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Reposted by ComplexPortal

ComplexPortal @complexportal.bsky.social · 11d

See also @wojtekgalej.bsky.social and
tinyurl.com/3sfthabb

#MinorSpliceosome #RNAsplicing #snRNP #U12Introns

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IntAct @intact-ebi.bsky.social · 11d

🕸️ Explore the interactome on the IntAct tinyurl.com/35922511.

🆕 New feature: You can now group nodes by orthology 🧩 — stay tuned for more details!

#Immunology #Proteomics #MolecularInteractions #HumanImmuneSystem

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Reposted by ComplexPortal

ComplexPortal @complexportal.bsky.social · 11d

The minor spliceosome removes rare U12-type introns—found in essential genes for cell division, DNA repair, and development.

New entries in the Complex Portal cover its snRNPs (U11, U12, U4atac, U6atac) and active B-act complex (CPX-26509): tinyurl.com/4wxhkymf

🔬 More info: tinyurl.com/47ed3er6

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ComplexPortal @complexportal.bsky.social · 11d

See also @wojtekgalej.bsky.social and
tinyurl.com/3sfthabb

#MinorSpliceosome #RNAsplicing #snRNP #U12Introns

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ComplexPortal @complexportal.bsky.social · 11d

The minor spliceosome removes rare U12-type introns—found in essential genes for cell division, DNA repair, and development.

New entries in the Complex Portal cover its snRNPs (U11, U12, U4atac, U6atac) and active B-act complex (CPX-26509): tinyurl.com/4wxhkymf

🔬 More info: tinyurl.com/47ed3er6

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Reposted by ComplexPortal

ComplexPortal @complexportal.bsky.social · 20d

🧠 Today is #WorldAlzheimersDay.

📚 Visit the Complex Portal and learn more about gamma-secretase complexes, key to precise cleavage of amyloid precursor protein (APP), who's dysfunction is linked to disease progression
(tinyurl.com/37exu532).

#WorldAlzheimersDay #AlzheimersSociety
#Complexportal

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Reposted by ComplexPortal

IntAct @intact-ebi.bsky.social · 20d

💜🧠 World Alzheimer’s Day 🧠💜
IntAct highlights Tau-F 🧵 & amyloid beta 🧩 PPINs from human brain tissue. The Tau-F network shows mutations P301L/S 🧪 disrupting key pathways linked to Alzheimer’s.
🔗 Network: tinyurl.com/ynjwhy7y
Paper: doi.org/10.3390/ijms24032490
#WorldAlzheimersDay #AlzheimersSociety

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ComplexPortal @complexportal.bsky.social · 20d

🧠 Today is #WorldAlzheimersDay.

📚 Visit the Complex Portal and learn more about gamma-secretase complexes, key to precise cleavage of amyloid precursor protein (APP), who's dysfunction is linked to disease progression
(tinyurl.com/37exu532).

#WorldAlzheimersDay #AlzheimersSociety
#Complexportal

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Reposted by ComplexPortal

IntAct @intact-ebi.bsky.social · 20d

💜🧠 World Alzheimer’s Day 🧠💜

IntAct highlights Tau-F 🧵 & amyloid beta 🧩 PPINs from human brain tissue. The Tau-F network shows mutations P301L/S

🧪 disrupting key pathways linked to Alzheimer’s.

🔗 Network: tinyurl.com/ynjwhy7y
Paper: doi.org/10.3390/ijms24032490

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Reposted by ComplexPortal

IntAct @intact-ebi.bsky.social · Sep 12

IntAct release 251 is out! 1,726,205 binary interactions from 23,716 manually curated publications www.ebi.ac.uk/intact/about... (in sync with UniProt release 2025_03)

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Reposted by ComplexPortal

IntAct @intact-ebi.bsky.social · Sep 8

🧠 Alzheimer’s research meets precision medicine
📊 IMEx data from IntAct & Complex Portal
🧬 How AD mutations disrupt brain protein networks
🔍 Variant pathways, APP, miRNA
🚀 Toward targeted AD therapies
🔗 doi.org/10.1002/pmic...

#KalpanaPannerselvam #IntAct #ComplexPortal #AlzheimersSociety

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Reposted by ComplexPortal

IntAct @intact-ebi.bsky.social · Sep 8

🧬 New in IntAct: Curated dataset from Pichlmair lab reveals VZV–host interactions in SK-N-BE2 cells. NPHP4 identified as a restriction factor; S862N variant alters interactome.

🎉Congrats Virginie Girault et al!

🔍 Explore: www.ebi.ac.uk/intact/searc...

#IntAct #HostPathogen #@a_pichlmair

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ComplexPortal @complexportal.bsky.social · Aug 28

🧠 Ever wonder how your tongue detects umami or sweetness?
🧂 Umami is sensed by a GPCR made of TAS1R1 + TAS1R3; sweet by TAS1R2 + TAS1R3.
🍜 Both trigger gustducin proteins, sending signals to your brain (and beyond).
🔬 Learn more: Complex Portal: tinyurl.com/ymd4ews9

#TasteReceptors #GPCR

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ComplexPortal @complexportal.bsky.social · Aug 28

Complex Portal release 251 is out! 5,190 manually curated biological complexes. www.ebi.ac.uk/complexporta... (in sync with UniProt release 2025_03)

Complex Portal

EMBL-EBI

www.ebi.ac.uk

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ComplexPortal @complexportal.bsky.social · Jul 17

🐍 From Dark Myths to Eco Allies: Celebrating #WorldSnakeDay

Complex Portal holds several curated venom complexes from Crotalus durissus terrificus, a South American rattlesnake known for its pharmacologically active venom proteins.
🔬 Explore these fascinating complexes: (See tinyurl.com/mz5hmzdf)

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ComplexPortal @complexportal.bsky.social · Jul 2

Intronic repeats play big roles evolution, gene regulation & disease. They're linked to disorders like Haemophilia & cancer. Cells keep them in check through RNAi-driven heterochromatin formation. See the S. pombe CLR4 complex (CPX-9241) & learn about its involvement in transcriptional silencing.

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EMBL-EBI @ebi.embl.org · Jun 30

Do you use EMBL-EBI data resources? We would really appreciate your feedback!

Our Interim Director Jo McEntyre explains how you can help us demonstrate the value of our data resources: www.ebi.ac.uk/about/news/a...

Survey closes on 16 July: www.surveymonkey.com/r/QGFMBH8?ch...

Thank you!

User survey to understand the value of open data resources

EMBL-EBI user survey opens – please complete it before 16 July

www.ebi.ac.uk

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ComplexPortal @complexportal.bsky.social · Jun 27

Do you want to learn more about macromolecular complexes? Register for our webinar taking place on 𝗝𝘂𝗹𝘆 𝟵𝘁𝗵, 𝟮𝟬𝟮𝟱! 📅

🔍 Discover more about our latest updates including the Complex Navigator & the integration of ML-predicted complexes (huMap3.0 and MuSIC).

➡️ Register now:
tinyurl.com/bdy6wttv

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Reposted by ComplexPortal

EMBL Events @events.embl.org · Jun 25

What do Nobel laureates, early-career researchers, and pioneering scientists have in common?
🧬 They all attend EMBL Events!

Want in? Whether you're into molecules, cells, or data – there's something for you!

🚀 Subscribe now and stay in the loop:
👉 http://eepurl.com/dv95w9

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ComplexPortal @complexportal.bsky.social · Jun 3

This month features CUL4A (Q13619). Cullin4-RING E3 ubiquitin ligases (CRL4s) regulate processes including facilitating stalled fork stability & genome integrity. Search the CP using GO:0080008 (tinyurl.com/2zhsy43s) & use the Navigator to explore our range of CRL4 complexes! #MolBiol, #ubiquitin

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Reposted by ComplexPortal

Kevin Drew @ksdrew.bsky.social · May 29

Very excited that our work describing hu.MAP3.0 is published in @molsystbiol.org. Here we use machine learning to integrate >25k mass spectrometry experiments to place ~70% of human proteins into 15k protein complexes.

www.embopress.org/doi/full/10....

hu.MAP3.0: atlas of human protein complexes by integration of >25,000 proteomic experiments | Molecular Systems Biology

imageimagehu.MAP3.0 integrates mass spectrometry experiments to identify human protein complexes. Using this resource, this study characterizes covariation of complexes, identifies mutually exclusive ...

www.embopress.org

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Reposted by ComplexPortal

Kevin Drew @ksdrew.bsky.social · May 29

First off, this was a wonderful collaboration with @gkust.bsky.social, @kourtissavvas.bsky.social, @sdelcilab.bsky.social, and folks at @complexportal.bsky.social specifically Henning Hermjakob and Sandra Orchard. The project was beautifully led by Sam Fischer and Erin Claussen from my lab.

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Reposted by ComplexPortal

IntAct @intact-ebi.bsky.social · May 21

It is Skin Cancer awareness month! Explore manually curated interactomes of proteins associated with familial melanoma in IntAct. Access the network in IntAct (tinyurl.com/26tc7xtm). #IntAct-ebi, #ComplexPortal, #UniProt, #MelanomaAwareness, #HumanDisease, #SunSafety, #SpotSkinCancer,

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ComplexPortal @complexportal.bsky.social · May 21

May is skin cancer awareness month! We're highlighting Telomerase holoenzyme complex (CPX-265) featuring TERT(UniProt:O14746). ComplexPortal: tinyurl.com/mt7u4wbs & visit UniProt for all melanoma-linked proteins tinyurl.com/mryjvyu7 #MelanomaAwareness, #ComplexPortal, #IntAct-EBI, #UniProt

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Reposted by ComplexPortal

IntAct @intact-ebi.bsky.social · May 20

Thrilled to announce that the protein–protein interactions of 396 SLC transporters, characterized by interaction proteomics from the RESOLUTE project, is now integrated into IntAct!

Congratulations to #‪Superti-FurgaLab, #FabianFrommelt
Explore the interactome at www.ebi.ac.uk/intact/searc...

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