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Reposted by Jake Cornwall-Scoones

Levayer Lab @levayerr.bsky.social · 23h

Happy to share the last version of our story @currentbiology.bsky.social on the role of interfacial tension in mechanical cell competition led by @leovalon.bsky.social and Alexis Matamoro Vidal
www.sciencedirect.com/science/arti...

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Reposted by Jake Cornwall-Scoones

Bethan Clark @bethanclark.bsky.social · 10d

I wrote something on developmental biology and disability and put it up on the node last night:

thenode.biologists.com/developmenta...

I've been nervous to share because some of it veers a bit personal but they are thoughts that won't stay quiet. Would love to know what people think about it!

Developmental Biology and Disability - the Node

Hopeful monsters. Morphospace. Mutation. Natural variation. Mutagenesis screens. Polymorphism. Deformity. Phenotype. Disease. Adaptation. Anomaly.

thenode.biologists.com

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Reposted by Jake Cornwall-Scoones

Luca Giorgetti lab @FMI @lucagiorgetti.bsky.social · 15d

Really excited to share our latest work led by @mattiaubertini.bsky.social and @nesslfy.bsky.social: we report that cohesin loop extrusion creates rare but long-lived encounters between genomic sequences which underlie efficient enhancer-promoter communication.
www.biorxiv.org/content/10.1...
A🧵👇

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Reposted by Jake Cornwall-Scoones

Glover lab @glover-lab.bsky.social · 14d

🚨 Excited to introduce FuChi (Fucci chicken), the first avian cell cycle reporter line. Thank you to all those who contributed to putting this paper together. I really think it showcases the power and beauty of the chick embryo as a developmental biology model. 🐥 🥚 🔬 @roslininstitute.bsky.social

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Rashmi Priya @rashmi-priya.bsky.social · 21d

Development does not happen in isolation! Material properties, geometry, stiffness, fluid flows...can all steer how development unfolds. If you’re exploring these kinds of questions, we’d love to see your work @dev-journal.bsky.social
More info below ⬇️

Development @dev-journal.bsky.social · Sep 1

📢Call for papers. Submit your latest research to our upcoming special issue – The Extracellular Environment in Development, Regeneration and Stem Cells

Guest Editors: Alex Hughes and Rashmi Priya

📅 Deadline: 1 March 2026

journals.biologists.com/dev/pages/ex...

#DevBio

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Reposted by Jake Cornwall-Scoones

Zena Hadjivasiliou @zenahadjivasiliou.bsky.social · 23d

Fresh from the press💥 We asked what happens when you evolve gene regulatory networks computationally at scale. Do general principles of GRN evolution jump out? Is the process predictable? Read on to find out @prxlife.bsky.social @crick.ac.uk @ucl-ipls.bsky.social 👉 journals.aps.org/prxlife/abst...

Gene Network Organization, Mutation, and Selection Collectively Drive Developmental Pattern Evolvability and Predictability

The historical order in which mutations appear during evolution determine the evolutionary trajectory of gene regulatory networks and influence how developmental patterns change and diversify over tim...

journals.aps.org

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Reposted by Jake Cornwall-Scoones

Ollie Inge @oliveringe.bsky.social · 27d

1/3 After 6+ years at @crick.ac.uk I split my last cells and hung up my lab coat! Thank you to the brilliant community from fellow PhDs/Postdocs, LOAs, STPs, academic training team and to all past/present @santoslab.bsky.social members. My Crick journey would not have been the same without you all!

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Ricard Solé @ricardsole.bsky.social · Sep 10

Can a single cell learn? Even without a brain, some microbes show simple forms of cognition. Can this basal cognition be engineered? Check our new paper with @jordiplam.bsky.social on the minimal synthetic circuits & their cognitive limits. @drmichaellevin.bsky.social www.biorxiv.org/content/10.1...

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Jake Cornwall-Scoones @jcornwallscoones.bsky.social · Sep 9

Beautiful work led by @oliveringe.bsky.social. It was great fun to be involved with this project.

See Ollie’s paper and thread 👇

Ollie Inge @oliveringe.bsky.social · Sep 9

1/7 Really happy to see my PhD work published in ✨Developmental Cell✨ today! We find human endoderm is specified by two developmental trajectories 🔀, and the choice between alternate routes is dictated by the combinatorial BMP4/Activin signalling. www.cell.com/developmenta...

Combinatorial BMP4 and activin direct the choice between alternate routes to endoderm in a stem cell model of human gastrulation

Inge et al. show that human endoderm originates from two converging developmental routes with distinct dynamics and efficiencies yet similar developmental potential. Combinatorial activin and BMP4 sig...

www.cell.com

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Reposted by Jake Cornwall-Scoones

James Briscoe @jamesbriscoe.bsky.social · Aug 26

Our latest: We developed a chemo-optogenetic system for precise spatiotemporal control of morphogen production. Using dual light + small molecule control of Sonic Hedgehog production, we recapitulated neural tube patterning in vitro & measured spread of Shh

🧵

www.sciencedirect.com/science/arti...

Investigating morphogen and patterning dynamics with optogenetic control of morphogen production

Morphogen gradients provide the patterning cues that instruct cell fate decisions during development. Here, we establish an optogenetic system for the…

www.sciencedirect.com

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Reposted by Jake Cornwall-Scoones

Laura Boulan @lboulan.bsky.social · Aug 10

Our new paper is out in @currentbiology.bsky.social! Using 3D reconstructions and volume measurements in Drosophila wing primordia, we show that growth can be uncoupled from cell proliferation and uncover a new time window for growth arrest.
With @leopoldlab.bsky.social
www.cell.com/current-biol...

A switch to non-proliferative growth sustains Drosophila wing development during the early pupal stage

Using precise tissue volume quantification, El Marzkioui, Gaugué, et al. show that wing primordia continue to grow during the early pupal stage, a phase of increased cell volume driven by insulin/IGF ...

www.cell.com

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Reposted by Jake Cornwall-Scoones

Biomedical Picture of the Day BPoD @bpodaily.bsky.social · Aug 18

How the functional architecture of the zebrafish heart is shaped during development

📹 @tobyandrews.bsky.social et al @rashmi-priya.bsky.social
lab @crick.ac.uk in @cellpress.bsky.social Developmental Cell

➡️ bpod.org.uk/archive/2025...

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Reposted by Jake Cornwall-Scoones

Giulia Paci @giuliapaci.bsky.social · Aug 11

Thrilled to share the first story from my postdoc! 🎉 A wonderful experiment + simulations collaboration. In the Drosophila wing, we find that 3D cell shapes affect signalling range and fine-tune developmental patterning www.biorxiv.org/content/10.1... Thread below ⬇️

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Jake Cornwall-Scoones @jcornwallscoones.bsky.social · Aug 11

Apply by Friday! 👇

Jake Cornwall-Scoones @jcornwallscoones.bsky.social · Jul 30

We’re excited to announce that Naomi Moris @nmoris.bsky.social will join us in Oct

Don’t forget to register before the 15th August for a chance to give a short talk

Talk submissions can be received only after confirmation of registration (link 👇) so sign up ASAP if you’re interested in presenting

Sally Lowell @cellysally.bsky.social · Jul 28

Speaker update for our Generative Biology workshop: we are delighted to have @nmoris.bsky.social join us. See full list of speakers on the attached flyer or on our website.

Apply by 15th August. Places available for short talks.

royalsociety.org/science-even...

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Jake Cornwall-Scoones @jcornwallscoones.bsky.social · Aug 7

Beautiful work from @tobyandrews.bsky.social @rashmi-priya.bsky.social. It was a joy to collaborate on the modelling here.

Check out Toby’s paper and thread 👇

Toby Andrews @tobyandrews.bsky.social · Aug 6

Thrilled to bits to see our latest work online in Dev Cell! 🥳

We wanted to know how cells build functional organs with precision🫀🫁📏 Here we show how coupling of cell shape and organ function fine tunes the form and contractile power of the developing #zebrafish heart 1/n

tinyurl.com/cell-stretch

Mechanochemical coupling of cell shape and organ function optimizes heart size and contractile efficiency in zebrafish

Andrews et al. demonstrate that multiscale feedback between mechanical and chemical cues builds a functional heart to support zebrafish embryonic life. Cell recruitment and organ-scale forces drive tr...

tinyurl.com

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Jake Cornwall-Scoones @jcornwallscoones.bsky.social · Aug 7

8 days left to submit an abstract!

Jake Cornwall-Scoones @jcornwallscoones.bsky.social · Jul 30

We’re excited to announce that Naomi Moris @nmoris.bsky.social will join us in Oct

Don’t forget to register before the 15th August for a chance to give a short talk

Talk submissions can be received only after confirmation of registration (link 👇) so sign up ASAP if you’re interested in presenting

Sally Lowell @cellysally.bsky.social · Jul 28

Speaker update for our Generative Biology workshop: we are delighted to have @nmoris.bsky.social join us. See full list of speakers on the attached flyer or on our website.

Apply by 15th August. Places available for short talks.

royalsociety.org/science-even...

Reposted by Jake Cornwall-Scoones

Toby Andrews @tobyandrews.bsky.social · Aug 6

Thrilled to bits to see our latest work online in Dev Cell! 🥳

We wanted to know how cells build functional organs with precision🫀🫁📏 Here we show how coupling of cell shape and organ function fine tunes the form and contractile power of the developing #zebrafish heart 1/n

tinyurl.com/cell-stretch

Mechanochemical coupling of cell shape and organ function optimizes heart size and contractile efficiency in zebrafish

Andrews et al. demonstrate that multiscale feedback between mechanical and chemical cues builds a functional heart to support zebrafish embryonic life. Cell recruitment and organ-scale forces drive tr...

tinyurl.com

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Reposted by Jake Cornwall-Scoones

Kavli Institute for Theoretical Physics @kitp-ucsb.bsky.social · Jun 27

New KITP Program! #MORPHO26

Geometry and Intercellular Interactions in Morphogenesis of Animals and Plants

Dates: 7/20/2026 - 8/20/2026

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Reposted by Jake Cornwall-Scoones

Ruben Perez-Carrasco @perez-carrasco.bsky.social · Aug 4

We wrote this introductory review on how concepts from dynamical systems can help us understand developmental biology, hope it’s useful to somebody! It was a lot of fun to put together, and great to collaborate with brilliant colleagues across theory and experiments

Pau Formosa-Jordan @pauformosa.bsky.social · Aug 4

Introducing five concepts from dynamical systems to decode developmental regulatory mechanisms, have a read! @perez-carrasco.bsky.social‬ @roederlab.bsky.social @mpipz.bsky.social This effort started in a morphogenesis meeting @kitp-ucsb.bsky.social‬ in 2023. journals.biologists.com/dev/article/...

Adapted from Fig. 1 from Kadiyala et al 2025.

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Jake Cornwall-Scoones @jcornwallscoones.bsky.social · Jul 30

We’re excited to announce that Naomi Moris @nmoris.bsky.social will join us in Oct

Don’t forget to register before the 15th August for a chance to give a short talk

Talk submissions can be received only after confirmation of registration (link 👇) so sign up ASAP if you’re interested in presenting

Sally Lowell @cellysally.bsky.social · Jul 28

Speaker update for our Generative Biology workshop: we are delighted to have @nmoris.bsky.social join us. See full list of speakers on the attached flyer or on our website.

Apply by 15th August. Places available for short talks.

royalsociety.org/science-even...

Flyer for Royal Society Generative Biology workshop. Full list of speakers can also be found on the website linked to in the post.

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Jake Cornwall-Scoones @jcornwallscoones.bsky.social · Jul 24

Beautiful work from @isazhang.bsky.social @joadelas.bsky.social @jamesbriscoe.bsky.social. An honour to have played a small part

Joaquina Delas @joadelas.bsky.social · Jul 21

Excited to share our latest work with @jamesbriscoe.bsky.social .

A global #cis-regulatory temporal program guides how spatial cues are interpreted in neural progenitors. We show how #space and #time can be integrated to generate cell type diversity in the #spinalcord.

Congrats to all authors.

UCL Faculty of Life Sciences @ucllifesciences.bsky.social · Jul 21

A study from @crick.ac.uk and @ucllifesciences.bsky.social reveals how timing mechanisms, not just spatial cues, shape cell identity during spinal cord development. The findings open up new avenues for both basic developmental biology and clinical applications.
www.sciencedirect.com/science/arti...

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Reposted by Jake Cornwall-Scoones

Petr Znamenskiy @petrznam.bsky.social · Jul 21

1/ Mapping synaptic connectivity between individual neurons is extremely laborious. We developed BRISC, a new method that makes it possible to map inputs onto 100s of neurons in the same animal in a matter of weeks! Led by Alex Becalick and @antblot.bsky.social. 🧵

www.biorxiv.org/content/10.1...

Barcoded Rabies In Situ Connectomics for high-throughput reconstruction of neural circuits

Sequencing of oligonucleotide barcodes holds promise as a high-throughput approach for reconstructing synaptic connectivity at scale. Rabies viruses can act as a vehicle for barcode transmission, than...

www.biorxiv.org

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Reposted by Jake Cornwall-Scoones

Hiscock Lab @hiscocklab.bsky.social · Jun 27

🚨Job alert in theory/math devbio 🚨
I’m currently advertising postdoc positions to join my group. We’re building reaction-diffusion models to understand some of the crazy things embryos can do. We are based in a beautiful part of Scotland :). Please share! www.abdnjobs.co.uk/vacancy/rese...

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Reposted by Jake Cornwall-Scoones

James Briscoe @jamesbriscoe.bsky.social · Jul 17

Just published: The cis-regulatory logic integrating spatial and temporal patterning in the vertebrate neural tube

A global temporal chromatin program, operating across the CNS, directs binding of specific spatial TFs & hence when/where neurons & glia are born

authors.elsevier.com/sd/article/S...

ScienceDirect.com | Science, health and medical journals, full text articles and books.

authors.elsevier.com

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Reposted by Jake Cornwall-Scoones

PLOS Biology @plosbiology.org · Jul 18

Measuring properties of individual cells in relation to their neighbors in 3D tissues is challenging. @cellysally.bsky.social &co develop a computational toolkit to facilitate this, analyzing developmental patterning in mouse, chick & #Drosophila #embryo @plosbiology.org 🧪 plos.io/4lQMeNu

Patterning of cell identities in the posterior E8.5 mouse embryo. Co-expression of mesoderm marker TBXT (blue) and neural marker SOX2 (green) identifies cells in the neuromesodermal (NMP) progenitor region at the intersection of their respective gene expression gradients. TBX6 (red) marks paraxial mesoderm and also marks sporadic mesoderm-committed cells emerging within the NMP region. LAMINB1 (white) marks the nuclear envelope of all cells. Credit: Matthew French.

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