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Jens Lund @lundjens.bsky.social · 4d

A framework from @easoobesity.bsky.social to guide pharmacological treatment of 'fat mass diseases' versus 'sick fat diseases' 👇
www.nature.com/articles/s41...

Framework for the pharmacological treatment of obesity and its complications from the European Association for the Study of Obesity (EASO) - Nature Medicine

Obesity and associated complications can be managed by obesity medications, prompting the revision of criteria for the diagnosis and staging of this disease.

www.nature.com

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Jens Lund @lundjens.bsky.social · 23d

⚖️ I will also provide critical perspectives on some of the other ‘hyped’ metabolites that are claimed to have “anti-obesity” effects . . .

@cbmr.science

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Jens Lund @lundjens.bsky.social · 23d

😱 I will present two ‘horror stories’, one on lactate and one on pyruvate (unpublished), illustrating major overlooked methodological problems in e.g. metabolic toletance tests used to assess glucose homeostasis. 3/4

@clemmensenc.bsky.social @zgerharthines.bsky.social

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Jens Lund @lundjens.bsky.social · 23d

Then you should join the @easdnews.bsky.social Rising Star Symposium tomorrow (thursday) at 🕗 08.30-10.10 in📍London Hall (or online). 2/4

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Jens Lund @lundjens.bsky.social · 23d

Are you using metabolic tolerance tests in your research? 💉Are you interested in metabolites? Or do you study the effects of exercise? 🏃🏻‍♂️‍➡️ 1/4

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Jens Lund @lundjens.bsky.social · 25d

👉 Legacy effect
👉 Novel subtype of T2D
👉 MASLD screening in newly diagnosed T2D
👉T2D and cardiorenal comorbidities
👉 Stressors and MetS
👉 Psychosocial inequality and foot compl. in newly diagnosed T2D
👉 Sex diff. in vascular compl.
👉 How MetS contributes to global disease burden

Jens Lund @lundjens.bsky.social · 25d

Then join the epidemiology-focused short oral discussion session (Event A) today (Tuesday) from 12.00 – 13.00 at Station 03 in Hall C. It will include presentations on 👇 2/3

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Jens Lund @lundjens.bsky.social · 25d

Are you at the 61st @easdnews.bsky.social meeting this week? And are you working with metabolic and vascular complications of diabetes - or do you just want a brief break from the omnipresent and rapidly progressing developments in pharmacotherapies for obesity and cardiometabolic diseases? 1/3

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Reposted by Jens Lund

Katie Fleeman @fleemanator.bsky.social · Sep 9

As the world focuses on its billion-plus obese citizens, there remain people at the other end of the spectrum who are skinny, often painfully so, but don’t want to be. This recent @knowablemag.bsky.social article explores the “real enigma” of a condition. knowablemagazine.org/content/arti...

The other end of the weight spectrum: Very thin people

Researchers are exploring why some individuals are naturally super-lean and may struggle to gain weight. The causes of such constitutional thinness offer clues to the physiology of weight control.

knowablemagazine.org

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Reposted by Jens Lund

Knowable Magazine @knowablemag.bsky.social · Sep 9

In a world focused on obesity, there remain people who struggle to gain weight. Genetic differences play a role.

The other end of the weight spectrum: Very thin people

Researchers are exploring why some individuals are naturally super-lean and may struggle to gain weight. The causes of such constitutional thinness offer clues to the physiology of weight control.

knowmag.org

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Jens Lund @lundjens.bsky.social · 28d

Take-home 📨: Thin people are battling their own biology. The forces they try to overcome to gain weight are similar, if not the same, to those that people with high BMIs fight when trying to lose weight 👉 illustrating that biology largely determines our body weight!

www.nature.com/articles/s41...

Tracing the biological roots of obesity resistance in humans - Nature Reviews Endocrinology

Nature Reviews Endocrinology - Tracing the biological roots of obesity resistance in humans

www.nature.com

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Jens Lund @lundjens.bsky.social · 28d

. . . . as discussed by myself, @zgerharthines.bsky.social and @clemmensenc.bsky.social in this open access paper from @cp-trendsendomet.bsky.social 7/8

www.cell.com/trends/endoc...

Role of Energy Excretion in Human Body Weight Regulation

Food intake and energy expenditure are the typical determinants of body weight. Yet, recent observations underscore that a third and often-neglected factor, fecal energy loss, can influence energy bal...

www.cell.com

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Jens Lund @lundjens.bsky.social · 28d

But there are also people that seem to eat more than they burn. The observation that certain individuals with constitutional thinness remain weight stable while seemingly eating more calories than they expend might be explained by increased loss of calories in the toilet 💩 6/8

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Jens Lund @lundjens.bsky.social · 28d

But what might explain weight gain resistance in people with constitutional thinness? For some thin people,
enhanced satiety might play a role 🍔 For others, increased energy expenditure could be an answer 🔥 as suggested by
@johnspeakman4.bsky.social's group 5/8

www.cell.com/cell-metabol...

Higher than predicted resting energy expenditure and lower physical activity in healthy underweight Chinese adults

www.cell.com

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Jens Lund @lundjens.bsky.social · 28d

The numerous anecdotes and stories appearing in this network illustrate that:

1) Weight stigma hits both ends of the BMI spectrum!

2) People with thinness might also help us improve the treatment of other cardiometabolic diseases! 4/8

royalsocietypublishing.org/doi/10.1098/...

Physiological protection against weight gain: evidence from overfeeding studies and future directions | Philosophical Transactions of the Royal Society B: Biological Sciences

Body weight is under physiological regulation. When body fat mass decreases, a series of responses are triggered to promote weight regain by increasing food intake and decreasing energy expenditure. Analogous, in response to experimental overfeeding, ...

royalsocietypublishing.org

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Jens Lund @lundjens.bsky.social · 28d

In 2020, I started building a network for people living with constitutional thinness. This group now has more than 600 members that report to live with a persistent and healthy form of thinness. 3/8

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Jens Lund @lundjens.bsky.social · 28d

Building on work by Mélina Bailly et al., and myself and @clemmensenc.bsky.social, the article illustrates how constitutional thinness might hold the keys for better understanding obesity and finally unlocking its ‘The Gordian Knot’, i.e. preventing overweight. 2/8
annualreviews.org/content/jour...

Unique Energy Profile Associated with Persistent Thin Phenotype | Annual Reviews

The concept of constitutional thinness first emerged in the scientific literature at the beginning of the 20th century. Yet, this concept of a physiologically determined thinness, which clearly differ...

annualreviews.org

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Jens Lund @lundjens.bsky.social · 28d

If our environment promotes obesity, why do some people stay thin? 🤔

This new popular scientific article by Ute Eberle in
@knowablemag.bsky.social delves into this question 👇 1/8

@cbmr.science

knowablemagazine.org/content/arti...

The other end of the weight spectrum: Very thin people

Researchers are exploring why some individuals are naturally super-lean and may struggle to gain weight. The causes of such constitutional thinness offer clues to the physiology of weight control.

knowablemagazine.org

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Jens Lund @lundjens.bsky.social · 28d

Can we harness the biology behind weight gain resistance in people living with constitutional thinness to prevent and better treat obesity and cardiometabolic diseases? 👇 @cbmr.science

royalsocietypublishing.org/doi/10.1098/...

Longtail News @longtail.news · Sep 7

Feed: "Latest from Live Science in News"
By: Ute Eberle on Saturday, September 6, 2025

Extreme thinness: Scientists are investigating why some people struggle to gain weight

Researchers are exploring why some individuals are naturally super-lean and may struggle to gain weight. The causes of such constitutional thinness offer clues to the physiology of weight control.

www.livescience.com

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Reposted by Jens Lund

Sakamoto Lab @labsakamoto.bsky.social · Sep 9

Latest publication from the lab spearheaded by @shoreseashell.bsky.social & in collaboration with @zeqiraj.bsky.social is out. Using structural, biochemical & computational tools, this work sheds light on the mechanism of action of BAY-3827 in inhibiting #AMPK 1/3
www.science.org/doi/full/10....

Mechanism and cellular actions of the potent AMPK inhibitor BAY-3827

The mechanism and unique molecular/cellular features of the potent and selective AMPK inhibitor BAY-3827 are unraveled.

www.science.org

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Jens Lund @lundjens.bsky.social · Aug 8

In the Journal Club, we highlight potential uses, together with key limitations, of a novel mouse model for studying lactate biology. It is freely available. Take a look if you're into e.g. metabolite or exercise biology👇
physoc.onlinelibrary.wiley.com/doi/10.1113/...

Cutting through dogma: a novel tool to dissect lactate biology

Click on the article title to read more.

physoc.onlinelibrary.wiley.com

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Jens Lund @lundjens.bsky.social · Aug 8

We wrote one of these last year and I'm really happy to see the above recognition of our work which was led by @niclasrausch.bsky.social when he was visiting the @zgerharthines.bsky.social Lab at the @cbmr.science. 2/3

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Jens Lund @lundjens.bsky.social · Aug 8

@jphysiol.bsky.social, and several other journals, has a 'Journal Club' format targeted to early-career researchers. It is a great opportunity for young scientists to get started with scientific writing and cultivating independent thinking. Check it out! 1/3

The Journal of Physiology @jphysiol.bsky.social · Aug 7

Congratulations to Niclas Rausch, Rebecca L. McIntyre, Fabian Finger & Jens Lund of cbmr.science for winning the #JournalClub 2024 Prize! 📖 🏆

See their winning paper 'Cutting through dogma: a novel tool to dissect lactate biology'⬇️

physoc.onlinelibrary.wiley.com/doi/10.1113/...

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Reposted by Jens Lund

The Journal of Physiology @jphysiol.bsky.social · Aug 7

Congratulations to Niclas Rausch, Rebecca L. McIntyre, Fabian Finger & Jens Lund of cbmr.science for winning the #JournalClub 2024 Prize! 📖 🏆

See their winning paper 'Cutting through dogma: a novel tool to dissect lactate biology'⬇️

physoc.onlinelibrary.wiley.com/doi/10.1113/...

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Reposted by Jens Lund

Niclas Rausch @niclasrausch.bsky.social · Aug 7

Many thanks to @jphysiol.bsky.social for recognizing our contribution to the Journal Club series, where we discussed key considerations in lactate research. We're honored to receive this prize!

The Journal of Physiology @jphysiol.bsky.social · Aug 7

Congratulations to Niclas Rausch, Rebecca L. McIntyre, Fabian Finger & Jens Lund of cbmr.science for winning the #JournalClub 2024 Prize! 📖 🏆

See their winning paper 'Cutting through dogma: a novel tool to dissect lactate biology'⬇️

physoc.onlinelibrary.wiley.com/doi/10.1113/...

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