Francesca Ciccarelli
@ciccarellilab.bsky.social
We study the drivers of cancer evolution from initiation to response to therapy. We are part of the Centre for Cancer Evolution at Barts Cancer Institute and the Francis Crick Institute in London, UK. Posts from Francesca
Enjoying my time @theaacr.bsky.social KCA joint conference on Cancer Precision Medicine in beautiful Busan, Korea
November 13, 2025 at 10:05 PM
Enjoying my time @theaacr.bsky.social KCA joint conference on Cancer Precision Medicine in beautiful Busan, Korea
First time I give a talk literally in a football stadium 😎⚽️
October 8, 2025 at 8:24 AM
First time I give a talk literally in a football stadium 😎⚽️
Beautiful Bilbao
October 7, 2025 at 6:10 PM
Beautiful Bilbao
Our first Centre for Cancer Evolution PI retreat! A wonderful day at Goodenough House discussing science, strategy and forging new collaborations @qmbci.bsky.social
October 1, 2025 at 12:00 PM
Our first Centre for Cancer Evolution PI retreat! A wonderful day at Goodenough House discussing science, strategy and forging new collaborations @qmbci.bsky.social
Great science and good fun at the faculty retreat of the Centre for Cancer Evolution @qmbci.bsky.social. Here @stuartmcdonald.bsky.social explaining his big question!
October 1, 2025 at 10:56 AM
Great science and good fun at the faculty retreat of the Centre for Cancer Evolution @qmbci.bsky.social. Here @stuartmcdonald.bsky.social explaining his big question!
Peaceful early morning
August 15, 2025 at 6:03 AM
Peaceful early morning
Midsummer night 🌟🌙
July 3, 2025 at 10:19 PM
Midsummer night 🌟🌙
This is an important milestone: mutagenic drugs can increase TMB and induce a dMMR-like genetic profile, but do not improve response to immunotherapy in pMMR CRC patients. Some evidence of TIME remodelling, but likely not in the direction needed fro response... www.sciencedirect.com/science/arti...
Induction of a mismatch repair deficient genotype by tailored chemical mutagenesis in experimental models of cancer
Mismatch repair deficient (MMRd) tumors harbor thousands of somatic mutations enriched for insertion–deletion (indels) conferring high sensitivity to …
www.sciencedirect.com
June 14, 2025 at 5:23 AM
This is an important milestone: mutagenic drugs can increase TMB and induce a dMMR-like genetic profile, but do not improve response to immunotherapy in pMMR CRC patients. Some evidence of TIME remodelling, but likely not in the direction needed fro response... www.sciencedirect.com/science/arti...
Great meeting and great questions! Thanks for inviting me!
Francesca Ciccarelli @ciccarellilab.bsky.social is up next to tell us about spatial drivers of response to immunotherapy in colon cancer
Thank you to TransnetYX for sponsoring Francesca’s talk!
@qmbci.bsky.social | @crick.ac.uk | @cruk-cityoflondon.bsky.social | #BICC2025
Thank you to TransnetYX for sponsoring Francesca’s talk!
@qmbci.bsky.social | @crick.ac.uk | @cruk-cityoflondon.bsky.social | #BICC2025
May 28, 2025 at 11:52 AM
Great meeting and great questions! Thanks for inviting me!
Our very own @mirjana-efremova.bsky.social (very small compared to the very huge screen) speaking about her beautiful data on cell plasticity in cancer mets at the #Beatson International Cancer Conference. @qmbci.bsky.social @cruk-mi.bsky.social
May 27, 2025 at 11:03 AM
Our very own @mirjana-efremova.bsky.social (very small compared to the very huge screen) speaking about her beautiful data on cell plasticity in cancer mets at the #Beatson International Cancer Conference. @qmbci.bsky.social @cruk-mi.bsky.social
La Caixa panel dinners are always a treat! View of Barcelona from the museum of Catalan art
May 22, 2025 at 6:51 PM
La Caixa panel dinners are always a treat! View of Barcelona from the museum of Catalan art
I spent two days meeting students and faculty & delivering the keynote speech at the London Health Research Day @westernu.bsky.social. I truly enjoyed the enthusiasm and genuine engagements of the young generation of cancer researchers! Thanks @ggloor.bsky.social & colleagues for inviting me!
May 15, 2025 at 12:11 AM
I spent two days meeting students and faculty & delivering the keynote speech at the London Health Research Day @westernu.bsky.social. I truly enjoyed the enthusiasm and genuine engagements of the young generation of cancer researchers! Thanks @ggloor.bsky.social & colleagues for inviting me!
Street crossing in London, ON 🦆🦆🦆
May 14, 2025 at 9:53 PM
Street crossing in London, ON 🦆🦆🦆
Gorgeous day in NYC
May 11, 2025 at 9:04 PM
Gorgeous day in NYC
Familiar faces in Belfast! Enjoyable time at the meeting of the Irish Association for Cancer Research! @qmbci.bsky.social
March 7, 2025 at 2:02 PM
Familiar faces in Belfast! Enjoyable time at the meeting of the Irish Association for Cancer Research! @qmbci.bsky.social
Next Thu 13th March Ilaria Malanchi @ila07.bsky.social and I will host the next "Medicine at the Crick" event focusing on how tissues evolve over time and why this may initiate disease. Free in person/virtual registration @crick.ac.uk: www.eventbrite.co.uk/e/medicine-a...
March 5, 2025 at 2:46 PM
Next Thu 13th March Ilaria Malanchi @ila07.bsky.social and I will host the next "Medicine at the Crick" event focusing on how tissues evolve over time and why this may initiate disease. Free in person/virtual registration @crick.ac.uk: www.eventbrite.co.uk/e/medicine-a...
Reposted by Francesca Ciccarelli
Dear Volodymyr Zelenskyy, dear Ukrainian friends, you are not alone.
February 28, 2025 at 7:31 PM
Dear Volodymyr Zelenskyy, dear Ukrainian friends, you are not alone.
We have two open positions for #computationalbiologists to work on:
1. Early cancer initiation following our work in #NatureCancer (Ref 5028)
2. Response to cancer immunotherapy following our work in #CancerCell (Ref 5073)
To apply use the provided reference numbers: www.qmul.ac.uk/jobs/vacanci...
1. Early cancer initiation following our work in #NatureCancer (Ref 5028)
2. Response to cancer immunotherapy following our work in #CancerCell (Ref 5073)
To apply use the provided reference numbers: www.qmul.ac.uk/jobs/vacanci...
February 19, 2025 at 6:08 PM
We have two open positions for #computationalbiologists to work on:
1. Early cancer initiation following our work in #NatureCancer (Ref 5028)
2. Response to cancer immunotherapy following our work in #CancerCell (Ref 5073)
To apply use the provided reference numbers: www.qmul.ac.uk/jobs/vacanci...
1. Early cancer initiation following our work in #NatureCancer (Ref 5028)
2. Response to cancer immunotherapy following our work in #CancerCell (Ref 5073)
To apply use the provided reference numbers: www.qmul.ac.uk/jobs/vacanci...
Beautiful cover 😍 from an idea of our own @pedrandrei.bsky.social! Credits to Joe Brock from @crick.ac.uk
The February issue of Cancer Cell is fresh off the press! You can read it now: www.cell.com/cancer-cell/...
February 11, 2025 at 9:14 AM
Beautiful cover 😍 from an idea of our own @pedrandrei.bsky.social! Credits to Joe Brock from @crick.ac.uk
Very timely publication on World Cancer Day and spot on title considering the times we live in. I am very proud of all wonderful colleagues that dedicate their talent to understand, treat and eventually cure cancer @qmbci.bsky.social 💪💪💪
📖 Today on World Cancer Day, we're delighted to publish a special book celebrating two decades of cancer discoveries since the establishment of the BCI @qmul.ac.uk 🎉
#worldcancerday #WCD2025 #medsky 🧪 @qmulfmd.bsky.social @cruk-cityoflondon.bsky.social www.bci.qmul.ac.uk/general-news...
#worldcancerday #WCD2025 #medsky 🧪 @qmulfmd.bsky.social @cruk-cityoflondon.bsky.social www.bci.qmul.ac.uk/general-news...
Barts Cancer Institute book celebrates two decades of cancer discovery - Barts Cancer Institute - Queen Mary University of London
Barts Cancer Institute, Queen Mary Univerity of London, is delighted to announce the publication of a special commemorative book celebrating twenty years of cancer discoveries since the establishment ...
www.bci.qmul.ac.uk
February 4, 2025 at 5:13 PM
Very timely publication on World Cancer Day and spot on title considering the times we live in. I am very proud of all wonderful colleagues that dedicate their talent to understand, treat and eventually cure cancer @qmbci.bsky.social 💪💪💪
Reposted by Francesca Ciccarelli
Really enjoyed @mirjana-efremova.bsky.social talk on phenotypic plasticity in #ColorectalCancer
Super clear explanation of role of key genes ( #LRIG1 etc) in cell switch
@qmbci.bsky.social
@ciccarellilab.bsky.social
@drtanyasoliman.bsky.social
@mcclellandlab.bsky.social
@sibucz.bsky.social
Super clear explanation of role of key genes ( #LRIG1 etc) in cell switch
@qmbci.bsky.social
@ciccarellilab.bsky.social
@drtanyasoliman.bsky.social
@mcclellandlab.bsky.social
@sibucz.bsky.social
January 29, 2025 at 3:21 PM
Really enjoyed @mirjana-efremova.bsky.social talk on phenotypic plasticity in #ColorectalCancer
Super clear explanation of role of key genes ( #LRIG1 etc) in cell switch
@qmbci.bsky.social
@ciccarellilab.bsky.social
@drtanyasoliman.bsky.social
@mcclellandlab.bsky.social
@sibucz.bsky.social
Super clear explanation of role of key genes ( #LRIG1 etc) in cell switch
@qmbci.bsky.social
@ciccarellilab.bsky.social
@drtanyasoliman.bsky.social
@mcclellandlab.bsky.social
@sibucz.bsky.social
Reposted by Francesca Ciccarelli
Cool to be at #FoG2025 @fogenomics.bsky.social
A bit more #SpatialGenomics content this year which is great!
Surprise visit from #Darth & #Chewbacca!
@ciccarellilab.bsky.social @mirjana-efremova.bsky.social
@karlsmithbyrne.bsky.social
@qmbci.bsky.social
@omaiques.bsky.social
A bit more #SpatialGenomics content this year which is great!
Surprise visit from #Darth & #Chewbacca!
@ciccarellilab.bsky.social @mirjana-efremova.bsky.social
@karlsmithbyrne.bsky.social
@qmbci.bsky.social
@omaiques.bsky.social
January 29, 2025 at 12:58 PM
Cool to be at #FoG2025 @fogenomics.bsky.social
A bit more #SpatialGenomics content this year which is great!
Surprise visit from #Darth & #Chewbacca!
@ciccarellilab.bsky.social @mirjana-efremova.bsky.social
@karlsmithbyrne.bsky.social
@qmbci.bsky.social
@omaiques.bsky.social
A bit more #SpatialGenomics content this year which is great!
Surprise visit from #Darth & #Chewbacca!
@ciccarellilab.bsky.social @mirjana-efremova.bsky.social
@karlsmithbyrne.bsky.social
@qmbci.bsky.social
@omaiques.bsky.social
Great talk from Hrvoje Misetic on the context dependent role of Cdkn2a in cancer evolution @qmbci.bsky.social @cruk-cityoflondon.bsk.social. Well done 👏💪👌
January 28, 2025 at 3:02 PM
Great talk from Hrvoje Misetic on the context dependent role of Cdkn2a in cancer evolution @qmbci.bsky.social @cruk-cityoflondon.bsk.social. Well done 👏💪👌
Nathaniel MonPere from @benjaminwerner.bsky.social lab in the Centre for Cancer Evolution @qmbci.bsky.social modelling #clonalhaematopoiesis in ageig at the Annual Symposium of @cruk-cityoflondon.bsky.social
January 28, 2025 at 2:06 PM
Nathaniel MonPere from @benjaminwerner.bsky.social lab in the Centre for Cancer Evolution @qmbci.bsky.social modelling #clonalhaematopoiesis in ageig at the Annual Symposium of @cruk-cityoflondon.bsky.social
With Ilaria Malanchi @ila07.bsky.social we will host the #MedicineattheCrick event (13th March at the Crick @crick.ac.uk.) Join world experts to discuss how early mutant cells interact with surrounding niche to maintain homeostasis or start cancer. Free registration! Details in the poster 👇
January 25, 2025 at 9:45 AM
With Ilaria Malanchi @ila07.bsky.social we will host the #MedicineattheCrick event (13th March at the Crick @crick.ac.uk.) Join world experts to discuss how early mutant cells interact with surrounding niche to maintain homeostasis or start cancer. Free registration! Details in the poster 👇