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Alexandra Keinath @atkeinath.bsky.social · Jul 15

We'll be missing you too, David!

Reposted by Alexandra Keinath

Denise J. Cai, Ph.D. @denisejcai.bsky.social · Jul 14

What’s better than a one-channel #Miniscope? 🥁 A TWO-CHANNEL Miniscope!

Our new Miniscope2C is a dual-channel, open-source Miniscope that lets you record 2 fluorescent signals simultaneously in freely moving animals.

Read the paper here: www.science.org/doi/10.1126/...

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Screenshot of the top of the article, including the title, authors, and abstract.

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Alexandra Keinath @atkeinath.bsky.social · Jul 15

6\. Really excited about these results and about how this approach can be used in the future! Lots more to do, but I think these comparisons of rep geometry across assays can really help us add more nuance to our understanding of similarities and differences between species (and other comparisons).

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Alexandra Keinath @atkeinath.bsky.social · Jul 15

5\. Does the difference between these assays depend on the human visual advantage? In another cohort of participants, we demonstrate that masking the visual world with dense fog during retrieval does NOT impact representational geometry or cross-species resemblance. So it’s not just about vision!

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Alexandra Keinath @atkeinath.bsky.social · Jul 15

4\. Does this depend on the scale of the environment? We repeated our experiment in a room double the size (5x5 vs. 10x10 m). Here, the local impact of deformations scaled up, in turn preserving the rep geometry and cross-species resemblance. So it's not just about scale (at least for the humans)!

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Alexandra Keinath @atkeinath.bsky.social · Jul 15

3\. The geometry of human memory is similar but not the same as mouse CA1. Instead, it resembles a change-resistant version. CA1 subpopulations with higher firing rates, stability, and spatial specificity look more human-like. Low precision (but not low accuracy) memories look more mouse-like.

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Alexandra Keinath @atkeinath.bsky.social · Jul 15

2\. We then compare the geometry of these reps to those of mouse CA1 recorded during analogous deformations, leveraging a dataset that @markbrandonlab.bsky.social‬, @jquinnlee.bsky.social‬, and I published recently. (Check out that work if you haven’t already! www.cell.com/neuron/fullt....

www.cell.com

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Alexandra Keinath @atkeinath.bsky.social · Jul 15

1\. We use immersive VR to characterize the impact of a diverse deformations on human spatial memory. Across 3 experiments of 100+ participants each, we find that deformations induce compounding local distortions in memory.

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Alexandra Keinath @atkeinath.bsky.social · Jul 15

Trans rights are human rights.

Fresh work incoming: Here we quantitatively compare the representational geometry of mouse CA1 and human spatial memory during environmental deformations. Briefest TLDR: Human memory looks like a change-resistant version of mouse CA1.

www.biorxiv.org/cgi/content/...

Change-resistance distinguishes the representational geometries of human spatial memory and mouse CA1 in deformed environments

Prior work has highlighted qualitative similarities between the neural instantiations of cognitive maps in rodents and memory-guided navigation in humans, suggesting a conservation of representational...

www.biorxiv.org

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Alexandra Keinath @atkeinath.bsky.social · May 3

Gotta make sure your results generalize to mascots! #uic

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Alexandra Keinath @atkeinath.bsky.social · Apr 14

Super excited to share that one of our outstanding founding undergrad RAs @dahery.bsky.social will be headed to the Kempner postbac program at Harvard to work with @gershbrain.bsky.social after graduation! Congratulations David! You cannot be replaced, and I’m so proud and excited for you!

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Reposted by Alexandra Keinath

Quinn Lee @jquinnlee.bsky.social · Apr 8

The dataset and code for our recent paper in Neuron (tinyurl.com/yc48d6vr) is online now!
The data is available on Zenodo (zenodo.org/records/1486...) and code on Github (github.com/jquinnlee/ge...). Big thanks to @markbrandonlab.bsky.social and @atkeinath.bsky.social on this effort! #neuroskyence 🧠

Mouse CA1 Calcium Imaging and Behavioural Dataset in 3x3 Geometric Morph Paradigm

The following dataset was collected by Dr. J. Quinn Lee, Dr. Alexandra T. Keinath, and Erica Cianfarano in the laboratory of Dr. Mark P. Brandon. All methods and details are described in the original ...

zenodo.org

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Reposted by Alexandra Keinath

Mark Brandon @markbrandonlab.bsky.social · Apr 9

How good is your place cell model?

Come benchmark yours against real data - nearly 70K CA1 rate maps in various geometric shapes across weeks - collected and curated in my lab by the great @jquinnlee.bsky.social and @atkeinath.bsky.social

Quinn Lee @jquinnlee.bsky.social · Apr 8

The dataset and code for our recent paper in Neuron (tinyurl.com/yc48d6vr) is online now!
The data is available on Zenodo (zenodo.org/records/1486...) and code on Github (github.com/jquinnlee/ge...). Big thanks to @markbrandonlab.bsky.social and @atkeinath.bsky.social on this effort! #neuroskyence 🧠

Mouse CA1 Calcium Imaging and Behavioural Dataset in 3x3 Geometric Morph Paradigm

The following dataset was collected by Dr. J. Quinn Lee, Dr. Alexandra T. Keinath, and Erica Cianfarano in the laboratory of Dr. Mark P. Brandon. All methods and details are described in the original ...

zenodo.org

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Reposted by Alexandra Keinath

WIRED @wired.com · Feb 2

If you’ve been wondering what Elon Musk and his lackeys are up to since taking control of the US government, look no further. Our latest story names six 19- to 24-year-olds working with his DOGE organization, which now has access to sensitive federal systems. wrd.cm/4jzpiSN

The Young, Inexperienced Engineers Aiding Elon Musk's Government Takeover

Engineers between 19 and 24, most linked to Musk’s companies, are playing a key role as he seizes control of federal infrastructure.

wrd.cm

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Reposted by Alexandra Keinath

andy alexander @andyalexander.bsky.social · Feb 2

Shoutout to all the millennial junior faculty who finally got their dream jobs right as the scientific enterprise in the states is functionally dismantled.

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Reposted by Alexandra Keinath

Marisa Kabas @marisakabas.bsky.social · Feb 1

i think an important thing for people outside the US to understand is that elon musk seized control of the government today and most americans don’t even realize it happened.

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Reposted by Alexandra Keinath

Adam Serwer @adamserwer.bsky.social · Jan 29

The campaign against trans rights is also about stripping away everyone’s protections against discrimination, reviving, as Douglass put it “the moral blindness” of those who “persuade themselves that they are safe, though the rights of others may be struck down.”
www.theatlantic.com/ideas/archiv...

The Attack on Trans Rights Won’t End There

Once legal rights begin to fall, they fall for everyone.

www.theatlantic.com

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Reposted by Alexandra Keinath

Hugo Spiers @hugospiers.bsky.social · Jan 27

🚨 new publication from our lab in @pnas.org !
"Expert navigators deploy rational complexity–based decision precaching for large-scale real-world planning"

Entropy of streets & successor representations explain planning speed

Colab wth Daniel McNamee at Champalimaud

www.pnas.org/doi/10.1073/...

Map of london with the planned routes of 43 taxi drivers overlaid in yellow lines.

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Reposted by Alexandra Keinath

Mark Joseph Stern @mjsdc.bsky.social · Jan 28

Trump is attempting to unilaterally freeze trillions of dollars in federal spending that’s been duly appropriated by Congress. This is completely insane and illegal. He’s seizing unlawful control over the constitutional spending power? Five alarm fire www.washingtonpost.com/business/202...

White House pauses all federal grants, sparking confusion

The Trump administration has put a hold on all federal financial grants and loans, affecting tens of billions of dollars in payments.

www.washingtonpost.com

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Reposted by Alexandra Keinath

Nancy Kanwisher @nancykanwisher.bsky.social · Jan 25

RFkJr is a threat to human health: when the next pandemic hits we need disease tracking (CDC now silenced) and fast vaccine development (which he opposes). If you live in ME, NC, SD, LA, AK, ID, KY or SD call your senators to oppose his confirmation (hearing this Wed.).
(continued, please retweet):

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Reposted by Alexandra Keinath

Brooke Fitzwater, PhD (she/her) 🐟🪱🏳️‍🌈♾️ @oceanfilly.bsky.social · Jan 23

This is a very scary time for early career scientists like people looking for/who are postdocs and new faculty trying to get funding. Any words of encouragement to share for people in this category?

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Reposted by Alexandra Keinath

Blake Richards @tyrellturing.bsky.social · Jan 23

Okay, this is very cool: evidence from Peter Jonas' group that human CA3 follows a different logic of synaptic connectivity than rodent CA3, focussing more on sparser, but highly reliable synapses.
www.cell.com/cell/fulltex...

CC @dlevenstein.bsky.social & @repromancer.bsky.social

#neuroscience 🧪

Human hippocampal CA3 uses specific functional connectivity rules for efficient associative memory

Human hippocampal CA3 networks use sparse and broad synaptic connectivity, and their recurrent synapses employ reliability, precision, and long integration times to enhance memory capacity. Thus, the ...

www.cell.com

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Alexandra Keinath @atkeinath.bsky.social · Jan 23

It’s real rn!

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Alexandra Keinath @atkeinath.bsky.social · Jan 23

Can’t wait Andy! Definitely stoked to catch up!

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Alexandra Keinath @atkeinath.bsky.social · Jan 23

Tough week to be a trans neuroscientist with an immigrant spouse in the US…

… anyway, see y’all at Winter Brain!

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