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Hierarchical clustering uncovered disease patterns and further untangled complexities in immune complex-mediated idiopathic MPGN and C3 glomerulopathy

Cravedi Lab @cravedilab.bsky.social · 20h

Hierarchical clustering uncovered disease patterns and further untangled complexities in immune complex-mediated idiopathic MPGN and C3 glomerulopathy - Kidney International www.kidney-international.org/article/S008...

Membranoproliferative glomerulonephritis (MPGN) is currently stratified into complement C3 glomerulopathy (C3G) and immune complex-mediated MPGN (IC-MPGN). However, classification is subject to contin...

www.kidney-international.org

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Cravedi Lab @cravedilab.bsky.social · 1d

A cGAS-mediated mechanism in naked mole-rats potentiates DNA repair and delays aging | Science www.science.org/doi/10.1126/...

A cGAS-mediated mechanism in naked mole-rats potentiates DNA repair and delays aging

Efficient DNA repair might make possible the longevity of naked mole-rats. However, whether they have distinctive mechanisms to optimize functions of DNA repair suppressors is unclear. We find that na...

How Propensity Scores Work

Cravedi Lab @cravedilab.bsky.social · 1d

How Propensity Scores Work | NEJM Evidence evidence.nejm.org/doi/full/10....

This Stats, STAT! animated video explores the use of propensity scores — a method of controlling for observed confounders in non-randomized studies.

evidence.nejm.org

Cravedi Lab @cravedilab.bsky.social · 2d

Treatment Approaches for Alport Syndrome

journals.lww.com/jasn/abstrac...

journals.lww.com

Cravedi Lab @cravedilab.bsky.social · 4d

Noncanonical functions of T follicular helper cells | Science Immunology www.science.org/doi/10.1126/...

Noncanonical functions of T follicular helper cells

We review the roles TFH cells play in regulating immune responses and maintaining homeostasis that extend beyond helping B cell responses.

Inhibitory immune checkpoints in cancer immunotherapy

Cravedi Lab @cravedilab.bsky.social · 4d

Inhibitory immune checkpoints in cancer immunotherapy | Science Immunology www.science.org/doi/10.1126/...

Inhibitory immune checkpoints for cancer immunotherapy are reviewed.

www.nature.com/articles/s41...

Cravedi Lab @cravedilab.bsky.social · 4d

Enzyme-converted O kidneys allow ABO-incompatible transplantation without hyperacute rejection in a human decedent model - Nature Biomedical Engineering

An ex vivo model and pre-clinical study in a brain-dead recipient provide enzyme-converted O organs to avoid hyperacute rejection in ABO-incompatible kidney transplant patients.

www.nature.com/articles/d41...

Cravedi Lab @cravedilab.bsky.social · 4d

First human transplant of kidney modified to have ‘universal’ blood type

Recipient diagnosed with brain death received a type-O organ, which is compatible with all blood types.

The kidney slit diaphragm resembles a fishnet

Cravedi Lab @cravedilab.bsky.social · 4d

The kidney slit diaphragm resembles a fishnet - Kidney International www.kidney-international.org/article/S008...

An essential component of the kidney filtration barrier, the slit diaphragm, is a specialized cell-cell junction composed of the cell adhesion molecules Nephrin and Neph1.

www.kidney-international.org

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Cravedi Lab @cravedilab.bsky.social · 9d

www.nature.com/articles/d41...

NIH races to spend its 2025 grant money — but fewer projects win funding

Despite political obstacles, officials are on track to disburse all of the research funds allocated to US biomedical behemoth.

Randomized, double-blind, placebo-controlled phase 2a study assessing the efficacy and safety of felzartamab for IgA nephropathy

Cravedi Lab @cravedilab.bsky.social · 9d

Randomized, double-blind, placebo-controlled phase 2a study assessing the efficacy and safety of felzartamab for IgA nephropathy - Kidney International www.kidney-international.org/article/S008...

Felzartamab is a fully human anti-CD38 monoclonal antibody under investigation for treatment of IgA nephropathy (IgAN). IGNAZ (NCT05065970) is a randomized, double blind, placebo-controlled Phase 2a s...

www.kidney-international.org

The Truth About Organ Donation: Facts Behind the Headlines

Reposted by Cravedi Lab

American Society of Transplantation @astinfo.bsky.social · 10d

In Case You Missed It!

Organ donation saves thousands of lives each year, and the system is designed to be safe and reliable. Help your community get the facts - share this article with your patients or on your social channels.

Learn more: bit.ly/4mB2XV7

Make a difference in the field of transplantation by donating to support our cause.

bit.ly

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Cravedi Lab @cravedilab.bsky.social · 10d

T cells to fix a broken heart | Science www.science.org/doi/10.1126/...

T cells to fix a broken heart

In vivo engineered T cells provide a promising approach to treat cardiac diseases

Normothermic Kidney Perfusion: Current Status and Future Perspectives

Cravedi Lab @cravedilab.bsky.social · 17d

Normothermic Kidney Perfusion: Current Status and Future Perspectives - Kidney International Reports www.kireports.org/article/S246...

Normothermic machine perfusion (NMP), the most recent advancement in solid organ preservation, enables ex situ maintenance of grafts in a physiologically active state, offering a significant advantage...

www.kireports.org

In Vivo CD19 CAR T-Cell Therapy for Refractory Systemic Lupus Erythematosus | NEJM

Reposted by Cravedi Lab

The Night Science Podcast @nightsciencepod.bsky.social · 18d

🔥 New episode of the Night Science Podcast with Akiko Iwasaki @virusesimmunity.bsky.social Yale & HHMI professor, and one of Time Magazine’s 100 most influential people in 2024! Akiko explains how leading large collaborations requires managing expectations, not micromanaging the research.

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Cravedi Lab @cravedilab.bsky.social · 22d

In Vivo CD19 CAR T-Cell Therapy for Refractory Systemic Lupus Erythematosus | New England Journal of Medicine www.nejm.org/doi/full/10....

In patients with refractory systemic lupus erythematosus, in vivo generation of CD19 CAR T cells by means of lipid nanoparticles led to B-cell depletion, reduced disease activity, and no major toxi...

www.nejm.org

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Cravedi Lab @cravedilab.bsky.social · 23d

Exosome-primed T cell immunity is facilitated by complement activation - American Journal of Transplantation www.amjtransplant.org/article/S160...

Exosome-primed T cell immunity is facilitated by complement activation

Extracellular vesicles (EVs) contain proteins, lipids, and nucleic acids from their cells of origin. By delivering these cargo to distant acceptor cells, EVs modulate many biologic processes, includin...

Implications of the New NIH Policy on Animal Research for Transplant Science

Cravedi Lab @cravedilab.bsky.social · 23d

Implications of the New NIH Policy on Animal Research for Transplant Science

www.sciencedirect.com/science/arti...

www.sciencedirect.com

Cravedi Lab @cravedilab.bsky.social · 26d

The impact of the Banff v-lesion on rejection classification and outcomes: Insights from a multicenter study - American Journal of Transplantation www.amjtransplant.org/article/S160...

The impact of the Banff v-lesion on rejection classification and outcomes: Insights from a multicenter study

According to the Banff classification, intimal arteritis (v-lesion) contributes to diagnosing T cell–mediated rejection (TCMR) and antibody-mediated rejection (AMR) and signifies more severe TCMR. Thi...

www.nature.com/articles/d41...

Cravedi Lab @cravedilab.bsky.social · 28d

Your risk of dying from chronic disease has dropped — if you live in these countries

A report finds that death rates from cancer and heart disease have declined since 2010 in roughly 150 countries.

Mouse orthotopic liver transplantation: Challenges, achievements, and applications

Reposted by Cravedi Lab

The New York Times @nytimes.com · 28d

For the first time, children with obesity outnumber those who are underweight across the globe, according to a new report on child nutrition from UNICEF. nyti.ms/4gE3e8x

White text on a dark green card reads: "For the First Time, More Children Are Obese Than Underweight. One in 10 children worldwide now has obesity, a report from UNICEF found, and the number of overweight children has more than doubled in low- and middle-income countries since 2000."

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Cravedi Lab @cravedilab.bsky.social · 29d

Mouse orthotopic liver transplantation: Challenges, achievements, and applications - American Journal of Transplantation
www.amjtransplant.org/article/S160...

The surgically challenging mouse orthotopic liver transplant model has provided numerous insights into liver immunobiology, cellular and molecular regulation of liver transplant ischemia-reperfusion i...

2025 Report of the STAR Working Group on Donor Derived Cell Free DNA: Establishing Analytical Validity as the Basis for Appropriate and Effective Clinical Utilization

Cravedi Lab @cravedilab.bsky.social · 29d

2025 Report of the STAR Working Group on Donor Derived Cell Free DNA: Establishing Analytical Validity as the Basis for Appropriate and Effective Clinical Utilization - American Journal of Transplantation www.amjtransplant.org/article/S160...

A working group under the Sensitization in Transplant: Assessment of Risk (STAR) initiative was established in 2023 to develop guidelines for analytic and clinical validity of lab-based testing for do...