The Education Department laid off nearly everyone at the Office of Special Education and Rehabilitative Services.

Congenital vascular malformations result from abnormal development of the vascular tree, with the aneurysmal malformation of the vein of Galen (VGAM) being the most prevalent neurovascular malformation in neonates, associated with poor outcomes. This condition is linked to germline mutations in the RASA1 and EPHB4 genes, although the underlying developmental mechanisms remain unclear. Here we generate zebrafish models lacking rasa1a and ephb4a that replicate the genetic and structural features of VGAMs. Our findings connect the development of malformations to insufficient fusion of precursor blood vessels, a process regulated by blood flow and the responses of endothelial cells. RASA1 deficiency destabilizes the homeostatic response to blood flow and contributes to impaired flow-mediated activation of MAPK and phosphatidylinositol-3-kinase signaling. By pharmacologically targeting these signaling pathways in mutant models, we restore normal fusion in existing malformations, offering po

An axon guidance factor restricts gap growth in a non-neuronal migrating cell sheet, allowing organ sculpting.

Bone marrow health is central to transplantations, blood formation, and cancer progression. However, the bone marrow niche deteriorates with age, impairing haematopoietic stem cell function. Contrary ...

Democrats are demanding answers over the University of Virginia president’s resignation and warning the board against signing a proposed federal compact.

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Objective Matrix metalloproteinase 13 (MMP13) is an extracellular matrix protease that affects the progression of atherosclerotic plaques and arterial thrombi by degrading collagens, modifying…

We seek an accomplished scientist, at the Professor or Associate Professor level, to join the Rutgers Brain Health Institute (BHI) and The Rutgers School of Dental Medicine (RSDM) as Director of the n...

YouTube video by Kevin Bonham

ALT: a man in a suit and tie is standing in front of a painting .