Aligning Science Across Parkinson's
@asapresearch.parkinsonsroadmap.org
Global initiative rooted in Collaboration and Open Science to accelerate Parkinson's disease research. Programs include GP2 and CRN.
https://parkinsonsroadmap.org/#
https://parkinsonsroadmap.org/#
This month's Discover ASAP features Anastasia Filimontseva of CRN Team Vila 🧪
She shares a new deep learning–enabled platform for automated, standardized quantification of neuromelanin, unlocking faster, more precise insights into pigmented neuron loss in #Parkinsons.
📺 Watch: bit.ly/4jDTOuW
She shares a new deep learning–enabled platform for automated, standardized quantification of neuromelanin, unlocking faster, more precise insights into pigmented neuron loss in #Parkinsons.
📺 Watch: bit.ly/4jDTOuW
January 16, 2026 at 3:28 PM
This month's Discover ASAP features Anastasia Filimontseva of CRN Team Vila 🧪
She shares a new deep learning–enabled platform for automated, standardized quantification of neuromelanin, unlocking faster, more precise insights into pigmented neuron loss in #Parkinsons.
📺 Watch: bit.ly/4jDTOuW
She shares a new deep learning–enabled platform for automated, standardized quantification of neuromelanin, unlocking faster, more precise insights into pigmented neuron loss in #Parkinsons.
📺 Watch: bit.ly/4jDTOuW
🧠📈 We are excited to welcome Alain Dagher, MD, PhD, from McGill University, as the January LRRK2 #webinar speaker.
👇 Reserve your spot using the link below.
📅 January 22
⏰ 1:00 PM ET
RSVP: bit.ly/4qabhxN
👇 Reserve your spot using the link below.
📅 January 22
⏰ 1:00 PM ET
RSVP: bit.ly/4qabhxN
January 15, 2026 at 3:51 PM
🧠📈 We are excited to welcome Alain Dagher, MD, PhD, from McGill University, as the January LRRK2 #webinar speaker.
👇 Reserve your spot using the link below.
📅 January 22
⏰ 1:00 PM ET
RSVP: bit.ly/4qabhxN
👇 Reserve your spot using the link below.
📅 January 22
⏰ 1:00 PM ET
RSVP: bit.ly/4qabhxN
The ASAP website has a fresh, new look, making it easier for individuals to find what they need.
Check out the new site to see the updates, including our new homepage, improved highlights overview, a redesigned funding dashboard, and a dedicated tools & resources section!
🔗 bit.ly/3Mey2RX
Check out the new site to see the updates, including our new homepage, improved highlights overview, a redesigned funding dashboard, and a dedicated tools & resources section!
🔗 bit.ly/3Mey2RX
January 14, 2026 at 3:51 PM
The ASAP website has a fresh, new look, making it easier for individuals to find what they need.
Check out the new site to see the updates, including our new homepage, improved highlights overview, a redesigned funding dashboard, and a dedicated tools & resources section!
🔗 bit.ly/3Mey2RX
Check out the new site to see the updates, including our new homepage, improved highlights overview, a redesigned funding dashboard, and a dedicated tools & resources section!
🔗 bit.ly/3Mey2RX
Our new white paper, Investing in Open Science, is out 📄 🧪
What does it really take to fund #OpenScience? We unpack our 5 policy requirements, along with key barriers and cost drivers, from data infrastructure to OA/APCs and compliance reviews.
🔗 bit.ly/4sxzIH2
What does it really take to fund #OpenScience? We unpack our 5 policy requirements, along with key barriers and cost drivers, from data infrastructure to OA/APCs and compliance reviews.
🔗 bit.ly/4sxzIH2
January 13, 2026 at 4:03 PM
Our new white paper, Investing in Open Science, is out 📄 🧪
What does it really take to fund #OpenScience? We unpack our 5 policy requirements, along with key barriers and cost drivers, from data infrastructure to OA/APCs and compliance reviews.
🔗 bit.ly/4sxzIH2
What does it really take to fund #OpenScience? We unpack our 5 policy requirements, along with key barriers and cost drivers, from data infrastructure to OA/APCs and compliance reviews.
🔗 bit.ly/4sxzIH2
CRN Teams Cragg & Jakobsson's new #preprint maps the cell-type–specific transcriptional landscape of the parkinsonian striatum in mouse models and human Parkinson's stages, revealing widespread gene expression changes and resilient neuron subtypes amid progressive dopamine loss 🧪
🔗 bit.ly/4ju4MmS
🔗 bit.ly/4ju4MmS
January 12, 2026 at 4:25 PM
CRN Teams Cragg & Jakobsson's new #preprint maps the cell-type–specific transcriptional landscape of the parkinsonian striatum in mouse models and human Parkinson's stages, revealing widespread gene expression changes and resilient neuron subtypes amid progressive dopamine loss 🧪
🔗 bit.ly/4ju4MmS
🔗 bit.ly/4ju4MmS
CRN Team Hurley developed AI-directed voxel extraction (AIVE), a segmentation strategy that refines AI-based organelle boundary predictions. Using AIVE, they identified a previously unknown mitochondrial contact termed the mitochondrial intrusion 🧪
🔗 Read the #publication: bit.ly/4qeZiOY
🔗 Read the #publication: bit.ly/4qeZiOY
January 9, 2026 at 3:51 PM
CRN Team Hurley developed AI-directed voxel extraction (AIVE), a segmentation strategy that refines AI-based organelle boundary predictions. Using AIVE, they identified a previously unknown mitochondrial contact termed the mitochondrial intrusion 🧪
🔗 Read the #publication: bit.ly/4qeZiOY
🔗 Read the #publication: bit.ly/4qeZiOY
📣 Don’t miss the upcoming @mito911.bsky.social #webinar featuring David Chan, MD, PhD, from the California Institute of Technology.
👇 Reserve your spot using the link below.
📅 January 14
⏰ 11:00 AM ET
🔗 RSVP: bit.ly/4p4OuC6
👇 Reserve your spot using the link below.
📅 January 14
⏰ 11:00 AM ET
🔗 RSVP: bit.ly/4p4OuC6
January 8, 2026 at 4:18 PM
📣 Don’t miss the upcoming @mito911.bsky.social #webinar featuring David Chan, MD, PhD, from the California Institute of Technology.
👇 Reserve your spot using the link below.
📅 January 14
⏰ 11:00 AM ET
🔗 RSVP: bit.ly/4p4OuC6
👇 Reserve your spot using the link below.
📅 January 14
⏰ 11:00 AM ET
🔗 RSVP: bit.ly/4p4OuC6
ICYMI: In 2025, we advanced #Parkinsons research, grounded in discovery and powered by open science 🧪
Through global collaboration, expanded genetics and biomarker efforts, and open data sharing, ASAP’s community set the stage for continued momentum.
🔗 See our 2025 #AnnualReport: bit.ly/48OZtcw
Through global collaboration, expanded genetics and biomarker efforts, and open data sharing, ASAP’s community set the stage for continued momentum.
🔗 See our 2025 #AnnualReport: bit.ly/48OZtcw
January 7, 2026 at 4:01 PM
ICYMI: In 2025, we advanced #Parkinsons research, grounded in discovery and powered by open science 🧪
Through global collaboration, expanded genetics and biomarker efforts, and open data sharing, ASAP’s community set the stage for continued momentum.
🔗 See our 2025 #AnnualReport: bit.ly/48OZtcw
Through global collaboration, expanded genetics and biomarker efforts, and open data sharing, ASAP’s community set the stage for continued momentum.
🔗 See our 2025 #AnnualReport: bit.ly/48OZtcw
GP2 just launched a new, #FreeCourse: Whole-Genome Sequencing (WGS) Data Analysis!
Build your skills in navigating WGS data from raw reads to validated genetic findings. Learn how these tools advance #ParkinsonsDisease genetics 🧪
Create an account: bit.ly/4nJfarZ
Take the course: bit.ly/46IASX9
Build your skills in navigating WGS data from raw reads to validated genetic findings. Learn how these tools advance #ParkinsonsDisease genetics 🧪
Create an account: bit.ly/4nJfarZ
Take the course: bit.ly/46IASX9
January 6, 2026 at 4:10 PM
GP2 just launched a new, #FreeCourse: Whole-Genome Sequencing (WGS) Data Analysis!
Build your skills in navigating WGS data from raw reads to validated genetic findings. Learn how these tools advance #ParkinsonsDisease genetics 🧪
Create an account: bit.ly/4nJfarZ
Take the course: bit.ly/46IASX9
Build your skills in navigating WGS data from raw reads to validated genetic findings. Learn how these tools advance #ParkinsonsDisease genetics 🧪
Create an account: bit.ly/4nJfarZ
Take the course: bit.ly/46IASX9
🧠 CRN Team Kordower developed a co-pathology mouse model combining tau, amyloid-β, & α-synuclein. They show co-pathologies synergistically trigger an amplified neuroimmune response, with expanded CD4+/CD8+ T cells & increased CD68+ microglia.
🔗 Check out the full #preprint: https://bit.ly/4jAHzzl
🔗 Check out the full #preprint: https://bit.ly/4jAHzzl
January 5, 2026 at 2:00 PM
🧠 CRN Team Kordower developed a co-pathology mouse model combining tau, amyloid-β, & α-synuclein. They show co-pathologies synergistically trigger an amplified neuroimmune response, with expanded CD4+/CD8+ T cells & increased CD68+ microglia.
🔗 Check out the full #preprint: https://bit.ly/4jAHzzl
🔗 Check out the full #preprint: https://bit.ly/4jAHzzl
CRN Team Calakos discovered that astrocyte mitochondria undergo extensive fission as they populate distal branches during postnatal cortical development. Loss of Drp1 reduces mitochondrial localization and decreases astrocyte complexity 🧪
🔗 Read the full #publication: bit.ly/48IL2rT
🔗 Read the full #publication: bit.ly/48IL2rT
December 30, 2025 at 4:59 PM
CRN Team Calakos discovered that astrocyte mitochondria undergo extensive fission as they populate distal branches during postnatal cortical development. Loss of Drp1 reduces mitochondrial localization and decreases astrocyte complexity 🧪
🔗 Read the full #publication: bit.ly/48IL2rT
🔗 Read the full #publication: bit.ly/48IL2rT
CRN Teams Hardy & Wood's new #preprint identifies a new molecular hallmark of #Parkinsons: widespread mis-splicing linked to loss of nuclear TDP-43 function 🧪
They show a robust signature across idiopathic cases and the LRRK2 p.G2019S mutation, validated in human & mouse models.
🔗 bit.ly/3L6ORxW
They show a robust signature across idiopathic cases and the LRRK2 p.G2019S mutation, validated in human & mouse models.
🔗 bit.ly/3L6ORxW
December 29, 2025 at 4:08 PM
CRN Teams Hardy & Wood's new #preprint identifies a new molecular hallmark of #Parkinsons: widespread mis-splicing linked to loss of nuclear TDP-43 function 🧪
They show a robust signature across idiopathic cases and the LRRK2 p.G2019S mutation, validated in human & mouse models.
🔗 bit.ly/3L6ORxW
They show a robust signature across idiopathic cases and the LRRK2 p.G2019S mutation, validated in human & mouse models.
🔗 bit.ly/3L6ORxW
CRN Team Alessi found that PPM1H has an allosteric binding site for non-phosphorylated Rab8A and Rab10, and that non-phosphorylated Rab GTPases keep PPM1H on membranes so it can reach its phosphoRab targets.
✏️ @suzannepfeffer.bsky.social, PhD
🔗 Read the full #publication: bit.ly/4pKzx9q
✏️ @suzannepfeffer.bsky.social, PhD
🔗 Read the full #publication: bit.ly/4pKzx9q
December 23, 2025 at 4:23 PM
CRN Team Alessi found that PPM1H has an allosteric binding site for non-phosphorylated Rab8A and Rab10, and that non-phosphorylated Rab GTPases keep PPM1H on membranes so it can reach its phosphoRab targets.
✏️ @suzannepfeffer.bsky.social, PhD
🔗 Read the full #publication: bit.ly/4pKzx9q
✏️ @suzannepfeffer.bsky.social, PhD
🔗 Read the full #publication: bit.ly/4pKzx9q
We’re proud to support the @parkinsondotorg.bsky.social PD GENEration study of 30,000+ participants, including nearly 10,000 this year 🧪
This growth is building a diverse PD genetics registry & expanding access to testing & counseling at no cost.
See more in our 2025 #AnnualReport: bit.ly/48OZtcw
This growth is building a diverse PD genetics registry & expanding access to testing & counseling at no cost.
See more in our 2025 #AnnualReport: bit.ly/48OZtcw
December 22, 2025 at 3:46 PM
We’re proud to support the @parkinsondotorg.bsky.social PD GENEration study of 30,000+ participants, including nearly 10,000 this year 🧪
This growth is building a diverse PD genetics registry & expanding access to testing & counseling at no cost.
See more in our 2025 #AnnualReport: bit.ly/48OZtcw
This growth is building a diverse PD genetics registry & expanding access to testing & counseling at no cost.
See more in our 2025 #AnnualReport: bit.ly/48OZtcw
We’re working with the Michael J. Fox Foundation to shift the #Parkinson’s timeline 🔬
This year, PPMI lowered its screening age to 40 to assess early disease stages.
Learn more through our 2025 #AnnualReport: bit.ly/48OZtcw
This year, PPMI lowered its screening age to 40 to assess early disease stages.
Learn more through our 2025 #AnnualReport: bit.ly/48OZtcw
December 19, 2025 at 3:54 PM
We’re working with the Michael J. Fox Foundation to shift the #Parkinson’s timeline 🔬
This year, PPMI lowered its screening age to 40 to assess early disease stages.
Learn more through our 2025 #AnnualReport: bit.ly/48OZtcw
This year, PPMI lowered its screening age to 40 to assess early disease stages.
Learn more through our 2025 #AnnualReport: bit.ly/48OZtcw
Grounded in discovery, powered by open science 🧪
This year, we pushed #Parkinsons research forward with new mechanistic insights, expanded global genetics studies, and progress in biomarker discovery across our programs.
Explore the highlights in our 2025 #AnnualReport: bit.ly/48OZtcw
This year, we pushed #Parkinsons research forward with new mechanistic insights, expanded global genetics studies, and progress in biomarker discovery across our programs.
Explore the highlights in our 2025 #AnnualReport: bit.ly/48OZtcw
December 18, 2025 at 3:32 PM
Grounded in discovery, powered by open science 🧪
This year, we pushed #Parkinsons research forward with new mechanistic insights, expanded global genetics studies, and progress in biomarker discovery across our programs.
Explore the highlights in our 2025 #AnnualReport: bit.ly/48OZtcw
This year, we pushed #Parkinsons research forward with new mechanistic insights, expanded global genetics studies, and progress in biomarker discovery across our programs.
Explore the highlights in our 2025 #AnnualReport: bit.ly/48OZtcw
GP2's 5th Annual Investigators Meeting in Honolulu brought together 230 investigators from 52 countries. It was an energizing event of new discoveries, expanded tools and training, and a big milestone as GP2 reached 100,000 genotyped samples.
📺 Watch the full video: bit.ly/4s7beUT
📺 Watch the full video: bit.ly/4s7beUT
GP2's Annual Investigators Meeting 2025
In October 2025, 230 investigators from 52 countries met in Honolulu for GP2’s 5th Annual Investigators Meeting. The event was full of energy, collaboration, and progress, including new GWAS discoveries, expanded data tools, training opportunities. It also marked an exciting milestone for the program as GP2 reached 100,000 genotyped samples. Take a look inside the event and the community powering GP2, and check out our recap blog: https://gp2.org/how-far-weve-come-and-the-journey-ahead-the-2025-gp2-annual-investigators-meeting/ Follow us on social media for updates: 🔗 LinkedIn: https://www.linkedin.com/company/asap-research 🔗 Bluesky: https://bsky.app/profile/asapresearch.parkinsonsroadmap.org #ParkinsonsDisease #ParkinsonsResearch
bit.ly
December 17, 2025 at 4:48 PM
GP2's 5th Annual Investigators Meeting in Honolulu brought together 230 investigators from 52 countries. It was an energizing event of new discoveries, expanded tools and training, and a big milestone as GP2 reached 100,000 genotyped samples.
📺 Watch the full video: bit.ly/4s7beUT
📺 Watch the full video: bit.ly/4s7beUT
In a new publication, Team Harper found that α-synuclein fibrils cause ESCRT-III loss through “collateral degradation,” weakening endolysosomes and promoting further aggregation🔬
🔗 Read the full #publication: bit.ly/4iPUayj
🔗 Read the full #publication: bit.ly/4iPUayj
December 16, 2025 at 4:08 PM
In a new publication, Team Harper found that α-synuclein fibrils cause ESCRT-III loss through “collateral degradation,” weakening endolysosomes and promoting further aggregation🔬
🔗 Read the full #publication: bit.ly/4iPUayj
🔗 Read the full #publication: bit.ly/4iPUayj
This month’s Discover ASAP features Madeline Klinger, PhD, with Leonardo Parra-Rivas, PhD, of CRN Team Gradinaru 🧬
They discuss a CRISPR-based protocol to precisely edit and visualize α-synuclein in neurons, advancing tools to study its role in #Parkinsons and beyond.
📺 : bit.ly/4iMyG5i
They discuss a CRISPR-based protocol to precisely edit and visualize α-synuclein in neurons, advancing tools to study its role in #Parkinsons and beyond.
📺 : bit.ly/4iMyG5i
December 15, 2025 at 4:06 PM
This month’s Discover ASAP features Madeline Klinger, PhD, with Leonardo Parra-Rivas, PhD, of CRN Team Gradinaru 🧬
They discuss a CRISPR-based protocol to precisely edit and visualize α-synuclein in neurons, advancing tools to study its role in #Parkinsons and beyond.
📺 : bit.ly/4iMyG5i
They discuss a CRISPR-based protocol to precisely edit and visualize α-synuclein in neurons, advancing tools to study its role in #Parkinsons and beyond.
📺 : bit.ly/4iMyG5i
This fall, global leaders joined GP2 in Hawai’i for our Annual Investigators Meeting. We shared progress and set future directions in #ParkinsonsDisease research. We’re grateful for the collaboration and momentum! 🌍
🔗 bit.ly/4rUL3Ay
🔗 bit.ly/4rUL3Ay
December 12, 2025 at 3:50 PM
This fall, global leaders joined GP2 in Hawai’i for our Annual Investigators Meeting. We shared progress and set future directions in #ParkinsonsDisease research. We’re grateful for the collaboration and momentum! 🌍
🔗 bit.ly/4rUL3Ay
🔗 bit.ly/4rUL3Ay
The ASAP website has a fresh, new look, making it easier for researchers to find what they need.
Check out the new site to see the updates, including our new homepage, improved highlights overview, and a dedicated tools & resources section!
🔗 bit.ly/3Mey2RX
Check out the new site to see the updates, including our new homepage, improved highlights overview, and a dedicated tools & resources section!
🔗 bit.ly/3Mey2RX
December 11, 2025 at 5:17 PM
The ASAP website has a fresh, new look, making it easier for researchers to find what they need.
Check out the new site to see the updates, including our new homepage, improved highlights overview, and a dedicated tools & resources section!
🔗 bit.ly/3Mey2RX
Check out the new site to see the updates, including our new homepage, improved highlights overview, and a dedicated tools & resources section!
🔗 bit.ly/3Mey2RX
Our 2025 #AnnualReport drops next week 🔬
We will highlight advances across #Parkinsons mechanisms, genetics, biomarkers, and open science, plus the global collaborations that made them possible.
Stay tuned for our 2025 Year in Review.
We will highlight advances across #Parkinsons mechanisms, genetics, biomarkers, and open science, plus the global collaborations that made them possible.
Stay tuned for our 2025 Year in Review.
December 10, 2025 at 9:25 PM
Our 2025 #AnnualReport drops next week 🔬
We will highlight advances across #Parkinsons mechanisms, genetics, biomarkers, and open science, plus the global collaborations that made them possible.
Stay tuned for our 2025 Year in Review.
We will highlight advances across #Parkinsons mechanisms, genetics, biomarkers, and open science, plus the global collaborations that made them possible.
Stay tuned for our 2025 Year in Review.
GP2’s 11th Data Release just passed 100k genotyped samples!
🧪 See how GP2 is shaping the future of #ParkinsonsResearch at bit.ly/4paucYC
🧪 See how GP2 is shaping the future of #ParkinsonsResearch at bit.ly/4paucYC
December 9, 2025 at 4:32 PM
GP2’s 11th Data Release just passed 100k genotyped samples!
🧪 See how GP2 is shaping the future of #ParkinsonsResearch at bit.ly/4paucYC
🧪 See how GP2 is shaping the future of #ParkinsonsResearch at bit.ly/4paucYC
👏 A huge milestone for the Parkinson’s Foundation: 30,000 participants enrolled in PD GENEration!
This groundbreaking study is expanding access to free genetic testing and building a diverse PD genetics registry.
🔗 Learn more: bit.ly/3JDbwRL
@parkinsondotorg.bsky.social
This groundbreaking study is expanding access to free genetic testing and building a diverse PD genetics registry.
🔗 Learn more: bit.ly/3JDbwRL
@parkinsondotorg.bsky.social
December 8, 2025 at 6:15 PM
👏 A huge milestone for the Parkinson’s Foundation: 30,000 participants enrolled in PD GENEration!
This groundbreaking study is expanding access to free genetic testing and building a diverse PD genetics registry.
🔗 Learn more: bit.ly/3JDbwRL
@parkinsondotorg.bsky.social
This groundbreaking study is expanding access to free genetic testing and building a diverse PD genetics registry.
🔗 Learn more: bit.ly/3JDbwRL
@parkinsondotorg.bsky.social
🔬New preprint from Team Rio! They released a study on 12 familial PD mutations, using midbrain dopaminergic neurons to map mutation-specific splicing changes. These patterns point to potential biomarkers and future therapeutic targets.
🔗 Read the full #preprint: bit.ly/48QeuMr
🔗 Read the full #preprint: bit.ly/48QeuMr
December 8, 2025 at 4:01 PM
🔬New preprint from Team Rio! They released a study on 12 familial PD mutations, using midbrain dopaminergic neurons to map mutation-specific splicing changes. These patterns point to potential biomarkers and future therapeutic targets.
🔗 Read the full #preprint: bit.ly/48QeuMr
🔗 Read the full #preprint: bit.ly/48QeuMr