How do cytokines tune immune helpers?
Nature Immunology study from @groomlab.bsky.social ’s lab at @wehi-research.bsky.social used @10xgenomics.bsky.social single-cell & spatial tech to map T follicular helper (TFH) cells diversity.
🔗 www.nature.com/articles/s41...

#Immunology #SpatialBiology

Thanks @10xgenomics.bsky.social for the shout out and for making your data publicly available

Why waste precious resources ($$) to reinvent data that already exists? Cool human datasets ready to go

(Although now we have scratched the spatial itch, we may need to do more @chinweetan.bsky.social 🤔)

"Biology is messy and sometimes we need to embrace the mess"
www.nature.com/articles/s41...

Huge thanks to Amy Weinmann and Danielle Chisolm for beautifully highlighting our work and the importance of our approaches @natimmunol.nature.com

Thrilled to make the cover of @natimmunol.nature.com this month.

A version of this warhol-inspired image has been in my head almost since we first conceived this Tfh diversity project (many, many years ago) @wehi-research.bsky.social

WEHI scientists led by @groomlab.bsky.social‬ @chinweetan.bsky.social map how Tfh cells tailor instructions based on infection type. A step toward smarter vaccines and therapies.

📄 In @natimmunol.nature.com: www.nature.com/articles/s41...

🔗 Read more: www.wehi.edu.au/news/unlocki...

Great work by @chinweetan.bsky.social , @Len Dalit and @groomlab.bsky.social and her team understanding the signatures behind T folicular helper heterogeneity! ⬇️

#ImmunoSky

Thrilled to have our latest research @wehi-research.bsky.social published in @natimmunol.nature.com
www.nature.com/articles/s41...

This work was an outstanding partnership between talented PhD student Len Dalit (now postdoc, no 🦋) and bioinformatician @chinweetan.bsky.social

Thread below...

Thrilled to share our latest publication! Huge thanks to the team @chinweetan.bsky.social, Melissa Davis, Ahmed Mohamed and @bhuvad.bsky.social for making this possible! Questions welcome! Would love to hear your thoughts on our approach!

Very excited that our work is out in Bioinformatics!
mastR: an R package for automated identification of tissue-specific gene signatures in multi-group differential expression analysis academic.oup.com/bioinformati...
@wehi-research.bsky.social led by the talented Jinjin Chen

Super glad to me part of this great team and work! Amazing!

Very excited our work out in @jem.org “Transient inhibition of type I interferon enhances CD8+ T cell stemness and vaccine protection”
@wehi-research.bsky.social led by talented (and determined) PhD student @benjbroom.bsky.social
Thread below.

@benjbroom.bsky.social et al. @groomlab.bsky.social show that early type I interferon blockade alters CXCR3 chemokine regulation & cell location to promote an antigen-dependent CD8+ T cell transition of precursor of exhausted T cells to stem cell–like memory CD8+ T cells rupress.org/jem/article/...

Have seen lab mates come and go but a great group to end 2024 with. I don't like it when some mention they were finishing grade 6 when I was starting in my role here though....

I could not be more thrilled to announce the Nature Methods @naturemethods.bsky.social Method of the Year is Spatial Proteomics! Please see our editorial as a roadmap to the fantastic content in this special issue! www.nature.com/articles/s41...

#Multiomics2024 was amazing and I was very proud to be invited to speak for @standardbiology.bsky.social. Here’s the cartoon version.

Huge thanks to @aruthak.bsky.social for bringing it all together. #spatialbio