CRC 1430
@crc1430.bsky.social
DFG funded Collaborative Research Centre 1430
"Molecular Mechanisms of Cell State Transitions"
@unidue.bsky.social
@unidue-zmb.bsky.social
"Molecular Mechanisms of Cell State Transitions"
@unidue.bsky.social
@unidue-zmb.bsky.social
Excited about today’s @crc1430.bsky.social @unidue.bsky.social talk by Roland Schwarz from the ICCB Cologne, hosted jointly with WTZ!
He will present on: "Inferring clonal evolution in chromosomally unstable tumours."
#ComputationalBiology #CancerGenomics #CancerEvolution
He will present on: "Inferring clonal evolution in chromosomally unstable tumours."
#ComputationalBiology #CancerGenomics #CancerEvolution
November 3, 2025 at 2:52 PM
Excited about today’s @crc1430.bsky.social @unidue.bsky.social talk by Roland Schwarz from the ICCB Cologne, hosted jointly with WTZ!
He will present on: "Inferring clonal evolution in chromosomally unstable tumours."
#ComputationalBiology #CancerGenomics #CancerEvolution
He will present on: "Inferring clonal evolution in chromosomally unstable tumours."
#ComputationalBiology #CancerGenomics #CancerEvolution
Looking forward to tomorrow’s
@crc1430.bsky.social seminar
@unidue.bsky.social! We are excited to welcome Viktor Korolchuk
@korolchuklab.bsky.social, who will present on:
"Selective autophagy in ageing: mechanisms and functions"
#Autophagy #CellBiology #Collaboration
@crc1430.bsky.social seminar
@unidue.bsky.social! We are excited to welcome Viktor Korolchuk
@korolchuklab.bsky.social, who will present on:
"Selective autophagy in ageing: mechanisms and functions"
#Autophagy #CellBiology #Collaboration
October 27, 2025 at 10:08 AM
Looking forward to tomorrow’s
@crc1430.bsky.social seminar
@unidue.bsky.social! We are excited to welcome Viktor Korolchuk
@korolchuklab.bsky.social, who will present on:
"Selective autophagy in ageing: mechanisms and functions"
#Autophagy #CellBiology #Collaboration
@crc1430.bsky.social seminar
@unidue.bsky.social! We are excited to welcome Viktor Korolchuk
@korolchuklab.bsky.social, who will present on:
"Selective autophagy in ageing: mechanisms and functions"
#Autophagy #CellBiology #Collaboration
Great news from our recent @crc1430.bsky.social Female Scientist Get-Together 🎉👩🔬☕ Participants shared experiences on balancing scientific careers and personal life - a topic many want to explore further in a future workshop 💪✨ #EquityInScience #CareerDevelopment
October 13, 2025 at 11:32 AM
Great news from our recent @crc1430.bsky.social Female Scientist Get-Together 🎉👩🔬☕ Participants shared experiences on balancing scientific careers and personal life - a topic many want to explore further in a future workshop 💪✨ #EquityInScience #CareerDevelopment
A new exciting paper by the @hemmo-lab.bsky.social in @embojournal.org highlights the role of ATXN3 in lysosome regeneration after damage. Especially proud of our @crc1430.bsky.social PhD student who is first author on this paper! 🎉✨
New work out by @hemmo-lab.bsky.social @icce-unidue.bsky.social @kulathu.bsky.social and others on how ATXN3 restores lysosome integrity after damage by targeting K48- and K63-branched ubiquitin chains. Full story: www.embopress.org/doi/full/10....
@unidue.bsky.social @crc1430.bsky.social @dfg.de
@unidue.bsky.social @crc1430.bsky.social @dfg.de
August 7, 2025 at 10:59 AM
A new exciting paper by the @hemmo-lab.bsky.social in @embojournal.org highlights the role of ATXN3 in lysosome regeneration after damage. Especially proud of our @crc1430.bsky.social PhD student who is first author on this paper! 🎉✨
Reposted by CRC 1430
@hellerschmiedlab.bsky.social and partners reveal 'Conformational plasticity of a BiP–GRP94 chaperone complex', a study made possible through funding by @crc1430.bsky.social @dfg.de
Find out more:
www.nature.com/articles/s41...
Find out more:
www.nature.com/articles/s41...
July 25, 2025 at 9:45 AM
@hellerschmiedlab.bsky.social and partners reveal 'Conformational plasticity of a BiP–GRP94 chaperone complex', a study made possible through funding by @crc1430.bsky.social @dfg.de
Find out more:
www.nature.com/articles/s41...
Find out more:
www.nature.com/articles/s41...
We’re proud to see five @crc1430.bsky.social subprojects come together in this joint publication in @natsmb.nature.com! 💥 Huge congratulations to @hellerschmiedlab.bsky.social, @poepsel-lab.bsky.social, and the labs of Sánchez-García, Kaiser & Kaschani.
🔗 www.nature.com/articles/s41...
🔗 www.nature.com/articles/s41...
July 23, 2025 at 8:21 AM
We’re proud to see five @crc1430.bsky.social subprojects come together in this joint publication in @natsmb.nature.com! 💥 Huge congratulations to @hellerschmiedlab.bsky.social, @poepsel-lab.bsky.social, and the labs of Sánchez-García, Kaiser & Kaschani.
🔗 www.nature.com/articles/s41...
🔗 www.nature.com/articles/s41...
Great news from yesterday’s @crc1430.bsky.social Female Scientists Get-Together 🎉👩🔬☕ We are now planning and preparing the negotiations workshop for women 💪✨ After the summer break ☀️, we’ll focus on publications 📚 to get ready for the workshop. #EquityInScience #CareerDevelopment
July 10, 2025 at 2:55 PM
Great news from yesterday’s @crc1430.bsky.social Female Scientists Get-Together 🎉👩🔬☕ We are now planning and preparing the negotiations workshop for women 💪✨ After the summer break ☀️, we’ll focus on publications 📚 to get ready for the workshop. #EquityInScience #CareerDevelopment
A fantastic example of what strong collaborations can achieve! Congrats 🎉 to our @crc1430.bsky.social members from @maltegersch.bsky.social, Grüner, Paschen, Knapp, Kaiser labs, and our core facilities ACE & @icce-unidue.bsky.social Especially proud of our PhD students for their excellent teamwork!
Really excited to share the first chapter of my PhD as a preprint titled: Targeted degradation of USP7 in solid cancer cells reveals disparate effects of deubiquitinase inhibition vs. acute protein depletion: www.biorxiv.org/content/10.1.... If that sounds interesting to you, small tweetorial below👇
Targeted degradation of USP7 in solid cancer cells reveals disparate effects of deubiquitinase inhibition vs. acute protein depletion
Proteolysis-targeting chimeras (PROTACs) co-op the ubiquitin system for targeted protein degradation, creating opportunities to interrogate cellular functions of proteins through "chemical knockdown"....
www.biorxiv.org
July 10, 2025 at 2:39 PM
A fantastic example of what strong collaborations can achieve! Congrats 🎉 to our @crc1430.bsky.social members from @maltegersch.bsky.social, Grüner, Paschen, Knapp, Kaiser labs, and our core facilities ACE & @icce-unidue.bsky.social Especially proud of our PhD students for their excellent teamwork!
🧭 What are my further career movements?
PhDs & Postdocs of @crc1430.bsky.social explored this key question in a career planning workshop. Through interactive exercises, they gained clarity on their skills, values, and future paths - inside or outside academia.
#PhDCareer #PostdocLife #CareerPlanning
PhDs & Postdocs of @crc1430.bsky.social explored this key question in a career planning workshop. Through interactive exercises, they gained clarity on their skills, values, and future paths - inside or outside academia.
#PhDCareer #PostdocLife #CareerPlanning
June 11, 2025 at 3:42 PM
🧭 What are my further career movements?
PhDs & Postdocs of @crc1430.bsky.social explored this key question in a career planning workshop. Through interactive exercises, they gained clarity on their skills, values, and future paths - inside or outside academia.
#PhDCareer #PostdocLife #CareerPlanning
PhDs & Postdocs of @crc1430.bsky.social explored this key question in a career planning workshop. Through interactive exercises, they gained clarity on their skills, values, and future paths - inside or outside academia.
#PhDCareer #PostdocLife #CareerPlanning
Great exchange at today´s @crc1430.bsky.social Female Scientists Get-Together! 👩🔬☕
Strong interest in the “Negotiations for Women” workshop - a small but important step toward closing the gender pay gap 💪🎯 and strengthening career paths for women in science 🧠🚀 #EquityInScience #CareerDevelopment
Strong interest in the “Negotiations for Women” workshop - a small but important step toward closing the gender pay gap 💪🎯 and strengthening career paths for women in science 🧠🚀 #EquityInScience #CareerDevelopment
May 28, 2025 at 4:26 PM
Great exchange at today´s @crc1430.bsky.social Female Scientists Get-Together! 👩🔬☕
Strong interest in the “Negotiations for Women” workshop - a small but important step toward closing the gender pay gap 💪🎯 and strengthening career paths for women in science 🧠🚀 #EquityInScience #CareerDevelopment
Strong interest in the “Negotiations for Women” workshop - a small but important step toward closing the gender pay gap 💪🎯 and strengthening career paths for women in science 🧠🚀 #EquityInScience #CareerDevelopment
Looking forward to tomorrow’s @crc1430.bsky.social seminar @unidue.bsky.social! We are excited to welcome Thorben Cordes @tu-dortmund.bsky.social, who will present on:
"Novel optical spectroscopy methods for mechanistic biochemical and biophysical studies of active membrane transporters" #Biophysics
"Novel optical spectroscopy methods for mechanistic biochemical and biophysical studies of active membrane transporters" #Biophysics
May 26, 2025 at 10:55 AM
Looking forward to tomorrow’s @crc1430.bsky.social seminar @unidue.bsky.social! We are excited to welcome Thorben Cordes @tu-dortmund.bsky.social, who will present on:
"Novel optical spectroscopy methods for mechanistic biochemical and biophysical studies of active membrane transporters" #Biophysics
"Novel optical spectroscopy methods for mechanistic biochemical and biophysical studies of active membrane transporters" #Biophysics
A successful @crc1430.bsky.social PhD Career Day is behind us!
Thank you to all participants for the lively discussions and to our six guest speakers for their valuable insights.
We enjoyed a day full of career advice, inspiring talks, and great networking over dinner.
#PhDCareers #JobsAfterPhD
Thank you to all participants for the lively discussions and to our six guest speakers for their valuable insights.
We enjoyed a day full of career advice, inspiring talks, and great networking over dinner.
#PhDCareers #JobsAfterPhD
May 19, 2025 at 11:19 AM
A successful @crc1430.bsky.social PhD Career Day is behind us!
Thank you to all participants for the lively discussions and to our six guest speakers for their valuable insights.
We enjoyed a day full of career advice, inspiring talks, and great networking over dinner.
#PhDCareers #JobsAfterPhD
Thank you to all participants for the lively discussions and to our six guest speakers for their valuable insights.
We enjoyed a day full of career advice, inspiring talks, and great networking over dinner.
#PhDCareers #JobsAfterPhD
We’re excited for tomorrow’s @crc1430.bsky.social PhD Career Day!
PhD students will explore career paths in and beyond academia — from an application workshop to talks and a panel with professionals.
Looking forward to a day full of exchange, ideas, and networking!
#FuturePhDs #PhDNetworking
PhD students will explore career paths in and beyond academia — from an application workshop to talks and a panel with professionals.
Looking forward to a day full of exchange, ideas, and networking!
#FuturePhDs #PhDNetworking
May 15, 2025 at 3:22 PM
We’re excited for tomorrow’s @crc1430.bsky.social PhD Career Day!
PhD students will explore career paths in and beyond academia — from an application workshop to talks and a panel with professionals.
Looking forward to a day full of exchange, ideas, and networking!
#FuturePhDs #PhDNetworking
PhD students will explore career paths in and beyond academia — from an application workshop to talks and a panel with professionals.
Looking forward to a day full of exchange, ideas, and networking!
#FuturePhDs #PhDNetworking
Exciting new paper from our @crc1430.bsky.social member from the Westermann Lab and their collaborators, just out in @embojournal.org! 🎉A key step toward understanding how kinetochores act as force-sensitive signaling scaffolds during sister chromatid biorientation. 🧬
🔗 doi.org/10.1038/s443...
🔗 doi.org/10.1038/s443...
The Spc105/Kre28 complex promotes mitotic error correction by outer kinetochore recruitment of Ipl1/Sli15 | The EMBO Journal
imageimageThe correction of erroneous kinetochore-microtubule attachments requires tension-dependent
phosphorylation of key substrates. This study reveals a novel and essential recruitment
mechanism o...
doi.org
May 8, 2025 at 3:54 PM
Exciting new paper from our @crc1430.bsky.social member from the Westermann Lab and their collaborators, just out in @embojournal.org! 🎉A key step toward understanding how kinetochores act as force-sensitive signaling scaffolds during sister chromatid biorientation. 🧬
🔗 doi.org/10.1038/s443...
🔗 doi.org/10.1038/s443...
Congratulations to our newest @crc1430.bsky.social member, Dana Branzei, who has been awarded the Humboldt Professorship! 🎉 The official award ceremony took place on Tuesday in Berlin – a well-deserved recognition of her exceptional work. #HumboldtProfessorship #AvHProfessor #OneHealth #UARuhr
May 8, 2025 at 3:43 PM
Congratulations to our newest @crc1430.bsky.social member, Dana Branzei, who has been awarded the Humboldt Professorship! 🎉 The official award ceremony took place on Tuesday in Berlin – a well-deserved recognition of her exceptional work. #HumboldtProfessorship #AvHProfessor #OneHealth #UARuhr
Congrats to our @crc1430.bsky.social members from the Nalbant Lab, Paschen Lab, and @icce-unidue.bsky.social , along with collaborators, on their exciting preprint in @biorxivpreprint.bsky.social — highlighted by @prelights.bsky.social! 🎉 A great example of what strong teamwork can achieve. 🧑🔬👩🔬
New #preLights post @vibhasingh.bsky.social!
#NalbantLab introduces a powerful new approach to study mechanobiological regulation in cancer. They describe how tumour cells manage to “pull” themselves away from the tumour bulk during invasion.
#preLight ⬇️
prelights.biologists.com/highlights/o...
#NalbantLab introduces a powerful new approach to study mechanobiological regulation in cancer. They describe how tumour cells manage to “pull” themselves away from the tumour bulk during invasion.
#preLight ⬇️
prelights.biologists.com/highlights/o...
Optogenetic stimulation of Lbc GEF-mediated Rho activity dynamics promotes cell invasion - preLights
Tumors break free! More contraction, more invasion.
prelights.biologists.com
April 30, 2025 at 1:33 PM
Congrats to our @crc1430.bsky.social members from the Nalbant Lab, Paschen Lab, and @icce-unidue.bsky.social , along with collaborators, on their exciting preprint in @biorxivpreprint.bsky.social — highlighted by @prelights.bsky.social! 🎉 A great example of what strong teamwork can achieve. 🧑🔬👩🔬
Join us tomorrow, April 29, for an exciting seminar hosted by @crc1430.bsky.social at @unidue.bsky.social! We’re happy to welcome Chunaram Choudhary choudharylabcpr.bsky.social, who will be presenting on "Proteomic exploration of lysine acetylation and ubiquitylation" #CellSignaling #Proteomics #PTM
April 28, 2025 at 3:39 PM
Join us tomorrow, April 29, for an exciting seminar hosted by @crc1430.bsky.social at @unidue.bsky.social! We’re happy to welcome Chunaram Choudhary choudharylabcpr.bsky.social, who will be presenting on "Proteomic exploration of lysine acetylation and ubiquitylation" #CellSignaling #Proteomics #PTM
Congratulations to our @crc1430.bsky.social member Batool Shannan 🎉 from the Rösch Lab for receiving the Animal Welfare Prize 🏆 for her innovative work on melanoma patient organoids, helping reduce the need for mice in developing metastasis-specific cancer therapies! 🐭
#AnimalWelfare #ScienceForGood
#AnimalWelfare #ScienceForGood
April 16, 2025 at 12:44 PM
Congratulations to our @crc1430.bsky.social member Batool Shannan 🎉 from the Rösch Lab for receiving the Animal Welfare Prize 🏆 for her innovative work on melanoma patient organoids, helping reduce the need for mice in developing metastasis-specific cancer therapies! 🐭
#AnimalWelfare #ScienceForGood
#AnimalWelfare #ScienceForGood
We’re thrilled to congratulate our @crc1430.bsky.social members from the Kaiser Lab and @hellerschmiedlab.bsky.social, along with their collaborators, on their fantastic publication in @natcomms.nature.com! 🎉 A great example of what strong teamwork can achieve. 🧑🔬👩🔬 udue.de/NovelClassIn...
Meldungen aus der UDE
udue.de
April 15, 2025 at 4:23 PM
We’re thrilled to congratulate our @crc1430.bsky.social members from the Kaiser Lab and @hellerschmiedlab.bsky.social, along with their collaborators, on their fantastic publication in @natcomms.nature.com! 🎉 A great example of what strong teamwork can achieve. 🧑🔬👩🔬 udue.de/NovelClassIn...
Congrats to our @crc1430.bsky.social member @vcmentowski.bsky.social on defending her PhD in the @andrea-musacchio.bsky.social Lab! 🎓👏 A remarkable achievement that showcases her dedication and hard work. We’re excited for her future successes! 🎉 #PhDDefense #ResearchExcellence #AcademicAchievement"
April 1, 2025 at 12:41 PM
Congrats to our @crc1430.bsky.social member @vcmentowski.bsky.social on defending her PhD in the @andrea-musacchio.bsky.social Lab! 🎓👏 A remarkable achievement that showcases her dedication and hard work. We’re excited for her future successes! 🎉 #PhDDefense #ResearchExcellence #AcademicAchievement"
Join us today for an exciting talk by Ginny Farías on 'Shaping the Axonal Proteome through Inter-Organelle Communication.'
April 1, 2025 at 7:02 AM
Join us today for an exciting talk by Ginny Farías on 'Shaping the Axonal Proteome through Inter-Organelle Communication.'
Every 6 weeks, @crc1430.bsky.social hosts Female Scientists Get-Togethers 👩🔬, providing a space for talented women to share research experiences 🔬, discuss career strategies 💡, and build supportive networks 🤝. #WomenInScience #FemaleScientists #Research #CareerGrowth #Networking
April 1, 2025 at 7:01 AM
Every 6 weeks, @crc1430.bsky.social hosts Female Scientists Get-Togethers 👩🔬, providing a space for talented women to share research experiences 🔬, discuss career strategies 💡, and build supportive networks 🤝. #WomenInScience #FemaleScientists #Research #CareerGrowth #Networking
Join us tomorrow, April 1, for an exciting seminar hosted by @crc1430.bsky.social at @unidue.bsky.social ! We’re happy to welcome Ginny Farías, who will be presenting on "Shaping the axonal proteome through inter-organelle communication." #AxonalProteome #NeuronalOrganelleDynamics
March 31, 2025 at 1:39 PM
Join us tomorrow, April 1, for an exciting seminar hosted by @crc1430.bsky.social at @unidue.bsky.social ! We’re happy to welcome Ginny Farías, who will be presenting on "Shaping the axonal proteome through inter-organelle communication." #AxonalProteome #NeuronalOrganelleDynamics
Strengthening the future for @crc1430.bsky.social female early-career researchers 👩🔬💡 Thank you all for the lively discussions, and a special thanks to Viktoria from Graduate Center Plus for her valuable insights and support! 🚀 #WomenInScience #EqualOpportunities #CareerGrowth
March 31, 2025 at 10:38 AM
Strengthening the future for @crc1430.bsky.social female early-career researchers 👩🔬💡 Thank you all for the lively discussions, and a special thanks to Viktoria from Graduate Center Plus for her valuable insights and support! 🚀 #WomenInScience #EqualOpportunities #CareerGrowth