Ever wondered how adult organs preserve epithelial barrier integrity while continuously exposed to mechanical stress? We tackled this question in our new preprint – led by our brilliant PhD student Vishnu Krishnakumar! (1/11)
🔗 www.biorxiv.org/content/10.1...

🚨 My lab is hiring at all levels!

Interested in animal origins & evolutionary cell biology?

I'm recruiting a postdoc, PhD students & a research assistant to study the molecular evolution of cell adhesion using marine invertebrates + comparative genomics.

🔗: clarkelab.com/join/

Please repost!

Thanks ☺️

PAK4 dynamics at actively remodeling vertices 🌟 ⚡👀

Check out our recent preprint
www.biorxiv.org/content/10.1...

This has been an amazing collaborative project. Huge shout out to Tomohito Higashi (Fukushima University) for brining our attention to PAK4 and collaborating with us.
Thanks to all the authors including my Undergrad Alex Chang, who made valuable contribution to the project.

Inhibiting endogenous PAK4 recruitment to the junctions disrupts barrier function, implicating PAK4 and Afadin as critical partners in vertex remodeling to preserve tissue integrity.

Inhibiting PAK4 disrupts tissue packing and compromises junctional continuity.
This video highlights impaired rosette resolution in PAK4 inhibitor treated embryos.

Our study sheds new light on how p21-activated kinase 4; PAK4 is recruited to epithelial junctions by Afadin, drives dynamic vertex remodeling in both cells and embryos.

Are you interested in how multicellular vertices resolve in epithelia?
Checkout our recent bioRxiv preprint www.biorxiv.org/content/10.1...
(Scroll down to see some cool videos)

PAK4 promotes vertex remodeling to maintain epithelial integrity and barrier function https://www.biorxiv.org/content/10.1101/2025.10.02.680170v1

Great meeting as always! #ToledoCellulArt

Beautiful work!! 👏
Amazing study showing the importance of mechanical context for crucial biological processes.
Also great to see research on pregnancy and women health!!

📢 Pre-print alert 📢 We are excited to share the lab's first research article! We used our artificial cortex system to investigate how membrane composition regulates self-organized cortical dyanamics. Check it out here: www.biorxiv.org/content/10.1...

I was so excited to meet everyone and share my scirnce at Cell Contact and Adhesion GRC, unfortunately I had to cancel my plans due to funding and travel uncertainties... Sad to miss this amazing conference 😞

Congrats Kate 🥳👏

Happy New Year!!

To celebrate 2025, here is our new pre-print showing a key role for cofilin and actin turnover in embryonic wound healing ... by modulating actin rigidity!! Work led by @anamcarmo.bsky.social, with key contributions by Ji Hong Sayo. 🪰🧪

www.biorxiv.org/content/10.1...

#nikonparty celebrations at #cellbi02024 @babliadhikary.bsky.social

I’m delighted to share that I will be starting my lab @univmiami.bsky.social in Spring 2025! We will study cellular and developmental biology in non-bilaterian animals – cnidarians, ctenophores, placozoans, and sponges – to explore early animal evolution.

Thanks Jen ☺️
Thank you all for your engagement and wonderful conversations
#CellBio2024 is amazing 😍

Are you interested in tissue patterning and junctional complexes?
I'm excited to present my work @ascbiology.bsky.social for the first time 😊 🥳 🐸
Looking forward to putting my work out there, getting feedback and building new connections 😁
#cellbio2024

We're hosting a subgroup at CellBio 2024 again, if you're interested in how cells build tissues across scales, join us for these exciting talks on Dec 15 3:15-4:45pm!🌟💫

Hello science peeps
A quick introduction to Miller lab shenanigans 🐸😄 @umichlawlib.bsky.social
We are very demure, very mindful labmates 🧪 🥼
#Scienceisfun