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Priya Prakash @pryprk.bsky.social · 7d

PICALM Alzheimer’s risk allele causes aberrant lipid droplets in microglia www-nature-com.ezproxy.med.nyu.edu/articles/s41...

Choose Your Affiliation - NYU Health Sciences Library

www-nature-com.ezproxy.med.nyu.edu

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Priya Prakash @pryprk.bsky.social · 13d

Huntington's disease successfully treated for first time www.bbc.com/news/article...

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Priya Prakash @pryprk.bsky.social · Aug 28

Mitochondrial transfer www.nature.com/articles/s42...

Mitochondrial transfer - Nature Metabolism

Intercellular mitochondrial transfer has recently attracted substantial attention, both from a fundamental and therapeutic point of view. At the same time, the topic continues to be met with scepticis...

www.nature.com

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Priya Prakash @pryprk.bsky.social · Aug 22

Happy to share that I have been awarded an @alzassociation.bsky.social grant to advance our work on astrocyte lipids in tau-mediated neurodegeneration. Important gaps remain in understanding glial lipid metabolism in AD and related diseases, and I’m excited to drive this work forward! #ALZFunded

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Reposted by Priya Prakash

André Nadler @nadlerlab.bsky.social · Aug 21

Out today in @nature.com: Together with the Honigmann, Shevchenko, Drobot and Hof labs, we present a general workflow for imaging the localization and transport of individual lipids in cells and mapping their metabolism.
www.nature.com/articles/s41...

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Priya Prakash @pryprk.bsky.social · Aug 18

Postdoc paper submitted! Venturing into a completely new research direction with incredible collaborators and a fascinating finding. Excited to see how it all pans out! 🚀

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Priya Prakash @pryprk.bsky.social · Aug 18

Dysregulated lipid metabolism in Alzheimer’s disease causes lipid buildup in microglia, reducing the immune cell’s ability to clear amyloid beta plaques.

Original article: www.cell.com/immunity/ful...

Amyloid-β induces lipid droplet-mediated microglial dysfunction via the enzyme DGAT2 in Alzheimer’s disease

Why microglia stop reducing amyloid deposits from Alzheimer’s disease (AD) brains is unknown. Prakash, Manchanda, et al. show that microglia increase their lipid droplets and lose their phagocytic cap...

www.cell.com

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Priya Prakash @pryprk.bsky.social · Aug 18

'Amyloid Beta Impairs Microglia Function in Alzheimer’s Disease' the-scientist.com/amyloid-beta... Our work on microglial lipid droplets in Alzheimer's disease featured on The Scientist by Shelby Bradford.

Amyloid Beta Impairs Microglia Function in Alzheimer’s Disease

Dysregulated lipid metabolism in Alzheimer’s disease causes lipid buildup in microglia, reducing the immune cell’s ability to clear amyloid beta plaques.

the-scientist.com

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Priya Prakash @pryprk.bsky.social · Aug 15

Of course!

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Priya Prakash @pryprk.bsky.social · Aug 15

We worked with Emma from Draw Impacts for our cover art submission for Immunity. bsky.app/profile/pryp...

Priya Prakash @pryprk.bsky.social · May 21

Meet M, our microglia superheroine 🦸‍♀️💥

After chugging the magical DGAT2-Stop! Kool-Aid 💊🧃, she breaks free from her lipid droplet shackles 💥💪

Supercharged, she lifts the amyloid beams 🧱 trapping neurons and saves the city of Brain 🧠🏙️!

Our cover submission for @cp-immunity.bsky.social. #notthecover

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Priya Prakash @pryprk.bsky.social · Aug 15

Glia-derived noncanonical fatty acid binding protein modulates brain lipid storage and clearance www.science.org/doi/10.1126/... Fly glia secrete Obp44a, a fatty acid binding protein, that binds long-chain fatty acids and shuttles between glia and neurons.

Glia-derived noncanonical fatty acid binding protein modulates brain lipid storage and clearance

Glial lipid chaperone Obp44a maintains brain health by regulating lipid transport, waste clearance, and stress responses.

www.science.org

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Priya Prakash @pryprk.bsky.social · Aug 15

Haha watch out!

a sign that says do not enter hangs above a woman

ALT: a sign that says do not enter hangs above a woman

media.tenor.com

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Priya Prakash @pryprk.bsky.social · Aug 14

Sadaf! I somehow missed this update. Congratulations! 🎉What a fantastic news! 🙌

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Priya Prakash @pryprk.bsky.social · Aug 14

If I have to read one more 'single cell atlas' paper... 😑

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Priya Prakash @pryprk.bsky.social · Aug 13

Brain myelin as a deficient energy source in aging and disease www.cell.com/trends/endoc... Excellent discussion on how myelin fatty acid reserves may be reallocated during aging and neurodegeneration

Brain myelin as a deficient energy source in aging and disease

Central nervous system (CNS) myelin may act as a dynamic energy store that supports brain metabolism; its consumption and replenishment is a newly recognized form of metabolic plasticity aimed at main...

www.cell.com

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Priya Prakash @pryprk.bsky.social · Aug 7

Lipid metabolism and neuroinflammation: What is the link? rupress.org/jem/article/... Another nice review covering lipid metabolism in the CNS, including discussion of interferon pathways and their connection to lipid regulation

Lipid metabolism and neuroinflammation: What is the link? | Journal of Experimental Medicine | Rockefeller University Press

Glial cells and lipoproteins coordinate lipid and immune signaling to regulate CNS inflammation. This review explores the relationship between lipid metabo

rupress.org

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Priya Prakash @pryprk.bsky.social · Aug 3

Triglycerides are an important fuel reserve for synapse function in the brain www.nature.com/articles/s42...

Triglycerides are an important fuel reserve for synapse function in the brain - Nature Metabolism

Kumar et al. show that under glucose-depleted conditions, neurons can use fatty acids as an alternative source of energy to support synaptic function.

www.nature.com

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Priya Prakash @pryprk.bsky.social · Jul 14

thank you! :)

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Priya Prakash @pryprk.bsky.social · Jul 13

Excited to share @thehindu.com coverage of our research: “Immune cells’ fat blocks brain’s ability to clean Alzheimer’s plaques” -- now out in print and online! Grateful to Manjeera Gowravaram for the thoughtful and clear storytelling. www.thehindu.com/sci-tech/sci...

Immune cells’ fat blocks brain’s ability to clean Alzheimer’s plaques

Alzheimer's disease progression linked to microglia fat metabolism, potential new treatment target identified in recent study.

www.thehindu.com

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Priya Prakash @pryprk.bsky.social · May 31

Thank you so much for your kind words!

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Priya Prakash @pryprk.bsky.social · May 31

thank you! the kool-aid is the DGAT2 degrader (i.e., that reduces lipid droplets in microglia so they can get rid of the amyloid) :)

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Reposted by Priya Prakash

Danielle Beckman @daniellebeckman.bsky.social · May 30

How this image is #notthecover? It's the coolest one I've seen in a while! All praise to M, our microglia savior, for destroying amyloid and rescuing neurons!

Priya Prakash @pryprk.bsky.social · May 21

Meet M, our microglia superheroine 🦸‍♀️💥

After chugging the magical DGAT2-Stop! Kool-Aid 💊🧃, she breaks free from her lipid droplet shackles 💥💪

Supercharged, she lifts the amyloid beams 🧱 trapping neurons and saves the city of Brain 🧠🏙️!

Our cover submission for @cp-immunity.bsky.social. #notthecover

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Priya Prakash @pryprk.bsky.social · May 30

Thank you, Danielle! @cp-immunity.bsky.social

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Priya Prakash @pryprk.bsky.social · May 21

tiny but significant* details 😅

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Priya Prakash @pryprk.bsky.social · May 21

Thanks so much, Kelsey! I'm a superman fan and wanted to make a microglia superwoman 😅 We also tossed around a Star Wars–themed cover idea but the superwoman ultimately won! 🦸‍♀️ @davalos.bsky.social came up with the idea of DGAT2 kool-aid, lipid droplet shackles, and all the tiny details! 🙌

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