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eLife
@elife.bsky.social
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The funder-researcher collaboration and open-access publisher for research in the life and biomedical sciences.

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eLife @elife.bsky.social · 20d
We’re pleased to announce our Trained Immunity Focus Issue 🎉

With original research and reviews spanning history, current state and future directions of trained immunity, explore today:
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Trained Immunity. a new focus issue. explore the collection
elife.bsky.social
1/ This Review Article from our new Focus Issue outlines how #epigenetic and metabolic rewiring enables innate immune cells to ‘remember’ past challenges, shaping protection, pathology, and new therapeutic strategies.
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Triggers of trained immunity across all tissues.
November 25, 2025 at 9:01 PM
elife.bsky.social
Catch up with the Community Voices podcast.

Our interviews with inspiring academics cover topics spanning citizenship as a privilege, how postdoc training needs to change, the intersection of queerness, religion, and science, and plenty more.
Community | eLife Community Voices · eLife
Hear from researchers across the globe about what matters to them in relation to research culture.
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November 25, 2025 at 4:11 PM
elife.bsky.social
Evidence from 14 research funding programmes confirms that early winners tend to keep winning (Matthew effect). But the idea that an early setback makes you stronger later doesn’t replicate widely.
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eLife Assessment This important study reports the results of efforts to replicate two phenomena of significant interest to early-career scientists and scientific policymakers: the Matthew effect and the early-career setback effect. Several previous studies of these effects have focused on early-career researchers with grant proposals that fell just below or just above a funding threshold. Those just above the threshold were more likely to be successful when they applied for funding later in the career (an example of the well-known Matthew effect), while those just below were more likely to go on to have stronger publication records (the early-career setback effect). In this study the Matthew effect was found to be robust across funders, and to generalize from those close to the funding threshold to the whole population. The early-career setback effect was not robust across funders and did not generalize to the whole population. The evidence reported is convincing.
November 25, 2025 at 11:02 AM
elife.bsky.social
Transgenerational Epigenetic Inheritance: Twists and turns in the story of learned avoidance

Evidence that learned avoidance of a pathogenic bacterium can be transmitted to future generations in C. elegans is growing.

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Transgenerational Epigenetic Inheritance: Twists and turns in the story of learned avoidance
Evidence that learned avoidance of a pathogenic bacterium can be transmitted to future generations in C. elegans is growing.
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November 24, 2025 at 11:28 PM
elife.bsky.social
We have an amazing opportunity for Early-Career Researchers to join our Board of Directors!

We're looking for someone with experience in leading #OpenScience projects to support and lead eLife in our mission to change research communication.

🔗 buff.ly/SZgtgVv
November 24, 2025 at 9:02 PM
elife.bsky.social
Looking for a home for your structural biology paper?

We welcome studies that advance our understanding of molecular mechanisms in biology, using experimental and computational approaches to provide quantitative insights.

See what we publish ⬇️
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November 24, 2025 at 11:44 AM
Reposted by eLife
renslolab.bsky.social
The version of record is now out in eLife! For the next chapter in this story check out www.biorxiv.org/content/10.1...

In @elife.bsky.social: The Mac1 ADP-ribosylhydrolase is a therapeutic target for SARS-CoV-2 doi.org/10.7554/eLif...
The Mac1 ADP-ribosylhydrolase is a therapeutic target for SARS-CoV-2
The development of new small molecules demonstrates how pharmacologic inhibition of the coronavirus macrodomain restores innate immunity, leading to reduced viral replication and improved outcomes in ...
doi.org
November 20, 2025 at 9:02 PM
Reposted by eLife
zebrafishrock.bsky.social
New work from @rohner.bsky.social & @alexckeene.bsky.social 🐟
elife.bsky.social eLife @elife.bsky.social · 4d
Elevated DNA damage without signs of ageing in the short-sleeping Mexican cavefish offers a unique model to study sleep, DNA repair, and ageing.
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November 24, 2025 at 9:08 AM
elife.bsky.social
Kinesin-1-driven microtubule sliding helps pancreatic β cells reorganise their cytoskeleton in response to glucose.
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November 23, 2025 at 11:28 PM
elife.bsky.social
Jumping spiders can recognise one another. This ability to learn, remember and represent images is quite surprising for such a tiny-brained animal!
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November 23, 2025 at 11:01 AM
elife.bsky.social
The pathogenic bacteria Shigella avoids detection inside host cells by degrading RNF213, the protein responsible for sensing the presence of intracellular pathogens.

Read more in the eLife Insight Article: buff.ly/1mIc6m0
November 23, 2025 at 9:21 AM
elife.bsky.social
Taking the same flu vaccine multiple times can actually broaden our immune responses.
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Vaccine boosting
Repeated vaccination with the same flu shot for a new strain can both boost existing antibodies and generate new ones, thereby broadening the immune response.
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November 22, 2025 at 11:44 PM
elife.bsky.social
Our newsletter delivers you the research summaries, thought-provoking opinion pieces, deep dives, and interviews you love from our magazine.

📥 Great content from eLife delivered directly to your inbox.
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Subscribe to receive the latest eLife magazine highlights fortnightly
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November 22, 2025 at 2:59 PM
elife.bsky.social
The 3D arrangement of DNA within a cell might influence the ability of a tumour to metastasise to specific locations.
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When cancer adapts to new organs
The three-dimensional arrangement of DNA within a cell might influence the ability of a tumor to metastasize to specific locations.
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November 22, 2025 at 11:01 AM
elife.bsky.social
Elevated DNA damage without signs of ageing in the short-sleeping Mexican cavefish offers a unique model to study sleep, DNA repair, and ageing.
buff.ly/6VrO19l
November 21, 2025 at 9:01 PM
elife.bsky.social
Working on a replication study? Publish it with eLife.

We publish Replication Studies as part of our commitment to reproducibility and transparency in science.
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November 21, 2025 at 2:59 PM
elife.bsky.social
Engineered “migrasomes” show promise as a stable, room-temperature vaccine platform, triggering strong immune responses in mice and potentially easing cold-chain challenges.
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November 21, 2025 at 9:21 AM
elife.bsky.social
Toxoplasma gondii carefully balances calcium between its organelles. This study shows the ER, via the SERCA pump, is central to controlling Ca²⁺ in the cytosol and mitochondria.

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November 20, 2025 at 11:28 PM
elife.bsky.social
In the latest episode of the Enago podcast, our Head of Publishing, Fiona Hutton, talks about rethinking research dissemination with host Andrew Smith.

🔗 You can catch up on the conversation here: buff.ly/p7fjcz2
November 20, 2025 at 9:01 PM
Reposted by eLife
neuralgrndstate.bsky.social
Nobody knows what is epithelial mesenchymal transition, but it is believed that it can explain cancer metastasis.

Neural stem/progenitor cells are well known for their single cell migration&the core property of cancer cell is neural stemness, but people avoid mentioning it.
@elife.bsky.social
November 20, 2025 at 5:52 AM
Reposted by eLife
neuralgrndstate.bsky.social
The basic relationship and cancer and cancer complexity
@elife.bsky.social

'Understanding Cancer as a Systemic Disease by Understanding Neural Stemness as the Core Property of Cancer Cell'
preprints.org/manuscript/2...
November 20, 2025 at 5:55 AM
Reposted by eLife
lauradugue.bsky.social
🚨New publication!
I am extremely happy to share this new review article in elife on #Traveling_Waves!

@erc.europa.eu
@upcite.bsky.social

elifesciences.org/articles/106...
Traveling waves across scales: Different mechanisms but same canonical computation?
The review proposes a novel mechanistic distinction between first- and second-order traveling waves that subserves a same canonical computation by ordering neuronal processing to impose a computationa...
elifesciences.org
November 19, 2025 at 3:54 PM
elife.bsky.social
1/ This Review Article from our Trained Immunity Focus Issue explores how inflammatory cues imprint long-lasting memory on haematopoietic stem cells, reshaping innate defences through conserved transcriptional programmes.
elifesciences.org/reviewed-pre...
November 20, 2025 at 2:44 PM
elife.bsky.social
1/ Helminth-derived products are emerging as tools to rebalance immunity, with new insights into how their diverse molecules imprint trained immunity to counter inflammation.

Read more in this Review Article from our Trained Immunity Focus Issue: elifesciences.org/articles/105...
The interplay between gut microbiota, immune system, and environmental factors.
November 19, 2025 at 11:28 PM
elife.bsky.social
Animals seamlessly combine what they see and hear. This study presents a simple, biologically inspired model that predicts how visual and auditory cues are integrated across humans, monkeys, and rats.

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November 19, 2025 at 4:15 PM