Aligning Science Across Parkinson's
@asapresearch.parkinsonsroadmap.org
Global initiative rooted in Collaboration and Open Science to accelerate Parkinson's disease research. Programs include GP2 and CRN.
https://parkinsonsroadmap.org/#
https://parkinsonsroadmap.org/#
📢 New #publication from CRN Team Wichmann!
Simulations using NEURON/NetPyNE showed that decreased PT5B neuron excitability increased beta-band power (~15 Hz) in the M1 network, revealing how small neuronal changes can amplify Parkinson's-related oscillations.
🔗 Read more: bit.ly/4omkIZj
Simulations using NEURON/NetPyNE showed that decreased PT5B neuron excitability increased beta-band power (~15 Hz) in the M1 network, revealing how small neuronal changes can amplify Parkinson's-related oscillations.
🔗 Read more: bit.ly/4omkIZj
November 24, 2025 at 4:14 PM
📢 New #publication from CRN Team Wichmann!
Simulations using NEURON/NetPyNE showed that decreased PT5B neuron excitability increased beta-band power (~15 Hz) in the M1 network, revealing how small neuronal changes can amplify Parkinson's-related oscillations.
🔗 Read more: bit.ly/4omkIZj
Simulations using NEURON/NetPyNE showed that decreased PT5B neuron excitability increased beta-band power (~15 Hz) in the M1 network, revealing how small neuronal changes can amplify Parkinson's-related oscillations.
🔗 Read more: bit.ly/4omkIZj
📣 Check out these new #publications from CRN Team Edwards!
⬅️ Developed a chemogenetic (DREADD) mouse model to increase dopamine neuron activity.
🔗 bit.ly/3XlA44T
➡️ Dopamine therapy, while easing motor symptoms in #Parkinsons, can trigger impulse control disorder (ICD).
🔗 bit.ly/3LyplBO
⬅️ Developed a chemogenetic (DREADD) mouse model to increase dopamine neuron activity.
🔗 bit.ly/3XlA44T
➡️ Dopamine therapy, while easing motor symptoms in #Parkinsons, can trigger impulse control disorder (ICD).
🔗 bit.ly/3LyplBO
November 21, 2025 at 4:39 PM
📣 Check out these new #publications from CRN Team Edwards!
⬅️ Developed a chemogenetic (DREADD) mouse model to increase dopamine neuron activity.
🔗 bit.ly/3XlA44T
➡️ Dopamine therapy, while easing motor symptoms in #Parkinsons, can trigger impulse control disorder (ICD).
🔗 bit.ly/3LyplBO
⬅️ Developed a chemogenetic (DREADD) mouse model to increase dopamine neuron activity.
🔗 bit.ly/3XlA44T
➡️ Dopamine therapy, while easing motor symptoms in #Parkinsons, can trigger impulse control disorder (ICD).
🔗 bit.ly/3LyplBO
🔬 November’s #OpenScience Champion is Chuyu Chen, PhD (Team Awatramani)!
She shared 4 image datasets from her recent preprint on the BioImage Archive, including confocal & 3D-SIM microscopy images, broadening access and collaboration across the CRN.
🔗 Read the full #preprint: bit.ly/3Lzu5Hd
She shared 4 image datasets from her recent preprint on the BioImage Archive, including confocal & 3D-SIM microscopy images, broadening access and collaboration across the CRN.
🔗 Read the full #preprint: bit.ly/3Lzu5Hd
November 20, 2025 at 3:59 PM
🔬 November’s #OpenScience Champion is Chuyu Chen, PhD (Team Awatramani)!
She shared 4 image datasets from her recent preprint on the BioImage Archive, including confocal & 3D-SIM microscopy images, broadening access and collaboration across the CRN.
🔗 Read the full #preprint: bit.ly/3Lzu5Hd
She shared 4 image datasets from her recent preprint on the BioImage Archive, including confocal & 3D-SIM microscopy images, broadening access and collaboration across the CRN.
🔗 Read the full #preprint: bit.ly/3Lzu5Hd
🧠 CRN Team Sulzer used RNAseq, spatial transcriptomics, and T cell receptor (TCR) sequencing to analyze T cell and glial cell states in post-mortem #Parkinsons brain tissue.
🔗 Check out the full #publication to read more about their findings: bit.ly/498amYW
🔗 Check out the full #publication to read more about their findings: bit.ly/498amYW
November 19, 2025 at 3:58 PM
🧠 CRN Team Sulzer used RNAseq, spatial transcriptomics, and T cell receptor (TCR) sequencing to analyze T cell and glial cell states in post-mortem #Parkinsons brain tissue.
🔗 Check out the full #publication to read more about their findings: bit.ly/498amYW
🔗 Check out the full #publication to read more about their findings: bit.ly/498amYW
🧬 CRN Team Gradinaru developed CRISPR-Cas9 tools to lower alpha-synuclein levels and tag the protein in living neurons.
These methods may help researchers better understand its role in #Parkinsons with contributions from @roylab-ucsd.bsky.social.
🔗 Check out the full #publication: bit.ly/43YpVyL
These methods may help researchers better understand its role in #Parkinsons with contributions from @roylab-ucsd.bsky.social.
🔗 Check out the full #publication: bit.ly/43YpVyL
November 18, 2025 at 4:46 PM
🧬 CRN Team Gradinaru developed CRISPR-Cas9 tools to lower alpha-synuclein levels and tag the protein in living neurons.
These methods may help researchers better understand its role in #Parkinsons with contributions from @roylab-ucsd.bsky.social.
🔗 Check out the full #publication: bit.ly/43YpVyL
These methods may help researchers better understand its role in #Parkinsons with contributions from @roylab-ucsd.bsky.social.
🔗 Check out the full #publication: bit.ly/43YpVyL
New CRN Team Desjardins #preprint and #publication!
⬅️ LRRK2(G2019S) disrupts iron balance in macrophages, blocking ferritinophagy under iron overload bit.ly/47VzxvC
➡️ LRRK2(G2019S) mutant mice show stronger gut inflammation post-infection, linking gut immune changes to early PD bit.ly/3LVKlCk
⬅️ LRRK2(G2019S) disrupts iron balance in macrophages, blocking ferritinophagy under iron overload bit.ly/47VzxvC
➡️ LRRK2(G2019S) mutant mice show stronger gut inflammation post-infection, linking gut immune changes to early PD bit.ly/3LVKlCk
November 17, 2025 at 3:59 PM
New CRN Team Desjardins #preprint and #publication!
⬅️ LRRK2(G2019S) disrupts iron balance in macrophages, blocking ferritinophagy under iron overload bit.ly/47VzxvC
➡️ LRRK2(G2019S) mutant mice show stronger gut inflammation post-infection, linking gut immune changes to early PD bit.ly/3LVKlCk
⬅️ LRRK2(G2019S) disrupts iron balance in macrophages, blocking ferritinophagy under iron overload bit.ly/47VzxvC
➡️ LRRK2(G2019S) mutant mice show stronger gut inflammation post-infection, linking gut immune changes to early PD bit.ly/3LVKlCk
CRN Team Chen released a new #preprint on AutoMorphoTrack, an open-source Python package for live-cell imaging. It enables automated detection, tracking, and colocalization of mitochondria and lysosomes.
🔗 Read more about their findings: bit.ly/48XZtc9
🔗 Read more about their findings: bit.ly/48XZtc9
November 14, 2025 at 4:25 PM
CRN Team Chen released a new #preprint on AutoMorphoTrack, an open-source Python package for live-cell imaging. It enables automated detection, tracking, and colocalization of mitochondria and lysosomes.
🔗 Read more about their findings: bit.ly/48XZtc9
🔗 Read more about their findings: bit.ly/48XZtc9
This month’s Discover ASAP features Madeline Klinger, PhD, in conversation with Juan Li, PhD, of CRN Team Schlossmacher 🧠
They discuss NeuroScent, a quick, low-cost smell test that could help detect #Parkinsons earlier & enable broader screening in clinics & research studies.
📺 : bit.ly/3LH2bsM
They discuss NeuroScent, a quick, low-cost smell test that could help detect #Parkinsons earlier & enable broader screening in clinics & research studies.
📺 : bit.ly/3LH2bsM
November 13, 2025 at 3:17 PM
This month’s Discover ASAP features Madeline Klinger, PhD, in conversation with Juan Li, PhD, of CRN Team Schlossmacher 🧠
They discuss NeuroScent, a quick, low-cost smell test that could help detect #Parkinsons earlier & enable broader screening in clinics & research studies.
📺 : bit.ly/3LH2bsM
They discuss NeuroScent, a quick, low-cost smell test that could help detect #Parkinsons earlier & enable broader screening in clinics & research studies.
📺 : bit.ly/3LH2bsM
AMP® PDRD is accepting applications from clinical investigators with study cohorts in #Parkinsons or related disorders.
Selected projects will receive fully funded biomarker analyses, at no cost to investigators 🧪
🧠 Apply by November 21, 2025
🔗 See the RFA: bit.ly/49yx7oW
Selected projects will receive fully funded biomarker analyses, at no cost to investigators 🧪
🧠 Apply by November 21, 2025
🔗 See the RFA: bit.ly/49yx7oW
November 12, 2025 at 5:38 PM
AMP® PDRD is accepting applications from clinical investigators with study cohorts in #Parkinsons or related disorders.
Selected projects will receive fully funded biomarker analyses, at no cost to investigators 🧪
🧠 Apply by November 21, 2025
🔗 See the RFA: bit.ly/49yx7oW
Selected projects will receive fully funded biomarker analyses, at no cost to investigators 🧪
🧠 Apply by November 21, 2025
🔗 See the RFA: bit.ly/49yx7oW
How do genetics shape Parkinson’s research? And what does global data mean for future discoveries?
In this episode of the Parkinson’s Life Podcast, J Solle explains why GP2’s globally diverse dataset is transforming what we know about Parkinson’s genetics 🧪
🎧 Listen now: bit.ly/493nQFp
In this episode of the Parkinson’s Life Podcast, J Solle explains why GP2’s globally diverse dataset is transforming what we know about Parkinson’s genetics 🧪
🎧 Listen now: bit.ly/493nQFp
November 11, 2025 at 3:51 PM
How do genetics shape Parkinson’s research? And what does global data mean for future discoveries?
In this episode of the Parkinson’s Life Podcast, J Solle explains why GP2’s globally diverse dataset is transforming what we know about Parkinson’s genetics 🧪
🎧 Listen now: bit.ly/493nQFp
In this episode of the Parkinson’s Life Podcast, J Solle explains why GP2’s globally diverse dataset is transforming what we know about Parkinson’s genetics 🧪
🎧 Listen now: bit.ly/493nQFp
CRN Team Strick found temporal features of GPi neural responses were related to motor impairment severity in MPTP-induced parkinsonism, while variations in neural response magnitude & duration didn't reliably reflect symptom severity.
🔗 Read the #publication: bit.ly/42MJ0Dx
🔗 Read the #publication: bit.ly/42MJ0Dx
November 10, 2025 at 4:42 PM
CRN Team Strick found temporal features of GPi neural responses were related to motor impairment severity in MPTP-induced parkinsonism, while variations in neural response magnitude & duration didn't reliably reflect symptom severity.
🔗 Read the #publication: bit.ly/42MJ0Dx
🔗 Read the #publication: bit.ly/42MJ0Dx
In their recent preprint, CRN Team Scherzer introduces EVscope, a new open-source computational pipeline designed to analyze extracellular vesicle (EV) RNA-seq data, which are often low in abundance and fragmented.
🔗 Check out the full #preprint to read more about EVscope: bit.ly/48Nzh3Q
🔗 Check out the full #preprint to read more about EVscope: bit.ly/48Nzh3Q
November 7, 2025 at 3:40 PM
In their recent preprint, CRN Team Scherzer introduces EVscope, a new open-source computational pipeline designed to analyze extracellular vesicle (EV) RNA-seq data, which are often low in abundance and fragmented.
🔗 Check out the full #preprint to read more about EVscope: bit.ly/48Nzh3Q
🔗 Check out the full #preprint to read more about EVscope: bit.ly/48Nzh3Q
Exciting news! 🎉 This year marks significant progress for the BLAAC PD study–1,000 participants enrolled. As one of the most extensive studies of Black and African American people with Parkinson’s, BLAAC PD is advancing genetic diversity in global #ParkinsonsResearch.
Learn more: bit.ly/4of0OzX
Learn more: bit.ly/4of0OzX
November 6, 2025 at 3:56 PM
Exciting news! 🎉 This year marks significant progress for the BLAAC PD study–1,000 participants enrolled. As one of the most extensive studies of Black and African American people with Parkinson’s, BLAAC PD is advancing genetic diversity in global #ParkinsonsResearch.
Learn more: bit.ly/4of0OzX
Learn more: bit.ly/4of0OzX
🎉 We’re proud to celebrate the incredible progress featured in the new CRN website’s Impact section!
Across 5 years & 35 teams, the CRN has advanced #ParkinsonsResearch through sharing 1,500+ research outputs, uniting 600+ PD donor brains, & integrating 100+ microbiome studies 🧪
🔗 www.asapcrn.org
Across 5 years & 35 teams, the CRN has advanced #ParkinsonsResearch through sharing 1,500+ research outputs, uniting 600+ PD donor brains, & integrating 100+ microbiome studies 🧪
🔗 www.asapcrn.org
November 5, 2025 at 3:57 PM
🎉 We’re proud to celebrate the incredible progress featured in the new CRN website’s Impact section!
Across 5 years & 35 teams, the CRN has advanced #ParkinsonsResearch through sharing 1,500+ research outputs, uniting 600+ PD donor brains, & integrating 100+ microbiome studies 🧪
🔗 www.asapcrn.org
Across 5 years & 35 teams, the CRN has advanced #ParkinsonsResearch through sharing 1,500+ research outputs, uniting 600+ PD donor brains, & integrating 100+ microbiome studies 🧪
🔗 www.asapcrn.org
We’re #hiring! 🧪
GP2 is looking for a Project Manager to lead global #Parkinson’s genetics research and advance discovery worldwide. Strong science background, PhD preferred, and PM experience. Share with others who may be interested!
Apply by November 7 👉 bit.ly/49dC32s
GP2 is looking for a Project Manager to lead global #Parkinson’s genetics research and advance discovery worldwide. Strong science background, PhD preferred, and PM experience. Share with others who may be interested!
Apply by November 7 👉 bit.ly/49dC32s
November 4, 2025 at 4:05 PM
We’re #hiring! 🧪
GP2 is looking for a Project Manager to lead global #Parkinson’s genetics research and advance discovery worldwide. Strong science background, PhD preferred, and PM experience. Share with others who may be interested!
Apply by November 7 👉 bit.ly/49dC32s
GP2 is looking for a Project Manager to lead global #Parkinson’s genetics research and advance discovery worldwide. Strong science background, PhD preferred, and PM experience. Share with others who may be interested!
Apply by November 7 👉 bit.ly/49dC32s
CRN Team Schlossmacher investigated how nasally-acquired influenza A H1N1 infections interact with #ParkinsonsDisease genes to affect long-term neurological outcomes 🧪
🔗 Check out the full #preprint to read more about their findings: bit.ly/4h7OQFw
🔗 Check out the full #preprint to read more about their findings: bit.ly/4h7OQFw
November 3, 2025 at 4:23 PM
CRN Team Schlossmacher investigated how nasally-acquired influenza A H1N1 infections interact with #ParkinsonsDisease genes to affect long-term neurological outcomes 🧪
🔗 Check out the full #preprint to read more about their findings: bit.ly/4h7OQFw
🔗 Check out the full #preprint to read more about their findings: bit.ly/4h7OQFw
👏 This month’s Network Spotlight goes to Teams Kordower, Liddle, & Rio!
Their open-access protocols ranked among the top 100 most viewed on @protocolsio.bsky.social in August 🎉
➡️ Mouse Perfusions (bit.ly/4qH6rIY)
➡️ Y-Maze (bit.ly/47aITTC)
➡️ Culture/transfection of HEK293T cells (bit.ly/4o4ytfR)
Their open-access protocols ranked among the top 100 most viewed on @protocolsio.bsky.social in August 🎉
➡️ Mouse Perfusions (bit.ly/4qH6rIY)
➡️ Y-Maze (bit.ly/47aITTC)
➡️ Culture/transfection of HEK293T cells (bit.ly/4o4ytfR)
October 31, 2025 at 3:05 PM
👏 This month’s Network Spotlight goes to Teams Kordower, Liddle, & Rio!
Their open-access protocols ranked among the top 100 most viewed on @protocolsio.bsky.social in August 🎉
➡️ Mouse Perfusions (bit.ly/4qH6rIY)
➡️ Y-Maze (bit.ly/47aITTC)
➡️ Culture/transfection of HEK293T cells (bit.ly/4o4ytfR)
Their open-access protocols ranked among the top 100 most viewed on @protocolsio.bsky.social in August 🎉
➡️ Mouse Perfusions (bit.ly/4qH6rIY)
➡️ Y-Maze (bit.ly/47aITTC)
➡️ Culture/transfection of HEK293T cells (bit.ly/4o4ytfR)
The Collaborative Research Network has a new home! Explore the new CRN website, a designated space to discover research teams, working groups, and impact highlights driving discovery in #ParkinsonsDisease 🧪
👉 www.asapcrn.org
👉 www.asapcrn.org
October 29, 2025 at 2:40 PM
The Collaborative Research Network has a new home! Explore the new CRN website, a designated space to discover research teams, working groups, and impact highlights driving discovery in #ParkinsonsDisease 🧪
👉 www.asapcrn.org
👉 www.asapcrn.org
13 countries. 16 trainees. 1 powerful hackathon 🌍
GP2 Hackathon united global minds in Lübeck, Germany to tackle #Parkinsons research with data, mentorship & collaboration.
🔗 Dive into the recap: bit.ly/4nfmeeX
GP2 Hackathon united global minds in Lübeck, Germany to tackle #Parkinsons research with data, mentorship & collaboration.
🔗 Dive into the recap: bit.ly/4nfmeeX
October 28, 2025 at 6:02 PM
13 countries. 16 trainees. 1 powerful hackathon 🌍
GP2 Hackathon united global minds in Lübeck, Germany to tackle #Parkinsons research with data, mentorship & collaboration.
🔗 Dive into the recap: bit.ly/4nfmeeX
GP2 Hackathon united global minds in Lübeck, Germany to tackle #Parkinsons research with data, mentorship & collaboration.
🔗 Dive into the recap: bit.ly/4nfmeeX
October’s Open Science Champions are Teams Hardy, Hurley, and Strick 👏
They’ve maintained a near-perfect record of preprinting with a CC BY or CC0 license, advancing accessibility and collaboration across the research community.
#OpenScience
They’ve maintained a near-perfect record of preprinting with a CC BY or CC0 license, advancing accessibility and collaboration across the research community.
#OpenScience
October 27, 2025 at 3:07 PM
October’s Open Science Champions are Teams Hardy, Hurley, and Strick 👏
They’ve maintained a near-perfect record of preprinting with a CC BY or CC0 license, advancing accessibility and collaboration across the research community.
#OpenScience
They’ve maintained a near-perfect record of preprinting with a CC BY or CC0 license, advancing accessibility and collaboration across the research community.
#OpenScience
CRN Team Hurley outputs with @jimhurley.bsky.social @mito911.bsky.social 🧪
⬅️ Identified a Mitophagic Stress Response (MitoSR) that supports mitochondrial quality. 🔗 bit.ly/4o3O4fD
➡️ Found that cells use autophagy to recycle damaged or unneeded material. 🔗 bit.ly/4hrGeKa
⬅️ Identified a Mitophagic Stress Response (MitoSR) that supports mitochondrial quality. 🔗 bit.ly/4o3O4fD
➡️ Found that cells use autophagy to recycle damaged or unneeded material. 🔗 bit.ly/4hrGeKa
October 24, 2025 at 5:11 PM
CRN Team Hurley outputs with @jimhurley.bsky.social @mito911.bsky.social 🧪
⬅️ Identified a Mitophagic Stress Response (MitoSR) that supports mitochondrial quality. 🔗 bit.ly/4o3O4fD
➡️ Found that cells use autophagy to recycle damaged or unneeded material. 🔗 bit.ly/4hrGeKa
⬅️ Identified a Mitophagic Stress Response (MitoSR) that supports mitochondrial quality. 🔗 bit.ly/4o3O4fD
➡️ Found that cells use autophagy to recycle damaged or unneeded material. 🔗 bit.ly/4hrGeKa
GP2 is hiring a Project Manager!
Help lead global #Parkinsons genetics research, manage 15+ projects, and support diverse cohorts worldwide. PhD + PM experience preferred.
Mission-driven. Science-forward.
Apply now 👉 bit.ly/49dC32s
Help lead global #Parkinsons genetics research, manage 15+ projects, and support diverse cohorts worldwide. PhD + PM experience preferred.
Mission-driven. Science-forward.
Apply now 👉 bit.ly/49dC32s
October 23, 2025 at 2:41 PM
GP2 is hiring a Project Manager!
Help lead global #Parkinsons genetics research, manage 15+ projects, and support diverse cohorts worldwide. PhD + PM experience preferred.
Mission-driven. Science-forward.
Apply now 👉 bit.ly/49dC32s
Help lead global #Parkinsons genetics research, manage 15+ projects, and support diverse cohorts worldwide. PhD + PM experience preferred.
Mission-driven. Science-forward.
Apply now 👉 bit.ly/49dC32s
New CRN Team Alessi outputs with @prosenjit.bsky.social
⬅️ New protein identified that may be a future drug target for PD.
#preprint 🔗 bit.ly/3W7KXH5
➡️ GBA1 mutations block a neuroprotective pathway by changing the lipid composition of primary cilia.
#publication 🔗 bit.ly/3W7LjgT
⬅️ New protein identified that may be a future drug target for PD.
#preprint 🔗 bit.ly/3W7KXH5
➡️ GBA1 mutations block a neuroprotective pathway by changing the lipid composition of primary cilia.
#publication 🔗 bit.ly/3W7LjgT
October 21, 2025 at 3:56 PM
New CRN Team Alessi outputs with @prosenjit.bsky.social
⬅️ New protein identified that may be a future drug target for PD.
#preprint 🔗 bit.ly/3W7KXH5
➡️ GBA1 mutations block a neuroprotective pathway by changing the lipid composition of primary cilia.
#publication 🔗 bit.ly/3W7LjgT
⬅️ New protein identified that may be a future drug target for PD.
#preprint 🔗 bit.ly/3W7KXH5
➡️ GBA1 mutations block a neuroprotective pathway by changing the lipid composition of primary cilia.
#publication 🔗 bit.ly/3W7LjgT
Open Access Week highlights the power of free, immediate access to research by ensuring science benefits all. Proud to join @parkinsondotorg.bsky.social, @parkinsons.org.uk, @cureparkinsons.org.uk, @alleninstitute.org, @dataseerai.bsky.social, @strategiesos.bsky.social, @orfg.bsky.social & others 🔓
October 20, 2025 at 3:57 PM
Open Access Week highlights the power of free, immediate access to research by ensuring science benefits all. Proud to join @parkinsondotorg.bsky.social, @parkinsons.org.uk, @cureparkinsons.org.uk, @alleninstitute.org, @dataseerai.bsky.social, @strategiesos.bsky.social, @orfg.bsky.social & others 🔓
👏 Congrats to Monther Abu-Remaileh, PhD, of CRN Team Alessi, recipient of the 2026 Walter A. Shaw Young Investigator Award in Lipid Research, honoring his groundbreaking contributions to lipid biology!
🔗 bit.ly/3KzsOzz
@abu-remaileh.bsky.social
🔗 bit.ly/3KzsOzz
@abu-remaileh.bsky.social
October 17, 2025 at 3:26 PM
👏 Congrats to Monther Abu-Remaileh, PhD, of CRN Team Alessi, recipient of the 2026 Walter A. Shaw Young Investigator Award in Lipid Research, honoring his groundbreaking contributions to lipid biology!
🔗 bit.ly/3KzsOzz
@abu-remaileh.bsky.social
🔗 bit.ly/3KzsOzz
@abu-remaileh.bsky.social