Gonçalo Castelo-Branco
@gocastelobranco.bsky.social
Professor of Glial Cell Biology @ Karolinska Institutet, Stockholm, Sweden • epigenomics • single-cell • spatial • oligodendrocytes • myelin • multiple sclerosis • 🎧 Stella Explorer • https://ki.se/en/people/goncalo-castelo-branco
Pinned
Spatial dynamics of brain development and neuroinflammation - Nature
A tri-omic atlas of the mouse brain from postnatal day 0 to P21 reveals that layer-specific projection neurons have a role in coordinating axonogenesis and myelination.
www.nature.com
Our latest collaboration with @rongfan8.bsky.social, spatial triomics to investigate myelin and cortical brain development, and demyelination, spearheaded by Leslie Kirby in our lab @ki.se and Di Zhang in Rong's lab! Check it out @nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Gonçalo Castelo-Branco
🧬 Gonçalo Castelo-Branco | Plenary Speaker
How do glial cells influence disease and brain repair? On 10 July at #FENS2026, join Prof. Gonçalo Castelo-Branco to explore the molecular mechanisms behind #oligodendrocyte lineage cells in development and #neuroinflammatory diseases.
How do glial cells influence disease and brain repair? On 10 July at #FENS2026, join Prof. Gonçalo Castelo-Branco to explore the molecular mechanisms behind #oligodendrocyte lineage cells in development and #neuroinflammatory diseases.
November 21, 2025 at 8:00 AM
🧬 Gonçalo Castelo-Branco | Plenary Speaker
How do glial cells influence disease and brain repair? On 10 July at #FENS2026, join Prof. Gonçalo Castelo-Branco to explore the molecular mechanisms behind #oligodendrocyte lineage cells in development and #neuroinflammatory diseases.
How do glial cells influence disease and brain repair? On 10 July at #FENS2026, join Prof. Gonçalo Castelo-Branco to explore the molecular mechanisms behind #oligodendrocyte lineage cells in development and #neuroinflammatory diseases.
Reposted by Gonçalo Castelo-Branco
A new study in @natneuro.nature.com by @gocastelobranco.bsky.social et al explores how oligodendrocytes respond in #MultipleSclerosis. The researchers identified distinct and early disease-related states and gene activity patterns that may help explain how #MS progresses 🧪 news.ki.se/oligodendroc...
Oligodendrocytes show early changes in multiple sclerosis
A new study from Karolinska Institutet, published in Nature Neuroscience, explores how oligodendrocytes, the cells that produce myelin in the brain and spinal cord, respond during the development of m...
news.ki.se
November 17, 2025 at 1:22 PM
A new study in @natneuro.nature.com by @gocastelobranco.bsky.social et al explores how oligodendrocytes respond in #MultipleSclerosis. The researchers identified distinct and early disease-related states and gene activity patterns that may help explain how #MS progresses 🧪 news.ki.se/oligodendroc...
Our paper, driven by Chao Zheng and Bastien Hervé in the lab @ki.se, is now out in @natneuro.nature.com!
Check it out at:
www.nature.com/articles/s41...
with @pkukanja.bsky.social, @deckardw.bsky.social, among others
Check it out at:
www.nature.com/articles/s41...
with @pkukanja.bsky.social, @deckardw.bsky.social, among others
Distinct transcriptomic and epigenomic responses of mature oligodendrocytes during disease progression in a mouse model of multiple sclerosis - Nature Neuroscience
Single-cell ATAC/RNA multiomic profiling was used to investigate how oligodendrocyte lineage cells respond across multiple disease stages within a mouse MS model, revealing early activation of immune ...
www.nature.com
November 17, 2025 at 10:30 AM
Our paper, driven by Chao Zheng and Bastien Hervé in the lab @ki.se, is now out in @natneuro.nature.com!
Check it out at:
www.nature.com/articles/s41...
with @pkukanja.bsky.social, @deckardw.bsky.social, among others
Check it out at:
www.nature.com/articles/s41...
with @pkukanja.bsky.social, @deckardw.bsky.social, among others
Our latest, a tour de force from @carlstrom.bsky.social ! And here is my soundtrack for the journey, The Bike Song, by Mark Ronson and The Business Intl, dedicated to Karl's bike!
youtu.be/rVELTxKRoHA?...
youtu.be/rVELTxKRoHA?...
November 14, 2025 at 5:32 AM
Our latest, a tour de force from @carlstrom.bsky.social ! And here is my soundtrack for the journey, The Bike Song, by Mark Ronson and The Business Intl, dedicated to Karl's bike!
youtu.be/rVELTxKRoHA?...
youtu.be/rVELTxKRoHA?...
Join us for the inaugural annual Ernest Arenas Memorial Lecture at the Nobel Forum at @ki.se.
with Prof. Roger Barker, University of Cambridge
"Repairing the human brain using transplants - is it possible? The story of Parkinson's disease"
Tuesday November 25th at 15:00
news.ki.se/calendar/the...
with Prof. Roger Barker, University of Cambridge
"Repairing the human brain using transplants - is it possible? The story of Parkinson's disease"
Tuesday November 25th at 15:00
news.ki.se/calendar/the...
The Ernest Arenas Memorial Lecture: Repairing the human brain using transplants- Is it possible? The story of Parkinson's disease.
Welcome to The Ernest Arenas Memorial Lecture with Professor Roger Barker, Professor of Clinical Neuroscience at the University of Cambridge and Consultant Neurologist at Addenbrooke's Hospital.
news.ki.se
November 10, 2025 at 9:58 PM
Join us for the inaugural annual Ernest Arenas Memorial Lecture at the Nobel Forum at @ki.se.
with Prof. Roger Barker, University of Cambridge
"Repairing the human brain using transplants - is it possible? The story of Parkinson's disease"
Tuesday November 25th at 15:00
news.ki.se/calendar/the...
with Prof. Roger Barker, University of Cambridge
"Repairing the human brain using transplants - is it possible? The story of Parkinson's disease"
Tuesday November 25th at 15:00
news.ki.se/calendar/the...
Reposted by Gonçalo Castelo-Branco
Researchers @ki.se and Yale University have created a multidimensional, molecular map of how the mouse #brain develops after birth and how it reacts to #inflammation #research supported by Knut and Alice Wallenberg Foundation #MS #neuroscience
@gocastelobranco.bsky.social
news.ki.se/scientists-m...
@gocastelobranco.bsky.social
news.ki.se/scientists-m...
Scientists map how the brain develops – and how it resolves inflammation
Researchers at Karolinska Institutet and Yale University have created a multidimensional, molecular map of how the mouse brain develops after birth and how it reacts to inflammation. The study, which ...
news.ki.se
November 6, 2025 at 9:38 AM
Researchers @ki.se and Yale University have created a multidimensional, molecular map of how the mouse #brain develops after birth and how it reacts to #inflammation #research supported by Knut and Alice Wallenberg Foundation #MS #neuroscience
@gocastelobranco.bsky.social
news.ki.se/scientists-m...
@gocastelobranco.bsky.social
news.ki.se/scientists-m...
Reposted by Gonçalo Castelo-Branco
Researchers at KI and @yale.edu have created a multidimensional, molecular map of how the mouse #brain develops after birth and how it reacts to #inflammation. The study is published in @nature.com. 🧪 #neuroscience news.ki.se/scientists-m...
November 6, 2025 at 10:45 AM
Researchers at KI and @yale.edu have created a multidimensional, molecular map of how the mouse #brain develops after birth and how it reacts to #inflammation. The study is published in @nature.com. 🧪 #neuroscience news.ki.se/scientists-m...
Our latest collaboration with @rongfan8.bsky.social, spatial triomics to investigate myelin and cortical brain development, and demyelination, spearheaded by Leslie Kirby in our lab @ki.se and Di Zhang in Rong's lab! Check it out @nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Spatial dynamics of brain development and neuroinflammation - Nature
A tri-omic atlas of the mouse brain from postnatal day 0 to P21 reveals that layer-specific projection neurons have a role in coordinating axonogenesis and myelination.
www.nature.com
November 5, 2025 at 4:03 PM
Our latest collaboration with @rongfan8.bsky.social, spatial triomics to investigate myelin and cortical brain development, and demyelination, spearheaded by Leslie Kirby in our lab @ki.se and Di Zhang in Rong's lab! Check it out @nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Gonçalo Castelo-Branco
🧠 The Lipid #Brain Atlas is out now! If you think #lipids are boring and membranes are all the same, prepare to be surprised. Led by @lucafusarbassini.bsky.social with Giovanni D'Angelo's lab, we mapped membrane lipids in the mouse brain at high resolution.
www.biorxiv.org/cgi/content/...
www.biorxiv.org/cgi/content/...
October 16, 2025 at 6:23 AM
🧠 The Lipid #Brain Atlas is out now! If you think #lipids are boring and membranes are all the same, prepare to be surprised. Led by @lucafusarbassini.bsky.social with Giovanni D'Angelo's lab, we mapped membrane lipids in the mouse brain at high resolution.
www.biorxiv.org/cgi/content/...
www.biorxiv.org/cgi/content/...
Fantastic Gioele!
🧠 The Lipid #Brain Atlas is out now! If you think #lipids are boring and membranes are all the same, prepare to be surprised. Led by @lucafusarbassini.bsky.social with Giovanni D'Angelo's lab, we mapped membrane lipids in the mouse brain at high resolution.
www.biorxiv.org/cgi/content/...
www.biorxiv.org/cgi/content/...
October 16, 2025 at 7:47 AM
Fantastic Gioele!
Developing Brains on!
October 8, 2025 at 7:06 AM
Developing Brains on!
Reposted by Gonçalo Castelo-Branco
The 2025 #NobelPrize in Physiology or Medicine has been awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi for their groundbreaking discoveries concerning peripheral immune tolerance that prevents the immune system from harming the body 🧪 www.nobelprize.org/prizes/medic...
October 6, 2025 at 9:42 AM
The 2025 #NobelPrize in Physiology or Medicine has been awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi for their groundbreaking discoveries concerning peripheral immune tolerance that prevents the immune system from harming the body 🧪 www.nobelprize.org/prizes/medic...
Ana Falcão's lab latest on multi-omics profiling of the Lateral Ventricle Choroid Plexus!
@icvs-uminho.bsky.social
www.biorxiv.org/content/10.1...
@icvs-uminho.bsky.social
www.biorxiv.org/content/10.1...
Multi-omics Profiling of the Lateral Ventricle Choroid Plexus Reveals Developmental Cellular Remodeling, Early Immune Gene Activation, and a Novel Epithelial Subtype
Healthy brain development and function highly depend on the choroid plexus. Temporal alterations in the cellular landscape and gene expression of choroid plexus cells can alter immune cell trafficking...
www.biorxiv.org
September 1, 2025 at 7:03 PM
Ana Falcão's lab latest on multi-omics profiling of the Lateral Ventricle Choroid Plexus!
@icvs-uminho.bsky.social
www.biorxiv.org/content/10.1...
@icvs-uminho.bsky.social
www.biorxiv.org/content/10.1...
Deadline (September 2) approaching! Join us and start your lab at @ki.se!
The call just opened!
ki.se/en/about-ki/...
You can apply to several departments simultaneously, check out which depts better fit your profile! Here is the call for our Department of Medical Biochemistry and Biophysics
ki.varbi.com/what:job/job...
ki.se/en/about-ki/...
You can apply to several departments simultaneously, check out which depts better fit your profile! Here is the call for our Department of Medical Biochemistry and Biophysics
ki.varbi.com/what:job/job...
August 23, 2025 at 7:42 AM
Deadline (September 2) approaching! Join us and start your lab at @ki.se!
Reposted by Gonçalo Castelo-Branco
Please RP.
We are thrilled to announce that our lab’s first preprint is out!
”Whole-genome single-cell multimodal history tracing to reveal cell identity transition”
We report HisTrac-seq, a multiomic single-cell molecular recording platform.
www.biorxiv.org/content/10.1...
We are thrilled to announce that our lab’s first preprint is out!
”Whole-genome single-cell multimodal history tracing to reveal cell identity transition”
We report HisTrac-seq, a multiomic single-cell molecular recording platform.
www.biorxiv.org/content/10.1...
August 16, 2025 at 7:15 AM
Please RP.
We are thrilled to announce that our lab’s first preprint is out!
”Whole-genome single-cell multimodal history tracing to reveal cell identity transition”
We report HisTrac-seq, a multiomic single-cell molecular recording platform.
www.biorxiv.org/content/10.1...
We are thrilled to announce that our lab’s first preprint is out!
”Whole-genome single-cell multimodal history tracing to reveal cell identity transition”
We report HisTrac-seq, a multiomic single-cell molecular recording platform.
www.biorxiv.org/content/10.1...
Reposted by Gonçalo Castelo-Branco
Wallenberg Scholar @gocastelobranco.bsky.social @ki.se is seeking to discover what happens in the brain during the progression of #multiplesclerosis (MS). His findings may lead to new ways of diagnosing and treating the disease earlier than is currently possible #research tinyurl.com/3kb22kkh
New methods to map the progression of MS | Knut and Alice Wallenberg Foundation
Wallenberg Scholar Gonçalo Castelo-Branco is seeking to discover what happens in the brain during the progression of multiple sclerosis (MS). His findings may lead to new ways of diagnosing and treati...
tinyurl.com
August 13, 2025 at 8:09 AM
Wallenberg Scholar @gocastelobranco.bsky.social @ki.se is seeking to discover what happens in the brain during the progression of #multiplesclerosis (MS). His findings may lead to new ways of diagnosing and treating the disease earlier than is currently possible #research tinyurl.com/3kb22kkh
Join us at the FENS Single-Cell & Spatial Omics Winter School with:
@sarabiz86.bsky.social
@rongfan8.bsky.social
@gokcegroup.bsky.social
@gioelelamanno.bsky.social
@sj-marzi.bsky.social
@jplopez-atalaya.bsky.social
Ana Falcão
Florian Rosenberger
Gabriel Baró
Bosiljka Tasic
Barbara Treutlein
@sarabiz86.bsky.social
@rongfan8.bsky.social
@gokcegroup.bsky.social
@gioelelamanno.bsky.social
@sj-marzi.bsky.social
@jplopez-atalaya.bsky.social
Ana Falcão
Florian Rosenberger
Gabriel Baró
Bosiljka Tasic
Barbara Treutlein
🌟 Registration is now OPEN! 🌟
Join the 2025-2026 #FENS-Hertie #WinterSchool and explore this year's topic – Single-cell and Spatial Omics to Understand Brain Heterogeneity! 🔬
📍 Alicante, Spain
🗓️ 11-17 Jan 2026
🔗 https://loom.ly/RM55lFQ
Join the 2025-2026 #FENS-Hertie #WinterSchool and explore this year's topic – Single-cell and Spatial Omics to Understand Brain Heterogeneity! 🔬
📍 Alicante, Spain
🗓️ 11-17 Jan 2026
🔗 https://loom.ly/RM55lFQ
August 12, 2025 at 11:24 AM
Join us at the FENS Single-Cell & Spatial Omics Winter School with:
@sarabiz86.bsky.social
@rongfan8.bsky.social
@gokcegroup.bsky.social
@gioelelamanno.bsky.social
@sj-marzi.bsky.social
@jplopez-atalaya.bsky.social
Ana Falcão
Florian Rosenberger
Gabriel Baró
Bosiljka Tasic
Barbara Treutlein
@sarabiz86.bsky.social
@rongfan8.bsky.social
@gokcegroup.bsky.social
@gioelelamanno.bsky.social
@sj-marzi.bsky.social
@jplopez-atalaya.bsky.social
Ana Falcão
Florian Rosenberger
Gabriel Baró
Bosiljka Tasic
Barbara Treutlein
Reposted by Gonçalo Castelo-Branco
🧪Move over CUT&Tag, there’s a new #TranscriptionFactor mapping method in town.
Our newly developed DynaTag is faster, cleaner, more sensitive than #ChIPseq, #CUT&RUN and #CUT&Tag.
🔗 Our @natcomms.nature.com paper: www.nature.com/articles/s41...
🧵Let’s break down what makes DynaTag so powerful (1/7)
Our newly developed DynaTag is faster, cleaner, more sensitive than #ChIPseq, #CUT&RUN and #CUT&Tag.
🔗 Our @natcomms.nature.com paper: www.nature.com/articles/s41...
🧵Let’s break down what makes DynaTag so powerful (1/7)
July 28, 2025 at 9:10 AM
🧪Move over CUT&Tag, there’s a new #TranscriptionFactor mapping method in town.
Our newly developed DynaTag is faster, cleaner, more sensitive than #ChIPseq, #CUT&RUN and #CUT&Tag.
🔗 Our @natcomms.nature.com paper: www.nature.com/articles/s41...
🧵Let’s break down what makes DynaTag so powerful (1/7)
Our newly developed DynaTag is faster, cleaner, more sensitive than #ChIPseq, #CUT&RUN and #CUT&Tag.
🔗 Our @natcomms.nature.com paper: www.nature.com/articles/s41...
🧵Let’s break down what makes DynaTag so powerful (1/7)
Reposted by Gonçalo Castelo-Branco
🚨 Don’t forget to register for #Neuroepi25!
⏳ The deadline is fast approaching - Thursday 7th August 2025.
This is your last chance to join; don't miss out on a fantastic meeting!
Click here to register➡️ bit.ly/4f5Zpbq
#FusionNeuro #FusionAgingResearch #FusionEpigenetics
⏳ The deadline is fast approaching - Thursday 7th August 2025.
This is your last chance to join; don't miss out on a fantastic meeting!
Click here to register➡️ bit.ly/4f5Zpbq
#FusionNeuro #FusionAgingResearch #FusionEpigenetics
July 21, 2025 at 10:15 AM
🚨 Don’t forget to register for #Neuroepi25!
⏳ The deadline is fast approaching - Thursday 7th August 2025.
This is your last chance to join; don't miss out on a fantastic meeting!
Click here to register➡️ bit.ly/4f5Zpbq
#FusionNeuro #FusionAgingResearch #FusionEpigenetics
⏳ The deadline is fast approaching - Thursday 7th August 2025.
This is your last chance to join; don't miss out on a fantastic meeting!
Click here to register➡️ bit.ly/4f5Zpbq
#FusionNeuro #FusionAgingResearch #FusionEpigenetics
12th Dev Brains:
@junyuecao.bsky.social @alainchedotal.bsky.social
@cecilecharrier.bsky.social
@trayon.bsky.social
Isabel Espinosa-Medina
Beatriz Rico
Michael Ziller
Dwight Bergles
news.ki.se/calendar/dev...
@hjerling-leffler.bsky.social
@ulrikakmarklund.bsky.social
@flallemend.bsky.social
@junyuecao.bsky.social @alainchedotal.bsky.social
@cecilecharrier.bsky.social
@trayon.bsky.social
Isabel Espinosa-Medina
Beatriz Rico
Michael Ziller
Dwight Bergles
news.ki.se/calendar/dev...
@hjerling-leffler.bsky.social
@ulrikakmarklund.bsky.social
@flallemend.bsky.social
July 12, 2025 at 9:53 PM
12th Dev Brains:
@junyuecao.bsky.social @alainchedotal.bsky.social
@cecilecharrier.bsky.social
@trayon.bsky.social
Isabel Espinosa-Medina
Beatriz Rico
Michael Ziller
Dwight Bergles
news.ki.se/calendar/dev...
@hjerling-leffler.bsky.social
@ulrikakmarklund.bsky.social
@flallemend.bsky.social
@junyuecao.bsky.social @alainchedotal.bsky.social
@cecilecharrier.bsky.social
@trayon.bsky.social
Isabel Espinosa-Medina
Beatriz Rico
Michael Ziller
Dwight Bergles
news.ki.se/calendar/dev...
@hjerling-leffler.bsky.social
@ulrikakmarklund.bsky.social
@flallemend.bsky.social
Reposted by Gonçalo Castelo-Branco
Neuron programming! Pro-neural TFs + 480 morphogen conditions + scRNA-seq --> Diverse iN subtypes of forebrain, midbrain, hindbrain, spinal cord, and PNS. @hsiuchuanlin.bsky.social @jasperjanssens.bsky.social and Treutlein Lab! @science.org www.science.org/doi/10.1126/... #NGN2 #ASCL1
July 11, 2025 at 8:59 PM
Neuron programming! Pro-neural TFs + 480 morphogen conditions + scRNA-seq --> Diverse iN subtypes of forebrain, midbrain, hindbrain, spinal cord, and PNS. @hsiuchuanlin.bsky.social @jasperjanssens.bsky.social and Treutlein Lab! @science.org www.science.org/doi/10.1126/... #NGN2 #ASCL1
@carlstrom.bsky.social Clemens Ries, and Ting Sun rocking at #GLIA2025! And the launch of the Carlström lab!
July 11, 2025 at 6:55 PM
@carlstrom.bsky.social Clemens Ries, and Ting Sun rocking at #GLIA2025! And the launch of the Carlström lab!
Great to catch up with @rongfan8.bsky.social in Marseille, where we both end up for two completely unrelated conferences!
July 10, 2025 at 3:54 PM
Great to catch up with @rongfan8.bsky.social in Marseille, where we both end up for two completely unrelated conferences!
The call just opened!
ki.se/en/about-ki/...
You can apply to several departments simultaneously, check out which depts better fit your profile! Here is the call for our Department of Medical Biochemistry and Biophysics
ki.varbi.com/what:job/job...
ki.se/en/about-ki/...
You can apply to several departments simultaneously, check out which depts better fit your profile! Here is the call for our Department of Medical Biochemistry and Biophysics
ki.varbi.com/what:job/job...
June 25, 2025 at 1:59 PM
The call just opened!
ki.se/en/about-ki/...
You can apply to several departments simultaneously, check out which depts better fit your profile! Here is the call for our Department of Medical Biochemistry and Biophysics
ki.varbi.com/what:job/job...
ki.se/en/about-ki/...
You can apply to several departments simultaneously, check out which depts better fit your profile! Here is the call for our Department of Medical Biochemistry and Biophysics
ki.varbi.com/what:job/job...