Dan Kaplan
danhkaplan.bsky.social
Dan Kaplan
@danhkaplan.bsky.social
Immunologist and Dermatologist at the University of Pittsburgh. The lab is interested in the interactions between immune and non-immune cells, especially sensory neurons.
Derm on Drugs is a podcast where some current and former U of Pitt faculty talk about dermatology. Here is an episode where I joined to talk about itch and scratching. It was a really fun time and they did a great job. #dermatology #immunology #eczema podcasts.apple.com/us/podcast/d...
To Scratch or Not to Scratch, That Is the Question
Podcast Episode · Derms on Drugs · 03/14/2025 · 36m
podcasts.apple.com
March 19, 2025 at 12:51 PM
I was scheduled for study section starting tomorrow. Everything's all done and ready to go. Just heard it's being "rescheduled." No reason given.
February 26, 2025 at 5:27 PM
Why scratching makes a rash worse and a potential benefit to scratching--it reduced S. aureus on skin. Andrew Liu's paper from our lab is out now at #science #neuroimmune #immunology www.science.org/doi/10.1126/...
Scratching promotes allergic inflammation and host defense via neurogenic mast cell activation
Itch is a dominant symptom in dermatitis, and scratching promotes cutaneous inflammation, thereby worsening disease. However, the mechanisms through which scratching exacerbates inflammation and wheth...
www.science.org
January 30, 2025 at 8:31 PM
New paper from Kaplan Lab. Agonizing a specific glutamate receptor on mast cells in the skin renders them less function and can suppress several models of skin inflammation. Congrats to Youran Zhang and all co-authors. #skinimmunology #immunology #mastcells www.science.org/doi/10.1126/...
Agonism of the glutamate receptor GluK2 suppresses dermal mast cell activation and cutaneous inflammation
Small-molecule agonism of GluK2 reduces dermal mast cell responses to MrgprB2 ligation and suppresses skin inflammation.
www.science.org
December 11, 2024 at 7:06 PM