Ying Cao
@neuralgrndstate.bsky.social
Cancer is a systemic disease. Understanding a systemic disease needs systemic rules: Tumorigenesis is a process of progressive loss of original cell identity and gain of neural stemness, the general stemness that determines tumorigenicity and pluripotency.
Making correct association between gene/protein symbols with cellular states/properties is critical for correct understanding of cancer.
November 24, 2025 at 6:00 AM
Making correct association between gene/protein symbols with cellular states/properties is critical for correct understanding of cancer.
The core property of cancer cell is neural stemness,
and it is well-known that neural stem/progenitor cells undergo single-cell migration.
KRAS and AFDN are components of embryonic neural regulatory networks.
preprints.org/manuscript/2...
and it is well-known that neural stem/progenitor cells undergo single-cell migration.
KRAS and AFDN are components of embryonic neural regulatory networks.
preprints.org/manuscript/2...
November 24, 2025 at 5:58 AM
The core property of cancer cell is neural stemness,
and it is well-known that neural stem/progenitor cells undergo single-cell migration.
KRAS and AFDN are components of embryonic neural regulatory networks.
preprints.org/manuscript/2...
and it is well-known that neural stem/progenitor cells undergo single-cell migration.
KRAS and AFDN are components of embryonic neural regulatory networks.
preprints.org/manuscript/2...
Most cancer promoting genes are embryonic neural genes, incl. KRAS&AFDN. They confer cancer cell with neural stemness, which unifies cancer cell phenotypic traits incl. metastasis.
‘..Understanding Neural Stemness as the Core Property of Cancer Cell’
preprints.org/manuscript/2...
‘..Understanding Neural Stemness as the Core Property of Cancer Cell’
preprints.org/manuscript/2...
November 24, 2025 at 5:56 AM
Most cancer promoting genes are embryonic neural genes, incl. KRAS&AFDN. They confer cancer cell with neural stemness, which unifies cancer cell phenotypic traits incl. metastasis.
‘..Understanding Neural Stemness as the Core Property of Cancer Cell’
preprints.org/manuscript/2...
‘..Understanding Neural Stemness as the Core Property of Cancer Cell’
preprints.org/manuscript/2...
Cancer (tumorigenic) cell≈neural stem cell;
Cancer cell metabolism≈neural stem cell metabolism;
As generalized before, most cancer promoting genes are embryonic neural genes, including AACS.
preprints.org/manuscript/2...
@natmetabolism.nature.com
Cancer cell metabolism≈neural stem cell metabolism;
As generalized before, most cancer promoting genes are embryonic neural genes, including AACS.
preprints.org/manuscript/2...
@natmetabolism.nature.com
November 22, 2025 at 7:16 AM
Cancer (tumorigenic) cell≈neural stem cell;
Cancer cell metabolism≈neural stem cell metabolism;
As generalized before, most cancer promoting genes are embryonic neural genes, including AACS.
preprints.org/manuscript/2...
@natmetabolism.nature.com
Cancer cell metabolism≈neural stem cell metabolism;
As generalized before, most cancer promoting genes are embryonic neural genes, including AACS.
preprints.org/manuscript/2...
@natmetabolism.nature.com
The basic relationship and cancer and cancer complexity
@elife.bsky.social
'Understanding Cancer as a Systemic Disease by Understanding Neural Stemness as the Core Property of Cancer Cell'
preprints.org/manuscript/2...
@elife.bsky.social
'Understanding Cancer as a Systemic Disease by Understanding Neural Stemness as the Core Property of Cancer Cell'
preprints.org/manuscript/2...
November 20, 2025 at 5:55 AM
The basic relationship and cancer and cancer complexity
@elife.bsky.social
'Understanding Cancer as a Systemic Disease by Understanding Neural Stemness as the Core Property of Cancer Cell'
preprints.org/manuscript/2...
@elife.bsky.social
'Understanding Cancer as a Systemic Disease by Understanding Neural Stemness as the Core Property of Cancer Cell'
preprints.org/manuscript/2...
Nobody knows what is epithelial mesenchymal transition, but it is believed that it can explain cancer metastasis.
Neural stem/progenitor cells are well known for their single cell migration&the core property of cancer cell is neural stemness, but people avoid mentioning it.
@elife.bsky.social
Neural stem/progenitor cells are well known for their single cell migration&the core property of cancer cell is neural stemness, but people avoid mentioning it.
@elife.bsky.social
November 20, 2025 at 5:52 AM
Nobody knows what is epithelial mesenchymal transition, but it is believed that it can explain cancer metastasis.
Neural stem/progenitor cells are well known for their single cell migration&the core property of cancer cell is neural stemness, but people avoid mentioning it.
@elife.bsky.social
Neural stem/progenitor cells are well known for their single cell migration&the core property of cancer cell is neural stemness, but people avoid mentioning it.
@elife.bsky.social
'EMT' and cancer:
It is not the mysterious mesenchymal state but the neural stuff that is truly critical for understanding cancer.
The core property of cancer cell is neural stemness, which unifies different cancer cell phenotypic traits incl. metastasis.
@elife.bsky.social
It is not the mysterious mesenchymal state but the neural stuff that is truly critical for understanding cancer.
The core property of cancer cell is neural stemness, which unifies different cancer cell phenotypic traits incl. metastasis.
@elife.bsky.social
November 20, 2025 at 5:48 AM
'EMT' and cancer:
It is not the mysterious mesenchymal state but the neural stuff that is truly critical for understanding cancer.
The core property of cancer cell is neural stemness, which unifies different cancer cell phenotypic traits incl. metastasis.
@elife.bsky.social
It is not the mysterious mesenchymal state but the neural stuff that is truly critical for understanding cancer.
The core property of cancer cell is neural stemness, which unifies different cancer cell phenotypic traits incl. metastasis.
@elife.bsky.social
Is it possible to develop efficient cancer therapies without understanding cancer cell?
@elife.bsky.social
@elife.bsky.social
November 20, 2025 at 5:43 AM
Is it possible to develop efficient cancer therapies without understanding cancer cell?
@elife.bsky.social
@elife.bsky.social
Those who believe that the so-called epithelial-mesenchymal transition is helpful for understanding cancer and other things should first figure out
WHAT THE HELL IS THE BASIS on which EMT is established as a concept or rule.
@elife.bsky.social
WHAT THE HELL IS THE BASIS on which EMT is established as a concept or rule.
@elife.bsky.social
November 20, 2025 at 5:41 AM
Those who believe that the so-called epithelial-mesenchymal transition is helpful for understanding cancer and other things should first figure out
WHAT THE HELL IS THE BASIS on which EMT is established as a concept or rule.
@elife.bsky.social
WHAT THE HELL IS THE BASIS on which EMT is established as a concept or rule.
@elife.bsky.social
'...3D genome organization...breast cancer...epithelial to mesenchymal transition...metastasis...' 😜
@elife.bsky.social
'Lack of basic rationale in epithelial-mesenchymal transition and its related concepts'
cellandbioscience.biomedcentral.com/articles/10....
@elife.bsky.social
'Lack of basic rationale in epithelial-mesenchymal transition and its related concepts'
cellandbioscience.biomedcentral.com/articles/10....
November 20, 2025 at 5:39 AM
'...3D genome organization...breast cancer...epithelial to mesenchymal transition...metastasis...' 😜
@elife.bsky.social
'Lack of basic rationale in epithelial-mesenchymal transition and its related concepts'
cellandbioscience.biomedcentral.com/articles/10....
@elife.bsky.social
'Lack of basic rationale in epithelial-mesenchymal transition and its related concepts'
cellandbioscience.biomedcentral.com/articles/10....
Reposted by Ying Cao
Good morning from Sydney! Today is Day 2 of the @aimosinc.bsky.social conference
I am attending one of the discussion sessions: Addressing journal editors' failure to retract fraudulent and misleading publications
Speaker/Chair -Jon Jureidini, Leemon McHenry & George (Skip) Murgatroyd
#AIMOS2025
I am attending one of the discussion sessions: Addressing journal editors' failure to retract fraudulent and misleading publications
Speaker/Chair -Jon Jureidini, Leemon McHenry & George (Skip) Murgatroyd
#AIMOS2025
November 19, 2025 at 11:34 PM
Good morning from Sydney! Today is Day 2 of the @aimosinc.bsky.social conference
I am attending one of the discussion sessions: Addressing journal editors' failure to retract fraudulent and misleading publications
Speaker/Chair -Jon Jureidini, Leemon McHenry & George (Skip) Murgatroyd
#AIMOS2025
I am attending one of the discussion sessions: Addressing journal editors' failure to retract fraudulent and misleading publications
Speaker/Chair -Jon Jureidini, Leemon McHenry & George (Skip) Murgatroyd
#AIMOS2025
As generalized before, most cancer promoting (incl. therapy resistance) genes are embryonic neural/neural stemness genes, incl. zbtb16.
'Understanding Cancer as a Systemic Disease by Understanding Neural Stemness as the Core Property of Cancer Cell'
www.preprints.org/manuscript/2...
'Understanding Cancer as a Systemic Disease by Understanding Neural Stemness as the Core Property of Cancer Cell'
www.preprints.org/manuscript/2...
November 17, 2025 at 12:18 PM
As generalized before, most cancer promoting (incl. therapy resistance) genes are embryonic neural/neural stemness genes, incl. zbtb16.
'Understanding Cancer as a Systemic Disease by Understanding Neural Stemness as the Core Property of Cancer Cell'
www.preprints.org/manuscript/2...
'Understanding Cancer as a Systemic Disease by Understanding Neural Stemness as the Core Property of Cancer Cell'
www.preprints.org/manuscript/2...
The symbol ZBTB16 identifies a 'new type' of cancer cell.
But according to embryonic neural expression of ZBTB16, it does not.
Because cancer cell shares regulatory network with embryonic neural cells, &neural stemness unifies phenotypic traits of cancer cell incl. resistance.
But according to embryonic neural expression of ZBTB16, it does not.
Because cancer cell shares regulatory network with embryonic neural cells, &neural stemness unifies phenotypic traits of cancer cell incl. resistance.
November 17, 2025 at 12:17 PM
The symbol ZBTB16 identifies a 'new type' of cancer cell.
But according to embryonic neural expression of ZBTB16, it does not.
Because cancer cell shares regulatory network with embryonic neural cells, &neural stemness unifies phenotypic traits of cancer cell incl. resistance.
But according to embryonic neural expression of ZBTB16, it does not.
Because cancer cell shares regulatory network with embryonic neural cells, &neural stemness unifies phenotypic traits of cancer cell incl. resistance.
Researchers who believe EMT is helpful for understanding cancer&other things should first clarify
ON WHAT BASIS EMT IS ESTABLISHED AS A CONCEPT OR RULE.
'Lack of basic rationale in EMT..’ cellandbioscience.biomedcentral.com/articles/10....
@nataging.nature.com
ON WHAT BASIS EMT IS ESTABLISHED AS A CONCEPT OR RULE.
'Lack of basic rationale in EMT..’ cellandbioscience.biomedcentral.com/articles/10....
@nataging.nature.com
November 7, 2025 at 7:17 AM
Researchers who believe EMT is helpful for understanding cancer&other things should first clarify
ON WHAT BASIS EMT IS ESTABLISHED AS A CONCEPT OR RULE.
'Lack of basic rationale in EMT..’ cellandbioscience.biomedcentral.com/articles/10....
@nataging.nature.com
ON WHAT BASIS EMT IS ESTABLISHED AS A CONCEPT OR RULE.
'Lack of basic rationale in EMT..’ cellandbioscience.biomedcentral.com/articles/10....
@nataging.nature.com
'Lack of basic rationale in epithelial-mesenchymal transition and its related concepts'
cellandbioscience.biomedcentral.com/articles/10....
cellandbioscience.biomedcentral.com/articles/10....
November 2, 2025 at 7:17 AM
'Lack of basic rationale in epithelial-mesenchymal transition and its related concepts'
cellandbioscience.biomedcentral.com/articles/10....
cellandbioscience.biomedcentral.com/articles/10....
Those who believe that EMT/MET/EndMT can help understand cancer and other stuffs should at least and at first figure out
WHAT THE HELL IS THE MESENCHYMAL STATE or ON WHAT BASIS EMT/MET/EndMT ARE ESTABLISHED AS CONCEPTS OR RULES.
journals.physiology.org/doi/abs/10.1...
WHAT THE HELL IS THE MESENCHYMAL STATE or ON WHAT BASIS EMT/MET/EndMT ARE ESTABLISHED AS CONCEPTS OR RULES.
journals.physiology.org/doi/abs/10.1...
COL8A1 Regulates Endothelial Phenotype in Inflammatory Endothelial-to-Mesenchymal Transition | American Journal of Physiology-Heart and Circulatory Physiology | American Physiological Society
Background: Endothelial-to-mesenchymal transition (EndMT) has been implicated in inflammatory vascular pathologies such as atherosclerosis. The non-fibrillar collagen type VIII functions as a pivotal ...
journals.physiology.org
November 2, 2025 at 7:16 AM
Those who believe that EMT/MET/EndMT can help understand cancer and other stuffs should at least and at first figure out
WHAT THE HELL IS THE MESENCHYMAL STATE or ON WHAT BASIS EMT/MET/EndMT ARE ESTABLISHED AS CONCEPTS OR RULES.
journals.physiology.org/doi/abs/10.1...
WHAT THE HELL IS THE MESENCHYMAL STATE or ON WHAT BASIS EMT/MET/EndMT ARE ESTABLISHED AS CONCEPTS OR RULES.
journals.physiology.org/doi/abs/10.1...
'Understanding Cancer as a Systemic Disease by Understanding Neural Stemness as the Core Property of Cancer Cell'
preprints.org/manuscript/2...
preprints.org/manuscript/2...
November 2, 2025 at 7:12 AM
'Understanding Cancer as a Systemic Disease by Understanding Neural Stemness as the Core Property of Cancer Cell'
preprints.org/manuscript/2...
preprints.org/manuscript/2...
Beautiful mol. mechanisms👏
But evidence shows FIGNL1 is a cancer promoting factor.
As generalized before, most cancer promoting factors are embryonic neural factors, inclu. FIGNL1.
Therapy resistance is one of cancer cell phenotypic traits, which are unified by neural stemness.
But evidence shows FIGNL1 is a cancer promoting factor.
As generalized before, most cancer promoting factors are embryonic neural factors, inclu. FIGNL1.
Therapy resistance is one of cancer cell phenotypic traits, which are unified by neural stemness.
November 2, 2025 at 7:11 AM
Beautiful mol. mechanisms👏
But evidence shows FIGNL1 is a cancer promoting factor.
As generalized before, most cancer promoting factors are embryonic neural factors, inclu. FIGNL1.
Therapy resistance is one of cancer cell phenotypic traits, which are unified by neural stemness.
But evidence shows FIGNL1 is a cancer promoting factor.
As generalized before, most cancer promoting factors are embryonic neural factors, inclu. FIGNL1.
Therapy resistance is one of cancer cell phenotypic traits, which are unified by neural stemness.
Neural is fundamental.
'Understanding Cancer as a Systemic Disease by Understanding Neural Stemness as the Core Property of Cancer Cell'
www.preprints.org/manuscript/2...
'Understanding Cancer as a Systemic Disease by Understanding Neural Stemness as the Core Property of Cancer Cell'
www.preprints.org/manuscript/2...
November 1, 2025 at 3:55 AM
Neural is fundamental.
'Understanding Cancer as a Systemic Disease by Understanding Neural Stemness as the Core Property of Cancer Cell'
www.preprints.org/manuscript/2...
'Understanding Cancer as a Systemic Disease by Understanding Neural Stemness as the Core Property of Cancer Cell'
www.preprints.org/manuscript/2...
Those who believe that EMT is helpful for understanding cancer and other things should first figure out
what the hell is the so-called EMT?
'Lack of basic rationale in epithelial-mesenchymal transition and its related concepts'
cellandbioscience.biomedcentral.com/articles/10....
what the hell is the so-called EMT?
'Lack of basic rationale in epithelial-mesenchymal transition and its related concepts'
cellandbioscience.biomedcentral.com/articles/10....
November 1, 2025 at 3:51 AM
Those who believe that EMT is helpful for understanding cancer and other things should first figure out
what the hell is the so-called EMT?
'Lack of basic rationale in epithelial-mesenchymal transition and its related concepts'
cellandbioscience.biomedcentral.com/articles/10....
what the hell is the so-called EMT?
'Lack of basic rationale in epithelial-mesenchymal transition and its related concepts'
cellandbioscience.biomedcentral.com/articles/10....
Some told me that TME should be more concentrated in developing cancer therapy because of inefficiency in targeting cancer cell itself.
But how much is cancer cell really understood?
'..promote epithelial-mesenchymal transition and stemness in breast cancer cells'
sciencedirect.com/science/arti...
But how much is cancer cell really understood?
'..promote epithelial-mesenchymal transition and stemness in breast cancer cells'
sciencedirect.com/science/arti...
November 1, 2025 at 3:43 AM
Some told me that TME should be more concentrated in developing cancer therapy because of inefficiency in targeting cancer cell itself.
But how much is cancer cell really understood?
'..promote epithelial-mesenchymal transition and stemness in breast cancer cells'
sciencedirect.com/science/arti...
But how much is cancer cell really understood?
'..promote epithelial-mesenchymal transition and stemness in breast cancer cells'
sciencedirect.com/science/arti...
Everything in the animal world is ultimately the result of neural stemness, including cancer and cancer research.🤭😏😇
'Understanding Cancer as a Systemic Disease by Understanding Neural Stemness as the Core Property of Cancer Cell'
preprints.org/manuscript/2...
'Understanding Cancer as a Systemic Disease by Understanding Neural Stemness as the Core Property of Cancer Cell'
preprints.org/manuscript/2...
October 29, 2025 at 6:04 AM
Everything in the animal world is ultimately the result of neural stemness, including cancer and cancer research.🤭😏😇
'Understanding Cancer as a Systemic Disease by Understanding Neural Stemness as the Core Property of Cancer Cell'
preprints.org/manuscript/2...
'Understanding Cancer as a Systemic Disease by Understanding Neural Stemness as the Core Property of Cancer Cell'
preprints.org/manuscript/2...
While I have no chance to publish my research in eye-catching journals and have no chance to present them at any conferences, I made two PPT files to summarize my view on cancer and epithelial-msenchymal transition.
The links:
pan.baidu.com/s/15QX8uI1Aj...
pan.baidu.com/s/1LFm2Q-gYh...
The links:
pan.baidu.com/s/15QX8uI1Aj...
pan.baidu.com/s/1LFm2Q-gYh...
October 27, 2025 at 12:09 PM
While I have no chance to publish my research in eye-catching journals and have no chance to present them at any conferences, I made two PPT files to summarize my view on cancer and epithelial-msenchymal transition.
The links:
pan.baidu.com/s/15QX8uI1Aj...
pan.baidu.com/s/1LFm2Q-gYh...
The links:
pan.baidu.com/s/15QX8uI1Aj...
pan.baidu.com/s/1LFm2Q-gYh...
It would be not a surprise if basic rules in cancer are understood.😆😋🧐
1. Most oncoproteins are embryonic neural/neural stemness proteins, including CK2.
2. Inhibition of oncoproteins suppresses tumorigenicity&boost immunogenicity.
blog.google/technology/a...
1. Most oncoproteins are embryonic neural/neural stemness proteins, including CK2.
2. Inhibition of oncoproteins suppresses tumorigenicity&boost immunogenicity.
blog.google/technology/a...
How a Gemma model helped discover a new potential cancer therapy pathway
We’re launching a new 27 billion parameter foundation model for single-cell analysis built on the Gemma family of open models.
blog.google
October 17, 2025 at 12:20 PM
It would be not a surprise if basic rules in cancer are understood.😆😋🧐
1. Most oncoproteins are embryonic neural/neural stemness proteins, including CK2.
2. Inhibition of oncoproteins suppresses tumorigenicity&boost immunogenicity.
blog.google/technology/a...
1. Most oncoproteins are embryonic neural/neural stemness proteins, including CK2.
2. Inhibition of oncoproteins suppresses tumorigenicity&boost immunogenicity.
blog.google/technology/a...
LEADING EDGE study of Epithelial-mesenchymal transition in latest @cp-cell.bsky.social
@nature.com
@natureportfolio.nature.com
@scinews.bsky.social
cell.com/cell/fulltex...
'Lack of basic rationale in epithelial-mesenchymal transition ..'
cellandbioscience.biomedcentral.com/articles/10....
@nature.com
@natureportfolio.nature.com
@scinews.bsky.social
cell.com/cell/fulltex...
'Lack of basic rationale in epithelial-mesenchymal transition ..'
cellandbioscience.biomedcentral.com/articles/10....
October 8, 2025 at 7:57 AM
LEADING EDGE study of Epithelial-mesenchymal transition in latest @cp-cell.bsky.social
@nature.com
@natureportfolio.nature.com
@scinews.bsky.social
cell.com/cell/fulltex...
'Lack of basic rationale in epithelial-mesenchymal transition ..'
cellandbioscience.biomedcentral.com/articles/10....
@nature.com
@natureportfolio.nature.com
@scinews.bsky.social
cell.com/cell/fulltex...
'Lack of basic rationale in epithelial-mesenchymal transition ..'
cellandbioscience.biomedcentral.com/articles/10....