Author | Lightnews

Scientists grow 3D human brains for personalized medicine study

Citizens for Alternatives to Animal Research and Experimentation @caare.bsky.social · 2d

MIT’s new miBrains use patient-derived human tissue to model brain disease and test drugs, offering a more ethical and scientifically robust alternative to animal experiments:

Built from patient stem cells, MIT’s miBrains let scientists grow individualized human brain models to study disease and test new therapies.

interestingengineering.com

Citizens for Alternatives to Animal Research and Experimentation @caare.bsky.social · 3d

McGill University and the Douglas Institute used human-based research to identify brain-cell changes linked to depression, guiding future treatments.

For the first time, scientists pinpoint brain cells linked to depression

Scientists identified two types of brain cells, neurons and microglia, that are altered in people with depression. Through genomic mapping of post-mortem brain tissue, they found major differences in…

www.sciencedaily.com

Citizens for Alternatives to Animal Research and Experimentation @caare.bsky.social · 4d

Karolinska Institutet and Queen Mary researchers use human-based models to reveal how fat tissue structure fuels ovarian cancer spread.

The Hidden Role of Fat Tissue in Ovarian Cancer Metastasis

The physical structure of fat tissues helps ovarian cancer cells invade the body, not just chemical signals.

UC Irvine researchers invent a bioelectronic-integrated artificial colon for disease studies, drug screening

Citizens for Alternatives to Animal Research and Experimentation @caare.bsky.social · 7d

UC Irvine built a 3D artificial colon from human cells to improve drug testing accuracy and replace cruel and outdated animal studies.
news.uci.edu/2025/10/15/u...

Closely matching its human counterpart, replica eliminates need for animal testing

news.uci.edu

Citizens for Alternatives to Animal Research and Experimentation @caare.bsky.social · 8d

The University of Rochester created a brain-on-a-chip from human tissue to study how sepsis harms the brain—advancing neurodegenerative research without animal testing. medicalxpress.com/news/2025-10...

Brain-on-a-chip technology reveals how sepsis and neurodegenerative diseases damage the brain

In lieu of animal experiments, researchers from the University of Rochester are using state-of-the-art microchips with human tissue to better understand how the brain operates under healthy conditions...

medicalxpress.com

Citizens for Alternatives to Animal Research and Experimentation @caare.bsky.social · 9d

Tell NIH and UMB to end to cruel, unnecessary, and outdated experiments that cut babies out of pregnant baboons.

www.caareusa.org/end_abominab...

Alzheimer’s Drug May Improve Social Function in Individuals With Autism

Citizens for Alternatives to Animal Research and Experimentation @caare.bsky.social · 10d

Without animal testing, Mass General Brigham found memantine improved social behavior in autistic youth in a clinical trial that used human biomarkers and neuroimaging.
www.technologynetworks.com/drug-discove...

A clinical trial of 42 intellectually capable individuals with autism spectrum disorder found that participants tolerated the drug memantine well and showed significant improvements in social function...

Blood Test Diagnoses Chronic Fatigue Syndrome With 96% Accuracy

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Citizens for Alternatives to Animal Research and Experimentation @caare.bsky.social · 11d

University of East Anglia created a blood test that diagnoses chronic fatigue syndrome with 96% accuracy using human-based genomic data, and no animal testing.
www.technologynetworks.com/diagnostics/...

Scientists at the University of East Anglia and Oxford Biodynamics have developed a highly accurate blood test to diagnose Chronic Fatigue Syndrome, also known as Myalgic Encephalomyelitis (ME/CFS).

Brain-on-a-chip technology reveals how sepsis and neurodegenerative diseases damage the brain

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Citizens for Alternatives to Animal Research and Experimentation @caare.bsky.social · 14d

Hesperos and Bayer created a human-on-a-chip system to study the impact of stress on the brain —an ethical, animal-free breakthrough in stress-induced cognitive dysfunction. www.morningstar.com/news/busines...

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Citizens for Alternatives to Animal Research and Experimentation @caare.bsky.social · 15d

The University of Rochester created a brain-on-a-chip from human tissue to study how sepsis harms the brain—advancing neurodegenerative research without animal testing. medicalxpress.com/news/2025-10...

In lieu of animal experiments, researchers from the University of Rochester are using state-of-the-art microchips with human tissue to better understand how the brain operates under healthy conditions...

medicalxpress.com

AI Outperforms Nature at Designing Proteins To Edit the Genome

Citizens for Alternatives to Animal Research and Experimentation @caare.bsky.social · 16d

Integra Therapeutics and Pompeu Fabra University used AI and human-cell testing to design powerful new genome-editing proteins—advancing superior, human-based science without using animals. www.technologynetworks.com/biopharma/ne...

After studying the diversity of mobile elements in the genome to feed and train generative AI tools, researchers have been able to design and lab validate new synthetic proteins that can edit the geno...

Ketamine Therapies Reduce Symptom Severity in Hard-To-Treat Depression

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Citizens for Alternatives to Animal Research and Experimentation @caare.bsky.social · 17d

Mass General Brigham studied human patients and not animals to compare the ability of two forms of ketamine to reduce treatment-resistant depression.
www.technologynetworks.com/drug-discove...

Researchers compared ketamine infusions and esketamine nasal spray in more than 150 patients with severe depression who were treated at McLean Hospital. Both treatments reduced depression severity, wi...

Parkinson’s Protein Captured in Human Brains for the First Time

Citizens for Alternatives to Animal Research and Experimentation @caare.bsky.social · 18d

University of Cambridge scientists and collaborators used a new brain imaging method to map Parkinson’s-linked proteins in post-mortem human brains, advancing human-based research without cruel animal testing.
www.technologynetworks.com/proteomics/n...

University of Cambridge researchers have developed a new imaging technique that captures Parkinson's protein clusters in post-mortem brains.

Jane Goodall’s most radical message was not about saving the planet

Citizens for Alternatives to Animal Research and Experimentation @caare.bsky.social · 21d

We celebrate the life of Dr. Jane Goodall, environmentalist and animal advocate, who died last week at 91. She championed animal rights, conservation, and inspired global compassion.
www.vox.com/future-perfe...

The conservationist used her stature to advocate for one of the most important, yet most unpopular, causes in the world.

www.vox.com

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Citizens for Alternatives to Animal Research and Experimentation @caare.bsky.social · 22d

King’s College London & collaborators studied human COVID patients receiving inhaled heparin and demonstrated reduced deaths and need for mechanical ventilation. www.sciencedaily.com/releases/202...

Doctors tested a common drug on COVID. The results are stunning

Inhaled heparin significantly lowers the risk of death and ventilation in COVID-19 patients while also showing potential against other respiratory infections. With its unique triple-action benefits, i...

www.sciencedaily.com

Citizens for Alternatives to Animal Research and Experimentation @caare.bsky.social · 23d

University of Rochester & NCATS bypassed cruel animal experiments and studied mother/infant blood samples to show prenatal PFAS exposure alters infant immune cells.
ncats.nih.gov/news-events/...

Pre-Birth Exposure to Forever Chemicals May Harm the Immune System

A study following mother–baby pairs found that high PFAS exposure during pregnancy can harm babies’ immune systems and may weaken their vaccine response.

ncats.nih.gov

Automating Brain Organoids To Boost Neurodegenerative Research

Citizens for Alternatives to Animal Research and Experimentation @caare.bsky.social · 24d

Molecular Devices’ automated brain organoid system boosts reproducibility and scalability, advancing human-based neurodegenerative research without using animals. www.technologynetworks.com/neuroscience...

In this interview, Felix Spira, senior manager at Molecular Devices, discusses how automation and AI improve brain organoid cultivation, enabling consistent long-term models that advance research into...

Cocoa Extract Supplements Reduce Age-Related Markers of Inflammation

Citizens for Alternatives to Animal Research and Experimentation @caare.bsky.social · 25d

Mass General Brigham trial used human blood samples to show cocoa extract lowers inflammation with age—advancing science without animal use. www.technologynetworks.com/immunology/n...

Could cocoa extract supplements rich in cocoa flavanols reduce inflammation and, in turn, prevent age-related chronic diseases? A new study suggests they could.

Breathtaking Breakthrough: Lung-on-a-Chip Defends Itself

Citizens for Alternatives to Animal Research and Experimentation @caare.bsky.social · 28d

Georgia Tech & Vanderbilt U’s lung-on-a-chip with a working immune system offers a superior, human-relevant alternative to animal testing. news.gatech.edu/news/2025/09...

On a clear polymer chip, soft and pliable like a gummy bear, a microscopic lung comes alive — expanding, circulating, and, for the first time, protecting itself like a living organ.

news.gatech.edu

Epigenomic Atlas Uncovers Root Causes of Alzheimer’s Decline

Citizens for Alternatives to Animal Research and Experimentation @caare.bsky.social · 29d

MIT’s atlas of 3.5M brain cells from post-mortem donors reveals how gene regulation fails in Alzheimer’s— human-relevant insights that may slow memory decline. www.technologynetworks.com/genomics/new...

MIT researchers created the first large-scale atlas combining gene expression and regulation in over 3.5 million brain cells. They found that Alzheimer’s disease involves a collapse of nuclear compart...

Deep Learning Tool Helps Guide Precision Cancer Therapy

Citizens for Alternatives to Animal Research and Experimentation @caare.bsky.social · Oct 1

Max Delbrück Center introduces Flexynesis, a human-based, animal-free deep learning tool that integrates multi-omics and imaging data to guide personalized cancer therapy. www.technologynetworks.com/drug-discove...

Researchers have developed a new tool to more precisely guide cancer treatment. Described in a paper published in <i>Nature Communications</i>, the tool, called Flexynesis, uses deep neural networks a...

Psilocybin Provides Lasting Depression Relief Five Years After Trial

Citizens for Alternatives to Animal Research and Experimentation @caare.bsky.social · Sep 30

New animal-free research from Ohio State University on long-term outcomes of psilocybin-assisted therapy for depression finds that 67% of participants were still in remission five years after therapy. www.technologynetworks.com/drug-discove...

Five years after the clinical trial of psilocybin-assisted therapy for major depressive disorder, a majority of participants reported lasting depression remission as well as improvement in a range of ...

Daily eye drops could make reading glasses obsolete

Citizens for Alternatives to Animal Research and Experimentation @caare.bsky.social · Sep 29

Using only human research, the European Society of Cataract and Refractive Surgeons shows pilocarpine+diclofenac eye drops improve vision in far-sighted patients. www.sciencedaily.com/releases/202...

Eye drops combining pilocarpine and diclofenac helped patients read extra lines on vision charts, with effects lasting up to two years. The treatment could revolutionize presbyopia care as a safe, non...

www.sciencedaily.com