Mark Peifer (He, him)
@peiferlabunc.bsky.social
Cell adhesion, cytoskeletal regulation, Wnt signaling & wherever science leads us + wildflowers & my own idiosyncratic views. First gen college grad
Diversity, equity & Inclusion are core American Values
https://peiferlab.web.unc.edu
Diversity, equity & Inclusion are core American Values
https://peiferlab.web.unc.edu
Reposted by Mark Peifer (He, him)
I apologize to the kid who was waiting on our table tonight and walked up just as I was saying "cannibalism 👏 does not 👏 imply 👏 predation 👏" and look, it's a group of biologists out for dinner, I'm so sorry but this is our natural behavior
February 7, 2026 at 1:19 AM
I apologize to the kid who was waiting on our table tonight and walked up just as I was saying "cannibalism 👏 does not 👏 imply 👏 predation 👏" and look, it's a group of biologists out for dinner, I'm so sorry but this is our natural behavior
Reposted by Mark Peifer (He, him)
I do want to shout-out my fellow sociologists, who have collectively created a discipline so woke that not a single one of our introductory textbooks can make it past Florida's censors.
Great work everyone.
Great work everyone.
February 6, 2026 at 3:00 PM
I do want to shout-out my fellow sociologists, who have collectively created a discipline so woke that not a single one of our introductory textbooks can make it past Florida's censors.
Great work everyone.
Great work everyone.
Reposted by Mark Peifer (He, him)
Q: A number of Republicans are calling on you to apologize for that post. Is that something you're going to do?
Trump: No, I didn't make a mistake. It was fine. I guess it was a takeoff from The Lion King. And certainly it was a very strong post
Trump: No, I didn't make a mistake. It was fine. I guess it was a takeoff from The Lion King. And certainly it was a very strong post
February 7, 2026 at 1:12 AM
Q: A number of Republicans are calling on you to apologize for that post. Is that something you're going to do?
Trump: No, I didn't make a mistake. It was fine. I guess it was a takeoff from The Lion King. And certainly it was a very strong post
Trump: No, I didn't make a mistake. It was fine. I guess it was a takeoff from The Lion King. And certainly it was a very strong post
Reposted by Mark Peifer (He, him)
MERE HOURS after the President of the United States posted an AI video of the Obama’s as monkeys, the Science Tech Action Committee (led by @aaas.org and @researchamerica.bsky.social) posted a THANK YOU to TRUMP for SIGNING THE BUDGET.
Shot. Chaser.
sciencetechaction.org/aboutus/
Shot. Chaser.
sciencetechaction.org/aboutus/
February 7, 2026 at 1:18 AM
MERE HOURS after the President of the United States posted an AI video of the Obama’s as monkeys, the Science Tech Action Committee (led by @aaas.org and @researchamerica.bsky.social) posted a THANK YOU to TRUMP for SIGNING THE BUDGET.
Shot. Chaser.
sciencetechaction.org/aboutus/
Shot. Chaser.
sciencetechaction.org/aboutus/
Reposted by Mark Peifer (He, him)
Hey folks, Part II of “A Guide to the Epstein Files” is being published tomorrow morning, and Part III will be published Sunday afternoon.
Free to read and free to subscribe. No paywalls.
Get it to your inbox with just an email: charlotteclymer.substack.com
Free to read and free to subscribe. No paywalls.
Get it to your inbox with just an email: charlotteclymer.substack.com
February 7, 2026 at 1:15 AM
Hey folks, Part II of “A Guide to the Epstein Files” is being published tomorrow morning, and Part III will be published Sunday afternoon.
Free to read and free to subscribe. No paywalls.
Get it to your inbox with just an email: charlotteclymer.substack.com
Free to read and free to subscribe. No paywalls.
Get it to your inbox with just an email: charlotteclymer.substack.com
Reposted by Mark Peifer (He, him)
NEW: lawmakers in new york rolled out a proposed data center moratorium bill today, making NY at least the sixth state to introduce legislation pausing data center development in the past few *weeks*:
New York Is the Latest State to Consider a Data Center Pause
Red and blue states alike have introduced legislation in recent weeks that would halt data center development, citing concerns from climate to high energy prices.
www.wired.com
February 6, 2026 at 7:17 PM
NEW: lawmakers in new york rolled out a proposed data center moratorium bill today, making NY at least the sixth state to introduce legislation pausing data center development in the past few *weeks*:
Reposted by Mark Peifer (He, him)
Reposted by Mark Peifer (He, him)
Re: Science Mag editorial celebrating mainly the inside/quiet advocacy done this year, I offer this in lighthearted response. 🧪
This is a Myanmar woman doing her usual, longstanding dance routine while black cars speed by to carry out a coup. 1/4
This is a Myanmar woman doing her usual, longstanding dance routine while black cars speed by to carry out a coup. 1/4
February 7, 2026 at 1:01 AM
Re: Science Mag editorial celebrating mainly the inside/quiet advocacy done this year, I offer this in lighthearted response. 🧪
This is a Myanmar woman doing her usual, longstanding dance routine while black cars speed by to carry out a coup. 1/4
This is a Myanmar woman doing her usual, longstanding dance routine while black cars speed by to carry out a coup. 1/4
Reposted by Mark Peifer (He, him)
This weekend, New York City will experience some of the coldest – and most dangerous – weather we’ve seen in a long time.
If you see someone in need, please call 311 immediately so our outreach workers and first responders can provide assistance.
If you see someone in need, please call 311 immediately so our outreach workers and first responders can provide assistance.
February 6, 2026 at 10:18 PM
This weekend, New York City will experience some of the coldest – and most dangerous – weather we’ve seen in a long time.
If you see someone in need, please call 311 immediately so our outreach workers and first responders can provide assistance.
If you see someone in need, please call 311 immediately so our outreach workers and first responders can provide assistance.
Every member of Congress needs to make it their personal job to get at least one child out of the ICE concentration camps--it would only make a dent, but every child is worth the effort. @foushee.house.gov --which one will you help?
I am escorting the Crespo-Gonzalez family, including their seven year old daughter, back to Oregon now.
Out of respect for the family, additional information is not being shared at this time.
Out of respect for the family, additional information is not being shared at this time.
February 7, 2026 at 1:33 AM
Every member of Congress needs to make it their personal job to get at least one child out of the ICE concentration camps--it would only make a dent, but every child is worth the effort. @foushee.house.gov --which one will you help?
Reposted by Mark Peifer (He, him)
I am escorting the Crespo-Gonzalez family, including their seven year old daughter, back to Oregon now.
Out of respect for the family, additional information is not being shared at this time.
Out of respect for the family, additional information is not being shared at this time.
February 7, 2026 at 1:07 AM
I am escorting the Crespo-Gonzalez family, including their seven year old daughter, back to Oregon now.
Out of respect for the family, additional information is not being shared at this time.
Out of respect for the family, additional information is not being shared at this time.
OK--if you're still not paying attention to the cruelty of ICE, maybe this will convince you. Next they'll be detaining people in the ambulance on the way to the ER
A man taken into custody in Rochester Thursday by federal immigration agents and now held at the Whipple Federal Building in the Twin Cities is a recent organ transplant recipient who is without his needed anti-rejection medication, state Rep. Kim Hicks tells MPR News.
Transplant recipient arrested by federal agents in Rochester needs medicine, state representative says
State Rep. Kim Hicks told MPR News she drove to the Whipple Federal Building near Ft. Snelling Thursday night to give the man his medication but authorities wouldn't take it without a doctor's note. S...
www.mprnews.org
February 7, 2026 at 1:30 AM
OK--if you're still not paying attention to the cruelty of ICE, maybe this will convince you. Next they'll be detaining people in the ambulance on the way to the ER
Reposted by Mark Peifer (He, him)
A man taken into custody in Rochester Thursday by federal immigration agents and now held at the Whipple Federal Building in the Twin Cities is a recent organ transplant recipient who is without his needed anti-rejection medication, state Rep. Kim Hicks tells MPR News.
Transplant recipient arrested by federal agents in Rochester needs medicine, state representative says
State Rep. Kim Hicks told MPR News she drove to the Whipple Federal Building near Ft. Snelling Thursday night to give the man his medication but authorities wouldn't take it without a doctor's note. S...
www.mprnews.org
February 6, 2026 at 6:07 PM
A man taken into custody in Rochester Thursday by federal immigration agents and now held at the Whipple Federal Building in the Twin Cities is a recent organ transplant recipient who is without his needed anti-rejection medication, state Rep. Kim Hicks tells MPR News.
Great thread taking you step by step through defining at a molecular level the mechanisms driving a key step in membrane trafficking 🧪
As Fran was nice enough to highlight this, I thought I'd put up a brief thread. 3 in 10 proteins that our cells make are either embedded in membranes (ion channels, adhesion molecules, etc.) or secreted (insulin, antibodies). They move through the secretory pathway.
1/
1/
February 7, 2026 at 1:28 AM
Great thread taking you step by step through defining at a molecular level the mechanisms driving a key step in membrane trafficking 🧪
Reposted by Mark Peifer (He, him)
This is one of those punchline diagrams that represents YEARS of careful biochemistry:
/15
/15
February 6, 2026 at 7:31 PM
This is one of those punchline diagrams that represents YEARS of careful biochemistry:
/15
/15
Reposted by Mark Peifer (He, him)
And indeed, structural work on the SM proteins showed that Rothman's original proposed arrangement of SNARE proteins was unlikely to work, because, as Rick Baker, Fred Hughson and others showed, SMs place the R-SNARE *opposite* the Qa! So, FOUR different arrangements seemed plausible.
February 6, 2026 at 7:19 PM
And indeed, structural work on the SM proteins showed that Rothman's original proposed arrangement of SNARE proteins was unlikely to work, because, as Rick Baker, Fred Hughson and others showed, SMs place the R-SNARE *opposite* the Qa! So, FOUR different arrangements seemed plausible.
Reposted by Mark Peifer (He, him)
There is also an endolysosomal pathway that takes things into the cell from outside, for degradation. The pathways intersect. It gets very complicated. This nice diagram is from my friends Ben Glick and @juanbonifacino.bsky.social. Even it is hugely over-simplified.
4/
4/
February 6, 2026 at 6:46 PM
There is also an endolysosomal pathway that takes things into the cell from outside, for degradation. The pathways intersect. It gets very complicated. This nice diagram is from my friends Ben Glick and @juanbonifacino.bsky.social. Even it is hugely over-simplified.
4/
4/
Reposted by Mark Peifer (He, him)
Exciting preprint from the @merz.bsky.social lab proposing how fidelity of membrane fusion is achieved #membranes #trafficking
Sequential restriction of SNARE-mediated fusion by the COPII inner coat and SNARE chaperones www.biorxiv.org/content/10.6...
www.biorxiv.org
February 5, 2026 at 4:41 PM
Exciting preprint from the @merz.bsky.social lab proposing how fidelity of membrane fusion is achieved #membranes #trafficking
Reposted by Mark Peifer (He, him)
As Fran was nice enough to highlight this, I thought I'd put up a brief thread. 3 in 10 proteins that our cells make are either embedded in membranes (ion channels, adhesion molecules, etc.) or secreted (insulin, antibodies). They move through the secretory pathway.
1/
1/
February 6, 2026 at 6:39 PM
As Fran was nice enough to highlight this, I thought I'd put up a brief thread. 3 in 10 proteins that our cells make are either embedded in membranes (ion channels, adhesion molecules, etc.) or secreted (insulin, antibodies). They move through the secretory pathway.
1/
1/
Reposted by Mark Peifer (He, him)
🚘🚛 Today we began our PROTEST MARATHON—the first of 8 days of action, determination, and fun at Gorman Rd! The "Olympics" opening was a hoot, with 45+ folks; the photos tell our story! See the poster below for our overpass times on the days ahead!🍃
February 7, 2026 at 12:47 AM
🚘🚛 Today we began our PROTEST MARATHON—the first of 8 days of action, determination, and fun at Gorman Rd! The "Olympics" opening was a hoot, with 45+ folks; the photos tell our story! See the poster below for our overpass times on the days ahead!🍃
Reposted by Mark Peifer (He, him)
Friends, please help spread the word about our microbiology REU program at Montana State University.
www.montana.edu/mbi/reu/
Each student receives a stipend ($7000 for 10 wks). Travel compensation, room, and board are also provided.
Details in the attached pic--Feb 14 deadline
🧫🧪🦠#microsky
www.montana.edu/mbi/reu/
Each student receives a stipend ($7000 for 10 wks). Travel compensation, room, and board are also provided.
Details in the attached pic--Feb 14 deadline
🧫🧪🦠#microsky
January 28, 2026 at 7:46 PM
Friends, please help spread the word about our microbiology REU program at Montana State University.
www.montana.edu/mbi/reu/
Each student receives a stipend ($7000 for 10 wks). Travel compensation, room, and board are also provided.
Details in the attached pic--Feb 14 deadline
🧫🧪🦠#microsky
www.montana.edu/mbi/reu/
Each student receives a stipend ($7000 for 10 wks). Travel compensation, room, and board are also provided.
Details in the attached pic--Feb 14 deadline
🧫🧪🦠#microsky
Reposted by Mark Peifer (He, him)
Update: They succeeded: www.mississippifreepress.org/byhalia-ice-...
February 7, 2026 at 12:54 AM
Update: They succeeded: www.mississippifreepress.org/byhalia-ice-...
Reposted by Mark Peifer (He, him)
Another announcement! 📣 Our work on hybrid incompatibility in cohesin protection in 🐭oocytes is published!! Congrats Warif El Yakoubi and Eddie Pan!!🎉 We found hybrids with cohesion errors in two distinct genus.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Hybrid female sterility due to cohesin protection errors in mouse oocytes
Misregulation of chromosome cohesion during female meiosis serves as a reproductive isolating barrier in mice.
www.science.org
February 7, 2026 at 12:51 AM
Another announcement! 📣 Our work on hybrid incompatibility in cohesin protection in 🐭oocytes is published!! Congrats Warif El Yakoubi and Eddie Pan!!🎉 We found hybrids with cohesion errors in two distinct genus.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Mark Peifer (He, him)
BREAKING: The federal government has filed a motion seeking to end asylum claims for the family of Liam Conejo Ramos, according to the lawyer representing the family.
DHS has requested expedited deportation proceedings against family of Liam Conejo Ramos
The federal government has filed a motion seeking to end asylum claims for the family of Liam Conejo Ramos, according to the lawyer representing the family.
www.mprnews.org
February 6, 2026 at 2:17 AM
BREAKING: The federal government has filed a motion seeking to end asylum claims for the family of Liam Conejo Ramos, according to the lawyer representing the family.