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Sophie Breunig @breunigsophie.bsky.social · Jul 23

Congrats Fiona! So well deserved! 🥳

Sophie Breunig @breunigsophie.bsky.social · Jul 21

Our project, looking at the genetic relationships between immune diseases and psychiatric disorders, has finally been published! Now with gene expression analyses as well as additional sensitivity analyses, thanks to reviewers. Find the full article here: www.nature.com/articles/s41...

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Reposted by Sophie Breunig

Institute for Behavioral Genetics (IBG) @ibg.colorado.edu · Jul 21

Check out this new work from IBG graduate student @breunigsophie.bsky.social that applies Genomic SEM to examine the relationship between genomic factors for immune-mediated diseases and psychiatric disorders. www.nature.com/articles/s41...

Examining the genetic links between clusters of immune-mediated diseases and psychiatric disorders - Translational Psychiatry

Translational Psychiatry - Examining the genetic links between clusters of immune-mediated diseases and psychiatric disorders

www.nature.com

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Reposted by Sophie Breunig

Aoxing Liu @aoxing2.bsky.social · Apr 25

Type 1 diabetes (T1D) and other autoimmune diseases often co-occur in families. Leveraging data from 12.6K genotyped trios in @finngen.bsky.social, our work - online today in Cell Genomics - studied the transmission of parental autoimmune diseases on T1D in offspring.

www.cell.com/cell-genomic...

Effects of parental autoimmune diseases on type 1 diabetes in offspring can be partially explained by HLA and non-HLA polymorphisms

Leveraging Finnish nationwide multi-generational registers and the biobanks of FinnGen, Wang, Liu, et al. investigated the effect of parental autoimmune diseases on offspring T1D. Their creative and r...

www.cell.com

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Reposted by Sophie Breunig

medRxivpreprint @medrxivpreprint.bsky.social · Feb 6

Integrating HiTOP and RDoC Frameworks Part II: Shared and Distinct Biological Mechanisms of Externalizing and Internalizing Psychopathology https://www.medrxiv.org/content/10.1101/2025.02.05.25321732v1

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Reposted by Sophie Breunig

Andrew Grotzinger @andrewgrotzinger.bsky.social · Jan 28

One of my talented graduate students (@breunigsophie.bsky.social) is putting together an immune-psychiatric focused symposium submission for the Behavior Genetics Association 2025 meeting in Atlanta. She needs one more talk to fill the symposium; if interested send me a message!

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Reposted by Sophie Breunig

Michel Nivard @michelnivard.bsky.social · Nov 28

🚨 This will become a curated list of awesome tools for complex trait genetics, **add yours**! it may become a review in which case those who contribute are invited as co-authors.

GitHub - MichelNivard/awesome-complex-trait-genetics: A list of awesome tools for complex trait genetics.

A list of awesome tools for complex trait genetics. - MichelNivard/awesome-complex-trait-genetics

github.com

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Sophie Breunig @breunigsophie.bsky.social · Dec 19

Congrats, Leo!! So proud of you! 🎉

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Reposted by Sophie Breunig

Andrew Grotzinger @andrewgrotzinger.bsky.social · Dec 6

You've heard of DNA, but what about GNA? Very excited about this preprint with @jgthorp.bsky.social and others that introduces Genomic Network Analysis (GNA), an open-source multivariate tool for performing network analysis using GWAS summary statistics as input. 1/2
www.medrxiv.org/content/10.1...

Genomic network analysis characterizes genetic architecture and identifies trait-specific biology

Pervasive genetic overlap across human complex traits necessitates developing multivariate methods that can parse pleiotropic and trait-specific genetic signals. Here, we introduce Genomic Network Ana...

www.medrxiv.org

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Reposted by Sophie Breunig

Eric Turkheimer @ent3c.bsky.social · Oct 31

With @kph3k.bsky.social (Paige Harden) I have a comment on an execrable paper by Rindermann et al, about the IQs of recent immigrants to Germany. Blog post and link to article below. More to come.

ericturkheimer.substack.com/p/immigratio...

journalofcontroversialideas.org/article/4/2/...

Controversy Requires Competence: Comment on Rindermann et al. (2024)

Rindermann, Klauk, and Thompson (2024) purport to give evidence regarding the determinants of intelligence test scores among refugees who have immigrated to Germany from different countries of origin,...

journalofcontroversialideas.org

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Reposted by Sophie Breunig

Laura Helmuth @laurahelmuth.bsky.social · Oct 1

As an editor, I help people say what they mean--and not say what they don’t mean. Here are some common not-quite-right words or expressions that I often see. This is not to embarrass anybody--I've made many of these mistakes myself. Please share your favorite fixes at the end of the thread. (1/n)

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Sophie Breunig @breunigsophie.bsky.social · Sep 23

Come join our lab! 🧬

Andrew Grotzinger @andrewgrotzinger.bsky.social · Sep 23

🚨Writing to say that I am actively recruiting PhD students in the clinical -or- behavioral, psychiatric, and statistical genetics program (BPSG) at CU Boulder for a Fall 2025 start date. My lab focuses on genomic methods development and applications to psychiatric and aging outcomes (e.g., dementia)

Reposted by Sophie Breunig

Georg Henning @georghenning.bsky.social · Sep 20

I’ve seen the best minds of my generation ruined by Wissenschaftszeitvertragsgesetz

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Reposted by Sophie Breunig

Michel Nivard @michelnivard.bsky.social · Sep 2

I am recruiting a PhD student, co-supervised with George Davey-Smith, Gareth Hawkes and Laura Corbin to study trait residualized for known genetic influences, please Apply! gw4biomed.ac.uk/shining-a-li...

Shining a light on the un-common to identify novel health risk-factors - GW4 BioMed MRC DTP

Project Code MRCPHS25Br Nivard Research Theme Population Health Sciences Project Summary Download Summary Complex traits such as body mass index and height are influenced by a mixture of genetic and e...

gw4biomed.ac.uk

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Sophie Breunig @breunigsophie.bsky.social · Aug 15

This work would not have been possible without these amazing humans: Heather Lee, Elizabeth Karlson, Arjun Krishnan, Jeremy Lawrence, Luke Schaffer, and Andrew Grotzinger! 🦡

Sophie Breunig @breunigsophie.bsky.social · Aug 15

Overall, our findings provide a deeper and more detailed understanding of the varying levels of risk sharing among immune-mediated diseases and psychiatric disorders.

Sophie Breunig @breunigsophie.bsky.social · Aug 15

For example, autism spectrum disorder and ADHD, despite being part of the same neurodevelopmental disorders factor, exhibit directionally opposing relationships with autoimmune diseases.

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Sophie Breunig @breunigsophie.bsky.social · Aug 15

At the same time, we also find genetic relationships that are more specific to immune-psychiatric disease pairs and not explained well by the inter-factor relationships.

Sophie Breunig @breunigsophie.bsky.social · Aug 15

We identify broader pathways of risk sharing as indicated by latent factors of immune-mediated diseases correlating with factors of psychiatric disorders. For example, the autoinflammatory diseases factor is positively genetically correlated with the compulsive disorders factor.

Sophie Breunig @breunigsophie.bsky.social · Aug 15

We find that immune-mediated diseases cluster along the overlapping spectrum reaching from autoimmunity to autoinflammation.

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Sophie Breunig @breunigsophie.bsky.social · Aug 15

New preprint just dropped! 🧬🦠
For this project, we looked at the genetic relationships between psychiatric disorders and immune-mediated diseases.

Check out the full paper here: www.medrxiv.org/content/10.1...

Examining the Genetic Links between Clusters of Immune-mediated Diseases and Psychiatric Disorders

medRxiv - The Preprint Server for Health Sciences

www.medrxiv.org

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Reposted by Sophie Breunig

medRxivpreprint @medrxivpreprint.bsky.social · Jul 19

Examining the Genetic Links between Clusters of Immune-mediated Diseases and Psychiatric Disorders https://www.medrxiv.org/content/10.1101/2024.07.18.24310651v1

Importance: Autoimmune and autoinflammatory diseases have been linked to psychiatric disorders in th

www.medrxiv.org

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Sophie Breunig @breunigsophie.bsky.social · Jun 11

Really cool work, Dan!

Sophie Breunig @breunigsophie.bsky.social · Apr 18

I think they are making it safer all along Colorado Ave now by raising the bike lane up to the level of the sidewalk! 🚲

Sophie Breunig @breunigsophie.bsky.social · Mar 9

Wooohoo! And what a great lecture it was!

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