Matt Hall
@cispt2.bsky.social
🇦🇺 SD at NCATS, all about treatments for rare diseases, drug discovery and technologies. Views my own. Etc.
It’s buzzing like the first day of school!!!
November 13, 2025 at 4:28 PM
It’s buzzing like the first day of school!!!
How did we get to a place where lower-case ‘l’ is an acceptable symbol for liter/litre?
October 28, 2025 at 1:57 PM
How did we get to a place where lower-case ‘l’ is an acceptable symbol for liter/litre?
Reposted by Matt Hall
Reposted by Matt Hall
Online now! Discovery of a tau-aggregate clearing compound that covalently targets P4HB #chembiol
Discovery of a tau-aggregate clearing compound that covalently targets P4HB
Conway et al. integrate phenotypic screening with chemoproteomics to discover an aminoindole that potently clears tau aggregates across multiple tauopathy models via covalently targeting of the ER enzyme P4HB, revealing potential therapeutic strategies for neurodegenerative disease.
dlvr.it
October 8, 2025 at 3:30 PM
Online now! Discovery of a tau-aggregate clearing compound that covalently targets P4HB #chembiol
Reposted by Matt Hall
MOFs are pretty darn cool. Here's our story, in @cenmag.bsky.social cen.acs.org/people/nobel...
The 2025 chemistry Nobel goes to MOFs
Susumu Kitagawa, Richard Robson and Omar M. Yaghi win the prize for developing metal–organic frameworks
cen.acs.org
October 8, 2025 at 1:11 PM
MOFs are pretty darn cool. Here's our story, in @cenmag.bsky.social cen.acs.org/people/nobel...
Reposted by Matt Hall
Our new PNAS paper "Enhanced PIEZO1 function contributes to the pathogenesis of sickle cell disease" is out: www.pnas.org/doi/10.1073/... 1/3
Enhanced PIEZO1 function contributes to the pathogenesis of sickle cell disease | PNAS
Sickle cell disease (SCD), an inherited blood disorder caused by a mutation in the
β-globin gene, is characterized by sickle erythrocytes that are ...
www.pnas.org
October 3, 2025 at 4:53 PM
Our new PNAS paper "Enhanced PIEZO1 function contributes to the pathogenesis of sickle cell disease" is out: www.pnas.org/doi/10.1073/... 1/3
Reposted by Matt Hall
Scientists believe factors like diet and chemical exposure could play a role in a condition largely driven by genetics
www.statnews.com/2025/10/03/n...
www.statnews.com/2025/10/03/n...
As NIH launches new autism research effort, the focus is on environmental factors
The NIH is making a $50 million bet: Understanding environmental factors will help researchers better understand why some people have autism.
www.statnews.com
October 3, 2025 at 2:56 PM
Scientists believe factors like diet and chemical exposure could play a role in a condition largely driven by genetics
www.statnews.com/2025/10/03/n...
www.statnews.com/2025/10/03/n...
Reposted by Matt Hall
Ice freshly ejected from Enceladus contains complex organics
Reanalyzing data from Cassini's 2008 flyby reveals new, complex organic molecules in the spray from Saturn’s icy moon. cen.acs.org/physical-che... #chemsky 🧪
Reanalyzing data from Cassini's 2008 flyby reveals new, complex organic molecules in the spray from Saturn’s icy moon. cen.acs.org/physical-che... #chemsky 🧪
Ice freshly ejected from Enceladus contains complex organics
Reanalyzing data from <i>Cassini</i>'s 2008 flyby reveals new, complex organic molecules in the spray from Saturn’s icy moon
cen.acs.org
October 3, 2025 at 3:18 PM
Ice freshly ejected from Enceladus contains complex organics
Reanalyzing data from Cassini's 2008 flyby reveals new, complex organic molecules in the spray from Saturn’s icy moon. cen.acs.org/physical-che... #chemsky 🧪
Reanalyzing data from Cassini's 2008 flyby reveals new, complex organic molecules in the spray from Saturn’s icy moon. cen.acs.org/physical-che... #chemsky 🧪
Reposted by Matt Hall
This October I’m drawing one molecule a day inspired by proteins in pdb @rcsbpdb.bsky.social
Day 2/31
Prompt WEAVE
N-terminal domain of a Fibrion - a building block of silk fiber produced by silkworms.
Pdb: 3UA0
Next prompt is CROWN and I would love your suggestions!
Day 2/31
Prompt WEAVE
N-terminal domain of a Fibrion - a building block of silk fiber produced by silkworms.
Pdb: 3UA0
Next prompt is CROWN and I would love your suggestions!
October 3, 2025 at 3:29 AM
This October I’m drawing one molecule a day inspired by proteins in pdb @rcsbpdb.bsky.social
Day 2/31
Prompt WEAVE
N-terminal domain of a Fibrion - a building block of silk fiber produced by silkworms.
Pdb: 3UA0
Next prompt is CROWN and I would love your suggestions!
Day 2/31
Prompt WEAVE
N-terminal domain of a Fibrion - a building block of silk fiber produced by silkworms.
Pdb: 3UA0
Next prompt is CROWN and I would love your suggestions!
Reposted by Matt Hall
As a little boy, my grandparents gave me this book. This story of Pasteur is the one that made me want to be a scientist. And it doesn’t even mention optical activity!!
October 2, 2025 at 1:50 PM
As a little boy, my grandparents gave me this book. This story of Pasteur is the one that made me want to be a scientist. And it doesn’t even mention optical activity!!
Reposted by Matt Hall
As a little boy, my grandparents gave me this book. This story of Pasteur is the one that made me want to be a scientist. And it doesn’t even mention optical activity!!
October 2, 2025 at 1:50 PM
As a little boy, my grandparents gave me this book. This story of Pasteur is the one that made me want to be a scientist. And it doesn’t even mention optical activity!!
Reposted by Matt Hall
President Trump announced on Tuesday that Pfizer has agreed to offer lower prices on its drugs to the Medicaid program and directly to patients
www.statnews.com/2025/09/30/t...
www.statnews.com/2025/09/30/t...
Trump strikes deal with Pfizer aimed at lowering prescription drug prices
Pfizer will offer discounted prices on some of its drugs and avoid U.S. tariffs, in a deal with President Trump.
www.statnews.com
September 30, 2025 at 7:15 PM
President Trump announced on Tuesday that Pfizer has agreed to offer lower prices on its drugs to the Medicaid program and directly to patients
www.statnews.com/2025/09/30/t...
www.statnews.com/2025/09/30/t...
Reposted by Matt Hall
I rarely post about work, but in writing this email today asking how to be reimbursed for the cost of hosting a scientific visitor I wrote this explainer. This is not a complaint - but shows how we have to use our own salaries to enrich our environment and the commitment that takes
September 17, 2025 at 2:04 PM
I rarely post about work, but in writing this email today asking how to be reimbursed for the cost of hosting a scientific visitor I wrote this explainer. This is not a complaint - but shows how we have to use our own salaries to enrich our environment and the commitment that takes
Reposted by Matt Hall
We want to congratulate our President, Dr. Tony Letai, on his appointment as Director of the NCI. This announcement marks an historic moment for cancer research. Dr. Letai has been a tireless advocate and visionary leader for functional precision medicine 🧵
www.nih.gov/news-events/...
www.nih.gov/news-events/...
Secretary Kennedy Swears in Dr. Anthony Letai as Director of the National Cancer Institute
Dr. Letai will serve as NCI’s 18th director.
www.nih.gov
September 29, 2025 at 10:00 PM
We want to congratulate our President, Dr. Tony Letai, on his appointment as Director of the NCI. This announcement marks an historic moment for cancer research. Dr. Letai has been a tireless advocate and visionary leader for functional precision medicine 🧵
www.nih.gov/news-events/...
www.nih.gov/news-events/...
“dad can you can get me one of those retro digital cameras?”
September 29, 2025 at 10:57 PM
“dad can you can get me one of those retro digital cameras?”
I missed this paper at the time but love this kind of study:
"The total mass, number, and distribution of immune cells in the human body"
"an average individual’s immune system consists of approximately 1.8 trillion cells, weighing around 1.2 kg"
www.pnas.org/doi/10.1073/...
"The total mass, number, and distribution of immune cells in the human body"
"an average individual’s immune system consists of approximately 1.8 trillion cells, weighing around 1.2 kg"
www.pnas.org/doi/10.1073/...
September 22, 2025 at 4:51 PM
I missed this paper at the time but love this kind of study:
"The total mass, number, and distribution of immune cells in the human body"
"an average individual’s immune system consists of approximately 1.8 trillion cells, weighing around 1.2 kg"
www.pnas.org/doi/10.1073/...
"The total mass, number, and distribution of immune cells in the human body"
"an average individual’s immune system consists of approximately 1.8 trillion cells, weighing around 1.2 kg"
www.pnas.org/doi/10.1073/...
I rarely post about work, but in writing this email today asking how to be reimbursed for the cost of hosting a scientific visitor I wrote this explainer. This is not a complaint - but shows how we have to use our own salaries to enrich our environment and the commitment that takes
September 17, 2025 at 2:04 PM
I rarely post about work, but in writing this email today asking how to be reimbursed for the cost of hosting a scientific visitor I wrote this explainer. This is not a complaint - but shows how we have to use our own salaries to enrich our environment and the commitment that takes
Reposted by Matt Hall
Meeting my trainee for coffee and project strategizing in the amazing NIH Clinical Center. Inspiring.
September 9, 2025 at 7:34 PM
Meeting my trainee for coffee and project strategizing in the amazing NIH Clinical Center. Inspiring.
Reposted by Matt Hall
Reposted by Matt Hall
But the poster sessions are buzzing - so much amazing NIH science on show! I got in trouble for standing on a ledge to take this photo….. you’re welcome
September 9, 2025 at 3:09 PM
But the poster sessions are buzzing - so much amazing NIH science on show! I got in trouble for standing on a ledge to take this photo….. you’re welcome
Reposted by Matt Hall
It’s that time of year again - NIH Research Festival !
September 9, 2025 at 2:10 PM
It’s that time of year again - NIH Research Festival !
It’s that time of year again - NIH Research Festival !
September 9, 2025 at 2:10 PM
It’s that time of year again - NIH Research Festival !
I must be doing something right - daughter raided my vinyl.
September 3, 2025 at 12:44 AM
I must be doing something right - daughter raided my vinyl.