On a gray November morning in London, ministers, scientists, and animal welfare advocates did something rare: they all applauded the same announcement. The UK government unveiled a sweeping roadmap to phase out animal testing, promising to accelerate the shift toward humane, high-tech alternatives that could redefine modern science itself. Backed by £75 million in new funding, the plan outlines a decade-long mission to replace regulatory animal testing with technologies such as organ-on-a-chip systems, artificial intelligence models, and 3D bioprinted tissues.

Combined behavioural, circuit-level and cellular approaches are used to demonstrate how hypothalamic neurons integrate hunger and oestrous state to drive a switch in how female mice interact with pups...

Zuri Sullivan and Catherine Dulac discuss the reciprocal communication between the brain and the immune system in sickness behavior.

Carlos Ribeiro and Albino Oliveira-Maia propose how brain–body interactions may inform the study of ‘higher’ cognitive functions such as learning and memory across model systems.

Obesity and associated complications can be managed by obesity medications, prompting the revision of criteria for the diagnosis and staging of this disease.

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We fed people milkshakes containing 130g of fat to see what it did to their brains.

Glia cells mediate cytokine signaling between the gut and the brain, linking sleep to inflammation in the gut.

If you really want to understand why Americans are so unhealthy, you have to see that the problem is not just our willpower, and it’s not just our food itself. It’s our food policies.

The glucagon-like peptide 1 receptor agonist (GLP-1RA) class of medicines has emerged as transformative for the treatment of diabetes, obesity and other diseases. On the twentieth anniversary of the approval of exenatide (Byetta), three former employees of Amylin Pharmaceuticals acknowledge the contributions of some of the individuals and the innovation responsible for delivering the first approved GLP-1RA — the forerunner to the modern blockbuster drugs.