Bertoglio lab (FMC/UFSC)
@bertogliolab.bsky.social
Catch the latest updates on aversive learning & memory, anxiety, fear, stress, and effects of psychedelics and cannabinoids from our rodent lab in Florianopolis, Brazil, and others!
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Canabidiol, ansiedade e memórias aversivas: uma revisão das evidências pré-clínicas
| Revista Fitos
revistafitos.far.fiocruz.br
Excited to contribute to this piece on CBD effects on anxiety and fear memory, together with Marina Portes, @isabel-werle.bsky.social, Luciane Soares and Fernanda Guterres
revistafitos.far.fiocruz.br/index.php/re...
revistafitos.far.fiocruz.br/index.php/re...
MDMA-Assisted Psychotherapy for PTSD: A Systematic Review of Randomized Control Trials
www.tandfonline.com/doi/full/10....
www.tandfonline.com/doi/full/10....
www.tandfonline.com
November 27, 2025 at 10:39 AM
MDMA-Assisted Psychotherapy for PTSD: A Systematic Review of Randomized Control Trials
www.tandfonline.com/doi/full/10....
www.tandfonline.com/doi/full/10....
Modeling oxidative stress on neuronal dendrites and dendritic spines
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Modeling oxidative stress on neuronal dendrites and dendritic spines
The role of oxidative stress in chronic pathological conditions of the nervous system is well-established, contributing to neuronal dysfunction and ce…
www.sciencedirect.com
November 27, 2025 at 10:12 AM
Modeling oxidative stress on neuronal dendrites and dendritic spines
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Impact of distinct neurotransmitter release modes on neuronal signaling
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Impact of distinct neurotransmitter release modes on neuronal signaling - Molecular Psychiatry
Molecular Psychiatry - Impact of distinct neurotransmitter release modes on neuronal signaling
www.nature.com
November 27, 2025 at 10:08 AM
Impact of distinct neurotransmitter release modes on neuronal signaling
www.nature.com/articles/s41...
www.nature.com/articles/s41...
The NMDA receptor subunit GluN2D is a potential target for rapid antidepressant action
www.nature.com/articles/s41...
www.nature.com/articles/s41...
The NMDA receptor subunit GluN2D is a potential target for rapid antidepressant action - Nature Communications
Here authors identify GluN2D-containing NMDA receptors on interneurons as a specific target for rapid antidepressant action. Blocking GluN2D restores stress-impaired plasticity and mimics the effects ...
www.nature.com
November 27, 2025 at 10:06 AM
The NMDA receptor subunit GluN2D is a potential target for rapid antidepressant action
www.nature.com/articles/s41...
www.nature.com/articles/s41...
VTA dopamine neurons regulated by parabrachial nucleus mediate long-term aversive memory
www.biologicalpsychiatryjournal.com/article/S000...
www.biologicalpsychiatryjournal.com/article/S000...
Ventral Tegmental Area dopamine neurons regulated by Parabrachial Nucleus mediate long-term aversive memory
Ventral Tegmental Area (VTA) dopamine neurons are intermixed with glutamate and GABA
neurons, which had been implicated in aversion. While it is unclear the neuronal circuitry
involved in regulation o...
www.biologicalpsychiatryjournal.com
November 27, 2025 at 9:59 AM
VTA dopamine neurons regulated by parabrachial nucleus mediate long-term aversive memory
www.biologicalpsychiatryjournal.com/article/S000...
www.biologicalpsychiatryjournal.com/article/S000...
Effects of Psychedelic Microdosing on Cognitive Functions: A Systematic Review and Meta-Analysis
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Effects of Psychedelic Microdosing on Cognitive Functions: A Systematic Review and Meta-Analysis
Microdosing – the practice of consuming extremely low doses of classical psychedelic substances that do not elicit overt psychedelic effects – has gai…
www.sciencedirect.com
November 27, 2025 at 9:51 AM
Effects of Psychedelic Microdosing on Cognitive Functions: A Systematic Review and Meta-Analysis
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
The hippocampus as a central hub in ketamine’s antidepressant action: from molecules to circuit rewiring
www.nature.com/articles/s41...
www.nature.com/articles/s41...
The hippocampus as a central hub in ketamine’s antidepressant action: from molecules to circuit rewiring - Neuropsychopharmacology
Neuropsychopharmacology - The hippocampus as a central hub in ketamine’s antidepressant action: from molecules to circuit rewiring
www.nature.com
November 27, 2025 at 9:49 AM
The hippocampus as a central hub in ketamine’s antidepressant action: from molecules to circuit rewiring
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Therapeutic Use of Cannabis and Cannabinoids: A Review
jamanetwork.com/journals/jam...
jamanetwork.com/journals/jam...
Therapeutic Use of Cannabis and Cannabinoids
This review discusses current evidence about the therapeutic use of cannabis and cannabinoids in adults, potential harms, and evidence-based clinical guidance, including pretreatment screening and add...
jamanetwork.com
November 26, 2025 at 7:16 PM
Therapeutic Use of Cannabis and Cannabinoids: A Review
jamanetwork.com/journals/jam...
jamanetwork.com/journals/jam...
Best practices for first psychedelic experiences: harm reduction advice from the psychedelic community
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Best practices for first psychedelic experiences: harm reduction advice from the psychedelic community - Harm Reduction Journal
Background The use of psychedelics is currently increasing in the United States. Awareness of clinical trials investigating the therapeutic applications of psychedelics may result in a record number o...
link.springer.com
November 26, 2025 at 6:52 PM
Best practices for first psychedelic experiences: harm reduction advice from the psychedelic community
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Thalamocortical transcriptional gates coordinate memory stabilization
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Thalamocortical transcriptional gates coordinate memory stabilization - Nature
The sequential recruitment of a thalamocortical transcriptional cascade enables memory maintenance over long timescales.
www.nature.com
November 26, 2025 at 6:51 PM
Thalamocortical transcriptional gates coordinate memory stabilization
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Synaptic proteome diversity is shaped by the levels of glutamate receptors and their regulatory proteins
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Synaptic proteome diversity is shaped by the levels of glutamate receptors and their regulatory proteins - Nature Communications
Proteomics must target specific synapse types to reveal how molecules shape their unique functions. Here, authors show that hippocampal synapses differ in proteome and that neuron-specific glutamate r...
www.nature.com
November 26, 2025 at 9:34 AM
Synaptic proteome diversity is shaped by the levels of glutamate receptors and their regulatory proteins
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Inhibition of FABP5 prevents stress-induced anxiogenic and depressive-like symptoms through modulation of hippocampal neurogenesis, cannabinoid and neurotrophic signaling in the limbic circuitry
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Inhibition of fatty acid binding protein 5 prevents stress-induced anxiogenic and depressive-like symptoms through modulation of hippocampal neurogenesis, cannabinoid and neurotrophic signaling in the...
The endocannabinoid (eCB) system modulates many biological processes, including adult neurogenesis, emotional behaviour and stress-related signaling p…
www.sciencedirect.com
November 25, 2025 at 12:14 PM
Inhibition of FABP5 prevents stress-induced anxiogenic and depressive-like symptoms through modulation of hippocampal neurogenesis, cannabinoid and neurotrophic signaling in the limbic circuitry
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Fear and loathing in the laboratory: An experimental comparison of pavlovian fear and disgust learning
doi.org/10.1037/emo0...
doi.org/10.1037/emo0...
APA PsycNet
doi.org
November 25, 2025 at 10:10 AM
Fear and loathing in the laboratory: An experimental comparison of pavlovian fear and disgust learning
doi.org/10.1037/emo0...
doi.org/10.1037/emo0...
DNA methylation as a new frontier in treating fear-related disorders: A need for careful evaluation
doi.org/10.5498/wjp....
doi.org/10.5498/wjp....
doi.org
November 25, 2025 at 10:08 AM
DNA methylation as a new frontier in treating fear-related disorders: A need for careful evaluation
doi.org/10.5498/wjp....
doi.org/10.5498/wjp....
VTA GABA neurons integrate positive and negative valence
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Ventral tegmental area GABA neurons integrate positive and negative valence - Nature Communications
The role of ventral tegmental area GABA neurons in behavior is unclear. Here, authors show that VTA GABA but not dopamine neurons integrate positive and negative valence to encode motivational conflic...
www.nature.com
November 25, 2025 at 10:03 AM
VTA GABA neurons integrate positive and negative valence
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Stress-Buffer-Hypothesis: blood endocannabinoids in healthy males under standardized psychosocial stress induction and resting condition
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Stress-Buffer-Hypothesis: blood endocannabinoids in healthy males under standardized psychosocial stress induction and resting condition - Translational Psychiatry
Translational Psychiatry - Stress-Buffer-Hypothesis: blood endocannabinoids in healthy males under standardized psychosocial stress induction and resting condition
www.nature.com
November 25, 2025 at 9:56 AM
Stress-Buffer-Hypothesis: blood endocannabinoids in healthy males under standardized psychosocial stress induction and resting condition
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A mouse brain atlas based on dendritic microenvironments
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A mouse brain atlas based on dendritic microenvironments - Nature Neuroscience
The authors developed a mouse brain atlas using local dendritic morphological patterns from 101,136 neurons. This representation not only improves anatomical precision but also uncovers associations b...
www.nature.com
November 25, 2025 at 9:54 AM
A mouse brain atlas based on dendritic microenvironments
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Ultrastructural membrane dynamics of mouse and human cortical synapses
www.cell.com/neuron/fullt...
www.cell.com/neuron/fullt...
Ultrastructural membrane dynamics of mouse and human cortical synapses
Eddings et al. illustrate that synaptic membrane trafficking can be studied with millisecond
resolution in resected human brain tissues using the technique “zap-and-freeze” time-resolved
electron micr...
www.cell.com
November 25, 2025 at 9:52 AM
Ultrastructural membrane dynamics of mouse and human cortical synapses
www.cell.com/neuron/fullt...
www.cell.com/neuron/fullt...
Effects of sex and pre-exposure on Δ9-tetrahydrocannabinol (THC) vapor self-administration in rats
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Effects of sex and pre-exposure on Δ9-tetrahydrocannabinol (THC) vapor self-administration in rats - Psychopharmacology
Rationale Animal models of cannabinoid self-administration are critical for advancing our understanding of the neurobiology of cannabis use and for developing medications for Cannabis Use Disorder. Us...
link.springer.com
November 25, 2025 at 9:49 AM
Effects of sex and pre-exposure on Δ9-tetrahydrocannabinol (THC) vapor self-administration in rats
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Long-term dynamic profiles of cognitive kinases induced by different learning protocols
learnmem.cshlp.org/content/32/1...
learnmem.cshlp.org/content/32/1...
Long-term dynamic profiles of cognitive kinases induced by different learning protocols
Peer-reviewed scientific journal publishing basic neuroscience research in the areas of neuronal plasticity, learning and memory
learnmem.cshlp.org
November 25, 2025 at 9:47 AM
Long-term dynamic profiles of cognitive kinases induced by different learning protocols
learnmem.cshlp.org/content/32/1...
learnmem.cshlp.org/content/32/1...
Intrinsic excitability changes in amygdala neurons following observational fear conditioning in mice
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Intrinsic excitability changes in amygdala neurons following observational fear conditioning in mice
Observational fear conditioning (OFC) is used to study the social transmission of aversive information within a social context. In a typical experimen…
www.sciencedirect.com
November 25, 2025 at 9:46 AM
Intrinsic excitability changes in amygdala neurons following observational fear conditioning in mice
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Sex differences and the influence of sex hormones on fear extinction and exposure therapy across the lifespan
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Sex differences and the influence of sex hormones on fear extinction and exposure therapy across the lifespan: A systematic review of studies in rodents and humans
Fear extinction is a laboratory model that informs the mechanisms of exposure therapy for anxiety disorders. Although knowledge on fear extinction is …
www.sciencedirect.com
November 25, 2025 at 9:45 AM
Sex differences and the influence of sex hormones on fear extinction and exposure therapy across the lifespan
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Possible Involvement of Hallucinogenic Effects in the Aversive Effects Induced by Kappa-Opioid and 5-HT2A /2C Receptor Agonists in Mice
doi.org/10.1002/npr2...
doi.org/10.1002/npr2...
Possible Involvement of Hallucinogenic Effects in the Aversive Effects Induced by Kappa‐Opioid and 5‐HT2A/2C Receptor Agonists in Mice
This study developed a simple way to test new psychoactive substances (NPS) in mice. Two drugs, U50,488H and DOI caused aversive and abnormal behaviors in mice, likely linked to their hallucinogenic ...
doi.org
November 24, 2025 at 10:23 AM
Possible Involvement of Hallucinogenic Effects in the Aversive Effects Induced by Kappa-Opioid and 5-HT2A /2C Receptor Agonists in Mice
doi.org/10.1002/npr2...
doi.org/10.1002/npr2...
Sex and stress govern the function and innervation of a basolateral amygdala to nucleus accumbens corticotropin releasing hormone/GABA expressing projection
www.jneurosci.org/content/earl...
www.jneurosci.org/content/earl...
Sex and stress govern the function and innervation of a basolateral amygdala to nucleus accumbens corticotropin releasing hormone/GABA expressing projection
Motivated behaviors are executed by refined brain circuits. Early life adversity (ELA) is a risk for human affective disorders involving dysregulated reward behaviors. In mice, ELA causes anhedonia-li...
www.jneurosci.org
November 24, 2025 at 10:11 AM
Sex and stress govern the function and innervation of a basolateral amygdala to nucleus accumbens corticotropin releasing hormone/GABA expressing projection
www.jneurosci.org/content/earl...
www.jneurosci.org/content/earl...
Single prolonged stress in mice: interactions between alcohol drinking, negative affect, and fear learning
link.springer.com/article/10.1...
link.springer.com/article/10.1...
link.springer.com
November 24, 2025 at 10:10 AM
Single prolonged stress in mice: interactions between alcohol drinking, negative affect, and fear learning
link.springer.com/article/10.1...
link.springer.com/article/10.1...