sustainable and inclusive modes of communication to...

Help Wanted: CD4⁺ T Cells as Architects and Rescuers of CD8⁺ T Cell Responses Verena Van Der Heide, (Icahn School of Medicine at Mount Sinai ) Prolonged but finite antigen presentation promotes reversible...

Reading time: 5 minutes Anna Salamero Boix The tumor microenvironment has emerged as a potential therapeutic target in cancer therapy. Within the tumor microenvironment, tumor-associated immune cel…

“In life, the challenge is not so much to figure out how best to play the game;