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Bianca Dumitrascu

@bimidu.bsky.social

190 followers 150 following 14 posts

computational biologist and statistician interested in how genes encode shape, form, and dynamics during development and regeneration; assistant professor @Columbia University https://www.morpho-lab.com/

www.morpho-lab.com

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Bianca Dumitrascu @bimidu.bsky.social · Dec 24

Check out our newest preprint on #bioxiv. We developed Patches, a tool for extracting joint and condition specific signatures from scRNA-seq data in complex experimental designs like wound healing: www.biorxiv.org/content/10.1...

GitHub: github.com/Computationa...

Patches: A Representation Learning framework for Decoding Shared and Condition-Specific Transcriptional Programs in Wound Healing

Single-cell genomics enables the study of cell states and cell state transitions across biological conditions like aging, drug treatment, or injury. However, existing computational methods often strug...

www.biorxiv.org

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Bianca Dumitrascu @bimidu.bsky.social · 18d

An exciting collaboration with a wonderful team! Check out Kuba's tutorial!

kuba sędziński @kuba-sedzinski.bsky.social · 18d

🧵1/14 Preprint thread! Can we predict a cell’s fate based on its dynamics? 🔮 Our new study unveils a framework for watching development unfold in real-time, revealing how a cell's shape and movement encode info about its future fate. 🔬📄 Preprint: tinyurl.com/4shf8v4x

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Bianca Dumitrascu @bimidu.bsky.social · Apr 25

This is really nice! Congratulations 🎉🎉

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Bianca Dumitrascu @bimidu.bsky.social · Apr 2

Congratulations! 🎉 Excited for your new adventure!

Reposted by Bianca Dumitrascu

Berta Verd @bertaverd.bsky.social · Mar 25

Latest from the lab: a review led by @jamesehammond.bsky.social on the evolvability of vertebral counts and the developmental processes that make it possible.

James Hammond @jamesehammond.bsky.social · Mar 24

Latest work:

Review on the evolvability of vertebral number, and the developmental processes underpinning it

Written by Callum Bucklow, @bertaverd.bsky.social, and myself

Check it out here: doi.org/10.32942/X2K...

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Bianca Dumitrascu @bimidu.bsky.social · Mar 22

Congratulations Rory & James!

Reposted by Bianca Dumitrascu

Kristina Stapornwongkul @kstapornwongkul.bsky.social · Mar 20

Thrilled to announce that I am looking for a Research Technician/Assistant to join my lab @imbavienna.bsky.social. Please consider applying if you’re enthusiastic about #devbio #stemcells #teamwork and excited to help shaping a new lab!

Thankful for any retweet! 🫶

imba.onlyfy.jobs/job/l6u2m980

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Bianca Dumitrascu @bimidu.bsky.social · Mar 20

Congratulations Kristina and happy for those lucky to join your group!

Kristina Stapornwongkul @kstapornwongkul.bsky.social · Mar 5

Amidst these troubling times, I have some positive personal news to share: I will be joining @imbavienna.bsky.social as a new group leader this fall! 🎉 I am excited for fun projects, surprising discoveries, and great discussions within the fantastic science community @vbcscitraining.bsky.social

Institute of Molecular Biotechnology @imbavienna.bsky.social · Mar 5

Kristina Stapornwongkul is joining IMBA! The Stapornwongkul lab will study how the nutritional environment and metabolic processes influence embryonic development—an emerging research area with broad implications for both fundamental biology and biomedical applications. Welcome, Kristina!

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Bianca Dumitrascu @bimidu.bsky.social · Mar 19

Congratulations Dr. Joy!

Bianca Dumitrascu @bimidu.bsky.social · Mar 19

Thank you so much for the highlight and for the nice summary of our recent work!

Nature Methods @natmethods.nature.com · Mar 19

Please also check out the News & Views highlighting this cool work!

www.nature.com/articles/s41...

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Reposted by Bianca Dumitrascu

Irving Institute for Cancer Dynamics @cancerdynamics.bsky.social · Mar 18

Dr. Bianca Dumitrascu (bimidu.bsky.social) led a new study published in naturemethods.bsky.social on a computational pipeline linking spatial transcriptomics + mechanical forces in tissue development. Read more: bit.ly/4kCgT1q #CancerResearch #Mechanobiology #SpatialTranscriptomics #IICDColumbia

Bridging Biology and Biomechanics: The Dumitrascu Lab’s New Computational Framework Illuminates Tissue Development | Columbia University

bit.ly

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Bianca Dumitrascu @bimidu.bsky.social · Mar 12

Some light yesterday at Chimamanda Ngozi Adichie's new book reading.

Bianca Dumitrascu @bimidu.bsky.social · Mar 10

What a treat to be part of this effort! Congratulations @jcornwallscoones.bsky.social and team!

Jake Cornwall-Scoones @jcornwallscoones.bsky.social · Mar 10

Excited to share my latest work with @joadelas.bsky.social and @jamesbriscoe.bsky.social

Predictable Engineering of Signal-Dependent Cis-Regulatory Elements

www.biorxiv.org/content/10.1...
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Predictable Engineering of Signal-Dependent Cis-Regulatory Elements

www.biorxiv.org

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Bianca Dumitrascu @bimidu.bsky.social · Dec 24

c) It aims to be replicable and robust, the code is meant to be used by experts and non-experts. We are excited to find out how the tool can be broken and improved! We found many gaps in the #generativeAi for bio methodologies which we hope we can address

Bianca Dumitrascu @bimidu.bsky.social · Dec 24

b) It is the result of a collaborative effort with the Woappi Group who got us excited about wound healing. There are many directions to go from here, especially in the context of regeneration and cross species comparisons!

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Bianca Dumitrascu @bimidu.bsky.social · Dec 24

It's a particularly special project to me because:

a) It is our lab's first paper, led by my fantastic student Oz!

Bianca Dumitrascu @bimidu.bsky.social · Dec 24

Patches: A Representation Learning framework for Decoding Shared and Condition-Specific Transcriptional Programs in Wound Healing

www.biorxiv.org

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Bianca Dumitrascu @bimidu.bsky.social · Dec 24

Very excited about this first adventure in looking at regeneration! Thank you Maria and @smeetonlab.bsky.social for a fantastic first collaborative project :)

Joanna Smeeton @smeetonlab.bsky.social · Dec 17

📢🧪For your holiday travel reading, check out our new pre-print! Using a new joint resection injury model, we describe an innate regeneration program in adult #zebrafish that reestablishes all major synovial joint cell types, including lubricated articular cartilage. www.biorxiv.org/content/10.1...