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darkmatterproject.bsky.social
The Dark Matter Project
@darkmatterproject.bsky.social
110 followers 54 following 28 posts
Studying The Dark Matter of the Genome - everything noncoding 🧬
A collaborative scientific project at NYU Langone.
Account managed by Ran Brosh.
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darkmatterproject.bsky.social
🧬Sign up to our free online 2026 Genome Writing Workshop 🧬
www.thedarkmatterproject.org/2026-genome-...
January 20, 2026 at 7:23 PM
darkmatterproject.bsky.social
www.biorxiv.org/content/10.6...

Congrats to Dr. Noor Chalhoub who managed to defend her thesis and publish this paper on the same day!
Genome writing and Targeted Delivery of the NKX6-3/ANK1 gene cluster and its Type 2 Diabetes GWAS Variants to Human iPSCs
Genome-wide association studies (GWAS) identified over 600 loci containing single-nucleotide polymorphisms (SNPs) associated with type 2 diabetes (T2D), most of which reside in non-coding regions. Amo...
www.biorxiv.org
January 5, 2026 at 10:44 PM
darkmatterproject.bsky.social
Enhancer cooperativity in the folded genome www.sciencedirect.com/science/arti...
December 22, 2025 at 1:21 PM
darkmatterproject.bsky.social
Structure and evolution-guided design of minimal RNA-guided nucleases www.biorxiv.org/content/10.6...
Structure and evolution-guided design of minimal RNA-guided nucleases
The design of RNA-guided nucleases with properties not limited by evolution can expand programmable genome editing capabilities. However, generating diverse multi-domain proteins with robust enzymatic...
www.biorxiv.org
December 9, 2025 at 1:32 PM
darkmatterproject.bsky.social
High-fidelity human chromosome transfer and elimination | Science www.science.org/doi/abs/10.1...
High-fidelity human chromosome transfer and elimination
The synthesis of human genomes and other gigabase-scale genomes will require new strategies. Here, we realized key steps in our pipeline for building synthetic human chromosomes. We established: (i) t...
www.science.org
December 6, 2025 at 9:20 PM
darkmatterproject.bsky.social
How could one engineer a mouse carrying a LETHAL allele? A thread 🧵
October 29, 2025 at 3:30 AM
darkmatterproject.bsky.social
One step closer to an LLM that understands novel DNA🧬

𝗜𝘁𝗲𝗿𝗮𝘁𝗶𝘃𝗲 𝗶𝗺𝗽𝗿𝗼𝘃𝗲𝗺𝗲𝗻𝘁 𝗼𝗳 𝗱𝗲𝗲𝗽 𝗹𝗲𝗮𝗿𝗻𝗶𝗻𝗴 𝗺𝗼𝗱𝗲𝗹𝘀 𝘂𝘀𝗶𝗻𝗴 𝘀𝘆𝗻𝘁𝗵𝗲𝘁𝗶𝗰 𝗿𝗲𝗴𝘂𝗹𝗮𝘁𝗼𝗿𝘆 𝗴𝗲𝗻𝗼𝗺𝗶𝗰𝘀.

pubmed.ncbi.nlm.nih.gov/41125441

Congrats Andre Ribeiro-Dos-Santos and Matt Maurano!
October 25, 2025 at 1:10 PM
Reposted by The Dark Matter Project
pryprk.bsky.social
I am proud to share our work on X-linked Dystonia-Parkinsonism — a rare neurodegenerative movement disorder driven by a SINE-VNTR-Alu retrotransposon insertion in the TAF1 gene.

Read our two companion papers:
🔹 www.biorxiv.org/content/10.1...
🔹 www.biorxiv.org/content/10.1...

🧵 Highlights below!
October 24, 2025 at 4:32 PM
darkmatterproject.bsky.social
We're thrilled to publish 2 exciting preprints today on the molecular pathology of X-linked Dystonia Parkinsonism!
biorxiv.org/content/10.1...
AND
biorxiv.org/content/10.1...

@nyulangone.bsky.social
October 8, 2025 at 5:54 PM
darkmatterproject.bsky.social
Megabase-scale human genome rearrangement with programmable bridge recombinases | Science www.science.org/doi/10.1126/...
Megabase-scale human genome rearrangement with programmable bridge recombinases
Bridge recombinases are naturally occurring RNA-guided DNA recombinases that we previously demonstrated can programmably insert, excise, and invert DNA in vitro and in Escherichia coli. In this study,...
www.science.org
September 25, 2025 at 10:35 PM
darkmatterproject.bsky.social
Structure of a polymorphic repeat at the CACNA1C schizophrenia locus | PNAS www.pnas.org/doi/10.1073/...
Congrats to Raquel Moya and team!
Structure of a polymorphic repeat at the CACNA1C schizophrenia locus | PNAS
Genetic variation within intron 3 of the CACNA1C calcium channel gene is associated with schizophrenia and other neuropsychiatric disorders, but an...
www.pnas.org
September 12, 2025 at 1:53 PM
darkmatterproject.bsky.social
we're slow to post, but we do have a great website!
www.thedarkmatterproject.org
The Dark Matter Project
The Center for Synthetic Regulatory Genomics at NYU Langone Health is tasked with the study of the genome's Dark Matter - the noncoding DNA and its role in human diseases.
www.thedarkmatterproject.org
July 11, 2025 at 6:17 PM