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Reposted by Clem Bernard

Denis Jabaudon @djabaudon.bsky.social · 4d

Interested in the mechanisms of neurogenesis, and how they might converge/differ across species, regions, and life epochs? Check this out, wonderful location and great science! Please RT

neuro-unige.ch/news/csf-mee...

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Reposted by Clem Bernard

Emilia Favuzzi @emiliafavuzzi.bsky.social · 5d

WTI Postdoctoral Fellowship applications are open! Unique opportunity for those pivoting fields or working across disciplines. I’d be happy to support candidates with a background in immunology and/or in vivo 2-photon imaging, including collaborations with other WTI labs wti.yale.edu/initiatives/...

Postdoctoral Fellowships | Wu Tsai Institute

wti.yale.edu

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Reposted by Clem Bernard

Srivastava Lab @ KCL @ncndgroup.bsky.social · 17d

We are recruiting for a Research Associate / Project Manager to help us build and run a Brain Organoid Platform at King’s College London, as part of the UK Human Functional Genomics Neurodevelopment Cluster! www.kcl.ac.uk/jobs/125125-...

Research Associate - Project Manager - Brain Organoid Platform | King's College London

www.kcl.ac.uk

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Reposted by Clem Bernard

Timothy Bredy @twbredy.bsky.social · 19d

How do neurons deal with fitting large regulatory proteins into small spaces to control plasticity and memory? By generating micropeptides via local translation of circRNAs, of course! Here’s to shedding new light on the ‘dark’ proteome in the brain.

www.biorxiv.org/cgi/content/...

Local translation of circular RNAs is required for synaptic activity and memory

Circular RNAs (circRNAs) are enriched in synapses and implicated in cognitive processes, and recent studies have shown that circRNAs can encode micropeptides, which suggests that there may be novel sy...

www.biorxiv.org

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Reposted by Clem Bernard

Denis Jabaudon @djabaudon.bsky.social · 20d

Ever wondered how robust cellular identity is to external perturbations? Here we disrupt cellular environmnent in vivo and in vitro, and find cell population specific sensitivities. Environment sculpts development yes, but not all cells are made of the same wood. www.science.org/doi/10.1126/...

Cell-extrinsic controls over neocortical neuron fate and diversity

Cell-extrinsic cues are key for neocortical cell identity and diversity.

www.science.org

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Reposted by Clem Bernard

Butt Lab - Oxford @interneuron.bsky.social · 21d

A rather 'unique' paper from our lab is online in @cp-cellreports.bsky.social now. Unique in the sense that I don't think anyone else will be rushing to optotag cortical interneurons in the early postnatal brain... because it is nigh on impossible!

www.sciencedirect.com/science/arti...

GABAergic circuits reflect different requirements for sensory integration in postnatal mouse neocortex

Information transfer in mammalian cerebral cortex is dependent on GABAergic interneuron circuits that are widely assumed to be uniform across the neoc…

www.sciencedirect.com

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Reposted by Clem Bernard

Carol Yang @yhcarolyang.bsky.social · Sep 9

The Yang and Phillips labs have an exciting GW4 MRC BioMed DTP PhD project on beta-cell regeneration & designing new proteins with AI tools to control neural signals. Come join us at LSI-Exeter!
gw4biomed.ac.uk/regenerating...
@proteinmotion.bsky.social @lsiexeter.bsky.social #zebrafish #islet

Regenerating insulin cells by using new designer biologics to fine-tune neural signals - GW4 BioMed MRC DTP

Project Code MRCPHS26Ex Yang Project Type Wet lab Research Theme Population Health Science Project Summary Download Summary A hallmark of type 1 diabetes is elevated blood glucose levels caused by aut...

gw4biomed.ac.uk

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Reposted by Clem Bernard

Fong Kuan Wong @brainotopia.bsky.social · Sep 8

It was a pleasure writing this Perspective of our work. If you are interested in learning more about activity-dependent regulation of cortical cell numbers, do have a read.

tinyurl.com/4ede4jyb

Drawing of a pyramidal cell, interneuron and microglia in a Polaroid.

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Reposted by Clem Bernard

Julie Carnesecchi @jcarnesecchi.bsky.social · Sep 2

Hello #Drosophila & #insect people!
I am searching for libraries of ORF/RNA from Tribolium castaneum and Bombyx mori for cloning cDNA/proteins (or insects with unusual body plans).
Is there an existing resource centre where I can find them, please?
Thanks very much in advance for your help!

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Reposted by Clem Bernard

Sean Flynn @seanflynn.bsky.social · Sep 2

Please share!
PhD projects available through @gw4biomeddtp.bsky.social
Please get in touch if you are interested in studying chromatin biology in stem cell models

gw4biomed.ac.uk/architects-o...

gw4biomed.ac.uk/risk-vs-prot...

gw4biomed.ac.uk/rna-dependen...

gw4biomed.ac.uk/investigatin...

Architects of the Genome: Using genomic technologies to elucidate the role of CTCF in neurodevelopmental disorders - GW4 BioMed MRC DTP

Project Code MRCNMH26Ex Flynn Project Type The project is primarily wet-lab based, with a dry-lab component in Years 2 and 3. Research Theme Neuroscience and Mental Health Project Summary Download Sum...

gw4biomed.ac.uk

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Reposted by Clem Bernard

Julie Carnesecchi @jcarnesecchi.bsky.social · Aug 29

We are recruiting an enthusiastic engineer to work on the core project of our lab: identifying Hox protein-RNA networks in Drosophila
@igmm-montpel.bsky.social

Interested in BioID, UV-RIP and muscle development? Apply: emploi.cnrs.fr/Offres/CDD/U...

Please share! #jobOffer #RNA #hox #Drosophila

Portail Emploi CNRS - Offre d'emploi - Engineer in molecular biology (M/F)

emploi.cnrs.fr

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Reposted by Clem Bernard

Lisa Traunmüller @lisatraunmueller.bsky.social · Aug 22

Extremely excited to share the outcome of a fantastic collaboration with @erinduffyphd.bsky.social revealing how experiences reshape hippocamapl chromatin and gene expression.
Check out our searchable gene database and look up your favorite gene 🧬

www.nature.com/articles/s41...

Novel environment exposure drives temporally defined and region-specific chromatin accessibility and gene expression changes in the hippocampus - Nature Communications

Hippocampal neurons adapt to experience through changes in gene expression and chromatin accessibility. Here, authors show that novel environment exposure induces region- and cell-type specific transc...

www.nature.com

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Reposted by Clem Bernard

Julie Carnesecchi @jcarnesecchi.bsky.social · Aug 19

French only: article vulgarisé de nos premiers travaux d'équipe @igmm-montpel.bsky.social @wxiang007c.bsky.social #RNA #Hox #muscle
Merci pour votre soutien a notre recherche fondamentale 🙏 @afm-telethon.bsky.social @agencerecherche.bsky.social

CNRS Biologie @cnrsbiologie.bsky.social · Aug 19

#ResultatScientifique🔎| Les facteurs Hox ne lisent pas seulement l’ADN : ils dialoguent aussi avec l’ARN ! 🧬
🤝 @cnrs.fr @cnrsoccitanieest.bsky.social @umontpellier.bsky.social
✍️ @jcarnesecchi.bsky.social
📕 @narjournal.bsky.social

Quand le plan du corps s’écrit à deux voix : ADN et ARN, une nouvelle partition de la régulation génique

Les facteurs de transcription Hox, longtemps considérés comme des lecteurs d’ADN, s’avèrent aussi interagir directement avec

buff.ly

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Reposted by Clem Bernard

Fiona Doetsch @doetschlab.bsky.social · Aug 20

New pre-print on sex differences in the choroid plexus- the 🧠's fluid secretion organ. Important differences in secretory signaling & immune compartments that can impact the 🧠 in health & disease. ‪@karol-kaiser.bsky.social‬@violesilvar.bsky.social‬ Luca von Allmen. 🧪
www.biorxiv.org/content/10.1...

Choroid plexus sex differences in secretory signalling and immune compartments

The choroid plexus (ChP)- cerebrospinal fluid (CSF) axis is emerging as a key regulator of the brain environment. The ChP is a multi-functional structure, which forms the blood-CSF barrier, and acts a...

www.biorxiv.org

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Reposted by Clem Bernard

Michalis Averof @michalis-averof.bsky.social · Aug 8

Latest paper elifesciences.org/articles/107... closes an important cycle in our efforts to study regeneration: week-long recordings allow us to observe the behaviour of cells during the entire course of regeneration in a crustacean leg – bright objects in movie are fluorescent nuclei of cells. 1/6

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Reposted by Clem Bernard

Guille López-Bendito @guillelbendito.bsky.social · Jul 31

🚨New Review! We explore how thalamocortical circuits wire up by sensory modality — from genes to spontaneous activity and plasticity. @NatureReviewsNeuroscience @glb-lab.bsky.social @neuroalc.bsky.social
🔗https://doi.org/10.1038/s41583-025-00945-y

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Reposted by Clem Bernard

Baptiste Libé-Philippot @blibep.bsky.social · Jul 30

🧠 Opportunity for a post-doctoral position on human neurobiology, funded by the @erc.europa.eu!
🧫You want to use human pluripotent stem cell based models to understand the evolution of human cerebellar neurons and disorders, this position is for you!
🔗Apply here: emploi.cnrs.fr/Offres/CDD/U...

Portail Emploi CNRS - Offre d'emploi - Postdoctoral researcher in human neurobiology (M/F)

emploi.cnrs.fr

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Reposted by Clem Bernard

Yad Ghavi-Helm @yghavi.bsky.social · Jul 23

📢 We are recruiting!
Several projects are available and can be tailored to the candidate's profile. Most include confocal imaging/spatial OMICs technologies.
Please share and RT 🙏

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Reposted by Clem Bernard

mareikealbert.bsky.social @mareikealbert.bsky.social · Jul 23

How do epigenetic modifications contribute to human #neocortex #development? Excited to see our work out in #Neuron. We applied Epi-CyTOF and identified a novel role for PRC2 in regulating #ECM.

@crtd-tud.bsky.social @cp-neuron.bsky.social

www.sciencedirect.com/science/arti...

A thread below 👇

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Reposted by Clem Bernard

Sara Bizzotto @sarabiz86.bsky.social · Jul 18

Sharing our latest study on mosaic focal epilepsy. Huge thanks to @mayatalukdar.bsky.social Edward Stronge, Sattar Khoshkhoo, Chris Walsh, all the co-authors, the patients and their families!👇https://www.pnas.org/doi/10.1073/pnas.2509622122#bibliography

Cell-type-informed genotyping of mosaic focal epilepsies reveals cell-autonomous and non-cell-autonomous disease-associated transcriptional programs | PNAS

While it is widely accepted that somatic variants that activate the PI3K-mTOR pathway are a major cause of drug-resistant focal epilepsy, typically...

www.pnas.org

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Clem Bernard @clembrnrd.bsky.social · Jul 16

And check out the comics version of the paper by @brainotopia.bsky.social 🤩🏆

Fong Kuan Wong @brainotopia.bsky.social · Jul 16

Monika is such an amazing scientist. It has been such a privilege to see this story grow and develop during my time at @marinlab.bsky.social. I am so happy to see this finally out. Well done to all authors.

@martijnselten.bsky.social @clembrnrd.bsky.social

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Clem Bernard @clembrnrd.bsky.social · Jul 16

Fantastic to see the final version out @cellcellpress.bsky.social - it was a real pleasure to contribute to this beautiful work led by the very talented Monika Moissidis during her PhD in @marinlab.bsky.social!

Check it out: www.cell.com/cell/fulltex...

Oscar Marín Lab @marinlab.bsky.social · Jul 16

1/10 Our latest research, led by Monika Moissidis, identifies a mechanism regulating the maturation of PV interneurons in the #cortex. This is the story @cellcellpress.bsky.social www.cell.com/cell/fulltex... ⬇︎ thread @devneuro.bsky.social @kingsioppn.bsky.social
@wellcometrust.bsky.social

A postnatal molecular switch drives activity-dependent maturation of parvalbumin interneurons

Neuronal activity triggers PGC-1α-mediated transcriptional programs that drive the late maturation of PV+ interneurons, essential for cortical circuit function. PGC-1α partners with ERRγ and Mef2c to ...

www.cell.com

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Reposted by Clem Bernard

Grubb Lab @grubblabneuro.bsky.social · Jul 14

The paper is out in journal format at EJN! We thank the reviewers for their insightful comments, and how they shaped the final form of this story. Check it out here: onlinelibrary.wiley.com/doi/10.1111/...

As usual, it's open access! We're getting the data ready for sharing very soon 👀🧠🧪

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Clem Bernard @clembrnrd.bsky.social · Jul 5

Congrats Julie! I look forward to reading it 🤩

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Reposted by Clem Bernard

Julie Carnesecchi @jcarnesecchi.bsky.social · Jul 4

🎉 Thrilled to share our new paper in @narjournal.bsky.social!
We uncover how the Hox TF Ultrabithorax controls alternative splicing to shape muscle patterning and homeotic identity 🧬 @igmm-montpel.bsky.social
🔗 doi.org/10.1093/nar/...

Synergistic DNA and RNA binding of the Hox transcription factor Ultrabithorax coordinates splicing and shapes in vivo homeotic functions

Abstract. The dual interaction of many transcription factors (TFs) with both DNA and RNA is an underexplored issue that could fundamentally reshape our und

doi.org

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