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Reposted by Charles Ishak

Ronny Drapkin @rdrapkin8-penn.bsky.social · 19d

Excited to share the Ovarian Cancer Research Syndicate line-up of speakers for the fall. Please share. We have amazing trainees presenting and the latest from leaders in the field.
@powelldrescher.bsky.social @srocf.bsky.social @pennmedcso.bsky.social @penncancer.bsky.social

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Reposted by Charles Ishak

Trends in Genetics @cp-trendsgenetics.bsky.social · Sep 11

"Unmasked: transposable elements as drivers and targets in cancer"
by Ting Wang & colleagues

"This review synthesizes a growing body of work that positions TEs as both catalysts and antagonists of the tumor state."

Check it out!
authors.elsevier.com/sd/article/S...

Figure I. Origins of transposable element (TE)-encoded and TE-derived proteins in cancer.

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Reposted by Charles Ishak

Daniel De Carvalho @daniel-decarvalho.bsky.social · 15d

Excited to have this paper out today!

Repeats mimic pathogen-associated patterns across a vast evolutionary landscape."

It was a fun and productive collaboration with Benjamin Greenbaum John LaCava, Simona Cocco, Petr Šulc and many others!

www.cell.com/cell-genomic...

Repeats mimic pathogen-associated patterns across a vast evolutionary landscape

An emerging hallmark of disease is transcription of pathogen-associated molecular patterns from within the genome–known as viral mimicry. We propose a statistical physics framework to measure “selecti...

www.cell.com

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Reposted by Charles Ishak

Michael Meers @mpmeers.bsky.social · 19d

We published a detailed protocol for our Plate-CUT&Tag method on @protocolsio.bsky.social to accompany our recent preprint (www.biorxiv.org/content/10.1...) give it a try! Feedback welcome! dx.doi.org/10.17504/protocols.io.n2bvjed5wgk5/v1

Plate CUT&Tag (Meers Lab version)

This protocol describes a method for carrying out CUT&Tag-Direct in 96 well microplates for high-throughput processing of samples by a single operator with only standard lab...

dx.doi.org

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Reposted by Charles Ishak

Frank Beier @beierlab.bsky.social · Jul 24

In his memory, Western has opened an equity-based graduate scholarship. Please consider supporting his final initiative if you are able: www.westernconnect.ca/beier ; thank you for all the time you spent and laughs you shared with him. We love and miss him so much already. - The Beiers

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Charles Ishak @cishak.bsky.social · Jul 20

Congratulations Josh!

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Reposted by Charles Ishak

Van Andel Institute (VAI) @vai.org · Jul 1

Congratulations to VAI's Dr. H. Josh Jang, who has been appointed to assistant professor in our Department of Cell Biology.
www.vai.org/article/van-...

Van Andel Institute appoints cancer epigenetics expert Dr. H. Josh Jang as assistant professor – Van Andel Institute

Read about Van Andel Institute appoints cancer epigenetics expert Dr. H. Josh Jang as assistant professor on Van Andel Institute – Stay updated on the latest research and groundbreaking discoveries in...

www.vai.org

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Reposted by Charles Ishak

Rick Wood @riwood.bsky.social · Apr 25

Sharon Dent inducted to the National Academy of Sciences #nas162 @ekoutelou.bsky.social @srdent47.bsky.social @angelating.bsky.social @francescacole.bsky.social

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Charles Ishak @cishak.bsky.social · May 15

Dear @mdanderson.bsky.social ,

Please join us today in auditorium 4SCR1.1110 at 4pm for our Dept. seminar series. Today we welcome Dr. Marco Gallo from Baylor College of Medicine who will share the latest breakthroughs towards understanding chromatin regulation in brain malignancies.

Reposted by Charles Ishak

Jane Coffin Childs Fund for Medical Research @jcchildsfund.bsky.social · May 9

Check out Dr. Mendez-Dorantes' recent preprint for more details on his exciting research! www.biorxiv.org/content/10.1... 42/

Chromosomal rearrangements and instability caused by the LINE-1 retrotransposon

LINE-1 (L1) retrotransposition is widespread in many cancers, especially those with a high burden of chromosomal rearrangements. However, whether and to what degree L1 activity directly impacts genome...

www.biorxiv.org

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Reposted by Charles Ishak

Kate Chiappinelli @chiappinellilab.bsky.social · Apr 25

Looking forward to #AACR25! If you want to learn more about transposable elements in cancer, our educational session is at 10 am on Saturday 4/26!
@bengrbm.bsky.social @theaacr.bsky.social

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Reposted by Charles Ishak

ROME Therapeutics @rometx.bsky.social · Apr 18

Such a great article by Mitch Leslie in @science.org about the potential of inhibiting LINE-1 RT – a genomic, virus-like repetitive element – to address a spectrum of diseases, including ROME’s focus: #neurodegenerative and #autoimmune diseases. www.science.org/content/arti...
#darkgenome

Could blocking ‘jumping genes’ help fight disease and aging?

The first clinical trials are testing inhibitors of transposons, DNA sequences that hop around the genome on their own

www.science.org

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Charles Ishak @cishak.bsky.social · Apr 15

Thank you for your support @completegenomics.bsky.social !

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Reposted by Charles Ishak

completegenomics.bsky.social @completegenomics.bsky.social · Apr 15

Congrats to the 4 winners of our Spatial Xcellerator Grant Program who are using Stereo-seq technology for spatial transcriptomics to uncover deeper insights into complex challenges like cancer, spinal cord injury, Alzheimer’s, and pediatric brain tumors.

www.completegenomics.com/spatial-xcel...

Complete Genomics Names Four Winners of Spatial Xcellerator Grant Program - Complete Genomics

SAN JOSE, Calif., April 15, 2025 – Complete Genomics, a leading innovator in genomic sequencing, today announced four winners from 30 applicants to its Spatial Xcellerator Grant Program. Winning proje...

www.completegenomics.com

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Reposted by Charles Ishak

Princess Margaret Cancer Centre @pmresearch-uhn.bsky.social · Apr 11

🌟“Surprise is always the strongest signal that you found something new.”

Research from Gairdner awardee @daniel-decarvalho.bsky.social is unlocking powerful new tools impacting cancer clinical care, from interception, detection to therapy design and monitoring.

youtu.be/VpDpouQi8Wg

Meet Dr. Daniel De Carvalho: viral mimicry response, cancer detection and interception

YouTube video by UHN Research

youtu.be

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Charles Ishak @cishak.bsky.social · Apr 11

Congratulations to my postdoctoral mentor Dr. @daniel-decarvalho.bsky.social on receiving the 2025 Gairdner Momentum Award from the @gairdnerawards.bsky.social ! This is an amazing achievement!

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Reposted by Charles Ishak

Jim Woodgett @jwoodgett.bsky.social · Apr 6

Down to earth (as always) interview with @danieljdrucker.bsky.social on the impact of GLP1 agonists in fields of biology that he’d never anticipated but is leading the way on understanding - as awardee of th3 Breakthrough Prize with colleagues. www.ctvnews.ca/sci-tech/art...

Canadian scientist wins Breakthrough Prize for discovery of hormone used in Ozempic, Mounjaro

A Canadian researcher has won a 2025 Breakthrough Prize in Life Sciences for discovering the GLP-1 hormone used in diabetes and obesity medications — including Ozempic, Wegovy and Mounjaro — that have...

www.ctvnews.ca

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Ronny Drapkin @rdrapkin8-penn.bsky.social · Mar 27

Surprising findings of BRCA mutations on the Fallopian tubes. Result of a tremendous team effort with @shenhui1986.bsky.social @vainstitute.bsky.social, Chuck Drescher @fredhutch.bsky.social, and Jarrod Marto @danafarber.bsky.social.
@pennmedcso.bsky.social
www.nature.com/articles/s41...

Impact of BRCA mutations, age, surgical indication, and hormone status on the molecular phenotype of the human Fallopian tube - Nature Communications

The human Fallopian tube (FT) is implicated as a site of origin for pelvic serous cancers. Here the authors conduct multi-omics analysis on over 100 FTs. The results challenge the assumption that BRCA...

www.nature.com

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Reposted by Charles Ishak

Benoit Bruneau @benoitbruneau.bsky.social · Mar 27

exciting news for our scientific community! www.nygenome.org/news-events/...

Bing Ren Appointed Scientific Director and Chief Executive Officer of the New York Genome Center - March 27, 2025

Read about Bing Ren Appointed Scientific Director and Chief Executive Officer of the New York Genome Center at the New York Genome Center on March 27, 2025

www.nygenome.org

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Reposted by Charles Ishak

Francesca Cole @francescacole.bsky.social · Mar 21

So happy to join the dream dean team at the UT MD Anderson Cancer Center UTHealth Houston Graduate School of Biomedical Sciences!

Alejandro Aballay, PhD @aaballay.bsky.social · Mar 21

We are pleased to welcome MD Anderson Cancer Center scientist and educator Francesca Cole, PhD, as our new associate dean for academic affairs! She is pictured fourth from left in the Cole Laboratory. Read more at go.uth.edu/FrancescaCole-AssociateDean-AcademicAffairs
@francescacole.bsky.social

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Reposted by Charles Ishak

Ross Wilson @rosswilsonlab.org · Mar 19

I'm proud to share our protocol on CRISPR enzyme delivery in primary human cells using PERC, a non-viral & hardware-independent technology. We previously described PERC in T cells, and here we extend its use to hematopoietic stem/progenitor cells (HSPCs).
www.nature.com/articles/s41...

Peptide-enabled ribonucleoprotein delivery for CRISPR engineering (PERC) in primary human immune cells and hematopoietic stem cells - Nature Protocols

Peptide-enabled ribonucleoprotein delivery for CRISPR engineering (PERC) uses an amphiphilic peptide reagent to mediate intracellular delivery of CRISPR enzymes for high-efficiency editing of stimulat...

www.nature.com

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Reposted by Charles Ishak

Princess Margaret Cancer Centre @pmresearch-uhn.bsky.social · Mar 17

New Links: Cancer and Immune Evasion

Cancer cells without the tumor suppressor protein p53 become more resistant to the body's immune response and more likely to survive. A study led by Dr. Daniel De Carvalho at UHN’s Princess Margaret Cancer Centre.

www.uhnresearch.ca/news/new-lin...

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Reposted by Charles Ishak

Princess Margaret Cancer Centre @pmresearch-uhn.bsky.social · Mar 17

@uhnresearch.bsky.social @uhntoronto.bsky.social @theaacr.bsky.social

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Reposted by Charles Ishak

Ronny Drapkin @rdrapkin8-penn.bsky.social · Jan 24

The Ovarian Cancer Research Syndicate schedule is out from the @pennmedicine.bsky.social Ovarian Cancer Research Center. Great line up!

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Charles Ishak @cishak.bsky.social · Mar 6

Dear @mdanderson.bsky.social community,
We are excited to invite you to our dept. seminar featuring Dr. Katherine Chiappinelli (@chiappinellilab.bsky.social) tomorrow (Thursday March 6) at 4:00pm in auditorium room 4SCR1.1110.

Drop by to learn about TEs as therapeutic targets in (ovarian) cancer!

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