Wythe Lab at UVA School of Medicine
@wythelab.bsky.social
Vascular biologist. Brain AVMs and Kras, glioblastoma and angiogenesis, lymphatics, and developmental biology.
https://www.wythelab.com
https://www.wythelab.com
Pinned
Mapping the transcriptional and epigenetic landscape of organotypic endothelial diversity in the developing and adult mouse
Nature Cardiovascular Research - Cantu Gutierrez et al. identify the common and unique transcriptional regulatory networks in the endothelium of six different organs throughout development, and...
go.nature.com
Excited to share this paper that is a long time coming from the lab on epigenetic/transcriptional regulation of organotypic endothelial specialization out today @naturecvr.bsky.social go.nature.com/4krSJqh
Reposted by Wythe Lab at UVA School of Medicine
Then: Investigate and, if needed, blacklist all authors, reviewers, and editors that were involved with this paper. This is independent from the other thing, because no matter if there was AI involved or not, they have chosen not to fulfill their important duty for science.
5/6
5/6
November 28, 2025 at 12:36 PM
Then: Investigate and, if needed, blacklist all authors, reviewers, and editors that were involved with this paper. This is independent from the other thing, because no matter if there was AI involved or not, they have chosen not to fulfill their important duty for science.
5/6
5/6
Reposted by Wythe Lab at UVA School of Medicine
New paper from the @rouxlab.bsky.social on Nature Communications! We study how membrane tension is spatially organized in cells. Using the mechanosensitive probe Flipper-TR to visualize tension across the plasma membrane of adherent cells and to dissect the conditions needed for a gradient to happen
November 27, 2025 at 2:14 PM
New paper from the @rouxlab.bsky.social on Nature Communications! We study how membrane tension is spatially organized in cells. Using the mechanosensitive probe Flipper-TR to visualize tension across the plasma membrane of adherent cells and to dissect the conditions needed for a gradient to happen
Reposted by Wythe Lab at UVA School of Medicine
Reposted by Wythe Lab at UVA School of Medicine
🧪
@gingraslab.bsky.social
compared 10 enzymes used for proximity biotinylation proteomics experiments. UltraID is the winner.
www.biorxiv.org/content/10.1...
@gingraslab.bsky.social
compared 10 enzymes used for proximity biotinylation proteomics experiments. UltraID is the winner.
www.biorxiv.org/content/10.1...
Benchmarking of proximity-dependent biotinylation enzymes across cellular compartments and time windows
Proximity-dependent biotinylation has become a powerful approach for mapping protein interactions and subcellular organization in living cells. Although a growing number of engineered biotin ligases h...
www.biorxiv.org
November 26, 2025 at 1:31 PM
🧪
@gingraslab.bsky.social
compared 10 enzymes used for proximity biotinylation proteomics experiments. UltraID is the winner.
www.biorxiv.org/content/10.1...
@gingraslab.bsky.social
compared 10 enzymes used for proximity biotinylation proteomics experiments. UltraID is the winner.
www.biorxiv.org/content/10.1...
Reposted by Wythe Lab at UVA School of Medicine
If you know, you know.
Who cares if it's 6:00 o'clock in the morning? 😄
Who cares if it's 6:00 o'clock in the morning? 😄
November 26, 2025 at 12:01 PM
If you know, you know.
Who cares if it's 6:00 o'clock in the morning? 😄
Who cares if it's 6:00 o'clock in the morning? 😄
Reposted by Wythe Lab at UVA School of Medicine
Engineering a Bright Near-Infrared Fluorescent Protein by Screening a Comprehensive Phenotypic Landscape https://www.biorxiv.org/content/10.1101/2025.11.25.690577v1
November 26, 2025 at 12:02 PM
Engineering a Bright Near-Infrared Fluorescent Protein by Screening a Comprehensive Phenotypic Landscape https://www.biorxiv.org/content/10.1101/2025.11.25.690577v1
Reposted by Wythe Lab at UVA School of Medicine
The first time terrorists used planes to attack Americans wasn’t on 9/11 or at Pearl Harbor. It was the Tulsa Race Massacre of 1921 when white supremacists flew a dozen planes to drop turpentine or nitroglycerin bombs on Black Americans.
Viola Fletcher was there.
www.qasimrashid.com/p/viola-flet...
Viola Fletcher was there.
www.qasimrashid.com/p/viola-flet...
Viola Fletcher, Among Last Known Survivors of Tulsa Race Massacre, Dies at 111
Mother Fletcher's legacy will live on as the epitome of honor, courage, strength, and resilience in the face of violent terrorism, white supremacy, and cowardice
www.qasimrashid.com
November 25, 2025 at 11:14 PM
The first time terrorists used planes to attack Americans wasn’t on 9/11 or at Pearl Harbor. It was the Tulsa Race Massacre of 1921 when white supremacists flew a dozen planes to drop turpentine or nitroglycerin bombs on Black Americans.
Viola Fletcher was there.
www.qasimrashid.com/p/viola-flet...
Viola Fletcher was there.
www.qasimrashid.com/p/viola-flet...
Reposted by Wythe Lab at UVA School of Medicine
#DBfeature 🐠
A new powerful live imaging platform tracks Erk signalling dynamics in developing zebrafish hepatocytes at single-cell resolution.
By Faraz Ahmed Butt, Alessandro De Simone, Stefano Di Talia, Kenneth Poss
tinyurl.com/ve5vzp6c
A new powerful live imaging platform tracks Erk signalling dynamics in developing zebrafish hepatocytes at single-cell resolution.
By Faraz Ahmed Butt, Alessandro De Simone, Stefano Di Talia, Kenneth Poss
tinyurl.com/ve5vzp6c
November 25, 2025 at 12:35 PM
#DBfeature 🐠
A new powerful live imaging platform tracks Erk signalling dynamics in developing zebrafish hepatocytes at single-cell resolution.
By Faraz Ahmed Butt, Alessandro De Simone, Stefano Di Talia, Kenneth Poss
tinyurl.com/ve5vzp6c
A new powerful live imaging platform tracks Erk signalling dynamics in developing zebrafish hepatocytes at single-cell resolution.
By Faraz Ahmed Butt, Alessandro De Simone, Stefano Di Talia, Kenneth Poss
tinyurl.com/ve5vzp6c
Reposted by Wythe Lab at UVA School of Medicine
Breaking: Viola Ford Fletcher, the oldest living survivor of the 1921 Tulsa Race Massacre, has died. She was 111 years old
Viola Ford Fletcher, the oldest living survivor of the 1921 Tulsa Race Massacre, has died
Viola Ford Fletcher, the oldest living survivor of the 1921 Tulsa Race Massacre, has died. She was 111 years old.
www.whatimreading.net
November 24, 2025 at 8:45 PM
Breaking: Viola Ford Fletcher, the oldest living survivor of the 1921 Tulsa Race Massacre, has died. She was 111 years old
Reposted by Wythe Lab at UVA School of Medicine
This is concerning.
NIH is changing their policy so that staff have to prepare justification for every application that is funded BUT NO DOCUMENTATION FOR APPLICATIONS THAT ARE SKIPPED (BASED ON PERCENTILES).
1/2
NIH is changing their policy so that staff have to prepare justification for every application that is funded BUT NO DOCUMENTATION FOR APPLICATIONS THAT ARE SKIPPED (BASED ON PERCENTILES).
1/2
November 24, 2025 at 12:29 AM
This is concerning.
NIH is changing their policy so that staff have to prepare justification for every application that is funded BUT NO DOCUMENTATION FOR APPLICATIONS THAT ARE SKIPPED (BASED ON PERCENTILES).
1/2
NIH is changing their policy so that staff have to prepare justification for every application that is funded BUT NO DOCUMENTATION FOR APPLICATIONS THAT ARE SKIPPED (BASED ON PERCENTILES).
1/2
Reposted by Wythe Lab at UVA School of Medicine
It’s time to talk about epithelial geometry and cancer. How can the architecture of an epithelium affect how tumors will grow and spread? In this thread, @jorgealmagro.bsky.social
November 23, 2025 at 8:01 AM
It’s time to talk about epithelial geometry and cancer. How can the architecture of an epithelium affect how tumors will grow and spread? In this thread, @jorgealmagro.bsky.social
Reposted by Wythe Lab at UVA School of Medicine
Revealing acute consequences of rapid degradation of synaptic fusion proteins at individual synapses using Auxin-Inducible Degron 2 technology
www.nature.com/articles/s42...
www.nature.com/articles/s42...
November 22, 2025 at 7:59 PM
Revealing acute consequences of rapid degradation of synaptic fusion proteins at individual synapses using Auxin-Inducible Degron 2 technology
www.nature.com/articles/s42...
www.nature.com/articles/s42...
Reposted by Wythe Lab at UVA School of Medicine
As it's hiring season again I'm resharing the NeuroJobs feed. Add #NeuroJobs to your post if you're recruiting or looking for an RA, PhD, Postdoc, or faculty position in Neuro or an adjacent field.
bsky.app/profile/did:...
bsky.app/profile/did:...
September 3, 2025 at 3:25 PM
As it's hiring season again I'm resharing the NeuroJobs feed. Add #NeuroJobs to your post if you're recruiting or looking for an RA, PhD, Postdoc, or faculty position in Neuro or an adjacent field.
bsky.app/profile/did:...
bsky.app/profile/did:...
Reposted by Wythe Lab at UVA School of Medicine
Big new paper from us published yesterday: The synaptic ectokinase VLK triggers the EphB2–NMDAR interaction to drive injury-induced pain
www.science.org/doi/10.1126/...
Led by @hajisciencebaji.bsky.social in my lab and a wonderful collaboration with Matthew Dalva's lab at Tulane
www.science.org/doi/10.1126/...
Led by @hajisciencebaji.bsky.social in my lab and a wonderful collaboration with Matthew Dalva's lab at Tulane
The synaptic ectokinase VLK triggers the EphB2–NMDAR interaction to drive injury-induced pain
Phosphorylation of hundreds of protein extracellular domains is mediated by two kinase families but the functional role of these kinases is underexplored. We find that the presynaptic release of the t...
www.science.org
November 21, 2025 at 6:13 PM
Big new paper from us published yesterday: The synaptic ectokinase VLK triggers the EphB2–NMDAR interaction to drive injury-induced pain
www.science.org/doi/10.1126/...
Led by @hajisciencebaji.bsky.social in my lab and a wonderful collaboration with Matthew Dalva's lab at Tulane
www.science.org/doi/10.1126/...
Led by @hajisciencebaji.bsky.social in my lab and a wonderful collaboration with Matthew Dalva's lab at Tulane
Reposted by Wythe Lab at UVA School of Medicine
Reposted by Wythe Lab at UVA School of Medicine
About that exclusive, "closed-to-press" MAHA summit last week with RFK and JD Vance: I got in.
Here's what I saw. 🧵 🧪
www.nature.com/articles/d41...
Here's what I saw. 🧵 🧪
www.nature.com/articles/d41...
November 21, 2025 at 5:01 PM
About that exclusive, "closed-to-press" MAHA summit last week with RFK and JD Vance: I got in.
Here's what I saw. 🧵 🧪
www.nature.com/articles/d41...
Here's what I saw. 🧵 🧪
www.nature.com/articles/d41...
Reposted by Wythe Lab at UVA School of Medicine
In which I fruitlessly beg NIH grant-seeking folks to focus on what is actually important. drugmonkey.wordpress.com/2025/11/21/i...
In which I fruitlessly beg NIH grant-seeking folks to focus on what is actually important.
A new webpage on the NIH site called “Implementing a Unified NIH Funding Strategy to Guide Consistent and Clearer Award Decisions” is causing a small kerfuffle on the socials. As per us…
drugmonkey.wordpress.com
November 22, 2025 at 12:26 AM
In which I fruitlessly beg NIH grant-seeking folks to focus on what is actually important. drugmonkey.wordpress.com/2025/11/21/i...
Reposted by Wythe Lab at UVA School of Medicine
"Going forward, ICOs will be considering peer review information in its entirety. NIH ICOs will NOT rely on funding paylines in developing pay plans. Rather, ICOs will consider these scores in context of their and NIH’s priorities, strategic plans, and budgets..."
grants.nih.gov/news-events/...
grants.nih.gov/news-events/...
Implementing a Unified NIH Funding Strategy to Guide Consistent and Clearer Award Decisions | Grants & Funding
grants.nih.gov
November 21, 2025 at 10:51 PM
"Going forward, ICOs will be considering peer review information in its entirety. NIH ICOs will NOT rely on funding paylines in developing pay plans. Rather, ICOs will consider these scores in context of their and NIH’s priorities, strategic plans, and budgets..."
grants.nih.gov/news-events/...
grants.nih.gov/news-events/...
Reposted by Wythe Lab at UVA School of Medicine
Do Not miss this great @navbo.bsky.social online event😆
Specification of Endothelial Cell Phenotypes
Organized by Dr. Ralf Adams @ralfhadams.bsky.social
& Dr. Vicki Bautch
Abstract deadline November 20
members.navbo.org/calendar-of-...
Specification of Endothelial Cell Phenotypes
Organized by Dr. Ralf Adams @ralfhadams.bsky.social
& Dr. Vicki Bautch
Abstract deadline November 20
members.navbo.org/calendar-of-...
November 13, 2025 at 7:51 PM
Do Not miss this great @navbo.bsky.social online event😆
Specification of Endothelial Cell Phenotypes
Organized by Dr. Ralf Adams @ralfhadams.bsky.social
& Dr. Vicki Bautch
Abstract deadline November 20
members.navbo.org/calendar-of-...
Specification of Endothelial Cell Phenotypes
Organized by Dr. Ralf Adams @ralfhadams.bsky.social
& Dr. Vicki Bautch
Abstract deadline November 20
members.navbo.org/calendar-of-...
Reposted by Wythe Lab at UVA School of Medicine
New paper from the lab on a new Gateway compatible toolkit for transgenesis in eukaryotes, led by former technician Will Gillespie.
Open access @dev-journal.bsky.social
journals.biologists.com/dev/article/...
Open access @dev-journal.bsky.social
journals.biologists.com/dev/article/...
MultiSite Assembly of Gateway Induced Clones (MAGIC): a flexible cloning toolbox for use in vertebrate model systems
Summary: A comprehensive suite of Gateway-compatible plasmids for in vitro and in vivo transgenesis in vertebrate model systems has been developed, together with a relational, modifiable, open-source ...
journals.biologists.com
November 14, 2025 at 5:33 PM
New paper from the lab on a new Gateway compatible toolkit for transgenesis in eukaryotes, led by former technician Will Gillespie.
Open access @dev-journal.bsky.social
journals.biologists.com/dev/article/...
Open access @dev-journal.bsky.social
journals.biologists.com/dev/article/...
Reposted by Wythe Lab at UVA School of Medicine
NEW: Epstein survivors release the most powerful PSA I have ever seen.
Make this go viral so every member of the House of Representatives sees it.
Make this go viral so every member of the House of Representatives sees it.
November 16, 2025 at 11:43 PM
NEW: Epstein survivors release the most powerful PSA I have ever seen.
Make this go viral so every member of the House of Representatives sees it.
Make this go viral so every member of the House of Representatives sees it.
Reposted by Wythe Lab at UVA School of Medicine
My new ImageJ / Fiji toolkit is out 🔥! The goal is to make image handling & visualization easy, with an intuitive interface! Install it on Fiji with the "Image Viewer" update site
#microscopy #ImageJ #FluorescenceFriday #microscopyMonday
imagej.net/plugins/imag...
#microscopy #ImageJ #FluorescenceFriday #microscopyMonday
imagej.net/plugins/imag...
November 4, 2025 at 10:40 PM
My new ImageJ / Fiji toolkit is out 🔥! The goal is to make image handling & visualization easy, with an intuitive interface! Install it on Fiji with the "Image Viewer" update site
#microscopy #ImageJ #FluorescenceFriday #microscopyMonday
imagej.net/plugins/imag...
#microscopy #ImageJ #FluorescenceFriday #microscopyMonday
imagej.net/plugins/imag...
Reposted by Wythe Lab at UVA School of Medicine
Meningeal vascular remodeling in 2~4 mo ovariectomized🐭
⏬blood vessel length
⏫blood vessel tortuosity
⏫PDPL+ lymphatic vessel area fraction
Ectopic vessel muscularization
Perivascular scattered αSMA+ cells in dura mater
#Cells_MDPI 2025
www.mdpi.com/2073-4409/14...
⏬blood vessel length
⏫blood vessel tortuosity
⏫PDPL+ lymphatic vessel area fraction
Ectopic vessel muscularization
Perivascular scattered αSMA+ cells in dura mater
#Cells_MDPI 2025
www.mdpi.com/2073-4409/14...
November 15, 2025 at 11:20 PM
Meningeal vascular remodeling in 2~4 mo ovariectomized🐭
⏬blood vessel length
⏫blood vessel tortuosity
⏫PDPL+ lymphatic vessel area fraction
Ectopic vessel muscularization
Perivascular scattered αSMA+ cells in dura mater
#Cells_MDPI 2025
www.mdpi.com/2073-4409/14...
⏬blood vessel length
⏫blood vessel tortuosity
⏫PDPL+ lymphatic vessel area fraction
Ectopic vessel muscularization
Perivascular scattered αSMA+ cells in dura mater
#Cells_MDPI 2025
www.mdpi.com/2073-4409/14...
Such an iconic album. Insane.
In a world long forgotten, Jay-Z released his final album 22 years ago today.
And ill never forget the first time I heard "What More Can I Say."
Music just dont feel the same anymore. I rode the bus to Best Buy to get this album. What a time
"Ayo wassup pimp, this threats!!"
And ill never forget the first time I heard "What More Can I Say."
Music just dont feel the same anymore. I rode the bus to Best Buy to get this album. What a time
"Ayo wassup pimp, this threats!!"
November 15, 2025 at 1:45 AM
Such an iconic album. Insane.