ImmunityBio Shares Surge 40% on Positive FDA Feedback for ANKTIVA Expansion / X

Aging | doi:10.18632/aging.206340. Jose Perez-Maletzki, Jorge Sanz-Ros

2025: my best longevity therapies. It was a surprising year.

Aging is a core biological process observed in most species and tissues, which is studied with a vast array of technologies. We argue that the abilities of AI systems to emulate aging and to accurately interpret biodata in its context are the key criteria to judge an LLM’s utility in biomedical research. Here, we present LongevityBench — a collection of tasks designed to assess whether LLMs grasp the fundamental principles of aging biology and can use low-level biodata to arrive at phenotype-level conclusions. The benchmark covers a variety of prediction targets including human time-to-death, mutations’ effect on lifespan, and age-dependent expression patterns. It spans all common biodata types used in longevity research: transcriptomes, DNA methylation profiles, proteomes, genomes, clinical blood tests and biometrics, as well as natural language annotations. After ranking state-of-the-art LLMs using LongevityBench, we highlight their weaknesses and outline procedures to maximize their utility in aging research. ### Competing Interest Statement All authors are employees of Insilico Medicine, a publicly traded drug development company (HKEX:3696.HK) developing AI applications for target discovery and drug design.

Aging is a primary risk factor for multi-morbidity and declining quality of life. The geroscience hypothesis states that targeting biological aging mechanisms may prevent or delay morbidity; however, ...

Partial reprogramming has emerged as a promising strategy to ameliorate aging phenotypes, yet its cellular targets and mechanisms remain poorly defined. Cellular senescence is a central hallmark of aging and a plausible mediator of reprogramming-induced rejuvenation. Here we show that genetic and chemical partial reprogramming act directly on senescent cells without restoring proliferative capacity. OSKM expression or a reduced two-compound regimen, tranylcypromine and RepSox (2c), attenuates senescence-associated secretory activity, restores mitochondrial homeostasis and apoptotic priming, and improves functional and inflammatory parameters in aged mice, establishing senomorphic, identity-preserving reprogramming as a potentially safer aging intervention. ### Competing Interest Statement The authors have declared no competing interest.

What comes after GLP-1RAs make everyone skinny? What comes after myostatin inhibitors make everyone buff? One new candidate is: Safe, cheap, and easily-administered injections that locally remove fat. A new drug that just passed through phase 2 seems to do just that🧵 https://t.co/SWlxBOmwiq

KAIST researchers have developed a way to reprogram immune cells already inside tumors into cancer-killing machines. A drug injected directly into the tumor is absorbed by macrophages, prompting them ...

In a compelling new study from the Duke & University of North Carolina Alzheimer’s Disease Research Center (USA), published in the journal Alzheimer’s & Dementia, researchers have identified a specifi...

A recent review of literature investigated the risks and benefits of hormone replacement therapy. The authors point out that this approach could be used as a geroprotector […]

KAIST scientists have created a fast-acting, stable powder hemostat that stops bleeding in one second and could significantly improve survival in combat and emergency medicine. Severe blood loss remai...

Can Nattokinase Reverse Atherosclerosis? 🫀❤️‍🔥 (link in 6/6) 1/6) When it comes to cardiovascular health, few supplements have sparked as much public interest — or confusion — as #nattokinase. This enzyme, derived from Japanese fermented soybeans, has achieved near-legendary https://t.co/0Xi48z11q8

Osteoarthritis is a highly prevalent joint disease that leads to cartilage breakdown, pain and disability, yet there are still no FDA-approved treatments that can slow or reverse its progression. RNA-...

Hot on the heels of OpenAI's ChatGPT Health appearance last week, Anthropic unveils its AI offering.

Alzheimer’s symptoms were reversed in mice after just three doses. In a groundbreaking study co-led by researchers at University College London (UCL), along with collaborators including the Institute for Bioengineering of Catalonia (IBEC) and West China Hospital of Sichuan https://t.co/kE8jdPo6uv

Clearing amyloid-β pathology in Alzheimer's disease (AD) has been considered a prerequisite for restoring cognitive functions. Intriguingly, by application of a modality of scanning ultrasound (SUS) to mice that does not remove amyloid-β, we previously achieved significant cognitive improvements. Th …

The U.S. Food and Drug Administration today announced it is sharing information about the agency’s flexible approach to overseeing chemistry, manufacturing and control (CMC) requirements for cell and ...

A new study suggests it may be possible to regenerate cartilage lost to aging or arthritis with an oral drug or local injection, rendering knee and hip replacement unnecessary.

... and four other medical breakthroughs this week

Rapid recovery from Alzheimer's by enhancing lymphatic drainage. The brain can accumulate toxic proteins Tau + β-Amyloid plaques, over time resulting in Alzheimer's. The lymphatic system is there to drain out this "waste," but this process can become impaired and predisposes to https://t.co/KhM0ye7G3d

Researchers from University Hospitals, Case Western Reserve University and the Cleveland VA showed restoring the brain’s energy balance led to both pathological and functional recovery.

INTRODUCTION Aggregation of hyperphosphorylated tau (tauopathy) is associated with cognitive impairment in patients with Alzheimer's disease (AD). In AD, a metabolic shift due to the Warburg effect ...

Recent breakthroughs in protein structure prediction have opened new avenues for genome-wide drug discovery, yet existing virtual screening methods remain computationally prohibitive. We present DrugC...