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Synaptic priming: A framework for pharmacotherapy in depression

Bertoglio lab (FMC/UFSC) @bertogliolab.bsky.social · 1d

Synaptic priming: A framework for pharmacotherapy in depression
www.cell.com/neuron/fullt...

Through the perspective of metaplasticity, Brown et al. examine the therapeutic effects of intermittent ketamine administration and explore how targeting spatiotemporal features of antidepressant dosi...

www.cell.com

Nocebo effects are stronger and more persistent than placebo effects in healthy individuals

Bertoglio lab (FMC/UFSC) @bertogliolab.bsky.social · 1d

Nocebo effects are stronger and more persistent than placebo effects in healthy individuals
elifesciences.org/reviewed-pre...

elifesciences.org

A parabrachial hub for need-state control of enduring pain - Nature

Bertoglio lab (FMC/UFSC) @bertogliolab.bsky.social · 1d

A parabrachial hub for need-state control of enduring pain
www.nature.com/articles/s41...

Activity in a set of parabranchial neurons in the mouse brain is increased during chronic pain, predicts coping behaviour, and can be modulated by circuits activated by survival threats.

www.nature.com

Safety and efficacy with esketamine in treatment-resistant depression: long-term extension study

Bertoglio lab (FMC/UFSC) @bertogliolab.bsky.social · 1d

Safety and efficacy with esketamine in treatment-resistant depression: long-term extension study
doi.org/10.1093/ijnp...

AbstractImportance. The rates of relapse and suicide risk are higher in treatment-resistant depression (TRD) vs non-treatment-resistant major depressive di

Ketamine for Depression, but at What Cost? A Review of Ketamine’s Neurotoxic Effects From Preclinical and Human Studies | American Journal of Psychiatry

Bertoglio lab (FMC/UFSC) @bertogliolab.bsky.social · 1d

Ketamine for Depression, but at What Cost? A Review of Ketamine's Neurotoxic Effects From Preclinical and Human Studies
doi.org/10.1176/appi...

This review examines ketamine’s neurotoxic potential across preclinical and clinical studies. The authors synthesized data from preclinical models, then integrated findings from human clinical trials ...

Examining Volunteer Bias in Psychedelic Research

Bertoglio lab (FMC/UFSC) @bertogliolab.bsky.social · 1d

Examining Volunteer Bias in Psychedelic Research
doi.org/10.1080/0279...

Since its resurgence, psychedelic research has garnered considerable attention, especially in mental health. Preliminary findings have indicated positive results regarding psychedelic-assisted psyc...

Frontiers | The collective lie in ketamine therapy: a call to realign clinical practice with neurobiology

Bertoglio lab (FMC/UFSC) @bertogliolab.bsky.social · 1d

The collective lie in ketamine therapy: a call to realign clinical practice with neurobiology
doi.org/10.3389/fpsy...

In recent years, ketamine therapy has become increasingly entangled with psychedelic culture, leading to widespread misinterpretation of its therapeutic mech...

Frontiers | A clinical protocol for group-based ketamine-assisted therapy in a community of practice: the Roots To Thrive model

Bertoglio lab (FMC/UFSC) @bertogliolab.bsky.social · 1d

A clinical protocol for group-based ketamine-assisted therapy in a community of practice: the Roots To Thrive model
doi.org/10.3389/fpsy...

BackgroundKetamine-assisted therapy (KaT) has demonstrated therapeutic potential in treating depression, anxiety, and PTSD, driving interest in group-based m...

Bertoglio lab (FMC/UFSC) @bertogliolab.bsky.social · 2d

In silico insights on the binding site and function of cannabinoids and cannabinoid acids on human 5-HT1A receptor
doi.org/10.1016/j.jm...

Redirecting

Developing Medical Cannabis Competencies

Bertoglio lab (FMC/UFSC) @bertogliolab.bsky.social · 2d

Developing Medical Cannabis Competencies: A Consensus Statement
doi.org/10.1001/jama...

This consensus statement describes the development of a set of core competencies for educating medical students about medical cannabis, including its clinical utility, risks, legal landscape, and evid...

Ketamine Sustains and Enhances the Protective Effects of a Ketogenic Diet Against Relapses in an Anorexia Mouse Model

Bertoglio lab (FMC/UFSC) @bertogliolab.bsky.social · 2d

Ketamine Sustains and Enhances the Protective Effects of a Ketogenic Diet Against Relapses in an Anorexia Mouse Model
onlinelibrary.wiley.com/doi/10.1002/...

Anorexia nervosa (AN) has high mortality and relapse rates, yet no accepted pharmacotherapies. Reports based on six individuals suggest that ketogenic diet (KGD) combined with sub-anesthetic ketamine...

onlinelibrary.wiley.com

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Bertoglio lab (FMC/UFSC) @bertogliolab.bsky.social · 2d

Ketamine Sustains and Enhances the Protective Effects of a Ketogenic Diet Against Relapses in an Anorexia Mouse Model
onlinelibrary.wiley.com/doi/10.1002/...

Ketamine Sustains and Enhances the Protective Effects of a Ketogenic Diet Against Relapses in an Anorexia Mouse Model

Anorexia nervosa (AN) has high mortality and relapse rates, yet no accepted pharmacotherapies. Reports based on six individuals suggest that ketogenic diet (KGD) combined with sub-anesthetic ketamine...

onlinelibrary.wiley.com

Hippocampal drift rate reflects the temporal organization of memories

Bertoglio lab (FMC/UFSC) @bertogliolab.bsky.social · 2d

Hippocampal drift rate reflects the temporal organization of memories
www.jneurosci.org/content/earl...

When freely recalling events from the past, individuals tend to successively remember stimuli that were studied close together in time—a phenomenon known as temporal clustering. Temporal clustering is...

www.jneurosci.org

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Bertoglio lab (FMC/UFSC) @bertogliolab.bsky.social · 2d

Hippocampal drift rate reflects the temporal organization of memories
www.jneurosci.org/content/earl...

Hippocampal drift rate reflects the temporal organization of memories

When freely recalling events from the past, individuals tend to successively remember stimuli that were studied close together in time—a phenomenon known as temporal clustering. Temporal clustering is...

www.jneurosci.org

Bertoglio lab (FMC/UFSC) @bertogliolab.bsky.social · 2d

Biased signaling via serotonin 5-HT2A receptor: From structural aspects to in vitro and in vivo pharmacology
doi.org/10.1016/j.ap...

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Psychedelic-assisted therapy as a complex intervention: implications for clinical trial design - S. D. Muthumaraswamy, M. J. Baggott, E. E. Schenberg, D. Repantis, M. Wolff, A. Forsyth, T. Noorani, 20...

Bertoglio lab (FMC/UFSC) @bertogliolab.bsky.social · 2d

Psychedelic-assisted therapy as a complex intervention: implications for clinical trial design
doi.org/10.1177/2045...

Psychedelic-assisted therapy (PAT) has typically been evaluated using conventional randomised controlled trials (RCTs), which assess treatment efficacy under hi...

Extraction and Characterization of N,N-Dimethyltryptamine from Mimosa tenuiflora: A Multivariate Approach

Bertoglio lab (FMC/UFSC) @bertogliolab.bsky.social · 2d

Extraction and Characterization of N, N‑Dimethyltryptamine from Mimosa tenuiflora: A Multivariate Approach
doi.org/10.1021/acso...

N,N-Dimethyltryptamine (DMT), a plant-derived tryptamine alkaloid, has attracted growing interest due to its therapeutic potential in treating mental health disorders resistant to conventional pharmac...

Psychedelic compounds directly excite 5-HT2A layer V medial prefrontal cortex neurons through 5-HT2A Gq activation - Translational Psychiatry

Bertoglio lab (FMC/UFSC) @bertogliolab.bsky.social · 2d

Psychedelic compounds directly excite 5-HT2A layer V medial prefrontal cortex neurons through 5-HT2A Gq activation
doi.org/10.1038/s413...

Translational Psychiatry - Psychedelic compounds directly excite 5-HT2A layer V medial prefrontal cortex neurons through 5-HT2A Gq activation

27 things we wish we’d known when we started our PhDs

Bertoglio lab (FMC/UFSC) @bertogliolab.bsky.social · 3d

27 things we wish we’d known when we started our PhDs
www.nature.com/articles/d41...

Nature’s survey of PhD candidates reveals hard-won wisdom on choosing supervisors, managing mental health and surviving academic culture.

www.nature.com

Foraging as an ethological framework for neuroscience

Bertoglio lab (FMC/UFSC) @bertogliolab.bsky.social · 3d

Foraging as an ethological framework for neuroscience
www.cell.com/trends/neuro...

The study of foraging is central to a renewed interest in naturalistic behavior in neuroscience. Applying a foraging framework grounded in behavioral ecology has enabled probing of the mechanisms unde...

www.cell.com

Bertoglio lab (FMC/UFSC) @bertogliolab.bsky.social · 3d

Reactivation-coupled brain stimulation enables complete learning generalization
www.biorxiv.org/content/10.1...

Reactivation-coupled brain stimulation enables complete learning generalization

Generalization of learned knowledge to new contexts is essential for adaptive behavior. Despite extensive research on the brain plasticity mechanisms underlying learning specificity, the mechanisms th...

Sex Based Differences in Active Avoidance and Approach Strategy in the Platform Mediated Avoidance Task

Bertoglio lab (FMC/UFSC) @bertogliolab.bsky.social · 3d

Sex Based Differences in Active Avoidance and Approach Strategy in the Platform Mediated Avoidance Task
www.biorxiv.org/content/10.1...

Sex differences have been documented in threat conditioning, but research into potential sex differences in avoidance paradigms, particularly active avoidance, remains limited. This research gap is pa...

Lessons learned while evaluating how pairing aversive experiences with same or different sex social stimulus mice affects subsequent social engagement

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Bertoglio lab (FMC/UFSC) @bertogliolab.bsky.social · 3d

Lessons learned while evaluating how pairing aversive experiences with same or different sex social stimulus mice affects subsequent social engagement
www.biorxiv.org/content/10.1...

Mice offer a wealth of opportunities for investigating brain circuits regulating multiple behaviors, largely due to their genetic tractability. Social behaviors are translationally relevant, consideri...

Behavioral Decoding Reveals Cortical Endocannabinoid Potentiation during Δ9-THC Impairment

Bertoglio lab (FMC/UFSC) @bertogliolab.bsky.social · 3d

Behavioral Decoding Reveals Cortical Endocannabinoid Potentiation during Δ9-THC Impairment
www.biorxiv.org/content/10.1...

How Δ9-tetrahydrocannabinol (THC) impairs natural behaviors in mice remains unknown. We developed a video-monitored behavioral platform with machine learning classifiers to unravel discrete changes in...