A series of fluorescent probes is designed that act as dual agonists on both GLP1 and GIP receptors, and are used to image receptor binding activities in tissues and animals.

Nature Metabolism, Published online: 19 August 2025; doi:10.1038/s42255-025-01346-2Dual incretin agonists, such as tirzepatide (a GLP1R–GIPR agonist), show excellent efficacy for type 2 diabetes and obesity therapy. Research identifies the cells and neurons in the pancreas and brain that are targeted by dual agonists, providing further details on their modes of action.

Explore the role of GLP-1 in regulating hunger and appetite, uncovering its complex mechanisms in the brain and gut.

The physiological phenomenon whereby heart rate varies in phase with breathing in vertebrates has been known as ‘respiratory sinus arrhythmia’. In this Expert Recommendation, the authors argue that th...

This study, together with a companion manuscript, show that, in mice, weight loss as a result of GIP receptor antagonism requires, and potentiates, functional GLP-1 receptor signalling in the brain, e...

UCL is consistently ranked as one of the top ten universities in the world (QS World University Rankings 2010-2022) and is No.2 in the UK for research power (Research Excellence Framework 2021).

UCL is consistently ranked as one of the top ten universities in the world (QS World University Rankings 2010-2022) and is No.2 in the UK for research power (Research Excellence Framework 2021).

Learn about the groundbreaking science research behind the GLP-1 revolution - join us on 6 March

AbstractBackground and Aims. Vagal parasympathetic dysfunction is strongly associated with impaired exercise tolerance, indicating that coordinated autonom

Abstract figure legend This experimental animal (rat) study describes the regulation of systemic arterial blood pressure by an intracranial baroreceptor mechanism sensitive to changes in brain perfus...