Priya Prakash
@pryprk.bsky.social
Neuroscience postdoc at NYU Grossman School of Medicine researching glial cell contributions to neurodegeneration. www.pryprk.com
Pinned
Priya Prakash
@pryprk.bsky.social
· Oct 24
I am proud to share our work on X-linked Dystonia-Parkinsonism — a rare neurodegenerative movement disorder driven by a SINE-VNTR-Alu retrotransposon insertion in the TAF1 gene.
Read our two companion papers:
🔹 www.biorxiv.org/content/10.1...
🔹 www.biorxiv.org/content/10.1...
🧵 Highlights below!
Read our two companion papers:
🔹 www.biorxiv.org/content/10.1...
🔹 www.biorxiv.org/content/10.1...
🧵 Highlights below!
Reposted by Priya Prakash
PREPRINTS ON THEIR WORK:
Priya - www.biorxiv.org/content/10.1... and www.biorxiv.org/content/10.1... (press - www.npr.org/2024/10/07/n...)
Melissa - www.biorxiv.org/content/10.1... (press - www.thetransmitter.org/astrocytes/a...)
Priya - www.biorxiv.org/content/10.1... and www.biorxiv.org/content/10.1... (press - www.npr.org/2024/10/07/n...)
Melissa - www.biorxiv.org/content/10.1... (press - www.thetransmitter.org/astrocytes/a...)
www.biorxiv.org
November 18, 2025 at 8:58 PM
PREPRINTS ON THEIR WORK:
Priya - www.biorxiv.org/content/10.1... and www.biorxiv.org/content/10.1... (press - www.npr.org/2024/10/07/n...)
Melissa - www.biorxiv.org/content/10.1... (press - www.thetransmitter.org/astrocytes/a...)
Priya - www.biorxiv.org/content/10.1... and www.biorxiv.org/content/10.1... (press - www.npr.org/2024/10/07/n...)
Melissa - www.biorxiv.org/content/10.1... (press - www.thetransmitter.org/astrocytes/a...)
Reposted by Priya Prakash
#SfN #SocietyForGlia
STARTING NOW!
Ending strong with the last www.liddelowlab.com presentations of the week.
@pryprk.bsky.social
talking about a world first mouse model for XDP... and OLIGODENDROCYTES!
@melcooperphd.bsky.social
presenting on astrocyte networks in the mouse forebrain.
STARTING NOW!
Ending strong with the last www.liddelowlab.com presentations of the week.
@pryprk.bsky.social
talking about a world first mouse model for XDP... and OLIGODENDROCYTES!
@melcooperphd.bsky.social
presenting on astrocyte networks in the mouse forebrain.
November 18, 2025 at 8:58 PM
#SfN #SocietyForGlia
STARTING NOW!
Ending strong with the last www.liddelowlab.com presentations of the week.
@pryprk.bsky.social
talking about a world first mouse model for XDP... and OLIGODENDROCYTES!
@melcooperphd.bsky.social
presenting on astrocyte networks in the mouse forebrain.
STARTING NOW!
Ending strong with the last www.liddelowlab.com presentations of the week.
@pryprk.bsky.social
talking about a world first mouse model for XDP... and OLIGODENDROCYTES!
@melcooperphd.bsky.social
presenting on astrocyte networks in the mouse forebrain.
Reposted by Priya Prakash
IT'S A BUSY AFTERNOON FOR THE LAB!
@mrodea.bsky.social - astrocyte chromatin in reactive astrocytes across the forebrain
Nick Kathman - COCKROACH BRAIN ALERT! (is this the largest single cell atlas of an insect brain?)
@liddelowsa.bsky.social - multiomic approaches to study astrocyte reacitivity
@mrodea.bsky.social - astrocyte chromatin in reactive astrocytes across the forebrain
Nick Kathman - COCKROACH BRAIN ALERT! (is this the largest single cell atlas of an insect brain?)
@liddelowsa.bsky.social - multiomic approaches to study astrocyte reacitivity
November 17, 2025 at 8:39 PM
IT'S A BUSY AFTERNOON FOR THE LAB!
@mrodea.bsky.social - astrocyte chromatin in reactive astrocytes across the forebrain
Nick Kathman - COCKROACH BRAIN ALERT! (is this the largest single cell atlas of an insect brain?)
@liddelowsa.bsky.social - multiomic approaches to study astrocyte reacitivity
@mrodea.bsky.social - astrocyte chromatin in reactive astrocytes across the forebrain
Nick Kathman - COCKROACH BRAIN ALERT! (is this the largest single cell atlas of an insect brain?)
@liddelowsa.bsky.social - multiomic approaches to study astrocyte reacitivity
Reposted by Priya Prakash
Congrats to our very own Ipshita Zutshi on being awarded the Peter & Patricia Gruber International Research Award in Neuroscience!! #SfN25
November 16, 2025 at 11:42 PM
Congrats to our very own Ipshita Zutshi on being awarded the Peter & Patricia Gruber International Research Award in Neuroscience!! #SfN25
Very happy to have contributed to this new review on Lewy body dementia in @thelancetneuro.bsky.social led by Sonja W. Scholz. We highlight the latest advances in genetics and pathology. @liddelowsa.bsky.social Check it out! www.sciencedirect.com/science/arti...
Advances in the genetics and pathology of Lewy body dementia
Lewy body dementia is a heterogeneous disease that is underdiagnosed and poorly understood. Pathologically, Lewy body dementia is characterised by the…
www.sciencedirect.com
November 13, 2025 at 12:56 AM
Very happy to have contributed to this new review on Lewy body dementia in @thelancetneuro.bsky.social led by Sonja W. Scholz. We highlight the latest advances in genetics and pathology. @liddelowsa.bsky.social Check it out! www.sciencedirect.com/science/arti...
Looking forward to presenting our work on oligodendrocyte dysfunction in a rare neurodegenerative movement disorder X-linked Dystonia Parkinsonism. Come say hi if you're around on Tuesday, Nov 18 between 1-5 pm! @sfn.org #SfN2025 #SfN25
@sfn.org #SfN25 #SanDiego starts this Saturday. The lab is going to be there in full force - see our presentations below.
Represented this year by @borderbiologist.bsky.social, Nick Kathman, @mrodea.bsky.social, @melcooperphd.bsky.social, @pryprk.bsky.social, @kerrylimberg.bsky.social.
(1/2)
Represented this year by @borderbiologist.bsky.social, Nick Kathman, @mrodea.bsky.social, @melcooperphd.bsky.social, @pryprk.bsky.social, @kerrylimberg.bsky.social.
(1/2)
November 10, 2025 at 11:09 PM
Reposted by Priya Prakash
(1/2)
preprints:
@melcooperphd.bsky.social - astrocyte networks pubmed.ncbi.nlm.nih.gov/40777296/
@mrodea.bsky.social - single cell analysis & diversity www.biorxiv.org/content/10.1...
@pryprk.bsky.social - XDP www.biorxiv.org/content/10.1..., www.biorxiv.org/content/10.1...
See you in San Diego
preprints:
@melcooperphd.bsky.social - astrocyte networks pubmed.ncbi.nlm.nih.gov/40777296/
@mrodea.bsky.social - single cell analysis & diversity www.biorxiv.org/content/10.1...
@pryprk.bsky.social - XDP www.biorxiv.org/content/10.1..., www.biorxiv.org/content/10.1...
See you in San Diego
November 10, 2025 at 4:43 PM
(1/2)
preprints:
@melcooperphd.bsky.social - astrocyte networks pubmed.ncbi.nlm.nih.gov/40777296/
@mrodea.bsky.social - single cell analysis & diversity www.biorxiv.org/content/10.1...
@pryprk.bsky.social - XDP www.biorxiv.org/content/10.1..., www.biorxiv.org/content/10.1...
See you in San Diego
preprints:
@melcooperphd.bsky.social - astrocyte networks pubmed.ncbi.nlm.nih.gov/40777296/
@mrodea.bsky.social - single cell analysis & diversity www.biorxiv.org/content/10.1...
@pryprk.bsky.social - XDP www.biorxiv.org/content/10.1..., www.biorxiv.org/content/10.1...
See you in San Diego
Reposted by Priya Prakash
@sfn.org #SfN25 #SanDiego starts this Saturday. The lab is going to be there in full force - see our presentations below.
Represented this year by @borderbiologist.bsky.social, Nick Kathman, @mrodea.bsky.social, @melcooperphd.bsky.social, @pryprk.bsky.social, @kerrylimberg.bsky.social.
(1/2)
Represented this year by @borderbiologist.bsky.social, Nick Kathman, @mrodea.bsky.social, @melcooperphd.bsky.social, @pryprk.bsky.social, @kerrylimberg.bsky.social.
(1/2)
November 10, 2025 at 4:43 PM
@sfn.org #SfN25 #SanDiego starts this Saturday. The lab is going to be there in full force - see our presentations below.
Represented this year by @borderbiologist.bsky.social, Nick Kathman, @mrodea.bsky.social, @melcooperphd.bsky.social, @pryprk.bsky.social, @kerrylimberg.bsky.social.
(1/2)
Represented this year by @borderbiologist.bsky.social, Nick Kathman, @mrodea.bsky.social, @melcooperphd.bsky.social, @pryprk.bsky.social, @kerrylimberg.bsky.social.
(1/2)
Liver-brain axis in neuroinflammation. Hepatic acetyl-CoA metabolism modulates neuroinflammation and depression susceptibility via acetate. www.cell.com/cell-metabol...
Hepatic acetyl-CoA metabolism modulates neuroinflammation and depression susceptibility via acetate
Cao et al. show that hepatic hydrolysis of acetyl-CoA by acyl-CoA thioesterase 12
serves as a crucial source of circulating acetate mediating liver-brain communication,
which signals the brain to buff...
www.cell.com
November 7, 2025 at 1:47 PM
Liver-brain axis in neuroinflammation. Hepatic acetyl-CoA metabolism modulates neuroinflammation and depression susceptibility via acetate. www.cell.com/cell-metabol...
Reposted by Priya Prakash
Our latest collaboration with @rongfan8.bsky.social, spatial triomics to investigate myelin and cortical brain development, and demyelination, spearheaded by Leslie Kirby in our lab @ki.se and Di Zhang in Rong's lab! Check it out @nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Spatial dynamics of brain development and neuroinflammation - Nature
A tri-omic atlas of the mouse brain from postnatal day 0 to P21 reveals that layer-specific projection neurons have a role in coordinating axonogenesis and myelination.
www.nature.com
November 5, 2025 at 4:03 PM
Our latest collaboration with @rongfan8.bsky.social, spatial triomics to investigate myelin and cortical brain development, and demyelination, spearheaded by Leslie Kirby in our lab @ki.se and Di Zhang in Rong's lab! Check it out @nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Cholesterol metabolic reprogramming mediates microglia-induced chronic neuroinflammation and hinders neurorestoration following stroke www.nature.com/articles/s42...
Cholesterol metabolic reprogramming mediates microglia-induced chronic neuroinflammation and hinders neurorestoration following stroke - Nature Metabolism
Persistent microglial activation upon ischaemic injury leads to the formation of stroke-associated foamy microglia, perpetuating long-term inflammation, white matter damage and functional impairments....
www.nature.com
November 5, 2025 at 11:00 AM
Cholesterol metabolic reprogramming mediates microglia-induced chronic neuroinflammation and hinders neurorestoration following stroke www.nature.com/articles/s42...
Reposted by Priya Prakash
Heartbreaking, well crafted thread from an immigrant scientist who’s decided being in the US isn’t worth the struggle anymore.
After 13 years in the US, I’ve made the difficult decision to leave. Having packed up everything and rethought about priorities, rather painstakingly, while I’m sad to leave the life I’ve made here, I’m also relieved that I won’t have to plan my life around immigration policies anymore.
October 31, 2025 at 1:36 PM
Heartbreaking, well crafted thread from an immigrant scientist who’s decided being in the US isn’t worth the struggle anymore.
Reposted by Priya Prakash
After 13 years in the US, I’ve made the difficult decision to leave. Having packed up everything and rethought about priorities, rather painstakingly, while I’m sad to leave the life I’ve made here, I’m also relieved that I won’t have to plan my life around immigration policies anymore.
October 31, 2025 at 4:08 AM
After 13 years in the US, I’ve made the difficult decision to leave. Having packed up everything and rethought about priorities, rather painstakingly, while I’m sad to leave the life I’ve made here, I’m also relieved that I won’t have to plan my life around immigration policies anymore.
Oligodendroglial fatty acid metabolism as a central nervous system energy reserve www.nature.com/articles/s41...
Oligodendroglial fatty acid metabolism as a central nervous system energy reserve - Nature Neuroscience
Brain functions require a constant supply of glucose. However, the brain energy stores are unclear. Here, the authors show that oligodendroglial fatty acid metabolism can be an energy reserve for whit...
www.nature.com
November 1, 2025 at 1:29 AM
Oligodendroglial fatty acid metabolism as a central nervous system energy reserve www.nature.com/articles/s41...
Reposted by Priya Prakash
We're thrilled to publish 2 exciting preprints today on the molecular pathology of X-linked Dystonia Parkinsonism!
biorxiv.org/content/10.1...
AND
biorxiv.org/content/10.1...
@nyulangone.bsky.social
biorxiv.org/content/10.1...
AND
biorxiv.org/content/10.1...
@nyulangone.bsky.social
October 8, 2025 at 5:54 PM
We're thrilled to publish 2 exciting preprints today on the molecular pathology of X-linked Dystonia Parkinsonism!
biorxiv.org/content/10.1...
AND
biorxiv.org/content/10.1...
@nyulangone.bsky.social
biorxiv.org/content/10.1...
AND
biorxiv.org/content/10.1...
@nyulangone.bsky.social
Reposted by Priya Prakash
We've been doing some amazing stuff outside the astrocyte realm.
Check out our latest Oligo investigation led by @pryprk.bsky.social !
Check out our latest Oligo investigation led by @pryprk.bsky.social !
I am proud to share our work on X-linked Dystonia-Parkinsonism — a rare neurodegenerative movement disorder driven by a SINE-VNTR-Alu retrotransposon insertion in the TAF1 gene.
Read our two companion papers:
🔹 www.biorxiv.org/content/10.1...
🔹 www.biorxiv.org/content/10.1...
🧵 Highlights below!
Read our two companion papers:
🔹 www.biorxiv.org/content/10.1...
🔹 www.biorxiv.org/content/10.1...
🧵 Highlights below!
October 24, 2025 at 4:40 PM
We've been doing some amazing stuff outside the astrocyte realm.
Check out our latest Oligo investigation led by @pryprk.bsky.social !
Check out our latest Oligo investigation led by @pryprk.bsky.social !
I am proud to share our work on X-linked Dystonia-Parkinsonism — a rare neurodegenerative movement disorder driven by a SINE-VNTR-Alu retrotransposon insertion in the TAF1 gene.
Read our two companion papers:
🔹 www.biorxiv.org/content/10.1...
🔹 www.biorxiv.org/content/10.1...
🧵 Highlights below!
Read our two companion papers:
🔹 www.biorxiv.org/content/10.1...
🔹 www.biorxiv.org/content/10.1...
🧵 Highlights below!
October 24, 2025 at 4:32 PM
I am proud to share our work on X-linked Dystonia-Parkinsonism — a rare neurodegenerative movement disorder driven by a SINE-VNTR-Alu retrotransposon insertion in the TAF1 gene.
Read our two companion papers:
🔹 www.biorxiv.org/content/10.1...
🔹 www.biorxiv.org/content/10.1...
🧵 Highlights below!
Read our two companion papers:
🔹 www.biorxiv.org/content/10.1...
🔹 www.biorxiv.org/content/10.1...
🧵 Highlights below!
Myelin injury precedes axonal injury and symptomatic onset in multiple sclerosis www.nature.com/articles/s41...
Myelin injury precedes axonal injury and symptomatic onset in multiple sclerosis - Nature Medicine
Myelin damage in multiple sclerosis can be detected up to 7 years before symptoms, with early immune pathway activation and a 21-protein panel showing promise for presymptomatic diagnosis.
www.nature.com
October 22, 2025 at 2:50 AM
Myelin injury precedes axonal injury and symptomatic onset in multiple sclerosis www.nature.com/articles/s41...
Microglia-specific regulation of lipid metabolism in Alzheimer’s disease revealed by microglial depletion in 5xFAD mice www.nature.com/articles/s41...
Microglia-specific regulation of lipid metabolism in Alzheimer’s disease revealed by microglial depletion in 5xFAD Mice - Nature Communications
Alzheimer’s disease disrupts brain lipid metabolism; while microglia are likely implicated, the relationship is unclear. Here, the authors show that microglia selectively regulate lysosomal and myelin...
www.nature.com
October 19, 2025 at 3:49 PM
Microglia-specific regulation of lipid metabolism in Alzheimer’s disease revealed by microglial depletion in 5xFAD mice www.nature.com/articles/s41...
Reposted by Priya Prakash
🧠 The Lipid #Brain Atlas is out now! If you think #lipids are boring and membranes are all the same, prepare to be surprised. Led by @lucafusarbassini.bsky.social with Giovanni D'Angelo's lab, we mapped membrane lipids in the mouse brain at high resolution.
www.biorxiv.org/cgi/content/...
www.biorxiv.org/cgi/content/...
October 16, 2025 at 6:23 AM
🧠 The Lipid #Brain Atlas is out now! If you think #lipids are boring and membranes are all the same, prepare to be surprised. Led by @lucafusarbassini.bsky.social with Giovanni D'Angelo's lab, we mapped membrane lipids in the mouse brain at high resolution.
www.biorxiv.org/cgi/content/...
www.biorxiv.org/cgi/content/...
PICALM Alzheimer’s risk allele causes aberrant lipid droplets in microglia www-nature-com.ezproxy.med.nyu.edu/articles/s41...
Choose Your Affiliation - NYU Health Sciences Library
www-nature-com.ezproxy.med.nyu.edu
October 1, 2025 at 2:51 PM
PICALM Alzheimer’s risk allele causes aberrant lipid droplets in microglia www-nature-com.ezproxy.med.nyu.edu/articles/s41...
Huntington's disease successfully treated for first time www.bbc.com/news/article...
September 24, 2025 at 5:44 PM
Huntington's disease successfully treated for first time www.bbc.com/news/article...
Mitochondrial transfer www.nature.com/articles/s42...
Mitochondrial transfer - Nature Metabolism
Intercellular mitochondrial transfer has recently attracted substantial attention, both from a fundamental and therapeutic point of view. At the same time, the topic continues to be met with scepticis...
www.nature.com
August 28, 2025 at 11:37 AM
Mitochondrial transfer www.nature.com/articles/s42...
Happy to share that I have been awarded an @alzassociation.bsky.social grant to advance our work on astrocyte lipids in tau-mediated neurodegeneration. Important gaps remain in understanding glial lipid metabolism in AD and related diseases, and I’m excited to drive this work forward! #ALZFunded
August 22, 2025 at 8:21 PM
Happy to share that I have been awarded an @alzassociation.bsky.social grant to advance our work on astrocyte lipids in tau-mediated neurodegeneration. Important gaps remain in understanding glial lipid metabolism in AD and related diseases, and I’m excited to drive this work forward! #ALZFunded
Reposted by Priya Prakash
Out today in @nature.com: Together with the Honigmann, Shevchenko, Drobot and Hof labs, we present a general workflow for imaging the localization and transport of individual lipids in cells and mapping their metabolism.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
August 21, 2025 at 5:19 AM
Out today in @nature.com: Together with the Honigmann, Shevchenko, Drobot and Hof labs, we present a general workflow for imaging the localization and transport of individual lipids in cells and mapping their metabolism.
www.nature.com/articles/s41...
www.nature.com/articles/s41...