Dan Isom
@danisomlab.bsky.social
University of Miami, FL: molecular and cellular basis of proton sensing, synBio for health/energy and drug discovery, novel data science for protein structure-function informatics, and AI: https://www.isomlab.com
Grateful to our organizers—@danisomlab, Jennifer Arcuri, and Kerry Burnstein—and to everyone who made the retreat such a success. Here’s to the next chapter. 🌴🔬
December 6, 2025 at 3:32 PM
Grateful to our organizers—@danisomlab, Jennifer Arcuri, and Kerry Burnstein—and to everyone who made the retreat such a success. Here’s to the next chapter. 🌴🔬
The result: new collaborations, new ideas, and a stronger sense of departmental community than ever.
The takeaway is clear—our science is cutting-edge, and bringing people together like this is essential for moving both individual and team discoveries forward.
The takeaway is clear—our science is cutting-edge, and bringing people together like this is essential for moving both individual and team discoveries forward.
December 6, 2025 at 3:32 PM
The result: new collaborations, new ideas, and a stronger sense of departmental community than ever.
The takeaway is clear—our science is cutting-edge, and bringing people together like this is essential for moving both individual and team discoveries forward.
The takeaway is clear—our science is cutting-edge, and bringing people together like this is essential for moving both individual and team discoveries forward.
We just wrapped up the 7th Molecular & Cellular Pharmacology Retreat in the Florida Keys, and the energy was incredible.
Under the theme “Colab in the Cays,” scientists from 15+ labs shared 53 talks across two days, with every single participant presenting their work.
Under the theme “Colab in the Cays,” scientists from 15+ labs shared 53 talks across two days, with every single participant presenting their work.
December 6, 2025 at 3:32 PM
We just wrapped up the 7th Molecular & Cellular Pharmacology Retreat in the Florida Keys, and the energy was incredible.
Under the theme “Colab in the Cays,” scientists from 15+ labs shared 53 talks across two days, with every single participant presenting their work.
Under the theme “Colab in the Cays,” scientists from 15+ labs shared 53 talks across two days, with every single participant presenting their work.
PIONEER: A Periplasmic Display Platform for Synthetic Biology-Based Screening of Genetically Encoded Protein Regulators - Journal of Biological Chemistry www.jbc.org/article/S002...
PIONEER: A Periplasmic Display Platform for Synthetic Biology-Based Screening of Genetically Encoded Protein Regulators
Periplasmic display in yeast is a promising but underdeveloped method for screening
and studying genetically encoded biomolecules. We present PIONEER, a modular platform
that localizes peptides, prote...
www.jbc.org
November 29, 2025 at 4:03 PM
PIONEER: A Periplasmic Display Platform for Synthetic Biology-Based Screening of Genetically Encoded Protein Regulators - Journal of Biological Chemistry www.jbc.org/article/S002...
Support my running of the 5K! Funds go directory to research labs @SylvesterCancer: dolphinscancerchallenge.com/participant/...
Help me Challenge Cancer!
The DCC is a year-round collective community movement to raise money in support of Sylvester Comprehensive Cancer Center at the University of Miami. With your support, we are saving more lives. #OneTe...
dolphinscancerchallenge.com
January 13, 2025 at 3:51 PM
Support my running of the 5K! Funds go directory to research labs @SylvesterCancer: dolphinscancerchallenge.com/participant/...
These mutations mimic protonation (i.e., activation) and, along with abolishing Na+ negative allosteric modulation, were intended to fully activate GPR4, 65, and 68 precisely as they did
January 3, 2025 at 2:10 PM
These mutations mimic protonation (i.e., activation) and, along with abolishing Na+ negative allosteric modulation, were intended to fully activate GPR4, 65, and 68 precisely as they did
There is a misunderstanding here. These mutations were not designed to abolish proton-mediated activation but to achieve the exact opposite based on the predicted physical chemistry and self-energy considerations.
January 3, 2025 at 2:10 PM
There is a misunderstanding here. These mutations were not designed to abolish proton-mediated activation but to achieve the exact opposite based on the predicted physical chemistry and self-energy considerations.
"A recent study employing parallel mutagenesis of titratable residues in GPR68 identified a conserved triad of buried acidic residues in proton sensing GPCRs. Here, too, neutral mutations to these sites shift pH50 but do not abolish proton-mediated receptor activation."
January 3, 2025 at 2:10 PM
"A recent study employing parallel mutagenesis of titratable residues in GPR68 identified a conserved triad of buried acidic residues in proton sensing GPCRs. Here, too, neutral mutations to these sites shift pH50 but do not abolish proton-mediated receptor activation."
I have received many requests for this, so I am sharing it here. I hope it works (password: 7i+fFdMG) @Pap_Corps @SylvesterCancer @danIsomLab:
tinyurl.com/Pap-Corps-EC...
tinyurl.com/Pap-Corps-EC...
URL Shortener, Branded Short Links & Analytics | TinyURL
tinyurl.com
December 22, 2024 at 2:19 PM
I have received many requests for this, so I am sharing it here. I hope it works (password: 7i+fFdMG) @Pap_Corps @SylvesterCancer @danIsomLab:
tinyurl.com/Pap-Corps-EC...
tinyurl.com/Pap-Corps-EC...
The combined single-day profit of the top 25 US companies would fully fund the annual $3.2B NIGMS budget.
November 29, 2024 at 9:01 PM
The combined single-day profit of the top 25 US companies would fully fund the annual $3.2B NIGMS budget.
Happy Thanksgiving from Miami.
November 27, 2024 at 6:21 PM
Happy Thanksgiving from Miami.
Yay Defne! news.med.miami.edu/can-a-diabet...
Can a Diabetes Drug and Immunotherapy Help Treat Brain Cancer? - InventUM
Defne Bayik, Ph.D., is pioneering new treatments to find combination therapies that may help T-cell response against glioblastoma.
news.med.miami.edu
November 14, 2024 at 12:40 PM
Yay Defne! news.med.miami.edu/can-a-diabet...
In my excitement for his visit, I forgot to get a selfie with Henrik. This will have to do 😂
November 13, 2024 at 9:51 PM
In my excitement for his visit, I forgot to get a selfie with Henrik. This will have to do 😂
Our small review on using yeast synthetic biology to advance human GPCR biology and pharmacology.
tinyurl.com/2p88y72h
tinyurl.com/2p88y72h
Advances in yeast synthetic biology for human G protein–coupled receptor biology and pharmacology
G protein–coupled receptors (GPCRs) are the largest family of transmembrane receptors in humans. Over 800 GPCRs regulate the (patho)biology of every o…
tinyurl.com
September 15, 2024 at 2:12 PM
Our small review on using yeast synthetic biology to advance human GPCR biology and pharmacology.
tinyurl.com/2p88y72h
tinyurl.com/2p88y72h
What a wonderful scientific retreat for UM Pharmacology this week @bakerscayresort. Time is running out to join our faculty and enjoy the Keys and science for yourself! bit.ly/3GAxDD6
December 6, 2023 at 2:04 PM
What a wonderful scientific retreat for UM Pharmacology this week @bakerscayresort. Time is running out to join our faculty and enjoy the Keys and science for yourself! bit.ly/3GAxDD6
Looking for cool colleagues! Recruiting at assistant and associate levels. I am happy to answer any questions. www.nature.com/naturecareer...
November 10, 2023 at 1:46 PM
Looking for cool colleagues! Recruiting at assistant and associate levels. I am happy to answer any questions. www.nature.com/naturecareer...
SUP on Lake Tahoe today:
August 23, 2023 at 1:35 AM
SUP on Lake Tahoe today:
Happy to be among this fine assembly of protonators: https://www.biophysics.org/2023tahoe-protonreaction/program/daily-schedule
August 20, 2023 at 1:31 PM
Happy to be among this fine assembly of protonators: https://www.biophysics.org/2023tahoe-protonreaction/program/daily-schedule
That bill is strangely pleasing.
August 19, 2023 at 2:08 AM
That bill is strangely pleasing.
Wow, SoCal feeling SoFlo.
New Weather West post on #HurricaneHilary and major Southern California-related impacts expected this weekend into early next week. Please also consider attending addition (time TBD) YouTube live sessions Sat-Tue as the event evolves. #CAwx #CAwater https://weatherwest.com/archives/29462
Potentially historic summer storm event to unfold in SoCal this weekend as weakening Hurricane Hilar...
Hurricane Hilary will weaken dramatically on approach, but will bring major and even historic impacts in some parts of Southern California
Animation depicting recent satellite imagery of Category 4...
weatherwest.com
August 19, 2023 at 2:05 AM
Wow, SoCal feeling SoFlo.