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Sigolène Meilhac

@meilhacsigolene.bsky.social

230 followers 180 following 16 posts

Heart Morphogenesis laboratory Developmental biology, Congenital heart defects, Left-right asymmetry, Heterotaxy @Institut Pasteur, Institut Imagine, Inserm, UPC - Paris

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Sigolène Meilhac @meilhacsigolene.bsky.social · Dec 14

We hire ! Open #postdoc position to study the emergence of heart asymmetry in Paris !
#devbio

Post-doctoral position in Asymmetric heart morphogenesis | Institut Imagine

After a PhD in Life Sciences, you have a strong interest in developmental biology. Your previous research experience is solid in molecular biology or genetics. You value animal models. You work with r...

www.institutimagine.org

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Sigolène Meilhac @meilhacsigolene.bsky.social · 11d

We uncover that the caudal splanchnic mesoderm (in green) acts as a midline anchor of the heart tube. In Vangl2 and Shroom3 mutants, its bilateral symmetry is disrupted, leading to a rotation of the heart tube and ventricle malposition.

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Sigolène Meilhac @meilhacsigolene.bsky.social · 11d

In the dorsal pericardial wall, Vangl2 localises at multicellular junctions and is required for their resolution. This promotes cell rearrangements underlying elongation of the arterial pole of the heart tube.

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Sigolène Meilhac @meilhacsigolene.bsky.social · 11d

Paul Palmquist-Gomes, in collaboration with @gaellel.bsky.social, quantified the phenotype of a series of mutants to show that Vangl2 is required in two epithelia adjacent to the heart tube.

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Sigolène Meilhac @meilhacsigolene.bsky.social · 11d

New publication :
Despite being a core member of the PCP pathway, Vangl2 can play roles unrelated to planar polarity. This is the case during mouse heart morphogenesis.

bioRxiv Developmental Biology @biorxiv-devbio.bsky.social · Sep 5

VANGL2 shapes the mouse heart tube from adjacent epithelia and without planar polarity https://www.biorxiv.org/content/10.1101/2025.09.05.674213v1

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Sigolène Meilhac @meilhacsigolene.bsky.social · 13d

She analysed a mouse model of motile ciliopathy to show that the node can be dispensable to establish left-right asymmetry. Stay tuned !

Sigolène Meilhac @meilhacsigolene.bsky.social · 13d

Congratulations Dr Amaia Ochandorena-Saa for a beautiful PhD, defended in front of Hiroshi Hamada, @bakkerslab.bsky.social, Alice Meunier and Jeanne Amiel

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Sigolène Meilhac @meilhacsigolene.bsky.social · 14d

Abnormal D-LOOP are also observed in patients and tend to be associated with poorer prognosis. We reconstruct their developmental revertant trajectory in the mouse. Team work in collaboration with JB Masson and O Raisky.

Sigolène Meilhac @meilhacsigolene.bsky.social · 14d

@audreydsg.bsky.social performed a unique longitudinal analysis of heterotaxy by imaging the same mouse twice, at E9.5 and E18.5. We show that embryonic heart loop shape is a partial predictor of CHD.

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Sigolène Meilhac @meilhacsigolene.bsky.social · 14d

We report how ventricle can still change position after heart looping in Nodal mutants, questioning the clinical nomenclature of « D-LOOP ». D-LOOP ventricles at birth can arise from both rightward or leftward embryonic heart looping.

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Sigolène Meilhac @meilhacsigolene.bsky.social · 14d

New publication | Science Advances www.science.org/doi/10.1126/...

Plasticity of ventricle position after heart looping in heterotaxy with right isomerism

The left/right position of ventricles needs to be maintained after heart looping, an unexpected step affected in heterotaxy.

www.science.org

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Sigolène Meilhac @meilhacsigolene.bsky.social · Apr 1

In collaboration with MP Hitz, we identify 6 ultrarare NOTCH3 variants in a cohort of patients with congenital heart defects, reflecting the double role of Notch3 in laterality and heart development

Sigolène Meilhac @meilhacsigolene.bsky.social · Apr 1

We also show that Notch3 is expressed in the second heart field and required for ventricular and atrial septation, right ventricle wall thickness and the non coronary leaflet of the aortic valve

Sigolène Meilhac @meilhacsigolene.bsky.social · Apr 1

We identified Notch3 as a new asymmetric gene, amplified by Nodal and a genetic modifier of heart looping defects in Nodal mutants

Sigolène Meilhac @meilhacsigolene.bsky.social · Apr 1

New article of the lab on Notch3, not only involved in vascular or neural defects, but also in heart defects and laterality defects.

PLOS Biology @plosbiology.org · Apr 1

Creating an asymmetric heart: @tbonnely.bsky.social @audreydsg.bsky.social @meilhacsigolene.bsky.social &co identify Notch3 as a novel asymmetric factor in lateral plate mesoderm that acts as a genetic modifier of NODAL to regulate #heart #morphogenesis @plosbiology.org 🧪 plos.io/42q6H4L

Left: Expression of Notch3 (white) detected by whole mount RNAscope ISH in an E8.5d wild-type embryo, shown in frontal views (top, cranial part of the embryo) and transverse section (bottom). Filled and empty arrowheads point to high and low expression, respectively. Right: Segmentation of the cardiac region in 3D images, to quantify gene expression in the left (white) or right (yellow) heart field. The heart tube is colored in red. Somites are outlined by white dotted lines. Expression of Notch3 within the segmented second heart field is extracted in the right panel.

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Reposted by Sigolène Meilhac

Institut Imagine @institutimagine.bsky.social · Jan 24

🧬 Join Institut Imagine as a Junior Group Leader!

- Junior Group Leader in Systems and Computational Biology
- Junior Group Leader in RNA Biology and Epigenomics
- Junior Group Leader in Artificial Intelligence for Genetics, Biology & Medicine

To submit your application : lnkd.in/enm-U2tH

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Reposted by Sigolène Meilhac

Weinstein Conference @weinsteinconf.bsky.social · Jan 29

The Weinstein Committee is soliciting nominations for the 2025 Markwald Award. If you have a scientist you'd like to nominate send it to [email protected] by February 7th!

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Reposted by Sigolène Meilhac

Weinstein Conference @weinsteinconf.bsky.social · Jan 22

Join us for the 2025 Weinstein Cardiovascular Development and Regeneration Conference in Milwaukee, May 14-16! Registration and abstract submission are now open!!! Please share, retweet, and distribute! #WeinsteinCVD2025 REGISTER TODAY HERE childrenswi.org/weinstein

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Reposted by Sigolène Meilhac

Didier Mazel @amazeld.bsky.social · Dec 8

We are opening a call for applications 2025 – Creation of new junior research groups at the Institut Pasteur in Paris @pasteur.fr all details on our web site : research.pasteur.fr/en/call/call...

Call for applications 2025 – Creation of new research groups at the Institut Pasteur | Research - Institut Pasteur

research.pasteur.fr

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Reposted by Sigolène Meilhac

Weinstein Conference @weinsteinconf.bsky.social · Jan 16

Abstract submission is now open for the 2025 Weinstein Cardiovascular Development and Regeneration Conference at childrenswi.org/weinstein. The conference will be held in Milwaukee, May 14-16! Please share, retweet and distribute ❣️❣️❣️#WeinsteinCVD2025

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Reposted by Sigolène Meilhac

Karina Yaniv @karinayaniv.bsky.social · Dec 18

Yes! We are hiring! Looking for highly motivated people to make good use of our #ERC_SyG money 💶! The project is super cool, and the people are the best!! There are plenty of opportunities for international collaborations, too! Please help us spread the word!

Yaara Tevet @yaaratevet.bsky.social · Dec 18

Karina Yaniv Lab at the Weizmann Institute is seeking PhD students and postdoctoral researchers. Come work with us!

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Sigolène Meilhac @meilhacsigolene.bsky.social · Dec 14

Is Nodal the only determinant of left-right asymmetry? 🤔 If curious and willing to address the question with lab resources in transcriptomics, mouse genetics and quantitative 3D imaging, please contact me.

Sigolène Meilhac @meilhacsigolene.bsky.social · Dec 14

We hire ! Open #postdoc position to study the emergence of heart asymmetry in Paris !
#devbio

Post-doctoral position in Asymmetric heart morphogenesis | Institut Imagine

www.institutimagine.org

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Reposted by Sigolène Meilhac

Levayer Lab @levayerr.bsky.social · Dec 8

For the dev bio crowd : there is a call for junior group leader at Institut Pasteur in Paris and one of the axis covered is related to development. Come and join us in this exciting place and become one of our colleague @devstempasteur.bsky.social
Please RT !!
research.pasteur.fr/fr/call/call...

Call for applications 2025 – Creation of new research groups at the Institut Pasteur | Research - Institut Pasteur

research.pasteur.fr

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Reposted by Sigolène Meilhac

Frédéric Causeret @fredcauseret.bsky.social · Dec 6

🚨🚨🚨 Not one, but 3 calls for junior group leaders opening at Imagine!!! [please share]
- Systems and computational biology
- RNA biology and epigenomics
- AI for genetics, biology and medicine
Come and join us!
www.nature.com/naturecareer...

Jobs with Imagine Institute | Nature Careers

Search and apply for jobs with Imagine Institute on Nature Careers

www.nature.com

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