Anders Borgkvist
@borgkvistlab.bsky.social
Neurobiologist and basal ganglia specialist.
Reposted by Anders Borgkvist
A study by @borgkvistlab.bsky.social published in Science Advances shows that dopamine modulates basal ganglia output not via DA receptors, but through serotonin and 5-HT1B activation. Findings in mice suggest a new mechanism relevant to #Parkinsons therapy. #Neuroscience 🧪 doi.org/10.1126/scia...
Dopamine and serotonin cotransmission filters striatonigral synaptic activity via 5-HT1B receptor activation
A monoaminergic high-pass filter regulates basal ganglia output activity.
doi.org
November 6, 2025 at 5:27 PM
A study by @borgkvistlab.bsky.social published in Science Advances shows that dopamine modulates basal ganglia output not via DA receptors, but through serotonin and 5-HT1B activation. Findings in mice suggest a new mechanism relevant to #Parkinsons therapy. #Neuroscience 🧪 doi.org/10.1126/scia...
Reposted by Anders Borgkvist
💊✨ Exciting new collaboration with Laurence Lafanechère’s team (Grenoble)!
Our new study introduces Carba1, a bifunctional carbazole compound that protects against chemotherapy-induced peripheral neuropathy (CIPN) — a major unmet need in cancer therapy.
Our new study introduces Carba1, a bifunctional carbazole compound that protects against chemotherapy-induced peripheral neuropathy (CIPN) — a major unmet need in cancer therapy.
www.science.org
October 29, 2025 at 7:05 PM
💊✨ Exciting new collaboration with Laurence Lafanechère’s team (Grenoble)!
Our new study introduces Carba1, a bifunctional carbazole compound that protects against chemotherapy-induced peripheral neuropathy (CIPN) — a major unmet need in cancer therapy.
Our new study introduces Carba1, a bifunctional carbazole compound that protects against chemotherapy-induced peripheral neuropathy (CIPN) — a major unmet need in cancer therapy.
Reposted by Anders Borgkvist
1/n. New paper from us: here we explore the mechanisms underlying maternal aggression in mice as a means of addressing how an individual transiently can gain access to a behaviour normally outside of its repertoire. Lead investigator Stefanos Stagkourakis (not on 🦋)🧵:
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Maternal aggression driven by the transient mobilisation of a dormant hormone-sensitive circuit - Nature Communications
Mothers can fiercely defend their young, but how the brain triggers this response remains to a large extent a mystery. Here, authors show that a dormant, hormone-sensitive brain circuit switches on to spark maternal aggression during the lactation period.
www.nature.com
October 5, 2025 at 6:02 PM
1/n. New paper from us: here we explore the mechanisms underlying maternal aggression in mice as a means of addressing how an individual transiently can gain access to a behaviour normally outside of its repertoire. Lead investigator Stefanos Stagkourakis (not on 🦋)🧵:
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Postdoc Opportunity at Karolinska Institutet: We're seeking an electrophysiologist to join an exciting collaborative project focusing on diabetes and Parkinson's disease.
Join us!
ki.varbi.com/what:job/job...
Join us!
ki.varbi.com/what:job/job...
Postdoktor i Diabetes och Parkinsons sjukdom
Vill du bidra till medicinsk forskning av toppkvalitet? Det strategiska forskningsprogrammet för diabetes (SRP Diabetes) vid Karolinska Institutet finansierar ett prestigefyllt stipendieprogram för
ki.varbi.com
October 1, 2025 at 5:50 AM
Postdoc Opportunity at Karolinska Institutet: We're seeking an electrophysiologist to join an exciting collaborative project focusing on diabetes and Parkinson's disease.
Join us!
ki.varbi.com/what:job/job...
Join us!
ki.varbi.com/what:job/job...
Reposted by Anders Borgkvist
Happy to share this new paper from the lab in collaboration with George Augustine, characterizing synaptic connectivity between the claustrum and the anterior cingulate cortex. Congratulations to Roberto, Zach, and all co-authors. @robertodelator.bsky.social
Our new paper in Current Biology
"Presynaptic and postsynaptic determinants of claustro-cortical connectivity"
CLA→ACC projections are highly specific: defined by presynaptic identity, postsynaptic target, and cortical layer.
Check here:
www.sciencedirect.com/science/arti...
#Neuroscience #Claustrum
"Presynaptic and postsynaptic determinants of claustro-cortical connectivity"
CLA→ACC projections are highly specific: defined by presynaptic identity, postsynaptic target, and cortical layer.
Check here:
www.sciencedirect.com/science/arti...
#Neuroscience #Claustrum
Presynaptic and postsynaptic determinants of claustro-cortical connectivity
The claustrum (CLA) is a thin and elongated brain structure that is located between the insula and lateral striatum and is implicated in a wide range …
www.sciencedirect.com
June 18, 2025 at 9:21 PM
Happy to share this new paper from the lab in collaboration with George Augustine, characterizing synaptic connectivity between the claustrum and the anterior cingulate cortex. Congratulations to Roberto, Zach, and all co-authors. @robertodelator.bsky.social
Do you want to know how basal ganglia synaptic plasticity contribute to movement symtoms in PD? Can you achieve a giga seal? Good, then Join us! Please share.
ki.varbi.com/se/what:job/...
ki.varbi.com/se/what:job/...
Postdoctoral studies in Molecular and Synaptic Neurophysiology focusing on movement disorders (scholarship)
Do you want to contribute to top quality medical research? Join our dynamic and collaborative research team in Anders Borgkvist’s laboratory at the Department of Neuroscience, Karolinska Institute,
ki.varbi.com
February 18, 2025 at 2:17 PM
Do you want to know how basal ganglia synaptic plasticity contribute to movement symtoms in PD? Can you achieve a giga seal? Good, then Join us! Please share.
ki.varbi.com/se/what:job/...
ki.varbi.com/se/what:job/...
Reposted by Anders Borgkvist
🚨SAVE THE DATE‼️
Happy to announce that #DopamineMeeting2026 will be held in
S E V I L L A🧠.
May, 17-21, 2026
Happy to announce that #DopamineMeeting2026 will be held in
S E V I L L A🧠.
May, 17-21, 2026
November 21, 2024 at 4:47 PM
🚨SAVE THE DATE‼️
Happy to announce that #DopamineMeeting2026 will be held in
S E V I L L A🧠.
May, 17-21, 2026
Happy to announce that #DopamineMeeting2026 will be held in
S E V I L L A🧠.
May, 17-21, 2026
Excited to share our study on striatal dysfunctions in the eIF4E autism model! Understanding brain networks in ASD is key for targeted therapies. Huge thanks to PhD candidate Alina Aaltonen and our funders @Vetenskapsradet, @Wstiftelserna, @StratNeuro!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Postnatal reduction of eIF4E overexpression in D1-SPNs ameliorates KCNQ dysfunction, hyperexcitability and ASD-like behaviours.
An imbalance between the direct and indirect pathways of the striatum has been implicated in the pathophysiology of ASD, which corresponds with an increase in repetitive behaviours and hyperactivity. ...
www.biorxiv.org
January 18, 2025 at 10:19 PM
Excited to share our study on striatal dysfunctions in the eIF4E autism model! Understanding brain networks in ASD is key for targeted therapies. Huge thanks to PhD candidate Alina Aaltonen and our funders @Vetenskapsradet, @Wstiftelserna, @StratNeuro!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
What a fantastic Lucia performance by Biomedicum's own choir! The Lucia tradition marks the beginning of the darkest week of the year with only 5 hours of daylight in Stockholm. Heart-warming traditions like these are particularly important to maintain spirits high. @karolinskainst.bsky.social
December 13, 2024 at 9:42 PM
What a fantastic Lucia performance by Biomedicum's own choir! The Lucia tradition marks the beginning of the darkest week of the year with only 5 hours of daylight in Stockholm. Heart-warming traditions like these are particularly important to maintain spirits high. @karolinskainst.bsky.social
Attend the Swebags conference on November 5th for exciting talks and posters covering the state-of-the-art in basal ganglia research. Entirely a remote event, which means that you can tune in from across the globe. Visit swebags.ebrains.se for event info and registration.
Home - SWEBAGS
Welcome to SWEBAGS The Swedish Basal Ganglia Society, SWEBAGS, is an non-profit scientific organization providing a platform for discussions and education opportunities in the area of basal ganglia re...
swebags.ebrains.se
December 3, 2024 at 1:26 PM
Attend the Swebags conference on November 5th for exciting talks and posters covering the state-of-the-art in basal ganglia research. Entirely a remote event, which means that you can tune in from across the globe. Visit swebags.ebrains.se for event info and registration.
Happy to finally see our paper published in Cell Reports. @cellpress.bsky.social Thanks to all the hard work put in by our team and to the funders of this study, including @vetenskapsradet.bsky.social Wallenberg stiftelserna, Ollebyggmästare, Åhlens’ and others. www.cell.com/cell-reports...
Dysregulated acetylcholine-mediated dopamine neurotransmission in the eIF4E Tg mouse model of autism spectrum disorders
Basal ganglia dysfunction potentially causes behavioral alterations in ASD. Carbonell-Roig
et al. show that the eIF4E Tg mouse model of ASD exhibits behavioral inflexibility
and impaired striatal dopa...
www.cell.com
November 29, 2024 at 2:23 PM
Happy to finally see our paper published in Cell Reports. @cellpress.bsky.social Thanks to all the hard work put in by our team and to the funders of this study, including @vetenskapsradet.bsky.social Wallenberg stiftelserna, Ollebyggmästare, Åhlens’ and others. www.cell.com/cell-reports...
The purpose of academic life. Drumroll…
November 20, 2024 at 9:28 AM
The purpose of academic life. Drumroll…
(“Hello World”); seems like an appropriate first post.
November 19, 2024 at 7:30 PM
(“Hello World”); seems like an appropriate first post.