Luc Camoin
@camoinluc.bsky.social
Reposted by Luc Camoin
Solving the computational challenge of phosphoproteomics with 𝐏𝐡𝐨-𝐓𝐢𝐩: dephosphorylation on-tip identifies the sequences of phosphorylated peptides.
This serves as a basis for predicted spectral libraries, reducing the search space 10x-20x. www.biorxiv.org/content/10.1...
This serves as a basis for predicted spectral libraries, reducing the search space 10x-20x. www.biorxiv.org/content/10.1...
November 19, 2025 at 10:07 AM
Solving the computational challenge of phosphoproteomics with 𝐏𝐡𝐨-𝐓𝐢𝐩: dephosphorylation on-tip identifies the sequences of phosphorylated peptides.
This serves as a basis for predicted spectral libraries, reducing the search space 10x-20x. www.biorxiv.org/content/10.1...
This serves as a basis for predicted spectral libraries, reducing the search space 10x-20x. www.biorxiv.org/content/10.1...
Reposted by Luc Camoin
Isobaric labeling with the @thermofishersci.bsky.social TMT kit is super useful in proteomics! 🧬🔥
#Proteomics #TMT #MassSpec #ScienceLife
#Proteomics #TMT #MassSpec #ScienceLife
October 17, 2025 at 5:02 PM
Isobaric labeling with the @thermofishersci.bsky.social TMT kit is super useful in proteomics! 🧬🔥
#Proteomics #TMT #MassSpec #ScienceLife
#Proteomics #TMT #MassSpec #ScienceLife
Reposted by Luc Camoin
Great to welcome Sébastien JeanJean, Senior Sales Manager France at @thermofishersci.bsky.social, to visit our new #OrbitrapAstral mass spectrometer installation today!
Big thanks to our funders — CPER, LNCC, @ibisa.net, Amidex, and @inserm.fr.
#MassSpec #Proteomics @insermpacacorse.bsky.social
Big thanks to our funders — CPER, LNCC, @ibisa.net, Amidex, and @inserm.fr.
#MassSpec #Proteomics @insermpacacorse.bsky.social
October 2, 2025 at 2:50 PM
Great to welcome Sébastien JeanJean, Senior Sales Manager France at @thermofishersci.bsky.social, to visit our new #OrbitrapAstral mass spectrometer installation today!
Big thanks to our funders — CPER, LNCC, @ibisa.net, Amidex, and @inserm.fr.
#MassSpec #Proteomics @insermpacacorse.bsky.social
Big thanks to our funders — CPER, LNCC, @ibisa.net, Amidex, and @inserm.fr.
#MassSpec #Proteomics @insermpacacorse.bsky.social
Reposted by Luc Camoin
In DIA-NN 2.3.0, we have added Deamidation (NQ) as an option in the GUI. There are good reasons for it :) You can try InfinDIA with any number of modifications selected, and check the RT differences between modified vs respective stripped peptides, for each mod - a way to validate peptidoform FDR.
September 29, 2025 at 11:46 AM
In DIA-NN 2.3.0, we have added Deamidation (NQ) as an option in the GUI. There are good reasons for it :) You can try InfinDIA with any number of modifications selected, and check the RT differences between modified vs respective stripped peptides, for each mod - a way to validate peptidoform FDR.
Reposted by Luc Camoin
Time and time again, it's always the same picture. DIA-NN controls FDR correctly as data reliability has been the main goal at DIA-NN's conception back in 2017 and a priority since then.
July 25, 2025 at 11:22 AM
Time and time again, it's always the same picture. DIA-NN controls FDR correctly as data reliability has been the main goal at DIA-NN's conception back in 2017 and a priority since then.
Reposted by Luc Camoin
In fact, two essential companions were installed: the Evosep ENO @evosep.bsky.social and the Ionbench table #IonBench
July 23, 2025 at 4:37 PM
In fact, two essential companions were installed: the Evosep ENO @evosep.bsky.social and the Ionbench table #IonBench
Reposted by Luc Camoin
Today is a great day!
Our article accepted on March 19, 2025 is published in Wiley mLife journal.
Great collaborative work with JM Bolla's lab, @map-proteomique.bsky.social @canaanlab.bsky.social
Céline Crauste from @ibmm-balard.bsky.social, and more...
👉 onlinelibrary.wiley.com/doi/10.1002/...
Our article accepted on March 19, 2025 is published in Wiley mLife journal.
Great collaborative work with JM Bolla's lab, @map-proteomique.bsky.social @canaanlab.bsky.social
Céline Crauste from @ibmm-balard.bsky.social, and more...
👉 onlinelibrary.wiley.com/doi/10.1002/...
The polyamino‐isoprenyl enhancer NV716 enables the antibacterial activity of two families of multi‐target inhibitors against the ESKAPEE bacterium Enterobacter cloacae
Gram-negative bacteria are particularly prone to developing antimicrobial resistance (AMR), as evidenced by the WHO's ESKAPEE list of high-priority pathogens. One strategy that has increased is the u...
onlinelibrary.wiley.com
June 25, 2025 at 1:27 PM
Today is a great day!
Our article accepted on March 19, 2025 is published in Wiley mLife journal.
Great collaborative work with JM Bolla's lab, @map-proteomique.bsky.social @canaanlab.bsky.social
Céline Crauste from @ibmm-balard.bsky.social, and more...
👉 onlinelibrary.wiley.com/doi/10.1002/...
Our article accepted on March 19, 2025 is published in Wiley mLife journal.
Great collaborative work with JM Bolla's lab, @map-proteomique.bsky.social @canaanlab.bsky.social
Céline Crauste from @ibmm-balard.bsky.social, and more...
👉 onlinelibrary.wiley.com/doi/10.1002/...
Reposted by Luc Camoin
At the European Proteomics Congress in St Malo #EuPA2025, Marseille Proteomique @map-proteomique.bsky.social won 3rd prize in the sandcastle competition sponsored by @brukercorporation.bsky.social
June 20, 2025 at 6:06 AM
At the European Proteomics Congress in St Malo #EuPA2025, Marseille Proteomique @map-proteomique.bsky.social won 3rd prize in the sandcastle competition sponsored by @brukercorporation.bsky.social
Reposted by Luc Camoin
On the way to the European #proteomics association #EuPA2025 conference in St Malo
June 16, 2025 at 9:10 AM
On the way to the European #proteomics association #EuPA2025 conference in St Malo
Reposted by Luc Camoin
Our new mass spectrometer has come to life. Now we're going to have to feed it protein several times a day.
June 3, 2025 at 6:47 AM
Our new mass spectrometer has come to life. Now we're going to have to feed it protein several times a day.
Always a great pleasure to work with you
It is my real pleasure to share our ASAP article published in ACS Infect Dis.
Another great collaboration with @pierresantucci.bsky.social @canaanlab.bsky.social
@lkremer1.bsky.social
@ibmm-balard.bsky.social
@map-proteomique.bsky.social
and more...
Enjoy 😊
pubs.acs.org/doi/10.1021/...
Another great collaboration with @pierresantucci.bsky.social @canaanlab.bsky.social
@lkremer1.bsky.social
@ibmm-balard.bsky.social
@map-proteomique.bsky.social
and more...
Enjoy 😊
pubs.acs.org/doi/10.1021/...
Mapping of Mycobacterial Enzymes Involved in Triacylglycerol Accumulation as Intrabacterial Lipid Inclusions Using Activity-Based Multitarget Inhibitor Probes
Lipids play a critical role in the physiology, life cycle, and pathogenicity of mycobacteria. They largely participate in host–pathogen interactions and fulfill important functions ranging from cell w...
pubs.acs.org
June 2, 2025 at 6:52 AM
Always a great pleasure to work with you
Reposted by Luc Camoin
Further, there are significant improvements for phosphoproteomics. We will release a note in the next months describing how we benchmark phosphosite localisation and show the leading performance by the new DIA-NN on state-of-the-art Orbitrap Astral and timsTOF data.
May 30, 2025 at 8:39 AM
Further, there are significant improvements for phosphoproteomics. We will release a note in the next months describing how we benchmark phosphosite localisation and show the leading performance by the new DIA-NN on state-of-the-art Orbitrap Astral and timsTOF data.
Reposted by Luc Camoin
DIA-NN 2.2.0 is released! The new DIA-NN 2.2.0 Enterprise achieves up to ~1.6x median speedup on 64-cores under Windows (please see benchmark below). Release notes: github.com/vdemichev/Di..., download (Academia): github.com/vdemichev/Di...
May 30, 2025 at 8:36 AM
DIA-NN 2.2.0 is released! The new DIA-NN 2.2.0 Enterprise achieves up to ~1.6x median speedup on 64-cores under Windows (please see benchmark below). Release notes: github.com/vdemichev/Di..., download (Academia): github.com/vdemichev/Di...
Reposted by Luc Camoin
New Preprint ... This was a bit different of a project than what we normally do for hardware comparisons. I think there is a lot of potential in the methods mentioned here for calibrating the instrument response to a common scale. Nice work by @chrhsu.bsky.social!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Evaluation of an Orbitrap Astral Zoom mass spectrometer prototype for quantitative proteomics - beyond identification lists
Mass spectrometry instrumentation continues to evolve rapidly, yet quantifying these advances beyond conventional peptide and protein detections remains challenging. Here, we evaluate a modified Orbit...
www.biorxiv.org
June 1, 2025 at 4:47 AM
New Preprint ... This was a bit different of a project than what we normally do for hardware comparisons. I think there is a lot of potential in the methods mentioned here for calibrating the instrument response to a common scale. Nice work by @chrhsu.bsky.social!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Luc Camoin
Evaluation of an Orbitrap Astral Zoom mass spectrometer prototype for quantitative proteomics - beyond identification lists www.biorxiv.org/cont...
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#proteomics #prot-preprint
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#proteomics #prot-preprint
June 1, 2025 at 4:00 PM
Evaluation of an Orbitrap Astral Zoom mass spectrometer prototype for quantitative proteomics - beyond identification lists www.biorxiv.org/cont...
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#proteomics #prot-preprint
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#proteomics #prot-preprint
Reposted by Luc Camoin
Marseille Proteomics @map-proteomique.bsky.social begins is delighted to announce that our new spectrometer is now out of the box and will start running next week
May 23, 2025 at 2:46 PM
Marseille Proteomics @map-proteomique.bsky.social begins is delighted to announce that our new spectrometer is now out of the box and will start running next week
Courage Eddy and family
My wife is undergoing an important surgical procedure today. Our 6 year old made her this drawing to give her courage.
It represents a flying house with the surgeon operating her on the ground floor while she is also resting on the first floor at the same time.
My wife loved it. So poetic 🤩
It represents a flying house with the surgeon operating her on the ground floor while she is also resting on the first floor at the same time.
My wife loved it. So poetic 🤩
May 23, 2025 at 2:30 PM
Courage Eddy and family
Reposted by Luc Camoin
A new era for Marseille Proteomics have just reached 100 subscribers to @map-proteomique.bsky.social begins with the arrival of these boxes containing new generations of equipment.
May 23, 2025 at 9:16 AM
A new era for Marseille Proteomics have just reached 100 subscribers to @map-proteomique.bsky.social begins with the arrival of these boxes containing new generations of equipment.
Reposted by Luc Camoin
🚨 New preprint! 🚨
Presenting diaPASEF immunopeptidomics for bacterial epitope discovery.
💥 Showcasing DIA-NN immunopeptidomics using proteome-wide predicted HLA class I libraries!
🧬 Read more: biorxiv.org/cgi/content/...
#Immunopeptidomics #MassSpec #DIA #HLA
Presenting diaPASEF immunopeptidomics for bacterial epitope discovery.
💥 Showcasing DIA-NN immunopeptidomics using proteome-wide predicted HLA class I libraries!
🧬 Read more: biorxiv.org/cgi/content/...
#Immunopeptidomics #MassSpec #DIA #HLA
Data-independent immunopeptidomics discovery of low-abundant bacterial epitopes
Mass spectrometry-based immunopeptidomics is a powerful approach to uncover peptides presented by human leukocyte antigen (HLA) molecules that can guide vaccine design and immunotherapies. While data-...
biorxiv.org
May 16, 2025 at 7:50 AM
🚨 New preprint! 🚨
Presenting diaPASEF immunopeptidomics for bacterial epitope discovery.
💥 Showcasing DIA-NN immunopeptidomics using proteome-wide predicted HLA class I libraries!
🧬 Read more: biorxiv.org/cgi/content/...
#Immunopeptidomics #MassSpec #DIA #HLA
Presenting diaPASEF immunopeptidomics for bacterial epitope discovery.
💥 Showcasing DIA-NN immunopeptidomics using proteome-wide predicted HLA class I libraries!
🧬 Read more: biorxiv.org/cgi/content/...
#Immunopeptidomics #MassSpec #DIA #HLA
I'm definitely going to dig into this work
Was great to contribute to this fantastic work led by
Patrick Willems @impenslab.bsky.social. With the new proteoform confidence module in DIA-NN, we enabled non-specific digest searches. Here's how it now works for immunopeptidomics!
Patrick Willems @impenslab.bsky.social. With the new proteoform confidence module in DIA-NN, we enabled non-specific digest searches. Here's how it now works for immunopeptidomics!
May 16, 2025 at 5:38 PM
I'm definitely going to dig into this work
Reposted by Luc Camoin
Reposted by Luc Camoin
We're always delighted to work together on these exciting projects @jefcavalier.bsky.social @canaanlab.bsky.social
⚠️ Breaking News ⚠️
Another great collaborative work with Victoria Magrioti,
@canaanlab.bsky.social @map-proteomique.bsky.social
now just published in @rscmedchem.rsc.org
pubs.rsc.org/en/content/a...
Another great collaborative work with Victoria Magrioti,
@canaanlab.bsky.social @map-proteomique.bsky.social
now just published in @rscmedchem.rsc.org
pubs.rsc.org/en/content/a...
Synthesis and Anti-mycobacterial Activity of Novel Medium-chain β-Lactone Derivatives: A Multi-Target Strategy to combat Mycobacterium abscessus
The constant emergence of drug-resistant mycobacteria, together with the lack of new antibiotics entering the market, has become a global public health problem that threatens the effective treatment o...
pubs.rsc.org
April 29, 2025 at 4:59 PM
We're always delighted to work together on these exciting projects @jefcavalier.bsky.social @canaanlab.bsky.social
Reposted by Luc Camoin
Thank you to all our subscribers. We have just reached 100 subscribers to @map-proteomique.bsky.social
April 29, 2025 at 5:05 PM
Thank you to all our subscribers. We have just reached 100 subscribers to @map-proteomique.bsky.social
Reposted by Luc Camoin
Want to know how the ligands interact with proteins beyond model cell lines, e.g., in tissues or bacteria? Interested in membrane targets? Check out our High-Throughput PELSA method which allows you do all these cool screenings for dozens of ligands within two hours! www.biorxiv.org/content/10.1...
High-throughput peptide-centric local stability assay extends protein-ligand identification to membrane proteins, tissues, and bacteria
Systematic mapping of protein-ligand interactions is essential for understanding biological processes and drug mechanisms. Peptide-centric local stability assay (PELSA) is a powerful tool for detectin...
www.biorxiv.org
April 29, 2025 at 6:13 PM
Want to know how the ligands interact with proteins beyond model cell lines, e.g., in tissues or bacteria? Interested in membrane targets? Check out our High-Throughput PELSA method which allows you do all these cool screenings for dozens of ligands within two hours! www.biorxiv.org/content/10.1...
We're always delighted to work together on these exciting projects @jefcavalier.bsky.social @canaanlab.bsky.social
⚠️ Breaking News ⚠️
Another great collaborative work with Victoria Magrioti,
@canaanlab.bsky.social @map-proteomique.bsky.social
now just published in @rscmedchem.rsc.org
pubs.rsc.org/en/content/a...
Another great collaborative work with Victoria Magrioti,
@canaanlab.bsky.social @map-proteomique.bsky.social
now just published in @rscmedchem.rsc.org
pubs.rsc.org/en/content/a...
Synthesis and Anti-mycobacterial Activity of Novel Medium-chain β-Lactone Derivatives: A Multi-Target Strategy to combat Mycobacterium abscessus
The constant emergence of drug-resistant mycobacteria, together with the lack of new antibiotics entering the market, has become a global public health problem that threatens the effective treatment o...
pubs.rsc.org
April 29, 2025 at 4:59 PM
We're always delighted to work together on these exciting projects @jefcavalier.bsky.social @canaanlab.bsky.social