Denis Jabaudon
@djabaudon.bsky.social
Developmental neurobiologist, neurologist, & evo-devo aficionado. University of Geneva, Switzerland.
The deadline is nearing by, time to aign up if you are interested!
Interested in the mechanisms of neurogenesis, and how they might converge/differ across species, regions, and life epochs? Check this out, wonderful location and great science! Please RT
neuro-unige.ch/news/csf-mee...
neuro-unige.ch/news/csf-mee...
November 12, 2025 at 10:06 AM
The deadline is nearing by, time to aign up if you are interested!
Interested in the mechanisms of neurogenesis, and how they might converge/differ across species, regions, and life epochs? Check this out, wonderful location and great science! Please RT
neuro-unige.ch/news/csf-mee...
neuro-unige.ch/news/csf-mee...
October 5, 2025 at 12:16 PM
Interested in the mechanisms of neurogenesis, and how they might converge/differ across species, regions, and life epochs? Check this out, wonderful location and great science! Please RT
neuro-unige.ch/news/csf-mee...
neuro-unige.ch/news/csf-mee...
Co-lead by @nataliabaumann.bsky.social and Ilaria Morassut with Sabine Fièvre as senior author.
September 19, 2025 at 6:09 AM
Co-lead by @nataliabaumann.bsky.social and Ilaria Morassut with Sabine Fièvre as senior author.
Ever wondered how robust cellular identity is to external perturbations? Here we disrupt cellular environmnent in vivo and in vitro, and find cell population specific sensitivities. Environment sculpts development yes, but not all cells are made of the same wood. www.science.org/doi/10.1126/...
Cell-extrinsic controls over neocortical neuron fate and diversity
Cell-extrinsic cues are key for neocortical cell identity and diversity.
www.science.org
September 19, 2025 at 6:04 AM
Ever wondered how robust cellular identity is to external perturbations? Here we disrupt cellular environmnent in vivo and in vitro, and find cell population specific sensitivities. Environment sculpts development yes, but not all cells are made of the same wood. www.science.org/doi/10.1126/...
"You cannot not communicate". Paul Watzlawick.
Highlights that all human interactions, even silence, are forms of communication and convey a message. Everything we do —or don't do — can be interpreted as communication by others. E.g. ghosting. There's no way out of being social.
Highlights that all human interactions, even silence, are forms of communication and convey a message. Everything we do —or don't do — can be interpreted as communication by others. E.g. ghosting. There's no way out of being social.
June 7, 2025 at 6:34 AM
"You cannot not communicate". Paul Watzlawick.
Highlights that all human interactions, even silence, are forms of communication and convey a message. Everything we do —or don't do — can be interpreted as communication by others. E.g. ghosting. There's no way out of being social.
Highlights that all human interactions, even silence, are forms of communication and convey a message. Everything we do —or don't do — can be interpreted as communication by others. E.g. ghosting. There's no way out of being social.
Dear Reviewer #2, thank you for accepting to assess our revisions. After 60 days, the editor gave up, you never answered. The 1st author worked day & night to address your points, but you were too busy to even say no. The outcome is irrelevant, his disillusion isn't.
Review responsibly, it matters.
Review responsibly, it matters.
June 4, 2025 at 5:17 AM
Dear Reviewer #2, thank you for accepting to assess our revisions. After 60 days, the editor gave up, you never answered. The 1st author worked day & night to address your points, but you were too busy to even say no. The outcome is irrelevant, his disillusion isn't.
Review responsibly, it matters.
Review responsibly, it matters.
Reposted by Denis Jabaudon
Postdoc opportunity in the heart of Europe! Check out the flyer below.
Join our team on an international project with Anthony Holtmaat exploring synaptic plasticity and specificity in cortical and thalamocortical circuits.
Join our team on an international project with Anthony Holtmaat exploring synaptic plasticity and specificity in cortical and thalamocortical circuits.
April 8, 2025 at 12:48 PM
Postdoc opportunity in the heart of Europe! Check out the flyer below.
Join our team on an international project with Anthony Holtmaat exploring synaptic plasticity and specificity in cortical and thalamocortical circuits.
Join our team on an international project with Anthony Holtmaat exploring synaptic plasticity and specificity in cortical and thalamocortical circuits.
Reposted by Denis Jabaudon
Brilliant @natneuro.nature.com by @scienceyael.bsky.social
@lehtinenlab.bsky.social, uncovering “a fundamental secretory pathway in the
Choroid Plexus that shapes brain development” in mice 🧪🧠
www.nature.com/articles/s41...
@lehtinenlab.bsky.social, uncovering “a fundamental secretory pathway in the
Choroid Plexus that shapes brain development” in mice 🧪🧠
www.nature.com/articles/s41...
Choroid plexus apocrine secretion shapes CSF proteome during mouse brain development - Nature Neuroscience
The choroid plexus (ChP) provides molecular cues for brain development. However, the underlying mechanisms are unclear. This study identifies an apocrine secretion mechanism in the ChP that modulates ...
www.nature.com
May 28, 2025 at 1:13 PM
Brilliant @natneuro.nature.com by @scienceyael.bsky.social
@lehtinenlab.bsky.social, uncovering “a fundamental secretory pathway in the
Choroid Plexus that shapes brain development” in mice 🧪🧠
www.nature.com/articles/s41...
@lehtinenlab.bsky.social, uncovering “a fundamental secretory pathway in the
Choroid Plexus that shapes brain development” in mice 🧪🧠
www.nature.com/articles/s41...
Still openings, check it out!
🧠Job Opening!🧠
We are opening 2️⃣! positions
– bioinformatics / molecular biology –
in a project studying how temporal patterns set up connectivity in human brain tissue.
@institutimagine.bsky.social.
Full details below, contact me for details if interested.
And please retweet (re-bluesky?)!
We are opening 2️⃣! positions
– bioinformatics / molecular biology –
in a project studying how temporal patterns set up connectivity in human brain tissue.
@institutimagine.bsky.social.
Full details below, contact me for details if interested.
And please retweet (re-bluesky?)!
May 28, 2025 at 5:02 AM
Still openings, check it out!
Reposted by Denis Jabaudon
Success in academia often has more to do with luck, patronage and the job market than “hard work”.
Good academics acknowledge this.
I worked hard, but I was in the right place at the right time on occasion. Historians far more talented than I have fallen between the cracks.
Good academics acknowledge this.
I worked hard, but I was in the right place at the right time on occasion. Historians far more talented than I have fallen between the cracks.
May 21, 2025 at 7:16 AM
Success in academia often has more to do with luck, patronage and the job market than “hard work”.
Good academics acknowledge this.
I worked hard, but I was in the right place at the right time on occasion. Historians far more talented than I have fallen between the cracks.
Good academics acknowledge this.
I worked hard, but I was in the right place at the right time on occasion. Historians far more talented than I have fallen between the cracks.
Reposted by Denis Jabaudon
"One day, when it's safe, when there's no personal downside to calling a thing what it is, when it's too late to hold anyone accountable, everyone will have always been against this." - Omar El Akkad
75 days now of complete blockade/siege of Gaza. People are starving, babies elderly & sick already dying. Meanwhile Israel destroying what's left of Gaza so the living will have no place to return to. An atrocity for the ages and the world is so quiet.
May 18, 2025 at 1:25 PM
"One day, when it's safe, when there's no personal downside to calling a thing what it is, when it's too late to hold anyone accountable, everyone will have always been against this." - Omar El Akkad
Thanks; we only have access to the VZ progenitors in the transcriptomics analysis, and many cerebellar neurons are born from abventricular progenitors. In VZ progen, Fam210b is only rostral.
May 7, 2025 at 1:29 PM
Thanks; we only have access to the VZ progenitors in the transcriptomics analysis, and many cerebellar neurons are born from abventricular progenitors. In VZ progen, Fam210b is only rostral.
Reposted by Denis Jabaudon
🎉 Excited to share that our paper on FCDII is out today! 🙌🏻 Huge thanks to @sbaulac.bsky.social and @sara baldassari for bringing me on board and introducing me to the complexity of somatic mutations. Hope our work helps advance understanding of the disease mechanisms.
Single-cell genotyping and transcriptomic analysis reveals cell-type specific and non-autonomous effects of mTOR pathway mutations in mosaic focal cortical dysplasia type II (FCDII) 🧠🧪
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Single-cell genotyping and transcriptomic profiling of mosaic focal cortical dysplasia - Nature Neuroscience
In this work, the authors performed a single-cell genotyping and transcriptomics analysis, revealing cell-type-specific and nonautonomous effects of mTOR pathway mutations in mosaic focal cortical dys...
www.nature.com
April 30, 2025 at 7:47 PM
🎉 Excited to share that our paper on FCDII is out today! 🙌🏻 Huge thanks to @sbaulac.bsky.social and @sara baldassari for bringing me on board and introducing me to the complexity of somatic mutations. Hope our work helps advance understanding of the disease mechanisms.
This is a result of a long & intense effort by many folks in the lab, spearheaded throughout the years by @nataliabaumann.bsky.social, with strong contributions by R.Wagener and A.Javed. Great collab. with the @harschnitz.bsky.social lab too, as well as with other partners. Hope you enjoy it!
May 5, 2025 at 4:52 PM
This is a result of a long & intense effort by many folks in the lab, spearheaded throughout the years by @nataliabaumann.bsky.social, with strong contributions by R.Wagener and A.Javed. Great collab. with the @harschnitz.bsky.social lab too, as well as with other partners. Hope you enjoy it!
Hence, cellular clocks tick at different paces across brain regions due to distinct metabolic properties of progenitors. This work thus adds to research on metabolism setting cellular timing across species, by showing these differences regulate brain shape within species too!
May 5, 2025 at 4:52 PM
Hence, cellular clocks tick at different paces across brain regions due to distinct metabolic properties of progenitors. This work thus adds to research on metabolism setting cellular timing across species, by showing these differences regulate brain shape within species too!
Using in vivo gain- and loss- of function of FAM210B in the hindbrain and neocortex, respectively, we find that FAM210B elongates mitochondria and increases
lactate production, which promotes progenitor self-replicative divisions and, ultimately, a larger clonal size of their progeny.
lactate production, which promotes progenitor self-replicative divisions and, ultimately, a larger clonal size of their progeny.
May 5, 2025 at 4:52 PM
Using in vivo gain- and loss- of function of FAM210B in the hindbrain and neocortex, respectively, we find that FAM210B elongates mitochondria and increases
lactate production, which promotes progenitor self-replicative divisions and, ultimately, a larger clonal size of their progeny.
lactate production, which promotes progenitor self-replicative divisions and, ultimately, a larger clonal size of their progeny.
Using scRNA sequencing of all ventricular progenitors, we found genes with spatially and temporally restricted expression (baumannn.shinyapps.io/Ventriculome). Amongst these, the mitochondrial protein Fam210b was expressed where and when cell-cycle is the longest.
May 5, 2025 at 4:52 PM
Using scRNA sequencing of all ventricular progenitors, we found genes with spatially and temporally restricted expression (baumannn.shinyapps.io/Ventriculome). Amongst these, the mitochondrial protein Fam210b was expressed where and when cell-cycle is the longest.
When we examined regional cell-cycling behavior of progenitors, we found less consumptive divisions in cortical progenitors compared to hindbrain ones, resulting in a sustained availability of the progenitor pool in the cortex. Mitochondrial morphology was different across regions too!
May 5, 2025 at 4:52 PM
When we examined regional cell-cycling behavior of progenitors, we found less consumptive divisions in cortical progenitors compared to hindbrain ones, resulting in a sustained availability of the progenitor pool in the cortex. Mitochondrial morphology was different across regions too!
Using this atlas, we find that while both forebrain and hindbrain regions are born early, only in the forebrain – and particularly in the cortex – is there a prolonged time window of neurogenesis. Some regions thus show transient neurogenesis, while in others it is sustained.
May 5, 2025 at 4:52 PM
Using this atlas, we find that while both forebrain and hindbrain regions are born early, only in the forebrain – and particularly in the cortex – is there a prolonged time window of neurogenesis. Some regions thus show transient neurogenesis, while in others it is sustained.
As a first step to address this question, we built a spatio-temporal atlas of neuronal birth across brain structures, available at neurobirth.org (use your PC to navigate), building on Altman and Bayer’s seminal work on brain development (www.neurondevelopment.org).
May 5, 2025 at 4:52 PM
As a first step to address this question, we built a spatio-temporal atlas of neuronal birth across brain structures, available at neurobirth.org (use your PC to navigate), building on Altman and Bayer’s seminal work on brain development (www.neurondevelopment.org).
Why does the forebrain expand dramatically while other neural regions grow less? Our new publication reveals progenitor metabolism critically shapes region-specific brain growth. Thread below. authors.elsevier.com/a/1k-udL7PXu...
May 5, 2025 at 4:52 PM
Why does the forebrain expand dramatically while other neural regions grow less? Our new publication reveals progenitor metabolism critically shapes region-specific brain growth. Thread below. authors.elsevier.com/a/1k-udL7PXu...
#Standupforscience event today at Campus Biotech in Geneva. In solidarity for our colleagues in the US and in support of universal values of science: transparency, evidence, cooperation, and intellectual honesty.
March 7, 2025 at 3:57 PM
#Standupforscience event today at Campus Biotech in Geneva. In solidarity for our colleagues in the US and in support of universal values of science: transparency, evidence, cooperation, and intellectual honesty.
Open positions in human developmental neuroscience, check it out!
🧠Job Opening!🧠
We are opening 2️⃣! positions
– bioinformatics / molecular biology –
in a project studying how temporal patterns set up connectivity in human brain tissue.
@institutimagine.bsky.social.
Full details below, contact me for details if interested.
And please retweet (re-bluesky?)!
We are opening 2️⃣! positions
– bioinformatics / molecular biology –
in a project studying how temporal patterns set up connectivity in human brain tissue.
@institutimagine.bsky.social.
Full details below, contact me for details if interested.
And please retweet (re-bluesky?)!
March 5, 2025 at 4:34 PM
Open positions in human developmental neuroscience, check it out!
Open positions in neuroimmunology in Paris, check it out!
March 5, 2025 at 4:34 PM
Open positions in neuroimmunology in Paris, check it out!