Citizens for Alternatives to Animal Research and Experimentation
@caare.bsky.social
CAARE is a national non-profit 501(c)3 organization dedicated to sparing animal suffering by promoting research and testing without animals.
Human research by the Psychiatric Genomics Consortium showed 5 genetic clusters explain risk for psychiatric disorders, guiding more accurate treatments than animal tests. www.technologynetworks.com/genomics/new...
Five Genetic Clusters Explain Over Half of All Psychiatric Risk
A massive genomic study of over 1 million cases found that shared risk across 14 psychiatric disorders is reduced to 5 underlying genetic factors. Researchers linked each factor to specific brain cell...
www.technologynetworks.com
December 24, 2025 at 1:36 PM
Human research by the Psychiatric Genomics Consortium showed 5 genetic clusters explain risk for psychiatric disorders, guiding more accurate treatments than animal tests. www.technologynetworks.com/genomics/new...
Cornell researchers show how lab housing constrains mouse behavior. Given space and choice outdoors, mice explored, decided, and engaged with their world.
phys.org/news/2025-12...
phys.org/news/2025-12...
From cages to fields: Lab mice lose their anxiety after a week outdoors
When postdoctoral researcher Matthew Zipple releases lab mice into a large, enclosed field just off Cornell's campus, something remarkable happens.
phys.org
December 22, 2025 at 2:12 PM
Cornell researchers show how lab housing constrains mouse behavior. Given space and choice outdoors, mice explored, decided, and engaged with their world.
phys.org/news/2025-12...
phys.org/news/2025-12...
University of Basel researchers created an animal-free, human bone marrow model that better reflects human biology in blood and drug studies. www.thechemicalengineer.com/news/breakth...
Breakthrough bone marrow model could reduce need for animal testing
RESEARCHERS have replicated the body’s blood-producing system by creating a bone marrow model made entirely from reprogrammed human cells.
www.thechemicalengineer.com
December 19, 2025 at 1:07 PM
University of Basel researchers created an animal-free, human bone marrow model that better reflects human biology in blood and drug studies. www.thechemicalengineer.com/news/breakth...
Allen Institute scientists tracked immune shifts in rheumatoid arthritis patients years before symptoms emerged, revealing possible biomarkers and early treatment targets.https://www.sciencedaily.com/releases/2025/11/251126095037.htm
December 17, 2025 at 11:33 AM
Allen Institute scientists tracked immune shifts in rheumatoid arthritis patients years before symptoms emerged, revealing possible biomarkers and early treatment targets.https://www.sciencedaily.com/releases/2025/11/251126095037.htm
Penn State College of Medicine developed a smarter genomic tool to understand disease genetics, showing the potential of human-based methods over outdated animal studies. www.technologynetworks.com/genomics/new...
Scientists Built a Smarter Way To Find Genes Linked to Alzheimer’s and ALS
Researchers developed a method that integrates bulk and single-cell data to map how genetic variants influence gene expression across seven brain cell types. The tool identified about 75% more disease...
www.technologynetworks.com
December 16, 2025 at 12:18 PM
Penn State College of Medicine developed a smarter genomic tool to understand disease genetics, showing the potential of human-based methods over outdated animal studies. www.technologynetworks.com/genomics/new...
UC Riverside created a fully synthetic brain-tissue model using a PEG scaffold, avoiding cruel and unreliable animal products and improving research precision. www.futurity.org/first-synthe...
Team creates first totally synthetic brain tissue model
The new brain tissue model could enable significant advancements in neurological research.
www.futurity.org
December 15, 2025 at 12:09 PM
UC Riverside created a fully synthetic brain-tissue model using a PEG scaffold, avoiding cruel and unreliable animal products and improving research precision. www.futurity.org/first-synthe...
Arizona State University used human data to link low choline and obesity to early brain damage—a more ethical and scientifically sound method than animal testing. www.sciencedaily.com/releases/202...
A common nutrient deficiency may be silently harming young brains
Scientists studying young adults with obesity discovered early indicators of brain stress that resemble patterns seen in cognitive impairment. The group showed higher inflammation, signs of liver stra...
www.sciencedaily.com
December 12, 2025 at 12:06 PM
Arizona State University used human data to link low choline and obesity to early brain damage—a more ethical and scientifically sound method than animal testing. www.sciencedaily.com/releases/202...
A human MRI study at University of Seville links early schizophrenia to brain changes, demonstrating how human research can deliver findings unobtainable from animals.
www.technologynetworks.com/neuroscience...
www.technologynetworks.com/neuroscience...
Early Schizophrenia Leaves a Fingerprint on Brain Structure
Using MRI scans from 352 schizophrenia patients, researchers found widespread reductions in structural similarity across several brain regions. These disruptions tracked with symptom severity, cogniti...
www.technologynetworks.com
December 10, 2025 at 12:13 PM
A human MRI study at University of Seville links early schizophrenia to brain changes, demonstrating how human research can deliver findings unobtainable from animals.
www.technologynetworks.com/neuroscience...
www.technologynetworks.com/neuroscience...
In animal-free research, Washington State University grew artificial cartilage from stem cells that mimics natural joint properties, advancing human tissue engineering.
www.technologynetworks.com/applied-scie...
www.technologynetworks.com/applied-scie...
Artificial Cartilage Created Using Stem Cells From Bone Marrow
Researchers are working to create an artificial cartilage that resembles natural cartilage, with a recipe that can be adjusted along the way.
www.technologynetworks.com
December 9, 2025 at 12:12 PM
In animal-free research, Washington State University grew artificial cartilage from stem cells that mimics natural joint properties, advancing human tissue engineering.
www.technologynetworks.com/applied-scie...
www.technologynetworks.com/applied-scie...
In a human study, University of Gothenburg showed two drugs that can accelerate PFAS elimination in humans—highlighting human-based studies over animal testing. www.technologynetworks.com/analysis/new...
Certain Drugs Eliminate PFAS From the Body Faster
Discover how certain medications can aid in the elimination of PFAS from the body, revealing new avenues for managing this environmental toxin.
www.technologynetworks.com
December 8, 2025 at 12:08 PM
In a human study, University of Gothenburg showed two drugs that can accelerate PFAS elimination in humans—highlighting human-based studies over animal testing. www.technologynetworks.com/analysis/new...
Human-based testing using donated organs kept viable outside the body are part of the new technologies gaining momentum to replace animal testing.
pharmaphorum.com/rd/beyond-an...
pharmaphorum.com/rd/beyond-an...
Beyond animal testing: How human data trials are reshaping drug development
Researchers are beginning to imagine a future in which development pipelines are more predictive, more efficient, and ultimately more humane.
pharmaphorum.com
December 5, 2025 at 12:06 PM
Human-based testing using donated organs kept viable outside the body are part of the new technologies gaining momentum to replace animal testing.
pharmaphorum.com/rd/beyond-an...
pharmaphorum.com/rd/beyond-an...
University of Sydney developed 3D-printed human-based blood-vessel models to study clot formation and stroke risk without cruel and flawed animal testing.
healthcare-in-europe.com/en/news/3d-p...
healthcare-in-europe.com/en/news/3d-p...
'Artery on a chip' could unravel secrets of strokes
A new 3D printing technique is generating anatomically accurate replicas of blood vessels in just two hours. The device so far has helped researchers study blood clots that lead to stroke and could be...
healthcare-in-europe.com
December 4, 2025 at 12:12 PM
University of Sydney developed 3D-printed human-based blood-vessel models to study clot formation and stroke risk without cruel and flawed animal testing.
healthcare-in-europe.com/en/news/3d-p...
healthcare-in-europe.com/en/news/3d-p...
FDA’s new draft guidance reduces primate testing for certain antibodies and promotes animal-free methods—a strong step toward more ethical, human-relevant drug development.
www.fiercebiotech.com/biotech/fda-...
www.fiercebiotech.com/biotech/fda-...
FDA issues draft guidance to reduce primate testing for certain antibodies
The FDA has released a plan to stop or reduce | The FDA has released a plan to stop or reduce the use of primates for testing the safety of certain monoclonal antibodies, the latest expansion of the r...
www.fiercebiotech.com
December 3, 2025 at 12:05 PM
FDA’s new draft guidance reduces primate testing for certain antibodies and promotes animal-free methods—a strong step toward more ethical, human-relevant drug development.
www.fiercebiotech.com/biotech/fda-...
www.fiercebiotech.com/biotech/fda-...
Aarhus University used human genetic data to determine which antidepressants may work best for individual patients — information impossible to obtain from animal testing.
www.sciencedaily.com/releases/202...
www.sciencedaily.com/releases/202...
A simple DNA test could reveal the right antidepressant for you
Millions struggle with depression and anxiety, often enduring long waits for effective treatment. Scientists in Sweden, Denmark, and Germany are developing a genetic test to predict which medications ...
www.sciencedaily.com
December 2, 2025 at 12:30 PM
Aarhus University used human genetic data to determine which antidepressants may work best for individual patients — information impossible to obtain from animal testing.
www.sciencedaily.com/releases/202...
www.sciencedaily.com/releases/202...
University of Tennessee’s brain-on-a-chip offers a powerful way to study encephalitis viruses and test antivirals without problematic animal testing.
news.uthsc.edu/brain-on-a-c...
news.uthsc.edu/brain-on-a-c...
Brain-on-a-Chip Revolutionizes Fight Against Deadly Encephalitis Viruses - UTHSC News
Inside a lab at the University of Tennessee Health Science Center, a transparent chip no bigger than a stick of gum could be changing the way scientists study the human brain and how they fight some o...
news.uthsc.edu
December 1, 2025 at 12:12 PM
University of Tennessee’s brain-on-a-chip offers a powerful way to study encephalitis viruses and test antivirals without problematic animal testing.
news.uthsc.edu/brain-on-a-c...
news.uthsc.edu/brain-on-a-c...
Using human research methods and not animals, University of Illinois Chicago scientists find lidocaine may stop pancreatic cancer metastasis.
www.technologynetworks.com/cancer-resea...
www.technologynetworks.com/cancer-resea...
Attacking "Seeds of Metastasis" in Pancreatic Cancer
Lidocaine may mitigate metastasis and favorably affect patient outcomes in pancreatic cancer.
www.technologynetworks.com
November 28, 2025 at 1:41 PM
Using human research methods and not animals, University of Illinois Chicago scientists find lidocaine may stop pancreatic cancer metastasis.
www.technologynetworks.com/cancer-resea...
www.technologynetworks.com/cancer-resea...
UCSF’s clinical trial shows daily coffee may lower AFib recurrence by 39%, highlighting the value of human-based clinical evidence over outdated and cruel animal tests. www.sciencedaily.com/releases/202...
Surprising heart study finds daily coffee may cut AFib risk by 39%
New research finds that daily coffee drinking may cut AFib risk by nearly 40%, defying decades of medical caution. Scientists discovered that caffeine’s effects on activity, blood pressure, and inflam...
www.sciencedaily.com
November 26, 2025 at 2:02 PM
UCSF’s clinical trial shows daily coffee may lower AFib recurrence by 39%, highlighting the value of human-based clinical evidence over outdated and cruel animal tests. www.sciencedaily.com/releases/202...
Utrecht University’s 4D bioprinting creates more realistic human-based tissue models, improving poor drug testing results that are based on animal testing. www.uu.nl/en/news/4d-p...
4D printing makes human tissue models more realistic
In his PhD research at Utrecht University and UMC Utrecht, Marc Falandt developed biomaterials whose properties can be adjusted even after they have been 3D-printed, effectively adding a fourth dimens...
www.uu.nl
November 25, 2025 at 1:40 PM
Utrecht University’s 4D bioprinting creates more realistic human-based tissue models, improving poor drug testing results that are based on animal testing. www.uu.nl/en/news/4d-p...
Huge win: CDC ends all monkey testing and embraces more ethical, human-based science — a big step forward for animals and better research. www.science.org/content/arti...
Exclusive: CDC to end all monkey research
Studies related to HIV and other infectious diseases will be phased out, sources say; fate of the agency's animals remains unclear
www.science.org
November 24, 2025 at 1:40 PM
Huge win: CDC ends all monkey testing and embraces more ethical, human-based science — a big step forward for animals and better research. www.science.org/content/arti...
Weill Cornell Medicine and University of Adelaide unveil GoT-Multi, a human-based tool that tracks cancer evolution at single-cell detail, reducing use of animal tests. www.technologynetworks.com/proteomics/n...
New Tool Maps Cancer Evolution at Single-Cell Resolution
Researchers at Weill Cornell Medicine and the University of Adelaide have developed GoT-Multi, a tool that tracks multiple gene mutations and gene activity in individual cancer cells. Unlike earlier m...
www.technologynetworks.com
November 21, 2025 at 12:15 PM
Weill Cornell Medicine and University of Adelaide unveil GoT-Multi, a human-based tool that tracks cancer evolution at single-cell detail, reducing use of animal tests. www.technologynetworks.com/proteomics/n...
University of Glasgow developed a bioengineered human bone marrow model that improves leukemia therapy testing and reduces reliance on animal research. medicalxpress.com/news/2025-11...
Bioengineered bone marrow model successfully used in leukemia research
Scientists at the University of Glasgow have successfully used the first bioengineered bone marrow model to carry out vital cancer research, offering new insights into potential therapies for the dise...
medicalxpress.com
November 20, 2025 at 12:27 PM
University of Glasgow developed a bioengineered human bone marrow model that improves leukemia therapy testing and reduces reliance on animal research. medicalxpress.com/news/2025-11...
UC Davis Health study links anxiety to lower choline levels in the brain, advancing human-based understanding of mental health without poorly translatable animal tests. www.technologynetworks.com/neuroscience...
Anxiety Disorders Linked to Low Choline Levels in the Brain
People with anxiety disorders have lower levels of choline in their brains, according to new research.
www.technologynetworks.com
November 19, 2025 at 12:29 PM
UC Davis Health study links anxiety to lower choline levels in the brain, advancing human-based understanding of mental health without poorly translatable animal tests. www.technologynetworks.com/neuroscience...
Instead of cruel animal experiments, University of Sydney used advanced fMRI in humans to map pain response, revealing endocannabinoid pathways for targeted treatments.
www.sciencedaily.com/releases/202...
www.sciencedaily.com/releases/202...
Breakthrough brain discovery reveals a natural way to relieve pain
Using powerful 7-Tesla brain imaging, researchers mapped how the brainstem manages pain differently across the body. They discovered that distinct regions activate for facial versus limb pain, showing...
www.sciencedaily.com
November 18, 2025 at 12:49 PM
Instead of cruel animal experiments, University of Sydney used advanced fMRI in humans to map pain response, revealing endocannabinoid pathways for targeted treatments.
www.sciencedaily.com/releases/202...
www.sciencedaily.com/releases/202...
Certara’s AI platform aligns with FDA’s new policy to phase out animal tests by using sophisticated computer modeling to more accurately predict drug responses.
technical.ly/sponsored-ar...
technical.ly/sponsored-ar...
How Certara turned the FDA’s animal‑testing shift into innovation
As drug development enters a new era, Certara is expanding its global team of scientists and technologists to lead the shift toward AI-powered testing methods.
technical.ly
November 17, 2025 at 12:22 PM
Certara’s AI platform aligns with FDA’s new policy to phase out animal tests by using sophisticated computer modeling to more accurately predict drug responses.
technical.ly/sponsored-ar...
technical.ly/sponsored-ar...
Duke‑NUS created BrainSTEM , a detailed human brain cell atlas guiding better, animal-free Parkinson’s therapies by improving accuracy and safety of lab-grown human models.
www.sciencedaily.com/releases/202...
www.sciencedaily.com/releases/202...
A groundbreaking brain map could revolutionize Parkinson’s treatment
Duke-NUS scientists unveiled BrainSTEM, a revolutionary single-cell map that captures the full cellular diversity of the developing human brain. The project’s focus on dopamine neurons provides crucia...
www.sciencedaily.com
November 14, 2025 at 12:34 PM
Duke‑NUS created BrainSTEM , a detailed human brain cell atlas guiding better, animal-free Parkinson’s therapies by improving accuracy and safety of lab-grown human models.
www.sciencedaily.com/releases/202...
www.sciencedaily.com/releases/202...