ComplexPortal
@complexportal.bsky.social
The Complex Portal is an encyclopaedic resource of macromolecular complexes from a number of key model organisms.
http://www.ebi.ac.uk/complexportal
Also follow➡️@intact-ebi.bsky.social
http://www.ebi.ac.uk/complexportal
Also follow➡️@intact-ebi.bsky.social
Reposted by ComplexPortal
Reposted by ComplexPortal
🌿 Why it matters
• Excess NH₄⁺ disrupts growth and cellular balance
• Species differ in ammonium tolerance, influencing biodiversity
• Human-driven nitrogen favours ammonium-tolerant species
💡 Plants aren’t passive nitrogen absorbers-they actively regulate uptake to balance nutrition and stress.
• Excess NH₄⁺ disrupts growth and cellular balance
• Species differ in ammonium tolerance, influencing biodiversity
• Human-driven nitrogen favours ammonium-tolerant species
💡 Plants aren’t passive nitrogen absorbers-they actively regulate uptake to balance nutrition and stress.
December 2, 2025 at 2:54 PM
🌿 Why it matters
• Excess NH₄⁺ disrupts growth and cellular balance
• Species differ in ammonium tolerance, influencing biodiversity
• Human-driven nitrogen favours ammonium-tolerant species
💡 Plants aren’t passive nitrogen absorbers-they actively regulate uptake to balance nutrition and stress.
• Excess NH₄⁺ disrupts growth and cellular balance
• Species differ in ammonium tolerance, influencing biodiversity
• Human-driven nitrogen favours ammonium-tolerant species
💡 Plants aren’t passive nitrogen absorbers-they actively regulate uptake to balance nutrition and stress.
Reposted by ComplexPortal
🌱 Balancing Act: Plants & Ammonium
Plants constantly adjust to shifting nitrogen levels. Ammonium transporters (AMTs) mediate NH₄⁺ uptake, redistribution, & sensing.
💡At high ammonium, AMT complexes rapidly shut down uptake via phosphorylation & later reduce AMT gene expression.
Plants constantly adjust to shifting nitrogen levels. Ammonium transporters (AMTs) mediate NH₄⁺ uptake, redistribution, & sensing.
💡At high ammonium, AMT complexes rapidly shut down uptake via phosphorylation & later reduce AMT gene expression.
December 2, 2025 at 2:54 PM
🌱 Balancing Act: Plants & Ammonium
Plants constantly adjust to shifting nitrogen levels. Ammonium transporters (AMTs) mediate NH₄⁺ uptake, redistribution, & sensing.
💡At high ammonium, AMT complexes rapidly shut down uptake via phosphorylation & later reduce AMT gene expression.
Plants constantly adjust to shifting nitrogen levels. Ammonium transporters (AMTs) mediate NH₄⁺ uptake, redistribution, & sensing.
💡At high ammonium, AMT complexes rapidly shut down uptake via phosphorylation & later reduce AMT gene expression.
🌱 Balancing Act: Plants & Ammonium
Plants constantly adjust to shifting nitrogen levels. Ammonium transporters (AMTs) mediate NH₄⁺ uptake, redistribution, & sensing.
💡At high ammonium, AMT complexes rapidly shut down uptake via phosphorylation & later reduce AMT gene expression.
Plants constantly adjust to shifting nitrogen levels. Ammonium transporters (AMTs) mediate NH₄⁺ uptake, redistribution, & sensing.
💡At high ammonium, AMT complexes rapidly shut down uptake via phosphorylation & later reduce AMT gene expression.
December 2, 2025 at 2:54 PM
🌱 Balancing Act: Plants & Ammonium
Plants constantly adjust to shifting nitrogen levels. Ammonium transporters (AMTs) mediate NH₄⁺ uptake, redistribution, & sensing.
💡At high ammonium, AMT complexes rapidly shut down uptake via phosphorylation & later reduce AMT gene expression.
Plants constantly adjust to shifting nitrogen levels. Ammonium transporters (AMTs) mediate NH₄⁺ uptake, redistribution, & sensing.
💡At high ammonium, AMT complexes rapidly shut down uptake via phosphorylation & later reduce AMT gene expression.
Reposted by ComplexPortal
Registration is free but essential: tinyurl.com/4v3jf4e9
Speakers: Susie H. and Eliot Ragueneau
#Bioinformatics #IntAct #Modelling #BiologicalNetworks #Cytoscape
Speakers: Susie H. and Eliot Ragueneau
#Bioinformatics #IntAct #Modelling #BiologicalNetworks #Cytoscape
November 24, 2025 at 5:56 PM
Registration is free but essential: tinyurl.com/4v3jf4e9
Speakers: Susie H. and Eliot Ragueneau
#Bioinformatics #IntAct #Modelling #BiologicalNetworks #Cytoscape
Speakers: Susie H. and Eliot Ragueneau
#Bioinformatics #IntAct #Modelling #BiologicalNetworks #Cytoscape
Reposted by ComplexPortal
Would you like to learn more about molecular interactions and how to explore them across organisms?
Join us next week for an introductory webinar where we will walk through the IntAct Portal's approach to molecular network modelling and show how this is implemented within the IntAct Cytoscape app.
Join us next week for an introductory webinar where we will walk through the IntAct Portal's approach to molecular network modelling and show how this is implemented within the IntAct Cytoscape app.
November 24, 2025 at 5:56 PM
Would you like to learn more about molecular interactions and how to explore them across organisms?
Join us next week for an introductory webinar where we will walk through the IntAct Portal's approach to molecular network modelling and show how this is implemented within the IntAct Cytoscape app.
Join us next week for an introductory webinar where we will walk through the IntAct Portal's approach to molecular network modelling and show how this is implemented within the IntAct Cytoscape app.
Reposted by ComplexPortal
From a farm in the north of England to the frontiers of bioinformatics, our Group Leader Sandra Orchard reflects on a career building the data foundations of modern biology:
“AI is showing how vital data curation really is.”
www.ebi.ac.uk/about/news/p...
🖥️🧬
“AI is showing how vital data curation really is.”
www.ebi.ac.uk/about/news/p...
🖥️🧬
Sandra Orchard: what I’ve learned
EMBL-EBI Team Leader Sandra Orchard reflects on a life in protein science, UniProt data curation, and championing open data standards.
www.ebi.ac.uk
November 25, 2025 at 3:15 PM
From a farm in the north of England to the frontiers of bioinformatics, our Group Leader Sandra Orchard reflects on a career building the data foundations of modern biology:
“AI is showing how vital data curation really is.”
www.ebi.ac.uk/about/news/p...
🖥️🧬
“AI is showing how vital data curation really is.”
www.ebi.ac.uk/about/news/p...
🖥️🧬
Reposted by ComplexPortal
Upon her retirement from EMBL-EBI, we thank Sandra for her dedication and foundational work on important open data resources including:
UniProt
Complex Portal @complexportal.bsky.social
Gene Ontology @geneontology.bsky.social
IntAct @intact-ebi.bsky.social
InterPro @interprodb.bsky.social
UniProt
Complex Portal @complexportal.bsky.social
Gene Ontology @geneontology.bsky.social
IntAct @intact-ebi.bsky.social
InterPro @interprodb.bsky.social
November 25, 2025 at 3:21 PM
Upon her retirement from EMBL-EBI, we thank Sandra for her dedication and foundational work on important open data resources including:
UniProt
Complex Portal @complexportal.bsky.social
Gene Ontology @geneontology.bsky.social
IntAct @intact-ebi.bsky.social
InterPro @interprodb.bsky.social
UniProt
Complex Portal @complexportal.bsky.social
Gene Ontology @geneontology.bsky.social
IntAct @intact-ebi.bsky.social
InterPro @interprodb.bsky.social
Reposted by ComplexPortal
Reposted by ComplexPortal
Follow the link to uncover:
🧩 what the complex does in the cell
🔄 pathways it participates in (Reactome)
🧬 and curated disease links (EFO, MONDO, OMIM).
PDBe gives the structure — the Complex Portal adds the biology. Together they tell the full story: structure → function → system.
🧩 what the complex does in the cell
🔄 pathways it participates in (Reactome)
🧬 and curated disease links (EFO, MONDO, OMIM).
PDBe gives the structure — the Complex Portal adds the biology. Together they tell the full story: structure → function → system.
November 6, 2025 at 12:38 PM
Follow the link to uncover:
🧩 what the complex does in the cell
🔄 pathways it participates in (Reactome)
🧬 and curated disease links (EFO, MONDO, OMIM).
PDBe gives the structure — the Complex Portal adds the biology. Together they tell the full story: structure → function → system.
🧩 what the complex does in the cell
🔄 pathways it participates in (Reactome)
🧬 and curated disease links (EFO, MONDO, OMIM).
PDBe gives the structure — the Complex Portal adds the biology. Together they tell the full story: structure → function → system.
🔬 Noticed the new look PDBe?
The refreshed Protein Data Bank in Europe now includes direct links to the Complex Portal!
Example: PDB 6OOY → TNFA complex (CPX-8826).
The refreshed Protein Data Bank in Europe now includes direct links to the Complex Portal!
Example: PDB 6OOY → TNFA complex (CPX-8826).
November 6, 2025 at 12:38 PM
🔬 Noticed the new look PDBe?
The refreshed Protein Data Bank in Europe now includes direct links to the Complex Portal!
Example: PDB 6OOY → TNFA complex (CPX-8826).
The refreshed Protein Data Bank in Europe now includes direct links to the Complex Portal!
Example: PDB 6OOY → TNFA complex (CPX-8826).
Reposted by ComplexPortal
🧫 Explore the curated dataset in IntAct ➡️ tinyurl.com/candidalysin
🎨IntAct Cytoscape visualisation:
Candida albicans ECE1 peptides (orange) and their human protein targets (blue)
#IntActEBI #Interactome #EMBL
🎨IntAct Cytoscape visualisation:
Candida albicans ECE1 peptides (orange) and their human protein targets (blue)
#IntActEBI #Interactome #EMBL
November 5, 2025 at 12:10 PM
🧫 Explore the curated dataset in IntAct ➡️ tinyurl.com/candidalysin
🎨IntAct Cytoscape visualisation:
Candida albicans ECE1 peptides (orange) and their human protein targets (blue)
#IntActEBI #Interactome #EMBL
🎨IntAct Cytoscape visualisation:
Candida albicans ECE1 peptides (orange) and their human protein targets (blue)
#IntActEBI #Interactome #EMBL
Don’t just publish - be found! 🔍
I didn’t realize how vital biocuration was until I became a curator. A well-curated dataset doesn’t just sit in a paper - it lives on in databases and fuels new discoveries.
I didn’t realize how vital biocuration was until I became a curator. A well-curated dataset doesn’t just sit in a paper - it lives on in databases and fuels new discoveries.
October 19, 2025 at 1:25 PM
Don’t just publish - be found! 🔍
I didn’t realize how vital biocuration was until I became a curator. A well-curated dataset doesn’t just sit in a paper - it lives on in databases and fuels new discoveries.
I didn’t realize how vital biocuration was until I became a curator. A well-curated dataset doesn’t just sit in a paper - it lives on in databases and fuels new discoveries.
🧬 On #GlobalPNHAwarenessDay, we spotlight the GPI-GnT complex - a key enzyme disrupted in PNH, a rare and life-threatening blood disorder.
🧩 Its failure (often via PIGA mutations) removes GPI-anchored proteins, leaving blood cells unprotected from complement attack.
🧩 Its failure (often via PIGA mutations) removes GPI-anchored proteins, leaving blood cells unprotected from complement attack.
October 12, 2025 at 1:44 PM
🧬 On #GlobalPNHAwarenessDay, we spotlight the GPI-GnT complex - a key enzyme disrupted in PNH, a rare and life-threatening blood disorder.
🧩 Its failure (often via PIGA mutations) removes GPI-anchored proteins, leaving blood cells unprotected from complement attack.
🧩 Its failure (often via PIGA mutations) removes GPI-anchored proteins, leaving blood cells unprotected from complement attack.
Reposted by ComplexPortal
See also @wojtekgalej.bsky.social and
tinyurl.com/3sfthabb
#MinorSpliceosome #RNAsplicing #snRNP #U12Introns
tinyurl.com/3sfthabb
#MinorSpliceosome #RNAsplicing #snRNP #U12Introns
October 1, 2025 at 8:27 AM
Reposted by ComplexPortal
🕸️ Explore the interactome on the IntAct tinyurl.com/35922511.
🆕 New feature: You can now group nodes by orthology 🧩 — stay tuned for more details!
#Immunology #Proteomics #MolecularInteractions #HumanImmuneSystem
🆕 New feature: You can now group nodes by orthology 🧩 — stay tuned for more details!
#Immunology #Proteomics #MolecularInteractions #HumanImmuneSystem
October 1, 2025 at 9:31 AM
🕸️ Explore the interactome on the IntAct tinyurl.com/35922511.
🆕 New feature: You can now group nodes by orthology 🧩 — stay tuned for more details!
#Immunology #Proteomics #MolecularInteractions #HumanImmuneSystem
🆕 New feature: You can now group nodes by orthology 🧩 — stay tuned for more details!
#Immunology #Proteomics #MolecularInteractions #HumanImmuneSystem
Reposted by ComplexPortal
The minor spliceosome removes rare U12-type introns—found in essential genes for cell division, DNA repair, and development.
New entries in the Complex Portal cover its snRNPs (U11, U12, U4atac, U6atac) and active B-act complex (CPX-26509): tinyurl.com/4wxhkymf
🔬 More info: tinyurl.com/47ed3er6
New entries in the Complex Portal cover its snRNPs (U11, U12, U4atac, U6atac) and active B-act complex (CPX-26509): tinyurl.com/4wxhkymf
🔬 More info: tinyurl.com/47ed3er6
October 1, 2025 at 8:27 AM
The minor spliceosome removes rare U12-type introns—found in essential genes for cell division, DNA repair, and development.
New entries in the Complex Portal cover its snRNPs (U11, U12, U4atac, U6atac) and active B-act complex (CPX-26509): tinyurl.com/4wxhkymf
🔬 More info: tinyurl.com/47ed3er6
New entries in the Complex Portal cover its snRNPs (U11, U12, U4atac, U6atac) and active B-act complex (CPX-26509): tinyurl.com/4wxhkymf
🔬 More info: tinyurl.com/47ed3er6
The minor spliceosome removes rare U12-type introns—found in essential genes for cell division, DNA repair, and development.
New entries in the Complex Portal cover its snRNPs (U11, U12, U4atac, U6atac) and active B-act complex (CPX-26509): tinyurl.com/4wxhkymf
🔬 More info: tinyurl.com/47ed3er6
New entries in the Complex Portal cover its snRNPs (U11, U12, U4atac, U6atac) and active B-act complex (CPX-26509): tinyurl.com/4wxhkymf
🔬 More info: tinyurl.com/47ed3er6
October 1, 2025 at 8:27 AM
The minor spliceosome removes rare U12-type introns—found in essential genes for cell division, DNA repair, and development.
New entries in the Complex Portal cover its snRNPs (U11, U12, U4atac, U6atac) and active B-act complex (CPX-26509): tinyurl.com/4wxhkymf
🔬 More info: tinyurl.com/47ed3er6
New entries in the Complex Portal cover its snRNPs (U11, U12, U4atac, U6atac) and active B-act complex (CPX-26509): tinyurl.com/4wxhkymf
🔬 More info: tinyurl.com/47ed3er6
Reposted by ComplexPortal
🧠 Today is #WorldAlzheimersDay.
📚 Visit the Complex Portal and learn more about gamma-secretase complexes, key to precise cleavage of amyloid precursor protein (APP), who's dysfunction is linked to disease progression
(tinyurl.com/37exu532).
#WorldAlzheimersDay #AlzheimersSociety
#Complexportal
📚 Visit the Complex Portal and learn more about gamma-secretase complexes, key to precise cleavage of amyloid precursor protein (APP), who's dysfunction is linked to disease progression
(tinyurl.com/37exu532).
#WorldAlzheimersDay #AlzheimersSociety
#Complexportal
September 22, 2025 at 10:31 AM
🧠 Today is #WorldAlzheimersDay.
📚 Visit the Complex Portal and learn more about gamma-secretase complexes, key to precise cleavage of amyloid precursor protein (APP), who's dysfunction is linked to disease progression
(tinyurl.com/37exu532).
#WorldAlzheimersDay #AlzheimersSociety
#Complexportal
📚 Visit the Complex Portal and learn more about gamma-secretase complexes, key to precise cleavage of amyloid precursor protein (APP), who's dysfunction is linked to disease progression
(tinyurl.com/37exu532).
#WorldAlzheimersDay #AlzheimersSociety
#Complexportal
Reposted by ComplexPortal
💜🧠 World Alzheimer’s Day 🧠💜
IntAct highlights Tau-F 🧵 & amyloid beta 🧩 PPINs from human brain tissue. The Tau-F network shows mutations P301L/S 🧪 disrupting key pathways linked to Alzheimer’s.
🔗 Network: tinyurl.com/ynjwhy7y
Paper: doi.org/10.3390/ijms24032490
#WorldAlzheimersDay #AlzheimersSociety
IntAct highlights Tau-F 🧵 & amyloid beta 🧩 PPINs from human brain tissue. The Tau-F network shows mutations P301L/S 🧪 disrupting key pathways linked to Alzheimer’s.
🔗 Network: tinyurl.com/ynjwhy7y
Paper: doi.org/10.3390/ijms24032490
#WorldAlzheimersDay #AlzheimersSociety
September 22, 2025 at 9:35 AM
💜🧠 World Alzheimer’s Day 🧠💜
IntAct highlights Tau-F 🧵 & amyloid beta 🧩 PPINs from human brain tissue. The Tau-F network shows mutations P301L/S 🧪 disrupting key pathways linked to Alzheimer’s.
🔗 Network: tinyurl.com/ynjwhy7y
Paper: doi.org/10.3390/ijms24032490
#WorldAlzheimersDay #AlzheimersSociety
IntAct highlights Tau-F 🧵 & amyloid beta 🧩 PPINs from human brain tissue. The Tau-F network shows mutations P301L/S 🧪 disrupting key pathways linked to Alzheimer’s.
🔗 Network: tinyurl.com/ynjwhy7y
Paper: doi.org/10.3390/ijms24032490
#WorldAlzheimersDay #AlzheimersSociety
🧠 Today is #WorldAlzheimersDay.
📚 Visit the Complex Portal and learn more about gamma-secretase complexes, key to precise cleavage of amyloid precursor protein (APP), who's dysfunction is linked to disease progression
(tinyurl.com/37exu532).
#WorldAlzheimersDay #AlzheimersSociety
#Complexportal
📚 Visit the Complex Portal and learn more about gamma-secretase complexes, key to precise cleavage of amyloid precursor protein (APP), who's dysfunction is linked to disease progression
(tinyurl.com/37exu532).
#WorldAlzheimersDay #AlzheimersSociety
#Complexportal
September 22, 2025 at 10:31 AM
🧠 Today is #WorldAlzheimersDay.
📚 Visit the Complex Portal and learn more about gamma-secretase complexes, key to precise cleavage of amyloid precursor protein (APP), who's dysfunction is linked to disease progression
(tinyurl.com/37exu532).
#WorldAlzheimersDay #AlzheimersSociety
#Complexportal
📚 Visit the Complex Portal and learn more about gamma-secretase complexes, key to precise cleavage of amyloid precursor protein (APP), who's dysfunction is linked to disease progression
(tinyurl.com/37exu532).
#WorldAlzheimersDay #AlzheimersSociety
#Complexportal
Reposted by ComplexPortal
💜🧠 World Alzheimer’s Day 🧠💜
IntAct highlights Tau-F 🧵 & amyloid beta 🧩 PPINs from human brain tissue. The Tau-F network shows mutations P301L/S
🧪 disrupting key pathways linked to Alzheimer’s.
🔗 Network: tinyurl.com/ynjwhy7y
Paper: doi.org/10.3390/ijms24032490
IntAct highlights Tau-F 🧵 & amyloid beta 🧩 PPINs from human brain tissue. The Tau-F network shows mutations P301L/S
🧪 disrupting key pathways linked to Alzheimer’s.
🔗 Network: tinyurl.com/ynjwhy7y
Paper: doi.org/10.3390/ijms24032490
September 22, 2025 at 8:59 AM
💜🧠 World Alzheimer’s Day 🧠💜
IntAct highlights Tau-F 🧵 & amyloid beta 🧩 PPINs from human brain tissue. The Tau-F network shows mutations P301L/S
🧪 disrupting key pathways linked to Alzheimer’s.
🔗 Network: tinyurl.com/ynjwhy7y
Paper: doi.org/10.3390/ijms24032490
IntAct highlights Tau-F 🧵 & amyloid beta 🧩 PPINs from human brain tissue. The Tau-F network shows mutations P301L/S
🧪 disrupting key pathways linked to Alzheimer’s.
🔗 Network: tinyurl.com/ynjwhy7y
Paper: doi.org/10.3390/ijms24032490
Reposted by ComplexPortal
IntAct release 251 is out! 1,726,205 binary interactions from 23,716 manually curated publications www.ebi.ac.uk/intact/about... (in sync with UniProt release 2025_03)
September 12, 2025 at 9:08 AM
IntAct release 251 is out! 1,726,205 binary interactions from 23,716 manually curated publications www.ebi.ac.uk/intact/about... (in sync with UniProt release 2025_03)
Reposted by ComplexPortal
🧠 Alzheimer’s research meets precision medicine
📊 IMEx data from IntAct & Complex Portal
🧬 How AD mutations disrupt brain protein networks
🔍 Variant pathways, APP, miRNA
🚀 Toward targeted AD therapies
🔗 doi.org/10.1002/pmic...
#KalpanaPannerselvam #IntAct #ComplexPortal #AlzheimersSociety
📊 IMEx data from IntAct & Complex Portal
🧬 How AD mutations disrupt brain protein networks
🔍 Variant pathways, APP, miRNA
🚀 Toward targeted AD therapies
🔗 doi.org/10.1002/pmic...
#KalpanaPannerselvam #IntAct #ComplexPortal #AlzheimersSociety
September 8, 2025 at 1:11 PM
🧠 Alzheimer’s research meets precision medicine
📊 IMEx data from IntAct & Complex Portal
🧬 How AD mutations disrupt brain protein networks
🔍 Variant pathways, APP, miRNA
🚀 Toward targeted AD therapies
🔗 doi.org/10.1002/pmic...
#KalpanaPannerselvam #IntAct #ComplexPortal #AlzheimersSociety
📊 IMEx data from IntAct & Complex Portal
🧬 How AD mutations disrupt brain protein networks
🔍 Variant pathways, APP, miRNA
🚀 Toward targeted AD therapies
🔗 doi.org/10.1002/pmic...
#KalpanaPannerselvam #IntAct #ComplexPortal #AlzheimersSociety
Reposted by ComplexPortal
🧬 New in IntAct: Curated dataset from Pichlmair lab reveals VZV–host interactions in SK-N-BE2 cells. NPHP4 identified as a restriction factor; S862N variant alters interactome.
🎉Congrats Virginie Girault et al!
🔍 Explore: www.ebi.ac.uk/intact/searc...
#IntAct #HostPathogen #@a_pichlmair
🎉Congrats Virginie Girault et al!
🔍 Explore: www.ebi.ac.uk/intact/searc...
#IntAct #HostPathogen #@a_pichlmair
September 8, 2025 at 10:15 AM
🧬 New in IntAct: Curated dataset from Pichlmair lab reveals VZV–host interactions in SK-N-BE2 cells. NPHP4 identified as a restriction factor; S862N variant alters interactome.
🎉Congrats Virginie Girault et al!
🔍 Explore: www.ebi.ac.uk/intact/searc...
#IntAct #HostPathogen #@a_pichlmair
🎉Congrats Virginie Girault et al!
🔍 Explore: www.ebi.ac.uk/intact/searc...
#IntAct #HostPathogen #@a_pichlmair