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Wythe Lab at UVA School of Medicine

@wythelab.bsky.social

1.8K followers 630 following 380 posts

Vascular biologist. Brain AVMs and Kras, glioblastoma and angiogenesis, lymphatics, and developmental biology. https://www.wythelab.com

www.wythelab.com

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Wythe Lab at UVA School of Medicine @wythelab.bsky.social · Mar 17

Excited to share this paper that is a long time coming from the lab on epigenetic/transcriptional regulation of organotypic endothelial specialization out today @naturecvr.bsky.social go.nature.com/4krSJqh

Mapping the transcriptional and epigenetic landscape of organotypic endothelial diversity in the developing and adult mouse

Nature Cardiovascular Research - Cantu Gutierrez et al. identify the common and unique transcriptional regulatory networks in the endothelium of six different organs throughout development, and...

go.nature.com

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Reposted by Wythe Lab at UVA School of Medicine

Mike Feigin 🥯 @mikefeigin.bsky.social · 1d

Buffalo peeps! I am hosting a science spooktacular event at the new Third Space venue downtown on Oct 30 at 6PM! Come hear fun stories about science from trainees, all geared towards a non-specialist audience. Check the flyer for all the info! Please RT

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Reposted by Wythe Lab at UVA School of Medicine

Sherrilyn Ifill @sifill.bsky.social · 1d

You need to fix this @cnn.com.

Col. Boozy Badger @boozybadger.lawyersandliquor.com · 1d

Dunno man, seems a little misleading to write an article about Trump describing activity in Portland and Chicago as “insurrection” with a 33 year old photo of a burning donut shop taken in the 1992 LA Riots (sans caption explaining that) as the header on all your posts about it.

The picture from
The article with a picture of an armed men standing in front of a burning donut shop. You must click through to read the caption “
Two National guardsmen stand guard outside a burning donut shop in Los Angeles on April 30, 1992.
The National Guard was called in to aid police during the second day of rioting in the city.”

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Reposted by Wythe Lab at UVA School of Medicine

Joshua J. Friedman @joshuajfriedman.com · 2d

I'm so proud of my sister, who was head writer for Daniel Tiger's Neighborhood and is now the showrunner of this brand-new HORTON! series for Netflix.

Please watch with your family! It's hard to get preschool shows made these days, and the algo isn't built for this www.netflix.com/title/81388347

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Reposted by Wythe Lab at UVA School of Medicine

Jeremy Berg @jeremymberg.bsky.social · 2d

I have been trying to get this published as an op-ed, but I am going to post it here since I think it is timely in light of the "consent" extortion events.

Deafening Quiet from the Scientific Establishment

jeremymberg.github.io/jeremyberg.g...

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jeremymberg.github.io

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Reposted by Wythe Lab at UVA School of Medicine

eLife @elife.bsky.social · 2d

High-resolution #CryoET provides ‘compelling’ evidence for the true 3D architecture of glutamatergic synapses: a complex ‘synaptoplasm’ rather than the textbook postsynaptic density.
buff.ly/hOYKjHH

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Reposted by Wythe Lab at UVA School of Medicine

BWJones @bwjones.bsky.social · 3d

Your Sunday homework:

Take 17 minutes and 21 seconds to watch this film made in 1945 by the American government.

Then reflect upon the content of this film, and how it applies to your life and the lives of those people in your communities.

chasingmicrobes @chasingmicrobes.bsky.social · 3d

Full video here:

Don't Be A Sucker (1947)

YouTube video by Old TV Time

m.youtube.com

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Reposted by Wythe Lab at UVA School of Medicine

Kevin Bonham @kevinbonham.com · 5d

Inkscape for scientists 3 is up! In this video, learn how to set up your workspace, and how do you find that damn fill/stroke panel? 🧪
youtu.be/PFcnjuMhUHI

Inkscape for scientists 3 - Setting up your workspace

YouTube video by Kevin Bonham

youtu.be

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Wythe Lab at UVA School of Medicine @wythelab.bsky.social · 5d

WTF? www.cavalierdaily.com

a man in a suit and tie is standing in front of a painting .

ALT: a man in a suit and tie is standing in front of a painting .

media.tenor.com

Reposted by Wythe Lab at UVA School of Medicine

Osteoarthritis and Cartilage Journal @oacjournal.bsky.social · 6d

#New in #OAC ! The sphingolipid sphingomyelin 34:1 is upregulated in the synovial fluid of those with OA. Work from @phar.cam.ac.uk shows that SM34:1 causes inflammatory pain in mice, inducing neuronal hyperexcitability.
@psalmotoxin.bsky.social
@interlukein.bsky.social
@mayadannawi.bsky.social

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Wythe Lab at UVA School of Medicine @wythelab.bsky.social · 6d

Great talk by Azeez in the lab at the annual NIH REJOIN meeting on joint nerve and vessel innervation in osteoarthritis in Houston this afternoon.

Wythe Lab at UVA School of Medicine @wythelab.bsky.social · 7d

Beauty!

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Reposted by Wythe Lab at UVA School of Medicine

Merlin Lange @merlinlange.bsky.social · 7d

Update I'm back in France 🇫🇷! Joining Inserm to build a multi-omics team on retinal development, at the nexus of live imaging, omics & human embryology.

Huge thanks to CZ Biohub SF folks, esp. my mentor, friend & science soulmate @loicaroyer.bsky.social for the amazing time. More cool science soon🧪

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Reposted by Wythe Lab at UVA School of Medicine

Joachim Goedhart @joachimgoedhart.bsky.social · 8d

Identification of optimal fluorophores for use in the Drosophila embryo by Timothy E Saunders and team: www.biorxiv.org/content/10.1...

Figure 1: Fluorophore intensity in the Drosophila blastoderm (n.c. 14). Comparison of (A) green and (B) red fluorescence intensity using the same intensity scaling in n.c. 14. The fluorescence signal did
not saturate. Shown are single imaging planes. Normalised histograms of fluorescence intensity for green (C) and red (D) fluorophores averaged across at least n=3 embryos per line. Scale bars = 20 μm

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Reposted by Wythe Lab at UVA School of Medicine

Angela Harvey @nationsfilm.bsky.social · 8d

Gentle reminder that Republicans hold the House, Senate, and White House

Phil Lewis @phillewis.bsky.social · 8d

WASHINGTON (AP) — Democrats vote down GOP bill to keep the government open, putting it on track for shutdown after midnight.

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Reposted by Wythe Lab at UVA School of Medicine

Governor JB Pritzker @govpritzker.illinois.gov · 9d

In any other country, if federal agents fired upon journalists when unprovoked — what would we call it?

If federal agents marched down streets demanding papers — what would we say?

Authoritarianism — let’s not pretend it’s something else when it happens in our American cities.

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JazzReads📚 @jazzreads.bsky.social · 10d

So exhausting..

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Phil Lewis @phillewis.bsky.social · 11d

George Hardy, last of the Tuskegee Airmen's World War II combat pilots, dies at 100

Hardy, a lieutenant colonel, became the youngest Tuskegee fighter pilot at 19, and was among the first Black military pilots in the United States.

www.nbcnews.com

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CoreyWelch_STEM @coreywelch.bsky.social · 12d

Link for your students/postbac/grad students: forms.gle/GCZht2pDVPh4...

Student Application for "10th Annual 1-on-1 Mentoring with a SACNAS Leader" Workshop

Get advice from Faculty and STEM Mentors on Planning for your Science Career. Matches will be based on your interests and career advice need. Meetings with mentors are in-person 1on1 meetings. The e...

forms.gle

Reposted by Wythe Lab at UVA School of Medicine

ACLU @aclu.org · 12d

BREAKING: President Trump is again asking the Supreme Court to let him end birthright citizenship.

The administration can't dodge the fact this executive order is illegal.

We'll keep fighting to ensure no child's citizenship is stripped away by this cruel and unconstitutional order.

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Reposted by Wythe Lab at UVA School of Medicine

Prostate Cancer UK Professionals @prostateukprofs.bsky.social · 15d

Can specific gene mutations drive CDK7 inhibitor resistance in #ProstateCancer?

A brilliant team led by @simak.bsky.social @imperialcollegeldn.bsky.social share exciting new findings in @embojournal.org.

Grab a ☕ and read: doi.org/10.1038/s443...

Scientific Paper Published in The EMBO Journal, titled: Resistance to CDK7 inhibitors directed by acquired mutation of a conserved residue in cancer cells. Written by Lai et al.

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Reposted by Wythe Lab at UVA School of Medicine

Waggoner Lab @labwaggoner.bsky.social · 13d

Sensory neurons drive pancreatic cancer progression through glutamatergic neuron-cancer pseudo-synapses @cp-cancercell.bsky.social
www.cell.com/cancer-cell/...

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Wythe Lab at UVA School of Medicine @wythelab.bsky.social · 13d

Reposted by Wythe Lab at UVA School of Medicine

Jason Bryan Silverstein @jasonsilverstein.bsky.social · 14d

Rutgers October 13! Free copies of The People's Project to the first 50 @roxanegay.bsky.social @theferocity.bsky.social @aubreyhirsch.bsky.social

MONDAY OCT 13 @ 7 PM: Join Dr. Roxane Gay (@roxanegay74), the Gloria Steinem Endowed Chair in Media, Culture, and Feminist Studies at @rutgersu, for a conversation with “The People's Project” co-editor Saeed Jones (@theferocity), and contributors Aubrey Hirsch (@aubreyhirsch) and Jason Silverstein (@jasonbryansilverstein).

“The People's Project” is a liberatory anthology of twenty-seven writers featuring poems, essays, and visual art that chart paths ahead for action and care in the face of political uncertainty.

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Reposted by Wythe Lab at UVA School of Medicine

Sigolène Meilhac @meilhacsigolene.bsky.social · 14d

New publication | Science Advances www.science.org/doi/10.1126/...

Plasticity of ventricle position after heart looping in heterotaxy with right isomerism

The left/right position of ventricles needs to be maintained after heart looping, an unexpected step affected in heterotaxy.

www.science.org

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